12 unknown, 11 completed, 10 recruiting, 2 enrolling by invitation. 26 Not applicable, 3 Phase 4, 2 Phase 2, 2 Phase 3.
Follow Freezing of Gait: new trials by email Literature Review of Freezing of Gait trials Research Report on Freezing of Gait
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Decoding the Neural Mechanisms Underlying Postural Instability and Gait Dysfunction in Parkinson's Disease Multiple Deep Brain Stimulation (DBS) Conditions, Moving Overground in a Virtual Environment (MOVE), Cleveland Clinic Stair Ambulation and Functional Evaluation of Gait (SAFE-Gait) - Parkinson Disease, Freezing of Gait | Not applicable | Recruiting | The Cleveland Clinic | 5 | 2026-12-09 | 2026-10-26 |
| Etiology-Phenotype-Outcome Pathway Study on Freezing of Gait (FOG) Observational Data Collection - Freezing of Gait, Parkinson's Disease | Recruiting | Tianjin Huanhu Hospital | 700 | 2026-02-28 | 2026-03-10 | |
| Percept Transitions in FOG and PD OFF Parkinson's Medication(s), OFF Deep Brain Stimulation - Freezing of Gait, Parkinson Disease | Not applicable | Recruiting | University of Minnesota | 36 | 2026-02-26 | 2026-03-03 |
| Pharmacologically Modulating the Noradrenergic Arousal System to Reduce Freezing of Gait in Parkinson's Disease: a Multi-centre and Multi-modal Approach Atomoxetine, Placebo - Parkinson's Disease (PD), Freezing of Gait | Phase 3 | Recruiting | Radboud University Medical Center | 60 | 2026-01-01 | 2026-02-27 |
| Understanding Freezing of Gait Using Brain Signals and Virtual Reality VR Freezing Task, Dual Task, External Cueing - Parkinson&Amp;#39;s Disease, Freezing of Gait | Not applicable | Enrolling by invitation | University of California, Los Angeles | 36 | 2025-11-01 | 2026-02-17 |
| AID-FOG: Artificial Intelligence-Driven Freezing of Gait Detection in the Home Parkinson Disease, Idiopathic, Freezing of Gait | Recruiting | KU Leuven | 126 | 2025-09-22 | 2026-05-12 | |
| Spinal Cord Stimulation for Freezing of Gait in Parkinson's Disease Spinal Cord Stimulation, Spinal electrophysiological recordings - Freezing of Gait, Parkinson Disease | Phase 2 | Active not recruiting | Universitaire Ziekenhuizen KU Leuven | 29 | 2025-02-05 | 2026-09-21 |
| Vortioxetine for Depressive Symptoms and Freezing of Gait in Parkinson Disease Vortioxetine (tablet) - Parkinson Disease, Idiopathic, Freezing of Gait | Phase 4 | Not yet recruiting | Marianna Amboni | 40 | 2025-02-01 | 2025-02-06 |
| Remote Mental Practice for Freezing of Gait in Parkinson's Disease MPPG (Mental and Physical Practice Group), PPG (Physical Practice Group) - Parkinson Disease, Freezing of Gait | Not applicable | Recruiting | University of Sao Paulo General Hospital | 50 | 2025-01-25 | 2025-08-27 |
| Investigating the Neural Signature of Freezing of Gait in Parkinson's Disease Parkinson Disease, Freezing of Gait | Enrolling by invitation | KU Leuven | 28 | 2024-11-04 | 2025-02-24 | |
| Study of the Link Between Freezing of Gait and Oropharyngeal Freezing in Parkinson's Patients Parkinson's Disease, Dysphagia | Unknown | Hopital La Musse | 66 | 2024-10-04 | 2024-12-04 | |
| Application of Thoracic Epidural SCS for Managing FOG in Patients With Advanced Parkinson's Disease SCS electrode stimulation 1, SCS electrode stimulation 2, SCS electrode stimulation 3 - Parkinson Disease, Freezing of Gait | Not applicable | Recruiting | National Taiwan University Hospital | 5 | 2024-09-20 | 2025-11-20 |
