87 completed. 87 Phase 2, 19 Phase 1, 5 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 87 | Completed 87 |
| Phase 1 | 19 | Completed 19 |
| Phase 3 | 5 | Completed 5 |
Follow HIV Infection: new trials by email Literature Review of HIV Infection trials Research Report on HIV Infection
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| UNIVERSAL 1: Pharmacokinetic Study of a Novel DTG/FTC/TAF Dose Ratio for Children dolutegravir (DTG)/emtricitabine (FTC)/tenofovir alafenamide (TAF) regimen, Dolutegravir (DTG)/ Emtricitabine (FTC)/tenofovir alafenamide (TAF) - HIV Infection | Phase 2 | Completed | PENTA Foundation | 53 | 2024-12-11 | 2026-03-04 |
| Glecaprevir/Pibrentasvir Fixed-dose Combination Treatment for Acute Hepatitis C Virus Infection Glecaprevir/Pibrentasvir (G/P) - Hepatitis C Infection, HIV Infection | Phase 2 | Completed | Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections | 45 | 2019-11-20 | 2024-07-11 |
| Dual bNAb Treatment in Children ART, VRC01LS, 10-1074 - HIV Infection | Phase 1 / Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 30 | 2019-06-17 | 2026-05-04 |
| St. PETERsburg Pain and Alcohol Intervention With Naltrexone and Nalmefene Low dose naltrexone, Nalmefene - HIV Infection, Alcohol Use | Phase 1 / Phase 2 | Completed | Boston Medical Center | 11 | 2018-07-03 | 2020-08-24 |
| Studying Partial-agonists for Ethanol and Tobacco Elimination in Russians With HIV (St PETER HIV) Varenicline, Cytisine, Nicotine Replacement Therapy - HIV Infection, Alcohol Use | Phase 2 / Phase 3 | Completed | Boston Medical Center | 400 | 2017-07-19 | 2020-12-17 |
| Microbiota Restoration Therapy in HIV With Repeated Low-Dose Interventions FMT, Placebo - HIV Infection | Phase 1 / Phase 2 | Completed | Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal | 30 | 2017-01-01 | 2018-10-30 |
| High Intensity Lipid Lowering Following Acute Coronary Syndromes for Persons Living With HIV Pravastatin, Rosuvastatin - HIV Infection, Coronary Heart Disease | Phase 2 | Completed | Matthew Feinstein | 10 | 2016-11-01 | 2022-10-18 |
| ODYSSEY (PENTA 20) Dolutegravir, Standard of Care - HIV Infection | Phase 2 / Phase 3 | Completed | PENTA Foundation | 792 | 2016-09-20 | 2025-07-29 |
| Strategy for Maintenance of HIV Suppression With Once Daily Integrate Inhibitor+Darunavir/Ritonavir in Children DTG +DRV/r, SOC - HIV Infection | Phase 2 / Phase 3 | Completed | PENTA Foundation | 318 | 2016-06-01 | 2021-03-30 |
| Reducing the Residual Reservoir of HIV-1 Infected Cells in Patients Receiving Antiretroviral Therapy Panobinostat, Pegylated Interferon-alpha2a - HIV Infection | Phase 1 / Phase 2 | Completed | Massachusetts General Hospital | 17 | 2016-05-01 | 2024-02-28 |
| ABX464 in Fully Controlled HIV Infected Patients Treated With Boosted Protease Inhibitor Treatment ABX464, Placebo - HIV Infection | Phase 2 | Completed | Abivax S.A. | 30 | 2016-05-01 | 2024-09-19 |
| Feasibility, Tolerance and Efficacy of Interferon-free, Antiviral Treatment With Sofosbuvir + Ribavirin for the Treatment of Genotype 2 and Sofosbuvir/Ledipasvir for the Treatment of Genotype 1 and 4 Hepatitis C Virus-infected Patients in West and Central Africa Sofosbuvir, Ribavirin, Ledipasvir - Hepatitis C, HIV Infection | Phase 2 | Completed | ANRS, Emerging Infectious Diseases | 120 | 2015-10-01 | 2017-12-13 |
| Targeted Anticoagulation Therapy to Reduce Inflammation and Cellular Activation in Long-term HIV Disease Edoxaban 30mg daily, Matching placebo - Inflammation, Coagulation | Phase 2 | Completed | Hennepin Healthcare Research Institute | 44 | 2015-07-01 | 2019-09-06 |
| Surgery in Treating Patients With Early Stage Anal Canal or Perianal Cancer and HIV Infection Therapeutic Conventional Surgery - Anal Squamous Cell Carcinoma, HIV Infection | Phase 2 | Completed | AIDS Malignancy Consortium | 16 | 2015-04-01 | 2026-04-20 |
| Evaluation of a Dose Reduction of Darunavir (400 mg/d) in Virologically Suppressed HIV-1 Patients Darunavir - HIV INFECTION | Phase 2 | Completed | ANRS, Emerging Infectious Diseases | 100 | 2015-03-01 | 2026-04-03 |
| A Safety and Immune Response Study of 2 Experimental HIV Vaccines ALVAC-HIV, Bivalent Subtype C gp120/MF59®, ALVAC-HIV (vCP2438) Placebo - HIV Infection | Phase 1 / Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 252 | 2015-02-02 | 2021-11-05 |
