8 completed, 1 active not recruiting, 1 recruiting, 1 unknown. 3 Not applicable, 2 Phase 3, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 3 | Active not recruiting 1, Completed 1, Unknown 1 |
| Phase 3 | 2 | Completed 2 |
| Phase 2 | 1 | Completed 1 |
Follow Hypobetalipoproteinemias: new trials by email Literature Review of Hypobetalipoproteinemias trials Research Report on Hypobetalipoproteinemias
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| In Vivo Metabolism of apoB-containing Lipoproteins in ANGPTL3 Deficient Subjects Administration of deuterated compounds for kinetic study - Familial Hypobetalipoproteinemia, Familial Hypobetalipoproteinemia - Heterozygous Form | Not applicable | Unknown | Marcello Arca | 20 | 2022-09-30 | 2022-10-10 |
| CArotenoid in hypoChOlesterolemia Characterization of carotenoid status and plasma levels of oxidative stress markers in patients (case group only), Characterization, evaluation and comparison of macular pigment density - Primary Intestinal Hypocholesterolemia, Abetalipoproteinemia | Completed | Hospices Civils de Lyon | 10 | 2022-06-30 | 2025-12-04 | |
| Prevalence of fAmilial hypobetalipopRoTeinemIa in psychiaTrIc pOpulatioN (PARTITION) Psychiatric population - Familial Hypobetalipoproteinemia | Not applicable | Completed | Nantes University Hospital | 896 | 2018-08-22 | 2021-09-16 |
| Is Adrenal Insufficiency Under-diagnosed in Hospitalized Cirrhosis Patients? Cosyntropin - Adrenal Insufficiency, Cirrhosis | Phase 3 | Completed | University of Virginia | 100 | 2018-01-29 | 2021-12-09 |
| HYPOCHOL : A Genetically-based Strategy to Identify New Targets in Cholesterol Metabolism hypobetalipoproteinemia genetic and genotypic screening - Hypobetalipoproteinemia | Not applicable | Active not recruiting | Nantes University Hospital | 435 | 2016-01-07 | 2026-04-29 |
| Prevalence Assessment and Characterization of Psychological Disorders Associated With Hypobetalipoproteinemia Hypobetalipoproteinemia diagnosis (LDL-C ≤ 50 mg/dL without hypolipidemic treatment) - Hypobetalipoproteinemia | Completed | Nantes University Hospital | 3000 | 2015-05-01 | 2017-07-14 | |
| Inherited Retinal Degenerative Disease Registry Eye Diseases Hereditary, Retinal Disease | Recruiting | Foundation Fighting Blindness | 20000 | 2014-06-01 | 2026-05-19 | |
| Study of the Absorption of Vitamin E Water-soluble Form (Pegylated) in the Familial Hypocholesterolemia With Chylomicron Retention Tocofersolan, tocopherol alpha, Tocofersolan and tocopherol alpha - Hypobetalipoproteinemias | Phase 3 | Completed | Hospices Civils de Lyon | 14 | 2011-10-01 | 2025-08-22 |
| Measure Liver Fat Content After ISIS 301012 (Mipomersen) Administration mipomersen, Placebo - Lipid Metabolism, Inborn Errors, Hyperlipidemias | Phase 2 | Completed | Kastle Therapeutics, LLC | 38 | 2006-07-01 | 2016-10-21 |
| Vitamin Replacement in Abetalipoproteinemia Abetalipoproteinemia | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 1 | 2000-02-01 | 2008-03-04 | |
| Mechanisms of Low Levels of Apolipoprotein B Cardiovascular Diseases, Heart Diseases | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 1997-08-01 | 2016-07-29 |
Abetalipoproteinemia (4) · Retinitis Pigmentosa (3) · Cardiovascular Diseases (2) · Achromatopsia 3 (1) · Adrenal Insufficiency (1) · Ataxia (1) · Bardet-Biedl Syndrome (1) · Charcot-Marie-Tooth Disease (1) · Choroideremia (1) · Chylomicron retention disease (1) · Color Vision Defects (1) · Cone Dystrophy (1) · Cone-Rod Dystrophies (1) · Congenital Abnormalities (1)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (11) · Nutritional and Metabolic Diseases (11) · Dyslipidemias (10) · Genetic Diseases, Inborn (10) · Hypolipoproteinemias (10) · Lipid Metabolism Disorders (10) · Lipid Metabolism, Inborn Errors (10) · Metabolic Diseases (10) · Metabolism, Inborn Errors (10) · Eye Diseases (3) · Pathological Conditions, Signs and Symptoms (3) · Retinal Degeneration (3) · Retinal Dystrophies (3) · Eye Diseases, Hereditary (2)
Cosyntropin (1) · alpha-Tocopherol (1) · mipomersen (1) · tocophersolan (1)
Nantes University Hospital (3) · Hospices Civils de Lyon (2) · National Heart, Lung, and Blood Institute (NHLBI) (2) · Foundation Fighting Blindness (1) · Kastle Therapeutics, LLC (1) · Marcello Arca (1) · University of Virginia (1)
France (5) · United States (3) · Netherlands (1)
Francine Welty (1) · Todd Durham, PhD (1) · Zachary Henry, MD (1)
2005 (1), R01HL056895 (1)