14 unknown, 13 completed, 8 recruiting, 2 not yet recruiting. 11 Phase 2, 5 Not applicable, 4 Phase 1, 2 Phase 3, 1 Early Phase 1.
Follow Laryngeal Cancer: new trials by email Literature Review of Laryngeal Cancer trials Research Report on Laryngeal Cancer
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Machine Learning-Based Risk Prediction Model for Head and Neck Cancerous Lesions Hypopharyngeal Cancer, Laryngeal Cancer | Recruiting | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | 3000 | 2026-04-30 | 2026-09-02 | |
| Neoadjuvant Chemotherapy and Programmed Cell Death Protein 1(PD-1) Inhibition for Head and Neck Cancer Treatment De-escalation (NeoScorch HN) Toripalimab + Chemotherapy, Toripalimab, Chemoradiotherapy or radiation - Head and Neck Cancer, Squamous Cell Carcinoma | Phase 2 | Recruiting | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 75 | 2026-02-18 | 2026-04-23 |
| Validation of End-to-End Difficult Airway Pathway Planning Algorithm (EAP-LC) No Interventions - Laryngeal Cancer, Difficult Airway | Not yet recruiting | Eye & ENT Hospital of Fudan University | 70 | 2026-01-01 | 2026-01-07 | |
| p-PHOTOLARYNX- ANTHEM: Photon-Counting CT in Laryngeal Cancer Staging Photon Counting Computed Tomography - Laryngeal Cancer, Laryngeal Carcinoma | Enrolling by invitation | Humanitas University | 60 | 2025-05-16 | 2026-05-22 | |
| Thermotherapy for Locally Advanced Head and Neck Cancer Thermotherapy, radiotherapy - Head and Neck Cancer, Oropharyngeal Carcinoma | Phase 1 | Active not recruiting | Erasmus Medical Center | 2 | 2025-05-01 | 2026-09-02 |
| SBRT Followed by Chemoimmunotherapy of Toripalimab Plus Docetaxel and Cisplatin for Larynx Preservation in Patients with Locally Regionally Advanced Squamous Cell Carcinoma of the Larynx and Hypopharynx SBRT+Toripalimab Plus Docetaxel and Cisplatin - Laryngeal Cancer, Hypopharynx Cancer | Phase 2 | Recruiting | Sun Yat-sen University | 35 | 2024-09-11 | 2024-09-26 |
| Oncologic and Functional Outcome and Quality of Life in Patients Treated for Laryngeal Cancer Laryngeal Cancer | Unknown | IRCCS Azienda Ospedaliero-Universitaria di Bologna | 20 | 2024-09-01 | 2025-01-20 | |
| Tislelizumab and Induction Chemotherapy for Larynx Preservation in Resectable Advanced Laryngeal/Hypopharyngeal Cancer chemotherapy TP regimen combined with Tislelizumab - Laryngeal Cancer, Hypopharynx Cancer | Phase 2 | Not yet recruiting | Henan Cancer Hospital | 46 | 2024-08-01 | 2024-08-14 |
| European Larynx Organ Preservation Study (ELOS) [MK-3475-C44] KEYTRUDA® - Squamous Cell Carcinoma of Head and Neck, Hypopharyngeal Squamous Cell Carcinoma | Phase 2 | Recruiting | University of Leipzig | 140 | 2024-04-17 | 2024-09-20 |
| Study of the Risk of Pharyngocutaneous Fistula in a Population of Patients Undergoing Total Laryngectomy and Creation of a Score for Pre-operative Risk Stratification. Laryngeal Cancer | Unknown | Regina Elena Cancer Institute | 500 | 2023-12-01 | 2024-03-13 | |
| Workshops and Exchange Groups for Laryngectomized Patients Laryngectomy; Status, Laryngeal Cancer | Recruiting | Assistance Publique - Hôpitaux de Paris | 50 | 2023-10-10 | 2026-03-27 | |
| The Voice as a Tool to Detect Recurrence of Laryngeal and Hypopharyngeal Cancer Voice recording, ENT (Ear, Nose and Throat) examination including transnasal fiberendoscopy, and VHI-30-questionnaire - Laryngeal Cancer, Hypopharyngeal Cancer | Recruiting | Insel Gruppe AG, University Hospital Bern | 100 | 2023-08-02 | 2025-07-29 | |
| A Clinical Study on Oncolytic Virus Injection (R130 OV) for the Treatment of Relapsed/Refractory Head and Neck Cancer Recombinant oncolytic herpes simplex virus type 1 (R130) - Head and Neck Cancer, Esophageal Cancer | Early Phase 1 | Unknown | Shanghai Yunying Medical Technology | 9 | 2023-03-27 | 2023-04-26 |
| Using the Subglottic Pressure to Predict the Dysphagia After Partial Laryngectomy Open partial horizontal laryngectomy(OPHL), Type I-III, Transoral endoscopic laser cordectomy - Laryngeal Cancer, Dysphagia | Not applicable | Unknown | Guangdong Provincial People's Hospital | 50 | 2023-01-03 | 2023-09-13 |
