5 recruiting, 3 completed, 1 active not recruiting, 1 enrolling by invitation. 2 Not applicable, 2 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 2 | Not yet recruiting 1, Unknown 1 |
| Phase 2 | 2 | Completed 1, Recruiting 1 |
| Phase 3 | 1 | Recruiting 1 |
Follow Lipoprotein(a): new trials by email Literature Review of Lipoprotein(a) trials Research Report on Lipoprotein(a)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Electronic Letters to Improve Patient Activation in IHD: The NUDGE-IHD Trial LDL-C information letter, Lp(a) information letter - Ischemic Heart Disease, Coronary Artery Disease | Not applicable | Not yet recruiting | Tor Biering-Sørensen | 123000 | 2026-09-01 | 2026-09-08 |
| A Clinical Trial of MK-7262 and Enlicitide in Participants With High Lipoprotein(a) (MK-7262-004) MK-7262, Enlicitide, Placebo for MK-7262 - Lipoprotein(a) | Phase 2 | Recruiting | Merck Sharp & Dohme LLC | 750 | 2026-06-30 | 2026-10-20 |
| A Study to See if Lepodisiran Can Reduce Plaque in Coronary Arteries of Adults With Elevated Lp(a) Who Have Had Heart Events or Are at High Risk Lepodisiran, Placebo - Atherosclerosis, Cardiovascular Diseases | Phase 3 | Recruiting | Eli Lilly and Company | 252 | 2026-06-01 | 2026-10-08 |
| Implementation Research on the LILAC Method to Educate Management of Elevated Lipoprotein(a). Lipoprotein(a), Lipoprotein(a), Hyper-Lp(a)-Emia | Enrolling by invitation | Changi General Hospital | 20000 | 2025-09-09 | 2025-09-22 | |
| Case Series : Management of Elevated Lipoprotein(a) Using Double-Filtration Plasmapheresis (DFPP) in Hemodialysis Patients With Chronic Kidney Disease ; ( LiPo-A ) Lipoprotein(a), Lipoprotein-apheresis | Completed | Centre Hospitalier Régional Metz-Thionville | 5 | 2025-07-01 | 2026-02-05 | |
| Heart CT Imaging to Detect Early Coronary Artery Disease in First-Degree Relatives With High or Low Lipoprotein(a) Identified Through Family Screening Lipoprotein(a) | Recruiting | E.S.stroes | 150 | 2025-06-01 | 2025-05-29 | |
| Cardiovascular Risk in Children With Chronic Conditions Study Kidney Transplant, Familial Hypercholesterolaemia | Recruiting | Semmelweis University | 300 | 2025-04-01 | 2025-08-08 | |
| Lipoprotein(a) and Progression of Aortic Stenosis Lipoprotein(a) - Aortic Valve Stenosis, Lipoprotein(a) | Active not recruiting | Asan Medical Center | 364 | 2025-02-10 | 2025-12-29 | |
| Serum Lipoprotein-a as a Marker of Severity of Coronary Artery Disease in Aortic Valve Sclerosis Patients Serum Lipoprotein-a level - Serum, Lipoprotein(A) | Completed | Sohag University | 100 | 2024-10-01 | 2025-10-07 | |
| Effect of a Customised Lifestyle Medicine Strategy on Lowering Blood Lipid Levels in Indian Physicians Indian version of a 'Portfolio' diet, Physical Activity, Intermittent fasting - Lifestyle Risk Reduction, Cholesterol, Elevated | Not applicable | Unknown | Jubilee Mission Medical College and Research Institute | 50 | 2024-02-15 | 2024-05-20 |
| AI-assisted CT for Risk Stratification in Coronary Artery Disease (ACTION) Coronary Artery Disease (CAD), Computed Tomography Angiography | Recruiting | University of Galway | 10000 | 2022-12-21 | 2026-05-11 | |
| Evaluate SLN360 in Participants With Elevated Lipoprotein(a) at High Risk of Atherosclerotic Cardiovascular Disease Events SLN360, Placebo - Cardiovascular Diseases, Atherosclerosis | Phase 2 | Completed | Silence Therapeutics plc | 180 | 2022-12-13 | 2025-07-01 |
Coronary Artery Disease (4) · Atherosclerosis (3) · Aortic Valve Stenosis (2) · Cardiovascular Diseases (2) · Hypercholesterolemia (2) · Hypertension (2) · Myocardial Ischemia (2) · Renal Insufficiency, Chronic (2) · Aortic Coarctation (1) · Diabetes Mellitus, Type 1 (1) · Diabetes Mellitus, Type 2 (1) · HIV Infections (1) · Hyperlipoproteinemia Type II (1) · Hypertension, Pulmonary (1) · Inflammatory Bowel Diseases (1)
Vascular Diseases (8) · Cardiovascular Diseases (7) · Arterial Occlusive Diseases (6) · Arteriosclerosis (6) · Heart Diseases (6) · Coronary Disease (4) · Metabolic Diseases (4) · Nutritional and Metabolic Diseases (4) · Dyslipidemias (3) · Hyperlipidemias (3) · Lipid Metabolism Disorders (3) · Aortic Valve Disease (2) · Chronic Disease (2) · Disease Attributes (2) · Female Urogenital Diseases (2)
Apolipoproteins A (1) · Exercise (1) · MK-0616 (1) · Post-Exercise Recovery (1)
Asan Medical Center (1) · Centre Hospitalier Régional Metz-Thionville (1) · Changi General Hospital (1) · E.S.stroes (1) · Eli Lilly and Company (1) · Jubilee Mission Medical College and Research Institute (1) · Merck Sharp & Dohme LLC (1) · Semmelweis University (1) · Silence Therapeutics plc (1) · Sohag University (1) · Tor Biering-Sørensen (1) · University of Galway (1)
Netherlands (4) · Australia (3) · Denmark (3) · Czechia (2) · Hungary (2) · Spain (2) · United Kingdom (2) · United States (2) · Canada (1) · Colombia (1) · Egypt (1) · France (1) · Germany (1) · India (1) · Ireland (1)
Duk-Hyun Kang, MD. PhD. (1) · Faisal Sharif, MBBS, PhD, FRCPI, FESC, FACC (1) · Tamas Kiss, MD, PhD (1)
PMID 38682459, PMID 39329200, PMID 39556769, PMID 40699211
2025 (2)