10 recruiting, 5 completed, 2 not yet recruiting. 7 Phase 1, 7 Phase 2, 3 Early Phase 1, 2 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 7 | Recruiting 5, Completed 1, Not yet recruiting 1 |
| Phase 2 | 7 | Recruiting 4, Completed 3 |
| Early Phase 1 | 3 | Recruiting 2, Completed 1 |
| Not applicable | 2 | Not yet recruiting 1, Recruiting 1 |
Follow High Grade Gliomas: new trials by email Literature Review of High Grade Gliomas trials Research Report on High Grade Gliomas
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Phase 2 Trial of G207 + 5 Gy Radiation for Children With High-Grade Gliomas G207 - High Grade Gliomas | Phase 2 | Recruiting | M.D. Anderson Cancer Center | 38 | 2026-10-12 | 2026-10-13 |
| Brain Radiotherapy Imaging for High-grade Glioma Using Hypoxia Targeting Through Oxygen-Enhanced Response Oxygen-Enhanced MRI (OE-MRI) - High Grade Gliomas, Hypoxia Brain | Not applicable | Not yet recruiting | The Leeds Teaching Hospitals NHS Trust | 25 | 2026-09-01 | 2026-06-30 |
| NgFUS NIVO: NeuroNavigation-Guided Focused Ultrasound With Nivolumab in Relapsed and Progressive DMG and Other High Grade Brain Tumors NeuroNavigation-Guided Focused Ultrasound (NgFUS), Lumason, Nivolumab - Diffuse Midline Glioma or Diffuse Intrinsic Pontine Glioma, High Grade Gliomas | Phase 1 | Recruiting | Children's National Research Institute | 30 | 2026-09-01 | 2026-09-09 |
| Determine Maximum Tolerated Dose, Safety, and Tolerability of Rhenium (186Re) in Pediatric Recurrent, Refractory or Progressive Ependymoma and High-Grade Glioma Rhenium-186 Nanoliposome - Ependymoma, High Grade Gliomas | Phase 1 | Recruiting | Cerenome | 56 | 2026-08-01 | 2026-09-11 |
| Pre-Radiation Chemotherapy for Newly Diagnosed High-Grade Glioma. Pre-radiation temozolomide. - High Grade Gliomas, Glioblastoma | Phase 2 | Recruiting | The Cooper Health System | 70 | 2026-07-13 | 2026-10-09 |
| Preoperative Proton Irradiation for High-grade Brain Gliomas. Preoperative irradiation - High Grade Gliomas | Phase 1 | Recruiting | National Medical Research Radiological Centre of the Ministry of Health of Russia | 9 | 2026-07-01 | 2026-07-17 |
| Gallium Maltolate for the Treatment of Pediatric Patients With Relapsed or Refractory Pediatric High-Grade Glioma and Atypical Teratoid Rhabdoid Tumor Gallium maltolate - High Grade Gliomas, Atypical Teratoid Rhabdoid Tumors (ATRT) | Phase 1 | Not yet recruiting | Sarah Rumler | 15 | 2026-05-15 | 2026-01-09 |
| Study of an AAV Mediated Dual-Payload Gene Therapy in Patients With High Grade Glioma TGX-007, Valaciclovir - Glioblastoma (GBM), High Grade Gliomas | Phase 1 / Phase 2 | Recruiting | Trogenix ltd | 68 | 2026-04-21 | 2026-10-23 |
| Window Trial of Fluorescently Labeled Nivolumab-IRDye800 (Nivo800) in High Grade Glioma (HGG) Nivolumab, Nivolumab-IRDye800 - Brain Cancer, HGG | Early Phase 1 | Recruiting | Eben Rosenthal | 38 | 2026-03-27 | 2026-07-01 |
| A Phase 0/1 Study of cDNA for TP53, Checkpoint Inhibition and Radiation in Children With Recurrent, Progressive or Refractory CNS Malignancies. SGT-53, hypofractionated radiotherapy with immunotherapy, Nivolumab - CNS Malignancies, Medulloblastoma Recurrent | Early Phase 1 | Recruiting | Children's National Research Institute | 18 | 2025-12-16 | 2026-04-29 |
| Feasibility of Aspirate Tissue Monitoring in Neuro-oncological Surgery Aspirate tissue monitoring, Fluorescence-guided surgery - High Grade Gliomas | Not applicable | Recruiting | Kuopio University Hospital | 50 | 2024-09-30 | 2024-12-18 |