| Oxidative Stress and Inflammation Biomarkers in Surgically Treated Patients With Laryngeal Cancer Analgesics, Opioid, Analgesics, Non-Narcotic - Oxidative Stress Induction, Laryngeal Cancer | Unknown | Clinical Centre of Serbia | 100 | 2022-09-01 | 2023-05-12 | |
| SpeakFree Heat and Moisture Exchanger (HME) SpeakFree HME Hands Free Valve, Digital Occlusion, Digital Depression HME - Laryngeal Cancer, Laryngectomy | Not applicable | Completed | University of Miami | 18 | 2022-06-28 | 2025-02-03 |
| Immune Biomarker Study for Head and Neck Cancer Sampling - Head and Neck Cancer, Oral Cavity Cancer | Recruiting | University of Erlangen-Nürnberg Medical School | 1100 | 2022-05-16 | 2023-05-17 | |
| Effects of Oral Aloe Vera Juice on Chemotherapy and Radiation-induced Oral Mucositis and Esophagitis 100% Aloe Vera Juice, Magic Mouthwash, Salt and Baking soda rinse - Oral Cavity Cancer, Head and Neck Cancers - Tonsils | Phase 3 | Completed | Covenant Health Cancer Center | 100 | 2022-01-20 | 2024-10-10 |
| Induction Chemotherapy and Toripalimab Followed by Radiotherapy in Unresectable Laryngeal/Hypopharyngeal Carcinoma Toripalimab - Laryngeal Cancer, Hypopharyngeal Cancer | Phase 2 | Unknown | Fudan University | 61 | 2021-04-07 | 2022-06-15 |
| Induction Chemotherapy and Toripalimab for Larynx Preservation in Resectable Laryngeal/Hypopharyngeal Carcinoma chemotherapy TP regimen combined with Toripalimab - Laryngeal Cancer, Hypopharynx Cancer | Phase 2 | Unknown | Fudan University | 42 | 2021-04-07 | 2022-01-18 |
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Laryngeal Neoplasms (41) · Hypopharyngeal Neoplasms (15) · Head and Neck Neoplasms (12) · Mouth Neoplasms (9) · Oropharyngeal Neoplasms (7) · Carcinoma, Squamous Cell (5) · Pharyngeal Neoplasms (5) · Squamous Cell Carcinoma of Head and Neck (4) · Esophageal Neoplasms (3) · Laryngeal Diseases (3) · Deglutition Disorders (2) · Neoplasm Metastasis (2) · Adenomatous Polyposis Coli (1) · Agnosia (1) · Anus Neoplasms (1)
Neoplasms (41) · Neoplasms by Site (41) · Otorhinolaryngologic Diseases (41) · Respiratory Tract Diseases (41) · Respiratory Tract Neoplasms (41) · Otorhinolaryngologic Neoplasms (40) · Laryngeal Diseases (38) · Head and Neck Neoplasms (29) · Pharyngeal Diseases (24) · Stomatognathic Diseases (22) · Pharyngeal Neoplasms (17) · Neoplasms by Histologic Type (10) · Neoplasms, Glandular and Epithelial (10) · Carcinoma (9) · Mouth Diseases (9)
Cisplatin (6) · Docetaxel (3) · toripalimab (3) · Carboplatin (2) · Cetuximab (2) · Nutritional Status (2) · Radiation (2) · Radiotherapy (2) · Resistance Training (2) · pembrolizumab (2) · 130-nm albumin-bound paclitaxel (1) · Analgesics, Non-Narcotic (1) · Analgesics, Opioid (1) · Bortezomib (1) · Cefazolin (1)
National Taiwan University Hospital (3) · Fudan University (2) · University of Alabama at Birmingham (2) · Assistance Publique - Hôpitaux de Paris (1) · Ayhman Al Afif (1) · Clinical Centre of Serbia (1) · Covenant Health Cancer Center (1) · Erasmus Medical Center (1) · Eye & ENT Hospital of Fudan University (1) · First Affiliated Hospital, Sun Yat-Sen University (1) · Guangdong Provincial People's Hospital (1) · HealthCare Global Enterprise Ltd. (1) · Henan Cancer Hospital (1) · Humanitas University (1) · IRCCS Azienda Ospedaliero-Universitaria di Bologna (1)
United States (13) · China (9) · Italy (3) · Taiwan (3) · France (2) · Germany (2) · Switzerland (2) · India (1) · Iran (1) · Netherlands (1) · Serbia (1)
Carter Van Waes, M.D. (2) · Ching-Ting Tan, MD, PhD (2) · Laura Q Rogers, MD, MPH (2) · Xiayun He, M.D. (2) · Yu Wang, M.D. (2) · Ana D Jotic, MD, PhD (1) · Antoniu-Oreste Gostian, PD Dr. med. (1) · Ara A. Chalian, MD (1) · Benjamin Frey, PD Dr.-Ing. Dr. habil. med. (1) · Bevan Yueh, MD, MPH (1) · Cecilia Botti, MD, PhD (1) · Ching-Ting Tan, MD,PhD (1) · Daniel Scaperoth, MD (1)
PMID 17822322, PMID 22847995, PMID 26135695, PMID 28179349, PMID 28623906, PMID 29374733, PMID 31705729, PMID 31785250, PMID 32479189, PMID 32538771, PMID 33587847, PMID 35869710, PMID 39239277, PMID 39682700
2023 (1)