18 completed, 5 recruiting, 5 unknown, 2 withdrawn. 13 Not applicable, 6 Phase 4, 2 Phase 2, 2 Phase 3, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 13 | Completed 6, Recruiting 3, Unknown 3, Withdrawn 1 |
| Phase 4 | 6 | Completed 5, Unknown 1 |
| Phase 2 | 2 | Completed 2 |
| Phase 3 | 2 | Completed 1, Recruiting 1 |
| Phase 1 | 1 | Completed 1 |
Follow First Episode Psychosis: new trials by email Literature Review of First Episode Psychosis trials Research Report on First Episode Psychosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Stratification and Treatment in Early Psychosis Study - ENHANCE CBD 100 mg/mL Oral Solution, Placebo - Psychosis, First Episode Psychosis | Phase 3 | Recruiting | University of Oxford | 250 | 2026-10-05 | 2026-10-08 |
| On Track for Wellness (OTW) Stepped Wedge Cluster Randomized Trial On Track for Wellness - Sleep, Physical Activity | Not applicable | Recruiting | University of Illinois at Chicago | 365 | 2026-09-01 | 2026-10-09 |
| Digital Strategies to Advance Help-Seeking - Aim 3 Digital nudge - Clinical High Risk, Early Psychosis | Not applicable | Recruiting | Columbia University | 25000 | 2026-02-02 | 2026-06-18 |
| Recovery With Exogenous Ketones and Antipsychotics Medium chain triglyceride oil - First Episode Psychosis | Not applicable | Recruiting | Université de Sherbrooke | 15 | 2025-08-26 | 2026-05-22 |
| Digital Strategies to Advance Help-Seeking Aim 1 and 2 Clinical High Risk, Early Psychosis | Recruiting | Columbia University | 25000 | 2025-04-07 | 2026-05-05 | |
| Pilot RCT of Self-stigma Treatment for First Episode Psychosis Narrative Enhancement and Cognitive Therapy- Young Adult, Combined with Coordinated Specialty Care, Coordinated Specialty Care - First Episode Psychosis, Youth | Not applicable | Completed | John Jay College of Criminal Justice, City University of New York | 17 | 2023-08-01 | 2026-08-05 |
| Evaluation of Case Management for First Episode Psychosis Using the PEPsy-CM Checklist evaluation of professional practices - First Episode Psychosis | Completed | Centre Hospitalier Universitaire de Nīmes | 50 | 2023-02-01 | 2023-09-21 | |
| Optimizing Engagement in Services for First-Episode Psychosis Behavioral Activation for First Episode Psychosis, Treatment As Usual - Engagement, Patient, First Episode Psychosis | Not applicable | Completed | California State University, San Bernardino | 28 | 2022-03-01 | 2026-08-27 |
| Implementation of Digital CBT for Insomnia in First Episode Psychosis Sleepio - Insomnia, Psychosis | Not applicable | Unknown | NHS Greater Glasgow and Clyde | 22 | 2021-04-20 | 2021-09-20 |
| Artificial Intelligence to Measure Adherence to Oral Medication Smartphone App, Usual Care - First Episode Psychosis | Phase 4 | Completed | Northwell Health | 139 | 2020-11-20 | 2026-10-13 |
| ED to EPI: Using SMS to Improve the Transition From the Emergency Department to Early Psychosis Intervention Active SMS Intervention, Sham SMS - First Episode Psychosis, Psychosis | Not applicable | Completed | Centre for Addiction and Mental Health | 186 | 2020-09-21 | 2026-03-18 |
| Repetitive Transcranial Magnetic Stimulation in Early Psychosis and The Functional Connectivity Biotypes repetitive transcranial magnetic stimulation (rTMS) - Schizophrenia; Psychosis, First Episode Psychosis | Not applicable | Unknown | Shanghai Jiao Tong University School of Medicine | 300 | 2020-08-01 | 2023-12-29 |
| Disengagement in CSC: Identifying Those at Risk and Addressing Their Needs CSC Step-down intervention, Usual Care - First Episode Psychosis | Phase 4 | Unknown | Northwell Health | 300 | 2020-07-01 | 2024-09-19 |
| Using Digital Media Advertising to Reduce the Duration of Untreated Psychosis search engine advertisement campaign - Schizophrenia, First Episode Psychosis | Not applicable | Completed | Northwell Health | 698 | 2020-04-22 | 2023-11-03 |
