12 completed, 1 recruiting, 1 terminated, 1 unknown. 6 Not applicable, 6 Phase 2, 3 Phase 3, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 6 | Completed 6 |
| Phase 2 | 6 | Completed 3, Recruiting 1, Terminated 1, Withdrawn 1 |
| Phase 3 | 3 | Completed 2, Unknown 1 |
| Phase 1 | 1 | Completed 1 |
Follow Hot Flushes: new trials by email Literature Review of Hot Flushes trials Research Report on Hot Flushes
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Proof-of-Concept Trial to Assess the Efficacy and Safety of Fezolinetant in Improving Vasomotor Symptoms in Men With Prostate Cancer Undergoing Androgen Deprivation Therapy fezolinetant - reference formulation, Placebo - Prostate Cancer, Prostate Cancer (Adenocarcinoma) | Phase 2 | Recruiting | Shehzad Basaria, M.D. | 60 | 2026-01-14 | 2026-08-17 |
| Herbal Dietary Supplementation on Vasomotor Symptoms in Menopausal Women JDS-HF3.0 - Hot Flashes, Hot Flash | Not applicable | Completed | Bonafide Health | 112 | 2024-05-24 | 2026-02-12 |
| Stellate Ganglion Blockade in Post-Menopausal Women Stellate Ganglion Block Injection with Bupivicaine, Saline injection - Hot Flashes, Hot Flushes | Phase 2 | Withdrawn | Northwestern University | 2018-07-10 | 2025-07-23 | |
| Stellate Ganglion Block to Reduce Hot Flushes Bupivacaine block, Placebo ganglion block - Hot Flash, Stellate Ganglion Block | Not applicable | Completed | Rijnstate Hospital | 76 | 2017-09-01 | 2020-03-11 |
| Effects of Stellate Ganglion Block on Hot Flashes in Hispanic Women With Breast Cancer Stellate Ganglion Block injection with bupivicaine, Saline - Hot Flashes, Hot Flushes | Phase 2 | Terminated | Northwestern University | 2 | 2017-06-01 | 2022-08-09 |
| E4Relief (Response to Estetrol in Life Improvement for MEnopausal-associated Hot Flushes) Estetrol, Placebo - Hot Flushes | Phase 2 | Completed | Donesta Bioscience | 260 | 2016-05-01 | 2024-11-18 |
| Stellate Ganglion Block (SGB) For Women for Breast Cancer Bupivicaine, Saline - Hot Flushes, Hot Flashes | Phase 2 | Completed | Northwestern University | 37 | 2015-07-01 | 2023-06-05 |
| Vilazodone for Menopausal Hot Flashes vilazodone, placebo capsules - Hot Flushes | Not applicable | Completed | University of Pennsylvania | 36 | 2012-11-01 | 2015-01-14 |
| Alternative Treatments for Menopausal Women Placebo, Red Clover extract - Menopause, Hot Flushes | Not applicable | Completed | Aarhus University Hospital | 61 | 2012-06-01 | 2015-02-06 |
| Menopausal Treatment Using Relaxation Exercises (MaTURE) Paced Respiration, Music Therapy - Hot Flushes, Hot Flashes | Not applicable | Completed | University of California, San Francisco | 123 | 2012-01-01 | 2014-05-06 |
| A Study of MF101 in Postmenopausal Women MF101 5 g/day, Placebo, MF101 10 g/day - Hot Flushes, Vasomotor Symptoms | Phase 3 | Unknown | Bionovo | 1200 | 2011-10-01 | 2012-02-08 |
| Progesterone for Perimenopausal Night Sweats Oral micronized progesterone, placebo - Hot Flushes, Night Sweats | Phase 3 | Completed | University of British Columbia | 249 | 2011-10-01 | 2019-12-16 |
