15 completed, 3 terminated, 2 unknown. 20 Phase 2, 3 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 20 | Completed 15, Terminated 3, Unknown 2 |
| Phase 1 | 3 | Completed 2, Unknown 1 |
| Phase 3 | 1 | Completed 1 |
Follow Herpes Labialis: new trials by email Literature Review of Herpes Labialis trials Research Report on Herpes Labialis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Monoclonal Antibody Therapy Against Chronic Herpes Simplex Virus 1 Infection HDIT101 (blinded therapy), Placebo (blinded therapy), Photo documentation of orolabial herpes lesions - Herpes Labialis | Phase 2 | Terminated | Heidelberg ImmunoTherapeutics GmbH | 761 | 2020-10-08 | 2023-09-25 |
| An Open Label Study to Evaluate the Safety and Efficacy of BOR15001L7 for the Treatment of Cold Sores in Patients With Recurrent Herpes Labialis BOR15001L7, Docosanol Cream 10% - Recurrent Herpes Labialis | Phase 2 | Unknown | Laboratoire Boreaderme Inc. | 164 | 2020-09-01 | 2020-09-07 |
| Effectiveness and Clinical Mechanism of Huanglian-Jiedu Decoction in Patients With Intense-exuberant Stomach Fire Syndrome Huanglian-Jiedu Decoction - Intense-exuberant Stomach Fire Syndrom, Acute Pericoronitis | Phase 1 / Phase 2 | Unknown | China Academy of Chinese Medical Sciences | 240 | 2018-04-04 | 2018-04-10 |
| A Phase 2, Muti-Center Study of Repeat Dosing of Squaric Acid Dibutyl Ester in Subjects With Herpes Labialis Squaric Acid Dibutyl Ester - Herpes Labialis, HSV | Phase 2 | Terminated | Squarex, LLC | 40 | 2018-03-12 | 2021-08-06 |
| Safety and Efficacy of Merlin (Ethanol and Glycolic Acid Mixture) for Episodic Treatment of Cold Sores Merlin, Ethanol - Recurrent Herpes Labialis | Phase 2 | Completed | Topical Remedy | 451 | 2017-07-05 | 2018-09-12 |
| Double-blind, Vehicle-controlled Study of the Efficacy and Safety of SADBE in Subjects With Recurrent Herpes Labialis SADBE, Placebo - Herpes Labialis, Cold Sore | Phase 1 / Phase 2 | Completed | Squarex, LLC | 139 | 2016-12-01 | 2021-11-02 |
| Trial on Efficacy and Safety of Pritelivir Ointment for Treatment of Labial Herpes Pritelivir 5% w/w ointment, Pritelivir ointment matching placebo, Zovirax® cream - Herpes Labialis | Phase 2 | Completed | AiCuris Anti-infective Cures AG | 362 | 2016-11-29 | 2021-07-13 |
| Safety, Tolerability and Therapeutic Efficacy of Topical ZEP-3 Ointment (1.0%) for the Treatment of Cold Sores ZEP-3 ointment 1.0%, Acyclovir cream 5% - Herpes Labialis | Phase 2 | Completed | Shulov Innovate for Science Ltd. 2012 | 210 | 2015-09-01 | 2019-05-30 |
| A Double-Blind, Randomized, Placebo-Controlled Study of Topical VDO for the Treatment of Herpes Simplex Labialis VDO gel, placebo - Herpes Labialis | Phase 2 | Completed | Yung Shin Pharm. Ind. Co., Ltd. | 40 | 2014-07-01 | 2016-04-15 |
| Safety and Efficacy of Merlin (Ethanol and Glycolic Acid Mixture) for the Treatment of Cold Sores ethanol/glycolic acid solution, Placebo/Ethanol - Recurrent Herpes Labialis | Phase 2 | Completed | Topical Remedy | 469 | 2013-11-01 | 2015-07-16 |
| Evaluation of Cold Sore Treatments on Ultra Violet (UV) Induced Cold Sores Matching Placebo, BTL-TML-HSV - Oral Herpes Simplex | Phase 2 | Completed | Beech Tree Labs, Inc. | 303 | 2013-07-01 | 2016-04-28 |
| Safety and Efficacy Study of a New Treatment for Recurrent Symptoms of Oral Herpes Virus Infection BTL TML HSV, Matching placebo - Oral Herpes Simplex | Phase 1 / Phase 2 | Completed | Beech Tree Labs, Inc. | 171 | 2011-01-01 | 2013-08-13 |