| Study in Children and Adolescents of 177Lu-DOTATATE (Lutathera®) Combined With the PARP Inhibitor Olaparib for the Treatment of Recurrent or Relapsed Solid Tumours Expressing Somatostatin Receptor (SSTR) (LuPARPed). Olaparib; 177Lu-DOTATATE - Solid Tumor Cancer, Medulloblastoma | Phase 1 / Phase 2 | Recruiting | Fundación de investigación HM | 25 | 2024-09-20 | 2026-06-04 |
| SM-1 Combined With Temozolomide in Subjects With Refractory or Recurrent High-Grade Gliomas SM-1,TMZ - Glioma, Glioblastomas (GBM) | Phase 1 | Completed | Shenzhen Zhenxing Medical Technology Co., Ltd | 35 | 2022-09-19 | 2026-06-09 |
| Reproducibility of 18F Uptake by Solid Tumors Using PET Imaging Following Intravenous Administration of (18F) Injection Fluciclatide Injection - Solid Tumors, High Grade Gliomas | Phase 2 | Completed | GE Healthcare | 70 | 2009-06-01 | 2014-06-09 |
| Exploratory, Phase 0 Study of Positron Emission Tomography (PET) Imaging Agent, F-18 RGD-K5 F-18 RGD-K5 - Sarcoma, Melanoma | Early Phase 1 | Completed | Siemens Molecular Imaging | 16 | 2008-08-01 | 2009-02-02 |
| Short Course of Radiation for Gliomas in Elderly Patients CyberKnife - High Grade Gliomas | Phase 2 | Completed | Beth Israel Deaconess Medical Center | 26 | 2006-04-01 | 2017-01-27 |
| Valproic Acid With Temozolomide and Radiation Therapy to Treat Brain Tumors adjuvant therapy, Temozolomide, Valproic Acid - High Grade Gliomas, Brain Tumors | Phase 2 | Completed | National Cancer Institute (NCI) | 43 | 2006-03-01 | 2016-08-18 |
Glioblastoma (7) · Glioma (7) · Brain Neoplasms (6) · Astrocytoma (2) · Breast Neoplasms (2) · Diffuse Intrinsic Pontine Glioma (2) · Ependymoma (2) · Lung Neoplasms (2) · Oligodendroglioma (2) · Recurrence (2) · Rhabdoid Tumor (2) · Sarcoma (2) · Adrenal Cortex Neoplasms (1) · Adrenal Gland Neoplasms (1) · Carcinoma, Renal Cell (1)
Neoplasms (14) · Neoplasms by Histologic Type (14) · Neoplasms, Glandular and Epithelial (14) · Neoplasms, Nerve Tissue (13) · Neoplasms, Neuroepithelial (13) · Neuroectodermal Tumors (13) · Neoplasms, Germ Cell and Embryonal (12) · Neoplasms by Site (10) · Nervous System Diseases (8) · Nervous System Neoplasms (8) · Brain Diseases (7) · Central Nervous System Diseases (7) · Central Nervous System Neoplasms (7) · Astrocytoma (5) · Glioma (5)
Nivolumab (3) · AH 111585 (1) · Chemotherapy, Adjuvant (1) · Immunotherapy (1) · Injections (1) · Radiosurgery (1) · Radiotherapy (1) · Temozolomide (1) · Valacyclovir (1) · Valproic Acid (1) · gallium maltolate (1) · lutetium Lu 177 dotatate (1) · olaparib (1)
Children's National Research Institute (2) · Beth Israel Deaconess Medical Center (1) · Cerenome (1) · Eben Rosenthal (1) · Fundación de investigación HM (1) · GE Healthcare (1) · Kuopio University Hospital (1) · M.D. Anderson Cancer Center (1) · National Cancer Institute (NCI) (1) · National Medical Research Radiological Centre of the Ministry of Health of Russia (1) · Sarah Rumler (1) · Shenzhen Zhenxing Medical Technology Co., Ltd (1) · Siemens Molecular Imaging (1) · The Cooper Health System (1) · The Leeds Teaching Hospitals NHS Trust (1)
United States (11) · China (1) · Finland (1) · Norway (1) · Russia (1) · Spain (1) · United Kingdom (1)
Alexey Goryanov (1) · Anand Mahadevan, MD (1) · Antti-Pekka Elomaa, Docent (1) · Einar Vik-Mo, Professor (1) · Gregory Friedman, MD (1) · Igor Gulidov (1) · Jeffrey Winick, Ph.D. (1) · Joonas Haapasalo, Docent (1) · Kevin A Camphausen, M.D. (1) · Marta Osuna Marco, PhD (1) · Michael Yu, MD (1) · Patrick Kelly, MD (1)