| Early-Phase Schizophrenia: Practice-based Research to Improve Outcomes Coordinated Specialty Care (CSC) - First Episode Psychosis | Unknown | Northwell Health | 700 | 2020-04-01 | 2024-09-19 | |
| Early Psychosis Intervention - Spreading Evidence-based Treatment NAVIGATE, Treatment as Usual - First Episode Psychosis, Schizophrenia, Childhood | Not applicable | Completed | Centre for Addiction and Mental Health | 100 | 2020-01-03 | 2026-03-18 |
| Feasibility of an Early Detection Program for Early Psychosis on a College Campus Psychosis, First Episode Psychosis | Completed | University of New Mexico | 25 | 2019-10-01 | 2024-04-01 | |
| OnTrackNY's Learning Healthcare System Stakeholder feedback, Data infrastructure - First Episode Psychosis | Suspended | New York State Psychiatric Institute | 2100 | 2019-08-15 | 2026-06-23 | |
| Socially Inappropriate Behaviour in People With First Episode Psychosis: A Caregivers' Perspective Face-to face semi-structured in-depth interview - First Episode Psychosis | Completed | Chinese University of Hong Kong | 8 | 2018-06-12 | 2021-07-30 | |
| A Trial to Explore Acceptance and Performance of Using a Digital Medicine System With Healthcare Professionals and Adults With Schizophrenia, Schizoaffective Disorder, or First Episode Psychosis on an Oral Atypical Antipsychotic Digital Medicine System, Aripiprazole, Olanzapine - Schizophrenia, Schizoaffective Disorder | Phase 4 | Completed | Otsuka Pharmaceutical Development & Commercialization, Inc. | 44 | 2018-05-21 | 2020-07-16 |
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Psychotic Disorders (12) · Schizophrenia (9) · Schizophrenia Spectrum and Other Psychotic Disorders (3) · Affective Disorders, Psychotic (2) · Motor Activity (2) · Bipolar Disorder (1) · Health Behavior (1) · Ketosis (1) · Mental Disorders (1) · Patient Participation (1) · Psychological Well-Being (1) · Psychoses, Substance-Induced (1) · Schizophrenia, Childhood (1) · Schizotypal Personality Disorder (1) · Sleep Initiation and Maintenance Disorders (1)
Mental Disorders (15) · Schizophrenia Spectrum and Other Psychotic Disorders (13) · Behavior (4) · Acid-Base Imbalance (1) · Acidosis (1) · Bipolar and Related Disorders (1) · Chemically-Induced Disorders (1) · Dyssomnias (1) · Health Behavior (1) · Metabolic Diseases (1) · Mood Disorders (1) · Nervous System Diseases (1) · Neurodevelopmental Disorders (1) · Nutritional and Metabolic Diseases (1) · Patient Acceptance of Health Care (1)
Aripiprazole (2) · Therapeutics (2) · Folic Acid (1) · Health (1) · Minocycline (1) · Olanzapine (1) · Paliperidone Palmitate (1) · Quetiapine Fumarate (1) · Risperidone (1) · Solutions (1) · Transcranial Magnetic Stimulation (1) · Vitamin B 12 (1) · ziprasidone (1)
Northwell Health (4) · Chonbuk National University Hospital (3) · Centre for Addiction and Mental Health (2) · Columbia University (2) · California State University, San Bernardino (1) · Centre Hospitalier Universitaire de Nīmes (1) · Chinese University of Hong Kong (1) · Copenhagen University Hospital, Rigshospitalet (1) · John Jay College of Criminal Justice, City University of New York (1) · Lisa Dixon (1) · Melbourne Health (1) · NHS Greater Glasgow and Clyde (1) · New York State Psychiatric Institute (1) · Nicholas Breitborde (1) · Nordlandssykehuset HF (1)
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George Foussias, MD, PhD (2) · Michael Birnbaum, MD (2) · Albert HC Wong, MD, PhD (1) · Andrew Gumley (1) · Annette Crisanti, PhD (1) · Aristotle N Voineskos, MD, PhD (1) · Aristotle Voineskos, MD, PhD (1) · Dr Colin P O'Donnell, MB,MRCPsych (1) · Helle Schnor, Ph.D. (1) · Imran B Chaudhry, MD (1) · Iruma Bello, PhD (1) · Jaime EC Hallak, MD (1) · Janet Durbin, PhD, MSc (1) · Jijun Wang, M.D., Ph.D (1) · Judith A Cook, Ph.D (1)
PMID 30771856, PMID 31226959, PMID 31253613, PMID 32499262, PMID 33334839, PMID 34013257, PMID 34225817, PMID 34412705, PMID 38085556, PMID 39687049
R01MH133569 (2), 2025 (1), K23MH119313 (1), R01MH103830 (1), R01MH120597 (1), R34MH120777 (1), R34MH120790 (1)