119 completed, 38 recruiting, 33 unknown, 20 active not recruiting. 221 Not applicable, 2 Phase 1.
Follow Loneliness: new trials by email Literature Review of Loneliness trials Research Report on Loneliness
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| CommunityRx-Dementia + Peer Navigation (CRxDpeer) CommunityRx-Dpeer - Alzheimer s Disease, Dementia | Not applicable | Recruiting | University of Chicago | 330 | 2026-10-05 | 2026-10-13 |
| Thrive at Home: A Virtual Reality Social Intervention for Older Adults Full Virtual Reality Social Intervention, Abbreviated Virtual Reality Social Intervention - Mental Health (Depression), Mental Health and General Well-being | Not applicable | Not yet recruiting | University of California, Santa Barbara | 250 | 2026-10-01 | 2026-09-25 |
| Mindfulness for Lonely Older Adults With Emigrant Children Intervention, Active Control - Loneliness, Sleep Quality | Not applicable | Not yet recruiting | Hong Kong Metropolitan University | 90 | 2026-10-01 | 2026-07-17 |
| Applying Comfort Theory to an AI-Assisted Group Music Intervention: Psychosocial and Physiological Outcomes and Feasibility in Long-Term Care Residents. Group music intervention, AI-assisted monitoring system - Comfort Theory, AI-Assisted Group Music Intervention | Not applicable | Not yet recruiting | Yu Chia Chang | 60 | 2026-10-01 | 2026-10-20 |
| Effectiveness of a Psychological Intervention to Reduce Social Isolation and Promote Social Connectedness in Young Adults Digital-Assisted Group Social Skills Training - Social Isolation, Loneliness | Not applicable | Not yet recruiting | Korea University | 80 | 2026-09-30 | 2026-09-24 |
| Digital Storytelling-Based Psychoeducation for Loneliness and Self-Efficacy in Adults Aged 65-74 Digital Storytelling-Based Psychoeducation - Loneliness, Self-Efficacy | Not applicable | Recruiting | Şura KILIÇ | 60 | 2026-09-23 | 2026-10-16 |
| A Mechanism Randomised Controlled Trial of a Three-Agent LLM-Augmented mHealth Intervention for Late-Life Loneliness in Older Adults Hybrid conversational companion application, Rule-based conversational companion application - Loneliness, Social Isolation | Not applicable | Not yet recruiting | The University of Hong Kong | 72 | 2026-09-21 | 2026-09-16 |
| Nostalgia Intervention on Alleviating Loneliness Amongst Older Adults Nostalgia intervention - Loneliness | Not applicable | Not yet recruiting | Chinese University of Hong Kong | 294 | 2026-09-01 | 2025-12-23 |
| Student Precarity and Psychiatry Questionnaires - Depressive Disorder, Major, Generalized Anxiety Disorder | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 45000 | 2026-09-01 | 2026-06-15 | |
| Latin Dance and Psychological Health in Primary School Children Latin Dance Program, Regular Physical Education Program - Loneliness, Anxiety | Not applicable | Not yet recruiting | Xu Shuishui | 60 | 2026-09-01 | 2026-08-10 |
| Creating Encounters Between Generations - Together Instead of Alone (GemsE) Mechanisms and effectiveness of intergenerational tandems - Loneliness, Mental Well-being | Not applicable | Recruiting | Universitätsklinikum Hamburg-Eppendorf | 80 | 2026-09-01 | 2026-08-10 |
| The Effects of Psilocybin on Social Connectedness Psilocybin, Placebo - Loneliness, Grief | Phase 1 | Not yet recruiting | Yale University | 51 | 2026-08-31 | 2026-07-09 |
| Autobiographical Time Travel to Alleviate Loneliness in Older Adults Mental Time Travel Group, Social Engagement Group Activities - Aging, Loneliness | Not applicable | Not yet recruiting | Baycrest | 144 | 2026-08-15 | 2026-08-28 |
| The ALIVE-Project: Activity, Life Satisfaction, Inclusion, Vitality, Elderly Women Supervised Group Exercise in Fitness Clubs, Individual exercise - Loneliness, Social Isolation in Older Adults | Not applicable | Recruiting | Norwegian School of Sport Sciences | 213 | 2026-08-01 | 2026-08-27 |
| The WISE Study (WhatsApp Intervention for Sleep in the Elderly) Nurse-led WiSE intervention group - Loneliness, Insomnia | Not applicable | Not yet recruiting | Halu Oleo University | 50 | 2026-07-30 | 2026-08-07 |
| BabaCare: Testing a Care Copilot AI phone companion - Loneliness, Mood | Not applicable | Recruiting | Johns Hopkins University | 40 | 2026-07-13 | 2026-08-05 |
| Social Prescribing for a Mindful Lifestyle Mindfulness Lifestyle Social Prescribing Program - Depression and/or Anxiety in the Mild-to-moderate Range, Loneliness | Not applicable | Recruiting | Buddhist Tzu Chi General Hospital | 50 | 2026-07-09 | 2026-10-02 |
| Engage Coaching (R33 Phase) Social Engage Coaching (S-ENG) - Social Connection, Loneliness | Not applicable | Recruiting | University of Rochester | 120 | 2026-06-30 | 2026-08-17 |
| STEPS - Stress Training and Engagement Via Phone-Based Systems Equa, Feature-Enhanced Equa Training Program, Stress Management Training - Psychological Distress, Mindfulness Skills | Not applicable | Recruiting | Equa Health | 300 | 2026-06-17 | 2026-07-20 |
| Music Breathing in Enhancing Resilience Among Elders at Risk of Mental Health Problems Mindfulness-based music breathing intervention, control group - Resilience, Anxiety | Not applicable | Completed | Chinese University of Hong Kong | 40 | 2026-06-08 | 2026-10-22 |
Showing 20 of 248. Sign in to see all of them.
