Serum Lipoprotein-a as a Marker of Severity of Coronary Artery Disease in Aortic Valve Sclerosis Patients

NCT07209631 — Completed, 100 participants, Sohag University

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Is Lipoprotein-a Just a Lipid Marker or a Predictor for the Severity of Coronary Lesions in Aortic Valve Sclerosis Patients?

Registry	NCT07209631
Status	Completed
Study type	Observational
Enrollment	100 (Actual)
Sponsor	Sohag University (Other)
Conditions	Serum, Lipoprotein(A), Severity, Coronary Artery Disease, Aortic Valve Sclerosis
Interventions	Serum Lipoprotein-a level (Other)
Dates	start 2024-10-01, primary completion 2025-05-01, completion 2025-05-01, first posted 2025-10-07, last updated 2025-10-07
Locations	1 site in Egypt

-Summary

This work aimed to evaluate the association of serum level of Lp(a) with the severity of coronary artery disease (CAD) in aortic valve sclerosis (AVS) patients.

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+Detailed description

Aortic valve sclerosis (AVS) has a prevalence of 2% to 7% in the population above 65 years of age. In industrialized countries, aortic valve sclerosis is most frequently caused by progressive calcification and degeneration of the aortic cusps.

Coronary artery disease (CAD) is the most significant single cause of death in the world. In developed countries, more than 25% of all deaths in persons older than 35 years are due to CAD. More than half of acute myocardial infarctions occur without previous history or symptoms of CAD.

In recent years, there has been a special emphasis on lipoprotein(a) (Lp(a)), a significant, causal, and nonmodifiable predictor of valvular outcomes and CAD in the general population

+Arms and interventions

Arm	Type	Interventions	Description
Study group		Other: Serum Lipoprotein-a level	Patients with chest pain and/or dyspnea were diagnosed provisionally as having coronary artery disease.

Serum Lipoprotein-a level (Other): A venous blood sample was taken from each patient a month or so after discharge to check their Lp (a) levels. The samples were centrifuged for 10 minutes at 2-8 °C, after which the serum was divided into aliquots and stored at -20 ° C.

+Outcome measures

Primary outcomes

Incidence of significance of coronary lesions [1 month post-procedure]: Incidence of significance of coronary lesions in relation to lipoprotein (a) level was recorded.

+Eligibility

Sex: All, ages: 18 Years to any

Inclusion Criteria:

* Age ≥ 18 years.
* Both sexes.
* Patients with chest pain and/or dyspnea were diagnosed provisionally as having coronary artery disease.

Exclusion Criteria:

* Aortic stenosis.
* Aortic prosthesis.
* Untreated hypothyroidism.
* Severe chronic kidney failure.
* Administration of anti-inflammatory or immunosuppressive drugs.
* Pregnancy.

+Locations (1)

Facility	City	Country	Status
Sohag University	Sohag	Egypt