25 completed. 25 Phase 3, 6 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 25 | Completed 25 |
| Phase 2 | 6 | Completed 6 |
Follow Gallbladder Diseases: new trials by email Literature Review of Gallbladder Diseases trials Research Report on Gallbladder Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Role of Intra-Operative Aspiration in Distended GB in LC Laparoscopic needle - Acute Calculous Cholecystitis, Gallbladder Empyema | Phase 3 | Completed | Aswan University | 70 | 2023-07-01 | 2026-01-30 |
| Naldebain for Pain Management of Laparoscopic Cholecystectomy Dinalbuphine sebacate, Placebo solution - Pain, Postoperative, Pain, Chronic | Phase 2 / Phase 3 | Completed | E-DA Hospital | 80 | 2021-08-30 | 2022-04-20 |
| Pembrolizumab (MK-3475) Plus Gemcitabine/Cisplatin Versus Placebo Plus Gemcitabine/Cisplatin for First-Line Advanced and/or Unresectable Biliary Tract Carcinoma (BTC) (MK-3475-966/KEYNOTE-966)-China Extension Study Pembrolizumab, Gemcitabine, Cisplatin - Biliary Tract Carcinoma | Phase 3 | Completed | Merck Sharp & Dohme LLC | 158 | 2020-07-10 | 2026-04-15 |
| Pembrolizumab (MK-3475) Plus Gemcitabine/Cisplatin Versus Placebo Plus Gemcitabine/Cisplatin for First-Line Advanced and/or Unresectable Biliary Tract Carcinoma (BTC) (MK-3475-966/KEYNOTE-966) Pembrolizumab, Gemcitabine, Cisplatin - Biliary Tract Carcinoma | Phase 3 | Completed | Merck Sharp & Dohme LLC | 1069 | 2019-09-24 | 2026-03-24 |
| Gemcitabine Hydrochloride and Cisplatin With or Without Nab-Paclitaxel in Treating Patients With Newly Diagnosed Advanced Biliary Tract Cancers Cisplatin, Gemcitabine Hydrochloride, Nab-paclitaxel - Stage III Distal Bile Duct Cancer AJCC v8, Stage III Gallbladder Cancer AJCC v8 | Phase 3 | Completed | SWOG Cancer Research Network | 452 | 2019-02-07 | 2026-01-12 |
| Varlitinib in Combination With Capecitabine for Advanced or Metastatic Biliary Tract Cancer Varlitinib, Capecitabine, Placebo (for Varlitinib) - Biliary Tract Cancer | Phase 2 / Phase 3 | Completed | ASLAN Pharmaceuticals | 151 | 2017-07-04 | 2021-08-03 |
| Digital SpyGlass Confirmed Common Bile Duct Stones Clearance Without Fluoroscopy Endoscopic Retrograde Cholangioscopy by SpyGlass (ERCS) - Common Bile Duct Diseases, Stone - Biliary | Phase 3 | Completed | Chulalongkorn University | 51 | 2015-12-01 | 2016-11-18 |
| A Randomized Controlled Trial on EGBD vs PC for Acute Cholecystitis. EUS-guided gallbladder drainage (EGBD), Percutaneous cholecystostomy (PC) - Acute Cholecystitis | Phase 2 / Phase 3 | Completed | Chinese University of Hong Kong | 60 | 2014-08-01 | 2019-07-30 |
| Active Symptom Control Alone or With mFOLFOX Chemotherapy for Locally Advanced/ Metastatic Biliary Tract Cancers Active Symptom Control, L-folinic acid, 5 FU - Biliary Tract Cancer, Gallbladder Cancer | Phase 3 | Completed | The Christie NHS Foundation Trust | 162 | 2014-02-01 | 2020-01-28 |
| Renalof in the Treatment of Elderly Patients With Gallstones Renalof, Placebo - Cholelithiasis | Phase 3 | Completed | Catalysis SL | 40 | 2010-01-01 | 2012-05-08 |
| New Chemotherapy Regimen in the Treatment of Advanced Gallbladder Carcinoma Somatostatin, epirubicin, cisplatin, LV（Leucovorin）、 5-FU（5-Fluorouracil） - Gallbladder Neoplasms | Phase 3 | Completed | Shanghai Jiao Tong University School of Medicine | 216 | 2009-10-01 | 2013-12-20 |
| Gemcitabine Hydrochloride and Oxaliplatin or Observation in Treating Patients With Biliary Tract Cancer That Has Been Removed by Surgery gemcitabine hydrochloride, oxaliplatin, clinical observation - Extrahepatic Bile Duct Cancer, Gallbladder Cancer | Phase 3 | Completed | UNICANCER | 190 | 2009-07-01 | 2017-01-25 |
| Piperacllin Versus Placebo in Patients Undergoing Surgery for Acute Cholecystitis Piperacillin-tazobactam combination product, Saline solution - Cholecystitis, Acute | Phase 3 | Completed | Karolinska Institutet | 100 | 2009-03-01 | 2018-03-06 |
| Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Fentanyl sublingual spray, Placebo - Cancer | Phase 3 | Completed | INSYS Therapeutics Inc | 130 | 2007-10-01 | 2014-03-05 |
