14 completed. 14 Phase 3, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 14 | Completed 14 |
| Phase 2 | 3 | Completed 3 |
Follow Gallbladder Neoplasms: new trials by email Literature Review of Gallbladder Neoplasms trials Research Report on Gallbladder Neoplasms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pembrolizumab (MK-3475) Plus Gemcitabine/Cisplatin Versus Placebo Plus Gemcitabine/Cisplatin for First-Line Advanced and/or Unresectable Biliary Tract Carcinoma (BTC) (MK-3475-966/KEYNOTE-966)-China Extension Study Pembrolizumab, Gemcitabine, Cisplatin - Biliary Tract Carcinoma | Phase 3 | Completed | Merck Sharp & Dohme LLC | 158 | 2020-07-10 | 2026-04-15 |
| Pembrolizumab (MK-3475) Plus Gemcitabine/Cisplatin Versus Placebo Plus Gemcitabine/Cisplatin for First-Line Advanced and/or Unresectable Biliary Tract Carcinoma (BTC) (MK-3475-966/KEYNOTE-966) Pembrolizumab, Gemcitabine, Cisplatin - Biliary Tract Carcinoma | Phase 3 | Completed | Merck Sharp & Dohme LLC | 1069 | 2019-09-24 | 2026-03-24 |
| Gemcitabine Hydrochloride and Cisplatin With or Without Nab-Paclitaxel in Treating Patients With Newly Diagnosed Advanced Biliary Tract Cancers Cisplatin, Gemcitabine Hydrochloride, Nab-paclitaxel - Stage III Distal Bile Duct Cancer AJCC v8, Stage III Gallbladder Cancer AJCC v8 | Phase 3 | Completed | SWOG Cancer Research Network | 452 | 2019-02-07 | 2026-01-12 |
| Varlitinib in Combination With Capecitabine for Advanced or Metastatic Biliary Tract Cancer Varlitinib, Capecitabine, Placebo (for Varlitinib) - Biliary Tract Cancer | Phase 2 / Phase 3 | Completed | ASLAN Pharmaceuticals | 151 | 2017-07-04 | 2021-08-03 |
| Active Symptom Control Alone or With mFOLFOX Chemotherapy for Locally Advanced/ Metastatic Biliary Tract Cancers Active Symptom Control, L-folinic acid, 5 FU - Biliary Tract Cancer, Gallbladder Cancer | Phase 3 | Completed | The Christie NHS Foundation Trust | 162 | 2014-02-01 | 2020-01-28 |
| New Chemotherapy Regimen in the Treatment of Advanced Gallbladder Carcinoma Somatostatin, epirubicin, cisplatin, LV（Leucovorin）、 5-FU（5-Fluorouracil） - Gallbladder Neoplasms | Phase 3 | Completed | Shanghai Jiao Tong University School of Medicine | 216 | 2009-10-01 | 2013-12-20 |
| Gemcitabine Hydrochloride and Oxaliplatin or Observation in Treating Patients With Biliary Tract Cancer That Has Been Removed by Surgery gemcitabine hydrochloride, oxaliplatin, clinical observation - Extrahepatic Bile Duct Cancer, Gallbladder Cancer | Phase 3 | Completed | UNICANCER | 190 | 2009-07-01 | 2017-01-25 |
| Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Fentanyl sublingual spray, Placebo - Cancer | Phase 3 | Completed | INSYS Therapeutics Inc | 130 | 2007-10-01 | 2014-03-05 |
| Biliary Stenting With or Without Photodynamic Therapy in Treating Patients With Locally Advanced, Recurrent, or Metastatic Cholangiocarcinoma or Other Biliary Tract Tumors That Cannot Be Removed by Surgery porfimer sodium, biliary stenting - Extrahepatic Bile Duct Cancer, Gallbladder Cancer | Phase 3 | Completed | University College, London | 92 | 2007-07-01 | 2013-02-20 |
| Capecitabine or Observation After Surgery in Treating Patients With Biliary Tract Cancer capecitabine, clinical observation, adjuvant therapy - Extrahepatic Bile Duct Cancer, Gallbladder Cancer | Phase 3 | Completed | University Hospital Southampton NHS Foundation Trust | 360 | 2006-03-01 | 2013-08-26 |
