64 completed, 9 terminated, 7 recruiting, 6 withdrawn. 100 Phase 2, 8 Phase 1, 6 Phase 3.
Follow Hypogonadism: new trials by email Literature Review of Hypogonadism trials Research Report on Hypogonadism
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Testosterone Therapy With or Without Finasteride After Spinal Cord Injury: TRT-SCI Trial testosterone cypionate, finasteride, placebo injection - Spinal Cord Injury, Spinal Cord Injuries | Phase 2 / Phase 3 | Not yet recruiting | VA Office of Research and Development | 300 | 2027-10-01 | 2026-08-04 |
| A Dose Ranging Study to Examine TDS-Testosterone 5% Testosterone, Pump Sprayer - Hypogonadotropism | Phase 2 | Not yet recruiting | Transdermal Delivery Solutions Corp | 48 | 2027-06-01 | 2026-09-30 |
| Product Transference Study of Testagen™ TDS®-Testosterone Testagen® TDS Testosterone 5% HypoSpray® - Hypogonadotropism | Phase 2 | Not yet recruiting | Transdermal Delivery Solutions Corp | 96 | 2027-01-05 | 2026-05-27 |
| Clinical Trial to Observe the Effects of Tamoxifen on Testosterone Recovery in Medically Castrated Prostate Cancer Patients Tamoxifen - Hypogonadism, Prostate Cancer | Phase 2 | Recruiting | University Health Network, Toronto | 96 | 2026-12-31 | 2026-10-22 |
| Effect of Testosterone on Elderly Frail Men With Testosterone Deficiency Nebido (Testosterone Undecanoate) - Frail Elderly Patients, Hypogonadal Males | Phase 2 | Not yet recruiting | Rune Skovgaard Rasmussen | 96 | 2026-08-01 | 2026-05-06 |
| Clinical Evaluation of Subcutaneous Testosterone Implants in Men With Symptomatic Hypogonadism Subcutaneous Testosterone Implants - Male Hypogonadism, Testosterone Deficiency | Phase 2 | Not yet recruiting | University of Sao Paulo | 30 | 2026-03-01 | 2026-03-30 |
| Kisspeptin Administration Subcutaneously to Patients With Hypothalamic Amenorrhea kisspeptin 112-121 - Hypothalamic Amenorrhea, Hypogonadotropic Hypogonadism | Phase 2 | Recruiting | Stephanie B. Seminara, MD | 20 | 2025-12-09 | 2026-07-13 |
| A Long-Term Study of Bivamelagon in Participants With Hypothalamic Obesity (HO) Bivamelagon - Hypothalamic Obesity | Phase 2 | Enrolling by invitation | Rhythm Pharmaceuticals, Inc. | 25 | 2025-11-10 | 2026-02-10 |
| TRT as an Adjunctive ERAS Therapy in ESRD Patients Undergoing Kidney Transplantation Testosterone Replacement Therapy - Hypogonadism, Male, End Stage Renal Disease (ESRD) | Phase 1 / Phase 2 | Active not recruiting | University of California, Los Angeles | 50 | 2025-07-01 | 2025-12-17 |
| Efficacy and Safety of Phentermine/Topiramate in Youth With Hypothalamic Obesity Phentermine / Topiramate Extended Release Oral Capsule [Qsymia], Placebo - Hypothalamic Obesity, Hypothalamic Tumor | Phase 2 | Active not recruiting | Seattle Children's Hospital | 24 | 2025-03-01 | 2026-10-16 |
| A Study to Assess Efficacy and Safety of LB54640 in Patients With Hypothalamic Obesity Bivamelagon, Placebo - Hypothalamic Obesity | Phase 2 | Completed | Rhythm Pharmaceuticals, Inc. | 28 | 2024-07-11 | 2026-10-30 |
| Single-Dose Pharmacokinetics of Oral Testosterone Undecanoate With and Without Concomitant Inhibition of UGT2B17 Relugolix 120Mg Tab, Curcumin, Testosterone Undecanoate 237 MG Oral Capsule - Hypogonadism, Male | Phase 1 / Phase 2 | Unknown | University of Washington | 10 | 2024-06-01 | 2024-03-15 |
| A Study of RM-718 in Healthy Subjects and Patients With MC4R Pathway Impairment Part A: RM-718 or placebo (matched to specific RM-718 dose cohort), Part B: RM-718 or placebo (matched to specific RM-718 dose cohort), Part C: RM-718 - Hypothalamic Obesity, Prader-Willi Syndrome | Phase 1 / Phase 2 | Active not recruiting | Rhythm Pharmaceuticals, Inc. | 111 | 2024-03-05 | 2026-10-09 |
