8 completed, 2 recruiting, 1 active not recruiting, 1 terminated. 12 Phase 3, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 12 | Completed 8, Recruiting 2, Active not recruiting 1, Terminated 1 |
| Phase 2 | 1 | Terminated 1 |
Follow Failure to Thrive: new trials by email Literature Review of Failure to Thrive trials Research Report on Failure to Thrive
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Trial Investigating the Efficacy and Safety of Weekly Lonapegsomatropin Compared to Daily Somatropin in Children and Adolescents With Short Stature or Growth Failure Due to Growth Hormone Sufficient Disorders Lonapegsomatropin [SKYTROFA®], Somatropin Pen Injector - Turner Syndrome, Short Stature Homeobox Gene Mutation | Phase 3 | Recruiting | Ascendis Pharma A/S | 186 | 2025-12-12 | 2026-11-05 |
| Randomized Clinical Trial of Two Different Initial Growth Hormone Doses in Children Somatropin - Growth Disorders, Growth Failure | Phase 3 | Recruiting | Northwell Health | 50 | 2023-12-10 | 2026-10-21 |
| A Trial to Compare the Efficacy and Safety of Once-weekly Lonapegsomatropin With Placebo and a Daily Somatropin Product in Adults With Growth Hormone Deficiency Lonapegsomatropin, Placebo, Somatropin - Growth Hormone Deficiency, Endocrine System Diseases | Phase 3 | Completed | Ascendis Pharma Endocrinology Division A/S | 264 | 2020-12-03 | 2026-07-07 |
| A Long-Term Trial Investigating Safety and Efficacy of TransCon hGH in Children With Growth Hormone Deficiency Who Have Completed a Prior TransCon hGH Clinical Trial TransCon hGH - Growth Hormone Deficiency, Pediatric, Endocrine System Diseases | Phase 3 | Completed | Ascendis Pharma A/S | 298 | 2017-12-19 | 2026-07-07 |
| A Safety, Tolerability and Efficacy Study of TransCon hGH in Children With Growth Hormone Deficiency TransCon hGH - Growth Hormone Deficiency, Pediatric, Endocrine System Diseases | Phase 3 | Completed | Ascendis Pharma Endocrinology Division A/S | 146 | 2017-11-13 | 2026-07-07 |
| A Phase 3 Trial of the Safety, Tolerability and Efficacy of TransCon hGH Weekly Versus Daily hGH in Children With Growth Hormone Deficiency (GHD) Once weekly subcutaneous injection of TransCon hGH, Once daily subcutaneous injection of Genotropin - Growth Hormone Deficiency, Pediatric, hGH (Human Growth Hormone) | Phase 3 | Completed | Ascendis Pharma Endocrinology Division A/S | 162 | 2016-12-13 | 2026-07-07 |
| Long-Acting Growth Hormone in Children Compared to Daily rhGH Somavaratan, rhGH - Growth Disorders | Phase 3 | Completed | Versartis Inc. | 138 | 2015-08-26 | 2022-12-30 |
| Supplementing Maternal and Infant Diet With High-energy, Micronutrient Fortified Lipid-based Nutrient Supplements (LNS) IFA, MMN, LNS - Infant Malnutrition, Malnutrition in Pregnancy | Phase 3 | Active not recruiting | Tampere University | 1391 | 2011-02-01 | 2025-03-28 |
| Prevention of Linear Growth Failure in Infants and Young Children With Lipid-based Nutrient Supplements (iLiNS-DOSE) Lipid-based nutrient supplement, 10gM, Lipid-based nutrient supplement, 20gM, Lipid-based Nutrient Supplement, 20gNoM - Malnutrition | Phase 3 | Completed | Tampere University | 1920 | 2009-11-01 | 2015-05-27 |
| Growth Hormone in Children With Juvenile Rheumatoid Arthritis (JRA) and With Crohn's Disease somatropin [rDNA origin] for injection - Arthritis, Juvenile Rheumatoid, Crohn Disease | Phase 2 / Phase 3 | Terminated | Nationwide Children's Hospital | 10 | 2007-08-01 | 2018-04-12 |
| Study to Define Optimal IGF-1 Monitoring in Children Treated With NutropinAq Somatropin (rDNA origin) - Turner Syndrome, Renal Insufficiency, Chronic | Phase 3 | Completed | Ipsen | 251 | 2004-06-01 | 2019-12-09 |
| Somatropin Treatment in Patients With SHOX Deficiency and Turner Syndrome Somatropin (rDNA origin) for injection - Failure to Thrive | Phase 3 | Completed | Eli Lilly and Company | 75 | 2000-02-01 | 2010-12-20 |
Dwarfism, Pituitary (5) · Endocrine System Diseases (5) · Growth Disorders (4) · Pituitary Diseases (4) · Dwarfism (3) · Malnutrition (2) · Turner Syndrome (2) · Arthritis, Juvenile (1) · Chromosome Disorders (1) · Chronic Disease (1) · Crohn Disease (1) · Infant Nutrition Disorders (1) · Noonan Syndrome (1) · Renal Insufficiency, Chronic (1)
Pathological Conditions, Signs and Symptoms (12) · Signs and Symptoms (12) · Bone Diseases (8) · Bone Diseases, Developmental (8) · Musculoskeletal Diseases (8) · Brain Diseases (6) · Central Nervous System Diseases (6) · Hypothalamic Diseases (6) · Nervous System Diseases (6) · Pathologic Processes (6) · Bone Diseases, Endocrine (5) · Dwarfism (5) · Hypopituitarism (5) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (3) · Endocrine System Diseases (3)
Human Growth Hormone (4) · Growth Hormone (2) · WW Domain-Containing Oxidoreductase (2) · lonapegsomatropin (2)
Ascendis Pharma Endocrinology Division A/S (3) · Ascendis Pharma A/S (2) · Tampere University (2) · Eli Lilly and Company (1) · Ipsen (1) · Nationwide Children's Hospital (1) · Northwell Health (1) · Versartis Inc. (1)
United States (8) · Australia (4) · Greece (4) · Italy (4) · New Zealand (4) · Romania (4) · Ukraine (4) · Armenia (3) · France (3) · Georgia (3) · Germany (3) · Poland (3) · Russia (3) · Spain (3) · Belarus (2)
Per Ashorn, MD, PhD (2) · Aimee Shu, MD (1) · Benjamin U. Nwosu, MD (1) · Dana S Hardin, MD (1) · Kenneth Maleta, MBBS, PhD (1) · Will Charlton, MD (1)
PMID 27474016, PMID 28978680, PMID 30593271, PMID 31010435, PMID 24368436, PMID 25646337, PMID 25926413, PMID 25957793, PMID 25995276, PMID 26063066, PMID 26694646, PMID 26740684, PMID 26843155, PMID 26956611, PMID 27577112, PMID 27829430, PMID 28095801, PMID 28237085, PMID 28794206, PMID 29305501, PMID 29349922, PMID 29415730, PMID 30629202, PMID 30658632, PMID 31436705, PMID 31909811, PMID 33054890, PMID 33096556, PMID 34084993, PMID 34272849, PMID 34543432, PMID 35149871, PMID 35155983, PMID 35317414, PMID 35428884, PMID 35909334, PMID 36078607, PMID 37021807
2004 (1), 2016 (1), 2017 (1)