| Palliative Biliary Stenting on the Quality of Life of Patients With Unresectable Carcinoma Gallbladder With Hiliar Block. Biliary stenting - Gallbladder Cancer | Phase 2 / Phase 3 | Completed | All India Institute of Medical Sciences | 60 | 2006-01-01 | 2013-07-11 |
| Fluorouracil, Cisplatin, and Radiation Therapy or Gemcitabine and Oxaliplatin in Treating Patients With Nonmetastatic Biliary Tract Cancer That Cannot Be Removed By Surgery cisplatin, gemcitabine hydrochloride, oxaliplatin - Extrahepatic Bile Duct Cancer, Gallbladder Cancer | Phase 2 / Phase 3 | Completed | Federation Francophone de Cancerologie Digestive | 34 | 2005-10-01 | 2016-05-30 |
| Gemcitabine With or Without Cisplatin in Treating Patients With Unresectable Locally Advanced or Metastatic Cholangiocarcinoma or Other Biliary Tract Tumors cisplatin, gemcitabine hydrochloride - Extrahepatic Bile Duct Cancer, Gallbladder Cancer | Phase 3 | Completed | University College, London | 324 | 2005-05-01 | 2012-07-17 |
| Ondansetron With/Out Dexamethasone to Prevent Vomiting in Patients Receiving Radiation to the Upper Abdomen dexamethasone, ondansetron, quality-of-life assessment - Cancer | Phase 3 | Completed | NCIC Clinical Trials Group | 211 | 2001-02-28 | 2020-04-03 |
Bile Duct Neoplasms (10) · Cholangiocarcinoma (4) · Carcinoma, Hepatocellular (3) · Liver Neoplasms (3) · Neoplasms (3) · Appendiceal Neoplasms (2) · Biliary Tract Neoplasms (2) · Carcinoma, Ovarian Epithelial (2) · Colonic Neoplasms (2) · Pancreatic Neoplasms (2) · Parkinson Disease 4, Autosomal Dominant Lewy Body (2) · Stomach Neoplasms (2) · Uterine Cervical Neoplasms (2) · Adrenocortical Carcinoma (1)
Biliary Tract Diseases (14) · Digestive System Diseases (14) · Digestive System Neoplasms (14) · Gallbladder Diseases (14) · Neoplasms by Site (14) · Biliary Tract Neoplasms (12) · Neoplasms (11) · Bile Duct Diseases (10) · Adenocarcinoma (7) · Carcinoma (7) · Neoplasms by Histologic Type (7) · Neoplasms, Glandular and Epithelial (7) · Liver Diseases (5) · Adnexal Diseases (2) · Cecal Diseases (2)
Cisplatin (6) · Gemcitabine (6) · Oxaliplatin (3) · Capecitabine (2) · Chemotherapy, Adjuvant (2) · Watchful Waiting (2) · pembrolizumab (2) · 1,2-diaminocyclohexaneplatinum II citrate (1) · 130-nm albumin-bound paclitaxel (1) · ARRY-334543 (1) · Albumin-Bound Paclitaxel (1) · Dexamethasone (1) · Dihematoporphyrin Ether (1) · Epirubicin (1) · Fentanyl (1)
Merck Sharp & Dohme LLC (2) · University College, London (2) · ASLAN Pharmaceuticals (1) · All India Institute of Medical Sciences (1) · Federation Francophone de Cancerologie Digestive (1) · INSYS Therapeutics Inc (1) · NCIC Clinical Trials Group (1) · SWOG Cancer Research Network (1) · Shanghai Jiao Tong University School of Medicine (1) · The Christie NHS Foundation Trust (1) · UNICANCER (1) · University Hospital Southampton NHS Foundation Trust (1)
United Kingdom (5) · China (4) · United States (4) · France (3) · Australia (2) · Canada (2) · Hong Kong (2) · Japan (2) · South Korea (2) · Spain (2) · Taiwan (2) · Argentina (1) · Belgium (1) · Brazil (1) · Chile (1)
Bruno Chauffert (1) · Clive Stubbs (1) · Eveline Boucher, MD (1) · John A. Bridgewater (1) · Juan Valle, Prof (1) · Larry Dillaha, MD (1) · Pramod Garg, M.D, D.M. (1) · Rachna Shroff (1) · Rebecca Wong, MD (1) · Stephen P. Pereira, MD (1) · Vikram Bhatia, M.D, D.M. (1) · Zhi-wei Quan, MD (1)
PMID 38661512, PMID 42176183, PMID 16849762, PMID 20375404, PMID 22480131, PMID 25241229, PMID 27020837, PMID 33798493, PMID 37075781, PMID 39206260, PMID 39671534, PMID 40154623, PMID 40268484, PMID 41887529
2019 (1), 2023 (1), U10CA180888 (1)