| Kisspeptin Administration Subcutaneously to Patients With IHH kisspeptin 112-121, leuprolide acetate - Hypogonadotropic Hypogonadism | Phase 2 | Recruiting | Stephanie B. Seminara, MD | 36 | 2023-02-03 | 2026-07-13 |
| Testosterone Treatment in Men With Chronic Kidney Disease Jatenzo Pill - Hypogonadism, Male, Kidney Disease, Chronic | Phase 2 | Recruiting | St. Louis University | 20 | 2022-03-15 | 2026-04-30 |
| Rec-LH PD and Safety Profile in Hypogonadotropic Hypogonadism Men Lutropin alfa, Human chorionic gonadotropin - Acquired Hypogonadotropic Hypogonadism | Phase 2 | Unknown | Azienda Ospedaliero-Universitaria di Modena | 32 | 2022-01-19 | 2023-07-20 |
| Pain Alleviation With Testosterone in Opioid-Induced Hypogonadism Testosterone Undecanoate 250 MG/ML, Placebo - Opioid Use, Pain | Phase 2 | Recruiting | Brigham and Women's Hospital | 150 | 2022-01-10 | 2026-07-27 |
| Study of Tesomet With Open-label Extension in Subjects With Hypothalamic Obesity (HO) Placebo, Tesomet - Hypothalamic Obesity | Phase 2 | Withdrawn | Saniona | 2021-11-11 | 2022-12-13 | |
| Open-Label Study of Setmelanotide in Hypothalamic Obesity Setmelanotide - Hypothalamic Obesity | Phase 2 | Completed | Rhythm Pharmaceuticals, Inc. | 18 | 2021-06-07 | 2025-02-07 |
| Gonadal Dysfunction in Male Long-term Survivors of Malignant Lymphoma; Vitality AndroGel - Hypogonadism | Phase 2 | Completed | Lars Møller Pedersen | 7 | 2021-04-01 | 2022-11-29 |
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Eunuchism (17) · Sexual Infantilism (10) · Endocrine System Diseases (6) · Gonadal Disorders (6) · Craniopharyngioma (4) · Diabetes Mellitus, Type 2 (4) · Erectile Dysfunction (4) · Infertility (4) · Obesity (4) · Spinal Cord Injuries (4) · Bone Resorption (3) · Central Nervous System Diseases (3) · Genital Diseases, Male (3) · Infertility, Male (3)
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Testosterone (30) · testosterone undecanoate (14) · testosterone enanthate (7) · Clomiphene (6) · Enclomiphene (6) · Anastrozole (4) · Gonadotropin-Releasing Hormone (4) · Testosterone Propionate (4) · Finasteride (3) · fispemifene (3) · testosterone 17 beta-cypionate (3) · Chorionic Gonadotropin (2) · Dutasteride (2) · Exenatide (2) · Gels (2)
Clarus Therapeutics, Inc. (6) · Massachusetts General Hospital (5) · Repros Therapeutics Inc. (5) · Rhythm Pharmaceuticals, Inc. (4) · University of Washington (4) · VA Office of Research and Development (4) · Mereo BioPharma (3) · QuatRx Pharmaceuticals Company (3) · Stephanie B. Seminara, MD (3) · TesoRx Pharma, LLC (3) · Acerus Pharmaceuticals Corporation (2) · Antares Pharma Inc. (2) · Eli Lilly and Company (2) · Merck Sharp & Dohme LLC (2) · Seattle Institute for Biomedical and Clinical Research (2)
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David Meeker, MD (3) · Sandeep Dhindsa, MD (3) · Hugh Jones (2) · Janne Komi, MD, PhD (2) · Joshua F Yarrow, PhD MS BS (2) · Shana E McCormack, MD (2) · Shehzad Basaria, MD (2) · Stephanie Seminara, MD (2) · William J Bremner, MD, PhD (2) · Andrea Isidori, MD, PhD (1) · Andrea Lenzi, MD (1) · Andrew Herzog, M.D., M.Sc. (1) · Ashley Shoemaker, M.D. (1) · Barbara Troupin, MD, MBA (1)
PMID 21474786, PMID 17635942, PMID 18077826, PMID 21252493, PMID 21717386, PMID 23341491, PMID 23343764, PMID 23581697, PMID 24012740, PMID 24037890, PMID 24326421, PMID 24423356, PMID 24968251, PMID 24978674, PMID 25044085, PMID 25392748, PMID 25599449, PMID 26030346, PMID 26158605, PMID 26950683, PMID 27133664, PMID 27637014, PMID 27992261, PMID 28285751, PMID 28981994, PMID 29931143, PMID 30515210, PMID 31532522, PMID 32034419, PMID 37579053, PMID 38224135, PMID 39722695, PMID 41242020
U54HD028138 (2), 2014 (1), 2017 (1), I01RX001449 (1), K23HD045386 (1), R01AG019339 (1), R01AG025099 (1), R01AR050618 (1), R37HD043341 (1)