Depression (66) · Social Isolation (63) · Anxiety Disorders (52) · Psychological Well-Being (34) · Motor Activity (17) · Dementia (12) · Stress, Psychological (12) · Cognitive Dysfunction (11) · COVID-19 (10) · Sedentary Behavior (10) · Alzheimer Disease (7) · Mobility Limitation (7) · Caregiver Burden (6) · Emotional Regulation (6) · Mental Disorders (5)
Behavior (154) · Behavioral Symptoms (79) · Social Behavior (76) · Mental Disorders (73) · Personal Satisfaction (34) · Pathological Conditions, Signs and Symptoms (32) · Nervous System Diseases (26) · Neurocognitive Disorders (21) · Signs and Symptoms (20) · Brain Diseases (16) · Central Nervous System Diseases (16) · Pathologic Processes (14) · Respiratory Tract Diseases (14) · Infections (13) · RNA Virus Infections (13)
Cognitive Behavioral Therapy (5) · Methods (5) · Surveys and Questionnaires (5) · Caregivers (3) · Control Groups (3) · Therapeutics (3) · Animal Assisted Therapy (2) · Exercise (2) · Horticultural Therapy (2) · Mindfulness (2) · Cognitive Training (1) · Community Participation (1) · Drug Interactions (1) · Ecological Momentary Assessment (1) · Focus Groups (1)
University of Rochester (12) · University of British Columbia (8) · Education University of Hong Kong (6) · University of California, San Francisco (4) · University of Washington (4) · Chinese University of Hong Kong (3) · Columbia University (3) · Nanyang Technological University (3) · The University of Hong Kong (3) · Toronto Metropolitan University (3) · University College, London (3) · University of Manitoba (3) · VA Office of Research and Development (3) · Assistance Publique - Hôpitaux de Paris (2) · Baycrest (2)
United States (90) · Canada (25) · Turkey (Türkiye) (17) · Hong Kong (13) · Spain (11) · United Kingdom (9) · Germany (7) · Finland (5) · Italy (5) · Taiwan (5) · China (4) · Denmark (4) · Netherlands (4) · Norway (4) · Israel (3)
Heather A McKay, PhD (4) · Jill S Litt, PhD (3) · Joanie Sims Gould, PhD (3) · Andy HY Ho, PhD, EdD (2) · Antonia Errazuriz, PhD (2) · Dawn Mackey, PhD (2) · Eric B Loucks, PhD (2) · Kee Lee Chou, PhD (2) · Kimberly A Van Orden, PhD (2) · Kyle Rand, B.A. (2) · Nirmala Lekhak, PhD (2) · Acacia Parks, PhD (1) · Adam D Brown, PhD (1) · Adrian Bauman, PhD (1) · Alan R. Teo, MD MS (1)
PMID 42106778, PMID 41233872, PMID 10568646, PMID 11811629, PMID 12382592, PMID 12782977, PMID 12916575, PMID 15513768, PMID 15804635, PMID 15817019, PMID 16107450, PMID 16328899, PMID 16443717, PMID 16921004, PMID 16952717, PMID 17114313, PMID 17804082, PMID 18027121, PMID 18229988, PMID 18590603, PMID 19672065, PMID 19934640, PMID 20438238, PMID 20556342, PMID 20735860, PMID 21131675, PMID 21193179, PMID 21324944, PMID 21369952, PMID 21534675, PMID 22021272, PMID 22766606, PMID 23006425, PMID 23047959, PMID 23596271, PMID 23626697, PMID 23749730, PMID 23861299, PMID 23861306, PMID 23881690, PMID 23897864, PMID 23939715, PMID 24152691, PMID 24465433, PMID 24735743, PMID 24836081, PMID 25103270, PMID 25190638, PMID 25214877, PMID 25356084
P30AG064103 (6), 2025 (2), 1SB1AG090151-01A1 (1), 2018 (1), I01HX003428 (1), K01AG076888 (1), K23MH125078 (1), K99AG065457 (1), P01AG005842 (1), P30AG031679 (1), P30AG073104 (1), P50MH115837 (1), R00AG065457 (1), R01AG054457 (1), R01AG057855 (1)