| A Randomized Double-Blind Control-Comparison Crossover Trial of Oral Glutamine to Suppress Frequently Recurrent Herpes Labialis Glutamine, Glycine - Herpes Labialis, Herpes Simplex Virus | Phase 2 | Terminated | National Institute of Allergy and Infectious Diseases (NIAID) | 11 | 2009-06-01 | 2012-06-11 |
| Place Controlled Study to Treat Recurrent Herpes Labialis. Ointment - Recurrent Herpes Labialis | Phase 2 | Completed | University of Zurich | 40 | 2009-04-01 | 2011-08-08 |
| Safety and Pharmacokinetics of Famciclovir Single 1500 mg Dose in Adolescents With Recurrent Herpes Labialis Famciclovir - Herpes Labialis | Phase 2 / Phase 3 | Completed | Novartis Pharmaceuticals | 53 | 2009-03-25 | 2021-06-25 |
| Iontophoretic Application of Acyclovir Gel to Treat Cold Sores Iontophoretic delivery of acyclovir - Herpes Labialis | Phase 2 | Completed | Transport Pharmaceuticals | 810 | 2007-04-01 | 2008-02-04 |
| Safety, Pharmacokinetics, and Efficacy Study of NB-001 to Treat Recurrent Herpes Labialis NB-001 - Herpes Labialis | Phase 2 | Completed | NanoBio Corporation | 1000 | 2007-02-01 | 2008-05-30 |
| Iontophoretic Application of Acyclovir Cream to Treat Recurrent Herpes Labialis iontophoretic acyclovir - Herpes Labialis | Phase 2 | Completed | Transport Pharmaceuticals | 1800 | 2005-04-01 | 2006-07-04 |
| Valacyclovir+Temovate Gel for the Treatment of Herpes Labialis valacyclovir+clobetasol gel - Herpes Labialis | Phase 2 | Completed | University of Utah | 300 | 2004-09-01 | 2008-05-06 |
| Efficacy of Acyclovir in Combination With a Glucocorticosteroid on UV-Induced Herpes Labialis ME-609, Vehicle - Herpes Labialis | Phase 2 | Completed | Medivir | 417 | 1999-08-01 | 2008-08-15 |
Herpes Simplex (5) · Stomatitis, Herpetic (2) · Herpesviridae Infections (1) · Skin Diseases, Infectious (1) · Stomatitis, Aphthous (1)
DNA Virus Infections (20) · Infections (20) · Lip Diseases (20) · Mouth Diseases (20) · Skin Diseases (20) · Skin Diseases, Viral (20) · Skin and Connective Tissue Diseases (20) · Stomatognathic Diseases (20) · Virus Diseases (20) · Herpesviridae Infections (19) · Skin Diseases, Infectious (19) · Herpes Simplex (15) · Stomatitis (3)
Ethanol (2) · Neurofibromin 2 (2) · squaric acid dibutyl ester (2) · 5-((2-(6-Amino-9H-purin-9-yl) ethyl) amino)-1-pentanol (1) · Acyclovir (1) · Famciclovir (1) · Glutamine (1) · Glycine (1) · ME 609 (1) · Ointments (1) · Patient Reported Outcome Measures (1) · huanglian-jie-du decoction (1) · pritelivir (1)
Beech Tree Labs, Inc. (2) · Squarex, LLC (2) · Topical Remedy (2) · Transport Pharmaceuticals (2) · AiCuris Anti-infective Cures AG (1) · China Academy of Chinese Medical Sciences (1) · Heidelberg ImmunoTherapeutics GmbH (1) · Laboratoire Boreaderme Inc. (1) · Medivir (1) · NanoBio Corporation (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · Novartis Pharmaceuticals (1) · Shulov Innovate for Science Ltd. 2012 (1) · University of Utah (1) · University of Zurich (1)
United States (13) · China (1) · Germany (1) · Israel (1) · Switzerland (1) · Taiwan (1)
Alicia Bucko, DO (1) · Brian Bock, DO (1) · Christopher Hull, MD (1) · Christopher M Hull, MD (1) · Cynthia B Strout, MD (1) · Daniel H Brune, MD (1) · Daniel Stewart, MD (1) · David Fried, MD (1) · Dennis Riff, MD (1) · Douglass Forsha, MD (1) · Edward Pornoy, MD (1) · Elias Kolettis, MD (1) · Eric M Morrel, PhD (1) · Eugene Monroe, MD (1)