| Effect of Virtual Reality on Freezing Phenomenon, Balance, Functional Mobility, Participation in Parkinson's Patients Task-Oriented Virtual Reality Application with Crowd Simulation, Conventional Parkinson Rehabilitation - Parkinson's Disease, Freezing of Gait | Not applicable | Unknown | Ankara Yildirim Beyazıt University | 20 | 2024-08-01 | 2024-04-30 |
| Tackling Anxiety-related Freezing of Gait in People With Parkinson's Disease Psychological intervention - Freezing of Gait | Not applicable | Completed | Radboud University Medical Center | 41 | 2024-04-04 | 2026-03-12 |
| DBS and Levodopa for Treating Freezing of Gait in Parkinson's Disease STIM ON plus, MED ON plus - Freezing of Gait, Parkinson Disease | Phase 4 | Recruiting | IRCCS Istituto delle Scienze Neurologiche di Bologna | 20 | 2023-10-10 | 2024-03-18 |
| Spinal Cord Stimulation for Gait Dysfunction in Parkinson's Disease Spinal Cord Stimulation - High Frequency SCS, Spinal Cord Stimulation - Burst SCS, Spinal Cord Stimulation - Sham SCS - Parkinson Disease, Freezing of Gait | Not applicable | Unknown | Imperial College London | 8 | 2023-06-01 | 2023-08-22 |
| Efficacy of Deep-coil Based Repetitive Transcranial Magnetic Stimulation in the Treatment of Parkinson's Disease With Freezing of Gait and Its Neural Regulation Mechanism Study of Resting-state Cerebral Blood Flow repetitive transcranial magnetic stimulation (rTMS), Non-stimulation - Parkinson Disease, Freezing of Gait | Not applicable | Completed | Ningbo Medical Center Lihuili Hospital | 60 | 2023-02-01 | 2025-04-04 |
| Assessing and Understanding Freezing of Gait at Home: FOG@Home AX6 6-axis logging accelerometer - Parkinson Disease, Freezing of Gait | Not applicable | Unknown | Tel-Aviv Sourasky Medical Center | 30 | 2023-02-01 | 2023-02-08 |
| Dual-target, High-dose TMS for PD Patients With FOG transcranial magnetic stimulation - Transcranial Magnetic Stimulation, Freezing of Gait | Not applicable | Terminated | Anhui Medical University | 64 | 2022-12-22 | 2025-11-19 |
| Split-belt Treadmill Training for Freezing of Gait in Parkinson's Disease Split-belt treadmill training, Complex task practice, Upper-limb coordination and power - Parkinson Disease, Freezing of Gait | Not applicable | Completed | KU Leuven | 26 | 2022-12-16 | 2026-09-03 |
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Parkinson Disease (35) · Mobility Limitation (6) · Movement Disorders (3) · Gait Disorders, Neurologic (2) · Basal Ganglia Diseases (1) · Brain Diseases (1) · Deglutition Disorders (1) · Depression (1) · Hypokinesia (1) · Motor Disorders (1) · Neurodegenerative Diseases (1) · Parkinsonian Disorders (1)
Central Nervous System Diseases (35) · Nervous System Diseases (35) · Synucleinopathies (35) · Basal Ganglia Diseases (34) · Brain Diseases (34) · Neurodegenerative Diseases (34) · Parkinsonian Disorders (34) · Movement Disorders (32) · Pathological Conditions, Signs and Symptoms (8) · Signs and Symptoms (8) · Neurologic Manifestations (3) · Behavior (1) · Behavioral Symptoms (1) · Digestive System Diseases (1) · Dyskinesias (1)
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PMID 23185280, PMID 31524181, PMID 31771246, PMID 32940131, PMID 34816053, PMID 40651960, PMID 42239677, PMID 42310830
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