| Reversing Tissue Fibrosis to Improve Immune Reconstitution in HIV Losartan, Placebo - HIV Infection, HIV Infections | Phase 2 | Completed | University of Minnesota | 52 | 2014-09-01 | 2020-12-11 |
| Lactoferrin Treatment in HIV Patients Recombinant Lactoferrin, Placebo - HIV Infection | Phase 2 | Completed | Jason Baker | 55 | 2014-09-01 | 2024-12-31 |
| Dipyridamole for Immune Activation in HIV Dipyridamole, Placebo, then Dipyridamole - HIV Infection | Phase 1 / Phase 2 | Completed | Sharon Riddler | 40 | 2014-07-01 | 2019-04-11 |
| Immunogenicity and Safety of 4 Prime-boost Combinations of HIV Vaccine Candidates in Healthy Volunteers LIPO-5, MVA HIV-B (MVATG17401), GTU®-MultiHIV B: 0.5 mL IM via Biojector® 2000 and 0.5mL IntraDermic, 3 shots - HIV Infection | Phase 1 / Phase 2 | Completed | ANRS, Emerging Infectious Diseases | 92 | 2014-03-01 | 2026-04-14 |
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HIV Infections (87) · Acquired Immunodeficiency Syndrome (11) · Hepatitis C (6) · Inflammation (5) · Alcohol Drinking (2) · Coronary Disease (2) · Fibrosis (2) · Hepatitis B (2) · Infections (2) · Sexually Transmitted Diseases (2) · Anal Canal Carcinoma (1) · Anus Neoplasms (1) · Ascites (1) · Bone Diseases, Metabolic (1) · Bronchiolitis Obliterans Syndrome (1)
Blood-Borne Infections (87) · Communicable Diseases (87) · Genital Diseases (87) · Urogenital Diseases (87) · Immune System Diseases (86) · Immunologic Deficiency Syndromes (86) · Lentivirus Infections (86) · RNA Virus Infections (86) · Retroviridae Infections (86) · Sexually Transmitted Diseases, Viral (86) · Virus Diseases (86) · Infections (85) · Sexually Transmitted Diseases (85) · Pathological Conditions, Signs and Symptoms (13) · Pathologic Processes (12)
Emtricitabine (5) · Ribavirin (5) · Tenofovir (5) · Interleukin-2 (4) · etravirine (4) · peginterferon alfa-2a (4) · Maraviroc (3) · Raltegravir Potassium (3) · Ritonavir (3) · Calcium Carbonate (2) · Cholecalciferol (2) · Darunavir (2) · Doxorubicin (2) · Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination (2) · Panobinostat (2)
National Institute of Allergy and Infectious Diseases (NIAID) (14) · ANRS, Emerging Infectious Diseases (5) · National Cancer Institute (NCI) (4) · Tibotec Pharmaceuticals, Ireland (4) · French National Agency for Research on AIDS and Viral Hepatitis (3) · PENTA Foundation (3) · University of North Carolina, Chapel Hill (3) · Boston Medical Center (2) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (2) · University of California, Los Angeles (2) · ViiV Healthcare (2) · AIDS Healthcare Foundation (1) · AIDS Malignancy Consortium (1) · AIM ImmunoTech Inc. (1) · Abivax S.A. (1)
United States (47) · France (13) · Spain (9) · Germany (7) · Brazil (4) · Portugal (4) · Puerto Rico (4) · South Africa (4) · Uganda (4) · United Kingdom (4) · Belgium (3) · Canada (3) · Russia (3) · Thailand (3) · Zimbabwe (3)
Mathias Lichterfeld, MD, PhD (2) · Sybil Hosek, PhD (2) · Alberto JS Duarte, Professor (1) · Anatoli Kamali, MD (1) · Ann Woolfrey (1) · Antonio Rivero, MD, PhD (1) · Arthur Y. Kim, MD (1) · Babacar Sylla (1) · Christine Katlama, MD (1) · Dag Kvale, Professor/MD (1) · Daniel Kuritzkes, MD (1) · Daniel R Kuritzkes, MD (1)
PMID 31179503, PMID 16044019, PMID 17314338, PMID 17434849, PMID 17621237, PMID 18580611, PMID 18593294, PMID 18596069, PMID 18795960, PMID 18987623, PMID 19104016, PMID 19114852, PMID 19307941, PMID 21150563, PMID 21881478, PMID 21897852, PMID 22210755, PMID 22258265, PMID 22261571, PMID 22525109, PMID 22761759, PMID 22820809, PMID 23299011, PMID 23506243, PMID 23516440, PMID 23667266, PMID 24086333, PMID 24476350, PMID 25108027, PMID 25139963, PMID 25296098, PMID 25398137, PMID 25545673, PMID 26259542, PMID 26423811, PMID 26424549, PMID 26696749, PMID 27193748, PMID 27572401, PMID 27662551, PMID 27811319, PMID 28405623, PMID 28828489, PMID 28873128, PMID 29280762, PMID 29315307, PMID 29392418, PMID 29898870, PMID 29905808, PMID 30586364
2014 (3), 2009 (2), UM1CA121947 (2), 2008 (1), P01CA018029 (1), P30CA015704 (1), R01DA035054 (1), R01MH090899 (1), U01AA020780 (1), U01AI105872 (1), U01AI110410 (1), U01CA121947 (1), U19AI096111 (1), UH2AA026193 (1), UM1AI068636 (1)