| Dehydroepiandrosterone (DHEA) + Acolbifene Against Vasomotor Symptoms (Hot Flushes) in Postmenopausal Women Placebo, DHEA and Acolbifene - Vasomotor Symptoms, Hot Flushes | Phase 3 | Completed | EndoCeutics Inc. | 238 | 2011-10-01 | 2013-12-11 |
| The Role of Vitamin D in Menopause: Relationship to Menopausal Symptoms in Body Composition Vitamin D, Placebo - Hot Flushes, Menopause, Premature | Phase 1 | Completed | Kaiser Permanente | 23 | 2010-09-01 | 2013-05-30 |
| Aromatherapy and Yogatherapy for Hot Flashes Olfactory aromatherapy, Yogatherapy - Menopause, Hot Flashes | Not applicable | Completed | University of Sao Paulo | 108 | 2010-01-01 | 2013-03-22 |
| Soy Protein Supplement In Treating Hot Flashes in Postmenopausal Women Receiving Tamoxifen for Breast Disease soy protein, isoflavones, Tamoxifen - Breast Cancer, Hot Flashes | Phase 2 | Completed | Alliance for Clinical Trials in Oncology | 112 | 2002-03-01 | 2016-07-13 |
Hot Flashes (16) · Breast Neoplasms (2) · Adenocarcinoma (1) · Anxiety Disorders (1) · Breast Carcinoma In Situ (1) · Carcinoma, Intraductal, Noninfiltrating (1) · Depression (1) · Dyslipidemias (1) · Menopause, Premature (1) · Multiple Endocrine Neoplasia Type 1 (1) · Obesity (1) · Osteoporosis (1) · Parasomnias (1) · Prostatic Neoplasms (1) · Vitamin D Deficiency (1)
Pathological Conditions, Signs and Symptoms (16) · Signs and Symptoms (16) · Neoplasms (3) · Neoplasms by Site (3) · Breast Diseases (2) · Carcinoma (2) · Genital Diseases (2) · Neoplasms by Histologic Type (2) · Neoplasms, Glandular and Epithelial (2) · Nutritional and Metabolic Diseases (2) · Skin Diseases (2) · Skin and Connective Tissue Diseases (2) · Urogenital Diseases (2) · Adenocarcinoma (1) · Adnexal Diseases (1)
Bupivacaine (3) · Sodium Chloride (3) · Dehydroepiandrosterone (1) · Estetrol (1) · Injections (1) · Isoflavones (1) · Music Therapy (1) · Progesterone (1) · Soybean Proteins (1) · Tamoxifen (1) · Utrogestan (1) · Vilazodone Hydrochloride (1) · Vitamin D (1) · ritetronium (1)
Northwestern University (3) · Aarhus University Hospital (1) · Alliance for Clinical Trials in Oncology (1) · Bionovo (1) · Bonafide Health (1) · Donesta Bioscience (1) · EndoCeutics Inc. (1) · Kaiser Permanente (1) · Rijnstate Hospital (1) · Shehzad Basaria, M.D. (1) · University of British Columbia (1) · University of California, San Francisco (1) · University of Pennsylvania (1) · University of Sao Paulo (1)
United States (10) · Canada (2) · Belgium (1) · Brazil (1) · Denmark (1) · Netherlands (1)
David R. Walega, MD, MSCI (2) · Alison Huang, MD, MAS (1) · Cassandra S Lyra, MSc (1) · Charles W Hogue, MD (1) · Deborah Grady, MD, MPH (1) · Donesta Bioscience (1) · Ellen W Freeman, PhD (1) · Erin S. LeBlanc, MD, MPH (1) · Gini F. Fleming, MD (1) · Jan Willem Kallewaard, MD (1) · Jerilynn C Prior, MD, FRCPC (1) · Leonello Cusan, M.D., Ph.D. (1) · Mary Tagliaferri, M.D, L.Ac. (1) · Per B Jeppesen, Prof (1) · Shehzad S Basaria, MD (1)
PMID 25932840, PMID 28591133, PMID 33110036, PMID 36809193
2015 (1), U10CA076001 (1)