7 completed. 7 Phase 1, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 7 | Completed 7 |
| Phase 2 | 3 | Completed 3 |
Follow Liver Failure, Acute: new trials by email Literature Review of Liver Failure, Acute trials Research Report on Liver Failure, Acute
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pharmacokinetic Study on G1090N (Nitazoxanide) Capsules in Healthy Volunteers Single Dose G1090N, Multiple dosing of G1090N - Acute-on-Chronic Liver Failure | Phase 1 | Completed | Genfit | 52 | 2025-08-26 | 2026-01-16 |
| miroliverELAP® for the Treatment of Acute Liver Failure: A Phase 1 Trial miroliverELAP treatment - Acute Liver Failure, Acute Liver Injury, Drug Induced | Phase 1 | Completed | Miromatrix Medical Inc. | 10 | 2024-10-05 | 2026-03-06 |
| Efficacy and Safety of BMSCs (CG-BM1) for ACLF Patients Bone marrow mesenchymal stem cells (low dose), Solvent of CG-BM1, Bone marrow mesenchymal stem cells (medium dose) - Acute-On-Chronic Liver Failure | Phase 1 / Phase 2 | Completed | GuangZhou Cellgenes Biotechnology Co., Ltd. | 100 | 2023-03-01 | 2026-10-21 |
| Intravenous BCAA for HE in ACLF (BCAA-HE-ACLF) Branch Chain Amino Acid, Lactulose - Hepatic Encephalopathy, Acute-On-Chronic Liver Failure | Phase 1 | Completed | Post Graduate Institute of Medical Education and Research, Chandigarh | 114 | 2023-01-17 | 2025-06-08 |
| Intravenous Branched Chain Amino Acids for Hepatic Encephalopathy in ACLF Branched chain amino acid, Lactulose - Hepatic Encephalopathy, Acute-On-Chronic Liver Failure | Phase 1 | Completed | Post Graduate Institute of Medical Education and Research, Chandigarh | 70 | 2019-11-01 | 2022-08-16 |
| Mesenchymal Stem Cells After Renal or Liver Transplantation Mesenchymal Stem Cells - Liver Failure, Kidney Failure | Phase 1 / Phase 2 | Completed | University of Liege | 40 | 2012-02-01 | 2022-06-14 |
| Single Pass Albumin Dialysis in Patients With Cirrhosis Single pass albumin dialysis - Cirrhosis, Acute on Chronic Hepatic Failure | Phase 1 / Phase 2 | Completed | Assistance Publique - Hôpitaux de Paris | 11 | 2009-06-01 | 2015-02-25 |
Acute-On-Chronic Liver Failure (6) · Fibrosis (2) · Hepatic Encephalopathy (2) · Brain Diseases (1) · Brain Edema (1) · Chemical and Drug Induced Liver Injury (1) · Hepatorenal Syndrome (1) · Kidney Diseases (1) · Liver Diseases (1) · Liver Failure (1) · Neoplasms (1) · Renal Insufficiency (1)
Digestive System Diseases (7) · Hepatic Insufficiency (7) · Liver Diseases (6) · Liver Failure (6) · Central Nervous System Diseases (3) · Nervous System Diseases (3) · Brain Diseases (2) · Brain Diseases, Metabolic (2) · Female Urogenital Diseases (2) · Female Urogenital Diseases and Pregnancy Complications (2) · Male Urogenital Diseases (2) · Metabolic Diseases (2) · Nutritional and Metabolic Diseases (2) · Pathologic Processes (2)
Lactulose (2) · Amino Acids (1) · Amino Acids, Branched-Chain (1)
Post Graduate Institute of Medical Education and Research, Chandigarh (2) · Assistance Publique - Hôpitaux de Paris (1) · Genfit (1) · GuangZhou Cellgenes Biotechnology Co., Ltd. (1) · Miromatrix Medical Inc. (1) · University of Liege (1)
India (2) · United States (2) · Belgium (1) · China (1) · France (1)
Jack Lake, MD (1) · Madhumita Premkumar, MD, DM (1) · Yves Beguin, MD, PhD (1)
PMID 25715177, PMID 28284916, PMID 30568347, PMID 37975059, PMID 6749458, PMID 818729