25 completed, 10 recruiting, 10 unknown, 5 active not recruiting. 60 Phase 3, 18 Phase 2.
Follow Gallbladder Diseases: new trials by email Literature Review of Gallbladder Diseases trials Research Report on Gallbladder Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Hepatic Arterial Infusion Chemotherapy Versus Capecitabine as Adjuvant Therapy for Resected Biliary Tract Cancer Oxaliplatin, 5-Fluorouracil, Capecitabine - Biliary Tract Cancer, Cholangiocarcinoma | Phase 3 | Not yet recruiting | Zhai Wenlong | 90 | 2026-11-30 | 2026-11-04 |
| A Study to Select a Dose Regimen (Part A) and to Investigate Overall Survival (Part B) With Nanvuranlat Compared With Physician's Best Choice in Participants Aged 18 Years or Older With Biliary Tract Cancer Nanvuranlat, Physician's Best Choice - Advanced Biliary Tract Cancer, Biliary Tract Cancer (BTC) | Phase 3 | Recruiting | J-Pharma Co., Ltd. | 480 | 2026-05-11 | 2026-09-29 |
| A Study of Rilvegostomig or Durvalumab Plus Chemotherapy for First-Line Treatment of Biliary Tract Cancer (ARTEMIDE-Biliary02) Rilvegostomig, Durvalumab, Gemcitabine/Cisplatin - Biliary Tract Cancer | Phase 3 | Recruiting | AstraZeneca | 1100 | 2025-12-04 | 2026-09-28 |
| Impact of Comprehensive Geriatric Management on Morbidity and Quality of Life in Elderly Patients Undergoing Major Hepatectomy and Pancreaticoduodenectomy for Cancer Comprehensive Geriatric Assessment - Hepatobiliary Cancer, Pancreatic Cancer | Phase 2 / Phase 3 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 526 | 2025-09-01 | 2025-05-31 |
| Evaluating the Safety and Efficacy of Duloxetine in the Prevention of Post Endoscopic Retrograde Cholangiopancreatography Pancreatitis Duloxetine, Placebo capsule - Biliary Disease | Phase 3 | Recruiting | Tanta University | 44 | 2025-03-10 | 2026-08-18 |
| Neoadjuvant Chemotherapy for Locally Advanced Gall Bladder Cancer : a Randomized Control Trial (NEOGB) neoadjuvant chemotherapy, curative surgery - Gall Bladder Carcinoma | Phase 3 | Recruiting | Rajiv Gandhi Cancer Institute & Research Center, India | 114 | 2025-01-01 | 2025-04-16 |
| Evaluating Perioperative Outcomes: Dexmedetomidine vs Lignocaine in Laparoscopic Chlolecystectomy inj. dexmedetomidine infusion @ 0.2-0.4 μg/kg/h, inj. lignocaine infusion @1-2 mg/kg/h - Hemodynamics Instability, Post Operative Pain | Phase 2 / Phase 3 | Recruiting | Sahiwal medical college sahiwal | 140 | 2024-08-06 | 2024-12-18 |
| Efficacy and Safety of Zanidatamab With Standard-of-care Therapy Against Standard-of-care Therapy for Advanced HER2-positive Biliary Tract Cancer Zanidatamab, Cisplatin, Gemcitabine - Biliary Tract Cancer | Phase 3 | Recruiting | Jazz Pharmaceuticals | 286 | 2024-07-19 | 2026-10-28 |
| Radiation Therapy in Unresectable Gall Bladder Cancer Systemic therapy (Gemcitabine plus Cisplatin), RT, Systemic therapy (Gemcitabine plus oxaliplatin) - Gall Bladder Cancer | Phase 2 / Phase 3 | Recruiting | Tata Memorial Centre | 249 | 2024-03-07 | 2025-04-11 |
| Rilvegostomig + Chemotherapy as Adjuvant Therapy for Biliary Tract Cancer After Resection (ARTEMIDE-Biliary01) Rilvegostomig, Placebo, Capecitabine - Biliary Tract Cancer | Phase 3 | Active not recruiting | AstraZeneca | 760 | 2023-12-04 | 2026-10-16 |
| Primary Percutaneous Stenting Above the Ampulla Versus Endoscopic Drainage for Unresectable Malignant Hilar Biliary Obstruction Primary percutaneous stenting (PPS), Endoscopic biliary drainage - Cholangiocarcinoma Non-resectable, Gall Bladder Cancer | Phase 3 | Enrolling by invitation | Erasmus Medical Center | 148 | 2023-08-09 | 2024-11-04 |
| Role of Intra-Operative Aspiration in Distended GB in LC Laparoscopic needle - Acute Calculous Cholecystitis, Gallbladder Empyema | Phase 3 | Completed | Aswan University | 70 | 2023-07-01 | 2026-01-30 |
| EUS-GBD vs Antibiotics for Patients at High Risk for Cholecystectomy Endoscopic ultrasound-guided gallbladder drainage, Antibiotics first - Acute Cholecystitis | Phase 3 | Recruiting | Chinese University of Hong Kong | 110 | 2023-04-26 | 2026-04-07 |
| DETERMINE Trial Treatment Arm 04: Trastuzumab in Combination With Pertuzumab in Adult, Paediatric and Teenage/Young Adult Patients With Cancers With HER2 Amplification or Activating Mutations Trastuzumab, Pertuzumab - Haematological Malignancy, Colorectal Neoplasms | Phase 2 / Phase 3 | Recruiting | Cancer Research UK | 30 | 2023-03-07 | 2025-12-02 |