| Biliary Stenting With or Without Photodynamic Therapy in Treating Patients With Locally Advanced, Recurrent, or Metastatic Cholangiocarcinoma or Other Biliary Tract Tumors That Cannot Be Removed by Surgery porfimer sodium, biliary stenting - Extrahepatic Bile Duct Cancer, Gallbladder Cancer | Phase 3 | Completed | University College, London | 92 | 2007-07-01 | 2013-02-20 |
| Acute Cholecystitis - Early Laparoscopic Surgery Versus Antibiotic Therapy and Delayed Elective Cholecystectomy moxifloxacin, cholecystectomy - Acute Cholecystitis | Phase 3 | Completed | Heidelberg University | 644 | 2006-10-01 | 2012-07-23 |
| Small-incision Open Cholecystectomy or Laparoscopic Cholecystectomy for Gallbladder Disease Laparoscopic cholecystectomy, Small-incision open cholecystectomy - Biliary Tract Diseases, Gallbladder Diseases | Phase 2 / Phase 3 | Completed | Umeå University | 355 | 2006-09-01 | 2015-04-24 |
| Capecitabine or Observation After Surgery in Treating Patients With Biliary Tract Cancer capecitabine, clinical observation, adjuvant therapy - Extrahepatic Bile Duct Cancer, Gallbladder Cancer | Phase 3 | Completed | University Hospital Southampton NHS Foundation Trust | 360 | 2006-03-01 | 2013-08-26 |
| Palliative Biliary Stenting on the Quality of Life of Patients With Unresectable Carcinoma Gallbladder With Hiliar Block. Biliary stenting - Gallbladder Cancer | Phase 2 / Phase 3 | Completed | All India Institute of Medical Sciences | 60 | 2006-01-01 | 2013-07-11 |
| Fluorouracil, Cisplatin, and Radiation Therapy or Gemcitabine and Oxaliplatin in Treating Patients With Nonmetastatic Biliary Tract Cancer That Cannot Be Removed By Surgery cisplatin, gemcitabine hydrochloride, oxaliplatin - Extrahepatic Bile Duct Cancer, Gallbladder Cancer | Phase 2 / Phase 3 | Completed | Federation Francophone de Cancerologie Digestive | 34 | 2005-10-01 | 2016-05-30 |
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Gallbladder Neoplasms (14) · Bile Duct Neoplasms (10) · Cholecystitis (5) · Cholangiocarcinoma (4) · Cholecystitis, Acute (4) · Gallstones (4) · Carcinoma, Hepatocellular (3) · Liver Neoplasms (3) · Neoplasms (3) · Appendiceal Neoplasms (2) · Appendicitis (2) · Bacterial Infections and Mycoses (2) · Biliary Tract Neoplasms (2) · Carcinoma, Ovarian Epithelial (2) · Cholecystolithiasis (2)
Digestive System Diseases (25) · Biliary Tract Diseases (24) · Digestive System Neoplasms (14) · Neoplasms by Site (14) · Biliary Tract Neoplasms (12) · Bile Duct Diseases (11) · Neoplasms (11) · Adenocarcinoma (7) · Carcinoma (7) · Neoplasms by Histologic Type (7) · Neoplasms, Glandular and Epithelial (7) · Pathological Conditions, Signs and Symptoms (7) · Liver Diseases (5) · Calculi (4)
Cisplatin (6) · Gemcitabine (6) · Oxaliplatin (3) · Capecitabine (2) · Chemotherapy, Adjuvant (2) · Doripenem (2) · Watchful Waiting (2) · pembrolizumab (2) · 1,2-diaminocyclohexaneplatinum II citrate (1) · 130-nm albumin-bound paclitaxel (1) · ARRY-334543 (1) · Albumin-Bound Paclitaxel (1) · Cholecystectomy (1) · Cholecystectomy, Laparoscopic (1) · Dexamethasone (1)
Chinese University of Hong Kong (2) · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (2) · Merck Sharp & Dohme LLC (2) · University College, London (2) · ASLAN Pharmaceuticals (1) · All India Institute of Medical Sciences (1) · Aswan University (1) · Catalysis SL (1) · Chulalongkorn University (1) · E-DA Hospital (1) · Federation Francophone de Cancerologie Digestive (1) · Heidelberg University (1) · INSYS Therapeutics Inc (1) · Karolinska Institutet (1) · NCIC Clinical Trials Group (1)
China (6) · United Kingdom (5) · United States (4) · France (3) · Japan (3) · Spain (3) · Taiwan (3) · Australia (2) · Canada (2) · Germany (2) · Hong Kong (2) · South Korea (2) · Sweden (2) · Argentina (1) · Belgium (1)
Ali H Abdelaal (1) · Bruno Chauffert (1) · Clive Stubbs (1) · Eveline Boucher, MD (1) · Folke Hammarqvist, Ass Prof (1) · Frances KY Cheung, MBChB (1) · John A. Bridgewater (1) · Juan Valle, Prof (1) · Larry Dillaha, MD (1) · Markus W Buechler, Prof. (1)
PMID 19670912, PMID 20211892, PMID 38661512, PMID 42176183, PMID 16849762, PMID 17916243, PMID 20375404, PMID 22480131, PMID 23085096, PMID 23640665, PMID 24022431, PMID 25241229, PMID 27020837, PMID 28388942, PMID 32165407, PMID 32860109, PMID 33798493, PMID 37075781, PMID 39206260, PMID 39671534, PMID 40154623, PMID 40268484, PMID 41887529
2019 (1), 2023 (1), U10CA180888 (1)