3 completed, 2 recruiting, 2 terminated, 1 active not recruiting. 9 Phase 2, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 9 | Completed 3, Recruiting 2, Terminated 2, Active not recruiting 1, Unknown 1 |
| Phase 1 | 2 | Recruiting 1, Unknown 1 |
Follow Giant Cell Tumor of Bone: new trials by email Literature Review of Giant Cell Tumor of Bone trials Research Report on Giant Cell Tumor of Bone
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy of ICG-based NIR Imaging in Intralesional Curettage of Giant Cell Tumors of Bone in Limbs: a Prospective, Single-center, Single-arm, Open Study ICG (Indocyanine Green) - Giant Cell Tumor of Bone | Phase 1 / Phase 2 | Recruiting | Tang Xiaodong | 45 | 2024-08-23 | 2024-10-18 |
| Zoledronic Acid-loaded Bone Cement as a Local Adjuvant Therapy for Giant Cell Bone Tumor After Intralesional Curettage 4mg ZOL loaded gentamicin PMMA, gentamicin PMMA - Giant Cell Tumor of Bone | Phase 2 | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 153 | 2023-03-01 | 2023-03-15 |
| Efficacy and Safety of JMT103 in Patients With Giant Cell Tumor of Bone Dietary Supplement: Calcium/Vitamin D - Giant Cell Tumor of Bone | Phase 1 / Phase 2 | Unknown | Shanghai JMT-Bio Inc. | 139 | 2019-10-10 | 2022-10-14 |
| Reduced Dose-density of Denosumab for Unresectable GCTB Denosumab 120 MG/1.7 ML Subcutaneous Solution [XGEVA] - Bone Giant Cell Tumor | Phase 2 | Terminated | European Organisation for Research and Treatment of Cancer - EORTC | 2 | 2019-09-26 | 2021-01-06 |
| LN-145 or LN-145-S1 in Treating Patients With Relapsed or Refractory Ovarian Cancer, Triple Negative Breast Cancer (TNBC), Anaplastic Thyroid Cancer, Osteosarcoma, or Other Bone and Soft Tissue Sarcomas Aldesleukin, Autologous Tumor Infiltrating Lymphocytes LN-145, Autologous Tumor Infiltrating Lymphocytes LN-145-S1 - Bone Sarcoma, Dedifferentiated Chondrosarcoma | Phase 2 | Active not recruiting | M.D. Anderson Cancer Center | 30 | 2018-04-27 | 2026-05-22 |
| Adjuvant Zoledronic Acid in High Risk Giant Cell Tumour of Bone (GCT) Zoledronic acid - Giant Cell Tumor of Bone, Osteoclastoma | Phase 2 | Terminated | Leiden University Medical Center | 15 | 2008-12-01 | 2016-01-26 |
| Study of Denosumab in Subjects With Giant Cell Tumor of Bone Denosumab - Cancer, Giant Cell Tumors | Phase 2 | Completed | Amgen | 535 | 2008-09-09 | 2022-09-22 |
| Trial of Dasatinib in Advanced Sarcomas Dasatinib - Rhabdomyosarcoma, Malignant Peripheral Nerve Sheath Tumors | Phase 2 | Completed | Sarcoma Alliance for Research through Collaboration | 366 | 2007-05-01 | 2018-11-23 |
| Safety and Efficacy Study of Denosumab in Patients With Recurrent or Unresectable Giant Cell Tumor of Bone Denosumab, Calcium/Vitamin D - GCT, Giant Cell Tumor of Bone | Phase 2 | Completed | Amgen | 37 | 2006-07-10 | 2022-11-08 |
Sarcoma (2) · Bone Neoplasms (1) · Chondrosarcoma (1) · Chordoma (1) · Gastrointestinal Stromal Tumors (1) · Giant Cell Tumors (1) · Hemangiopericytoma (1) · Histiocytoma, Malignant Fibrous (1) · Neoplasms (1) · Neurofibrosarcoma (1) · Osteosarcoma (1) · Ovarian Neoplasms (1) · Rhabdomyosarcoma (1) · Sarcoma, Alveolar Soft Part (1)
Neoplasms by Histologic Type (9) · Neoplasms, Bone Tissue (9) · Neoplasms, Connective Tissue (9) · Neoplasms, Connective and Soft Tissue (9) · Giant Cell Tumors (8) · Neoplasms (8) · Neoplasms, Fibrous Tissue (2) · Adnexal Diseases (1) · Bone Diseases (1) · Breast Diseases (1) · Breast Neoplasms (1) · Carcinoma (1) · Digestive System Diseases (1) · Digestive System Neoplasms (1) · Endocrine Gland Neoplasms (1)
Denosumab (3) · Vitamin D (2) · CTLA-4 Antigen (1) · Calcium (1) · Cyclophosphamide (1) · Dasatinib (1) · Indocyanine Green (1) · Ipilimumab (1) · Nivolumab (1) · Zoledronic Acid (1) · aldesleukin (1) · fludarabine (1) · gentamicin-polymethylmethacrylate bead (1)
Amgen (2) · European Organisation for Research and Treatment of Cancer - EORTC (1) · Leiden University Medical Center (1) · M.D. Anderson Cancer Center (1) · Sarcoma Alliance for Research through Collaboration (1) · Second Affiliated Hospital, Zhejiang University, School of Medicine (1) · Shanghai JMT-Bio Inc. (1) · Tang Xiaodong (1)
China (3) · Netherlands (3) · United States (3) · Italy (2) · Spain (2) · United Kingdom (2) · Australia (1) · Austria (1) · Belgium (1) · Canada (1) · France (1) · Germany (1) · Poland (1) · Sweden (1)
A H Taminiau, MD PhD (1) · Amir A Jazaeri (1) · Emanuela Palmerini (1) · H Gelderblom, MD PhD (1) · Hans Gelderblom (1) · J R Kroep, MD PhD (1) · N A Hamdy, MD PhD (1) · P C Hogendoorn, MD PhD (1) · P D Dijkstra, MD PhD (1) · S E Papapoulos, MD PhD (1) · Scott Schuetze, MD, PhD (1)
PMID 25684041, PMID 29211870, PMID 30231890, PMID 31040253, PMID 33482769, PMID 39500883, PMID 41292259
2018 (1)