| A Study of CTX-009 in Combination With Paclitaxel in Adult Patients With Unresectable Advanced, Metastatic or Recurrent Biliary Tract Cancers (COMPANION-002) CTX-009, Paclitaxel - Biliary Tract Cancer, Cholangiocarcinoma | Phase 2 / Phase 3 | Active not recruiting | Compass Therapeutics | 168 | 2023-01-09 | 2026-11-10 |
| Addition of Everolimus to Standard of Care in Carcinoma Gallbladder Everolimus 10 mg, Standard of care - Gallbladder Cancer | Phase 2 / Phase 3 | Unknown | Banaras Hindu University | 56 | 2022-11-01 | 2024-08-13 |
| Ursodeoxycolic Acid for the Prevention of Relapsing Complications After Gallstone Acute Pancreatitis Ursodeoxycholic Acid, Placebo - Acute Pancreatitis Due to Gallstones | Phase 3 | Recruiting | Hospital General Universitario de Alicante | 332 | 2021-11-10 | 2025-03-20 |
| Naldebain for Pain Management of Laparoscopic Cholecystectomy Dinalbuphine sebacate, Placebo solution - Pain, Postoperative, Pain, Chronic | Phase 2 / Phase 3 | Completed | E-DA Hospital | 80 | 2021-08-30 | 2022-04-20 |
| Postoperative Pain Difference for 'IV Paracetamol' and TAP Block' in Acute Cholecystitis Intravenous Infusion, Local anesthesia - Transversus Abdominis Plane (TAP) Block | Phase 3 | Unknown | Bakirkoy Dr. Sadi Konuk Research and Training Hospital | 42 | 2021-03-15 | 2021-03-03 |
| Comparison of Chemotherapy Before and After Surgery Versus After Surgery Alone for the Treatment of Gallbladder Cancer Cisplatin, Gemcitabine Hydrochloride, Lymphadenectomy - Stage II Gallbladder Cancer AJCC v8, Stage IIA Gallbladder Cancer AJCC v8 | Phase 2 / Phase 3 | Active not recruiting | ECOG-ACRIN Cancer Research Group | 186 | 2021-02-24 | 2026-10-19 |
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Gallbladder Neoplasms (38) · Bile Duct Neoplasms (15) · Cholangiocarcinoma (14) · Biliary Tract Neoplasms (11) · Cholecystitis (8) · Cholecystitis, Acute (8) · Gallstones (8) · Liver Neoplasms (6) · Pancreatic Neoplasms (6) · Carcinoma, Hepatocellular (5) · Colonic Neoplasms (4) · Neoplasms (4) · Stomach Neoplasms (4) · Esophageal Neoplasms (3) · Lung Neoplasms (3)
Digestive System Diseases (60) · Biliary Tract Diseases (59) · Digestive System Neoplasms (38) · Neoplasms by Site (38) · Neoplasms (34) · Biliary Tract Neoplasms (27) · Adenocarcinoma (19) · Carcinoma (19) · Neoplasms by Histologic Type (19) · Neoplasms, Glandular and Epithelial (19) · Bile Duct Diseases (16) · Pathological Conditions, Signs and Symptoms (16) · Liver Diseases (9) · Pancreatic Diseases (9)
Gemcitabine (18) · Cisplatin (15) · Capecitabine (9) · Oxaliplatin (6) · Chemotherapy, Adjuvant (3) · Fluorouracil (3) · Leucovorin (3) · Ursodeoxycholic Acid (3) · durvalumab (3) · pembrolizumab (3) · 1,2-diaminocyclohexaneplatinum II citrate (2) · 130-nm albumin-bound paclitaxel (2) · Chemoradiotherapy (2) · Cholecystectomy, Laparoscopic (2) · Dihematoporphyrin Ether (2)
Chinese University of Hong Kong (3) · AstraZeneca (2) · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (2) · Merck Sharp & Dohme LLC (2) · NCIC Clinical Trials Group (2) · University College, London (2) · ASLAN Pharmaceuticals (1) · All India Institute of Medical Sciences (1) · American University of Beirut Medical Center (1) · Assistance Publique - Hôpitaux de Paris (1) · Aswan University (1) · Auron Healthcare GmbH (1) · Bakirkoy Dr. Sadi Konuk Research and Training Hospital (1) · Banaras Hindu University (1) · Beijing Friendship Hospital (1)
United States (15) · China (14) · United Kingdom (12) · France (9) · Germany (9) · South Korea (9) · Spain (9) · Canada (8) · India (8) · Italy (7) · Japan (7) · Taiwan (7) · Australia (6) · Belgium (5) · Brazil (5)
Adeel Riaz, MD (1) · Afshin Dowlati, MD (1) · Ali H Abdelaal (1) · Bruno Chauffert (1) · Clive Stubbs (1) · Cynthia Sirard, MD (1) · Enrique De Madaria, Medicine (1) · Eric K Rowinsky, MD (1) · Eveline Boucher, MD (1) · Folke Hammarqvist, Ass Prof (1) · Frances KY Cheung, MBChB (1) · Ghassan Abou-Alfa, MD (1)
PMID 19670912, PMID 20211892, PMID 38661512, PMID 42176183, PMID 16849762, PMID 17916243, PMID 20375404, PMID 21910897, PMID 21964736, PMID 22480131, PMID 23085096, PMID 23640665, PMID 24022431, PMID 25241229, PMID 26228433, PMID 26885872, PMID 27020837, PMID 28388942, PMID 29610513, PMID 31253621, PMID 32165407, PMID 32461347, PMID 32860109, PMID 33798493, PMID 34515993, PMID 37075781, PMID 38861293, PMID 38875119, PMID 39206260, PMID 39671534, PMID 40154623, PMID 40268484, PMID 40346549, PMID 41887529
2023 (3), 2019 (2), K23CA115908 (1), U10CA180820 (1), U10CA180888 (1)