6 completed, 6 terminated, 2 recruiting, 1 suspended. 16 Phase 2, 4 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 16 | Completed 6, Terminated 6, Recruiting 2, Suspended 1, Unknown 1 |
| Phase 1 | 4 | Terminated 2, Recruiting 1, Unknown 1 |
| Phase 3 | 1 | Terminated 1 |
Follow Ileitis: new trials by email Literature Review of Ileitis trials Research Report on Ileitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Etrasimod as Prevention of Pouchitis etrasimod, Placebo - Pouchitis | Phase 2 | Recruiting | Maia Kayal | 40 | 2026-07-01 | 2026-09-21 |
| CLF065 for Chronic Pouchitis CLF065, Placebo - Pouchitis | Phase 2 | Suspended | Calibr, a division of Scripps Research | 20 | 2026-06-01 | 2026-07-09 |
| Study of EXE-346 Live Biotherapeutic to Reduce High Bowel Movement Frequency in Subjects With an IPAA (PROF) EXE-346, Placebo - Ileal Pouch | Phase 1 / Phase 2 | Recruiting | Exegi Pharma, LLC | 50 | 2023-11-06 | 2026-05-28 |
| Efficacy of Liraglutide Therapy in Patients With IPAA Liraglutide Pen Injector, Placebo Pen Injector - Pouchitis, Irritable Pouch Syndrome | Phase 2 | Terminated | University of North Carolina, Chapel Hill | 8 | 2022-03-22 | 2024-07-23 |
| GM-CSF, Fosfomycin and Metronidazole for Pouchitis in Ulcerative Colitis Patients After Restorative IPAA Surgery GM-CSF, fosfomycin and metronidazole - Pouchitis | Phase 1 / Phase 2 | Unknown | Zealand University Hospital | 18 | 2021-09-06 | 2023-01-26 |
| Study of the Safety and Efficacy of AMT-101 in Subjects With Pouchitis AMT-101 (oral)-Dose A, AMT-101 (oral)-Dose B - Pouchitis | Phase 2 | Completed | Applied Molecular Transport | 22 | 2021-02-05 | 2022-09-14 |
| Tofacitinib For Treatment Of Chronic Pouchitis Tofacitinib 10 mg - Pouchitis, Ileal Pouchitis | Phase 2 | Terminated | Cedars-Sinai Medical Center | 6 | 2021-01-25 | 2024-04-04 |
| The Role of Secondary Bile Acids in Intestinal Inflammation ursodiol (ursodeoxycholic acid, UDCA) - Ulcerative Colitis, Pouchitis | Phase 2 / Phase 3 | Terminated | Stanford University | 2 | 2019-08-26 | 2026-03-11 |
| Fecal Microbiota Transplantation for Pouchitis Fecal microbiota transplantation, Placebos - Pouchitis | Phase 2 | Completed | McMaster University | 47 | 2019-04-17 | 2026-08-12 |
| Fecal Microbiota Transplantation (FMT) in the Treatment of Pouchitis Fecal microbiota transplantation, Placebo - Pouchitis, Ulcerative Colitis | Phase 2 | Completed | Helsinki University Central Hospital | 26 | 2018-02-27 | 2021-04-28 |
| Safety and Efficacy of Fecal Microbiome Transplantation (FMT) in the Treatment of Antibiotic Dependent Pouchitis (ADP) Active FMT, then open label FMT, Placebo FMT, then open label FMT - Pouchitis | Phase 1 / Phase 2 | Terminated | University of North Carolina, Chapel Hill | 6 | 2017-06-01 | 2019-05-14 |
| To Determine the Effect of Honey Enema in the Treatment of Patients With Acute Pouchitis Manuka honey enema - Pouchitis | Phase 2 | Completed | Dr. Carl J Brown | 10 | 2014-10-01 | 2017-04-26 |
| An Australian Study of Mesenchymal Stromal Cells for Crohn's Disease Mesenchymal stromal cells (MSC) for infusion - Crohn Disease | Phase 2 | Completed | R.P.Herrmann | 21 | 2010-01-01 | 2015-06-09 |
| Safety and Efficacy of AST-120 in the Treatment of Antibiotic-Refractory Pouchitis AST-120 - Pouchitis | Phase 2 | Terminated | Ocera Therapeutics | 2 | 2007-03-01 | 2014-06-18 |
| Safety and Efficacy of AST-120 in the Treatment of Pouchitis AST-120 - Pouchitis | Phase 2 | Completed | Ocera Therapeutics | 19 | 2007-02-01 | 2014-06-18 |
| Clotrimazole Enemas for Pouchitis in Children and Adults Clotrimazole - Ulcerative Colitis, Pouchitis | Phase 1 / Phase 2 | Terminated | Web | 11 | 2002-09-30 | 2022-12-09 |
Pouchitis (15) · Colitis, Ulcerative (4) · Colitis (2) · Inflammatory Bowel Diseases (2) · Crohn Disease (1)
Digestive System Diseases (16) · Enteritis (16) · Gastroenteritis (16) · Gastrointestinal Diseases (16) · Ileal Diseases (16) · Intestinal Diseases (16) · Colonic Diseases (5) · Inflammatory Bowel Diseases (4) · Colitis (3)
AST 120 (2) · Fecal Microbiota Transplantation (2) · Clotrimazole (1) · Fosfomycin (1) · Granulocyte-Macrophage Colony-Stimulating Factor (1) · Liraglutide (1) · Metronidazole (1) · Sodium Chloride (1) · Ursodeoxycholic Acid (1) · etrasimod (1) · tofacitinib (1)
Ocera Therapeutics (2) · University of North Carolina, Chapel Hill (2) · Applied Molecular Transport (1) · Calibr, a division of Scripps Research (1) · Cedars-Sinai Medical Center (1) · Dr. Carl J Brown (1) · Exegi Pharma, LLC (1) · Helsinki University Central Hospital (1) · Maia Kayal (1) · McMaster University (1) · R.P.Herrmann (1) · Stanford University (1) · Web (1) · Zealand University Hospital (1)
United States (11) · Canada (3) · Australia (1) · Belgium (1) · Denmark (1) · Finland (1) · France (1) · Germany (1) · Hungary (1) · Netherlands (1) · Spain (1) · Switzerland (1) · United Kingdom (1)
Hans Herfarth, MD, PhD (2) · Bo Shen, MD (1) · Carl Brown (1) · Darrell S. Pardi, MD (1) · Geoff Forbes, MD (1) · Julia Collins, MS (1) · Maia Kayal, MD (1) · Paul A. Rufo, MD, MMSc (1) · Sidhartha Sinha, MD (1)