34 completed, 6 unknown, 3 terminated, 1 withdrawn. 25 Phase 2, 11 Phase 1, 8 Phase 3, 3 Not applicable.
Follow Extragonadal Germ Cell Tumor: new trials by email Literature Review of Extragonadal Germ Cell Tumor trials Research Report on Extragonadal Germ Cell Tumor
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Clinical Study Investigating the Therapeutic Effects and Safety of an Investigational Cell Therapy Given With and Without an Additional Investigational Product in Males With Testicular Cancer or a Form of Cancer That Developed From Sperm CLDN6 CAR-T, CLDN6 RNA-LPX - Testicular Germ Cell Tumor, Extragonadal Germ Cell Tumor | Phase 2 | Withdrawn | BioNTech SE | 2025-07-01 | 2025-07-02 | |
| Studying Biomarkers in Samples From Younger Patients With Malignant Germ Cell Tumor Progression DNA methylation analysis, RNA analysis, mutation analysis - Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor | Completed | Children's Oncology Group | 90 | 2011-10-01 | 2016-05-18 | |
| High-Dose Chemotherapy and Stem Cell Transplant in Treating Patients With Metastatic Germ Cell Tumors That Have Not Responded to First-Line Therapy filgrastim, pegfilgrastim, carboplatin - Brain and Central Nervous System Tumors, Extragonadal Germ Cell Tumor | Phase 2 | Unknown | Fondazione IRCCS Istituto Nazionale dei Tumori, Milano | 47 | 2010-10-01 | 2013-08-12 |
| Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors carboplatin, dasatinib, etoposide phosphate - Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor | Phase 1 / Phase 2 | Terminated | City of Hope Medical Center | 7 | 2008-09-03 | 2023-07-14 |
| Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy sodium thiosulfate, examination - Brain Tumor, Central Nervous System Tumor | Phase 3 | Completed | Children's Oncology Group | 131 | 2008-06-23 | 2023-11-09 |
| Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment sunitinib malate - Extragonadal Germ Cell Tumor, Ovarian Cancer | Phase 2 | Completed | Memorial Sloan Kettering Cancer Center | 10 | 2007-03-01 | 2015-10-27 |
| Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors pegfilgrastim, cisplatin, ifosfamide - Brain and Central Nervous System Tumors, Extragonadal Germ Cell Tumor | Phase 2 | Completed | Memorial Sloan Kettering Cancer Center | 60 | 2007-03-01 | 2017-11-28 |
| Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors filgrastim, lenograstim, pegfilgrastim - Brain and Central Nervous System Tumors, Extragonadal Germ Cell Tumor | Phase 1 / Phase 2 | Unknown | University of Southampton | 23 | 2006-11-01 | 2013-01-23 |
| Paclitaxel, Ifosfamide, and Carboplatin Followed By Autologous Stem Cell Transplant in Treating Patients With Germ Cell Tumors That Did Not Respond to Cisplatin filgrastim, carboplatin, ifosfamide - Brain and Central Nervous System Tumors, Extragonadal Germ Cell Tumor | Phase 1 / Phase 2 | Completed | Memorial Sloan Kettering Cancer Center | 26 | 2006-08-01 | 2016-05-18 |
| Treatment Outcome and Quality of Life in Patients With Pediatric Extra-Cranial Germ Cell Tumors Previously Treated on Clinical Trial CCLG-GC-1979-01 or CCLG-GC-1989-01 assessment of therapy complications, quality-of-life assessment - Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor | Unknown | Children's Cancer and Leukaemia Group | 60 | 2006-06-01 | 2013-08-12 | |
| Lapatinib and Paclitaxel in Treating Patients With Advanced Solid Tumors lapatinib, paclitaxel - Bladder Cancer, Brain and Central Nervous System Tumors | Phase 1 | Completed | University of California, San Francisco | 28 | 2006-02-01 | 2014-07-02 |
| Combination Chemotherapy in Treating Male Patients With Germ Cell Tumors bleomycin sulfate, carboplatin, cisplatin - Extragonadal Germ Cell Tumor, Teratoma | Phase 2 | Completed | Medical Research Council | 88 | 2005-06-01 | 2013-08-26 |
| Observation and/or Combination Chemotherapy After Surgery or Biopsy in Treating Young Patients With Extracranial Germ Cell Tumors bleomycin sulfate, carboplatin, cisplatin - Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor | Phase 3 | Unknown | Children's Cancer and Leukaemia Group | 105 | 2005-05-01 | 2013-09-17 |
| Electroacupuncture in Treating Delayed Nausea and Vomiting in Patients Receiving Chemotherapy For Newly Diagnosed Childhood Sarcoma, Neuroblastoma, Nasopharyngeal Cancer, Germ Cell Tumors, or Hodgkin Lymphoma electroacupuncture therapy, sham intervention, quality-of-life assessment - Brain Tumors, Central Nervous System Tumors | Not applicable | Completed | Children's Oncology Group | 17 | 2005-04-01 | 2013-05-31 |
| Combination Chemotherapy and Pegfilgrastim in Treating Men With Metastatic Germ Cell Tumors bleomycin sulfate, pegfilgrastim, cisplatin - Extragonadal Germ Cell Tumor, Teratoma | Phase 2 | Completed | Cambridge University Hospitals NHS Foundation Trust | 20 | 2004-08-01 | 2013-08-07 |
| Combination Chemotherapy in Treating Children With Newly Diagnosed Malignant Germ Cell Tumors bleomycin sulfate, filgrastim, cisplatin - Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor | Not applicable | Completed | Children's Oncology Group | 19 | 2004-07-01 | 2013-10-17 |
| Cisplatin and Ifosfamide Combined With Either Paclitaxel or Vinblastine in Treating Men With Progressive or Recurrent Metastatic Germ Cell Tumors cisplatin, ifosfamide, paclitaxel - Extragonadal Germ Cell Tumor, Testicular Germ Cell Tumor | Phase 3 | Terminated | Alliance for Clinical Trials in Oncology | 1 | 2004-04-01 | 2016-07-04 |
| Combination Chemotherapy in Treating Patients With Stage II or Stage III Germ Cell Tumors bleomycin sulfate, cisplatin, etoposide - Extragonadal Germ Cell Tumor, Teratoma | Phase 3 | Completed | UNICANCER | 263 | 2003-11-26 | 2025-02-06 |
| Ixabepilone in Treating Patients With Advanced Cisplatin-Refractory Germ Cell Tumors ixabepilone - Brain and Central Nervous System Tumors, Extragonadal Germ Cell Tumor | Phase 2 | Completed | Memorial Sloan Kettering Cancer Center | 29 | 2003-08-01 | 2013-06-24 |
| Arsenic Trioxide in Treating Men With Germ Cell Cancer arsenic trioxide - Extragonadal Germ Cell Tumor, Testicular Germ Cell Tumor | Phase 2 | Completed | SWOG Cancer Research Network | 2002-04-01 | 2013-06-24 |
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Testicular Neoplasms (39) · Ovarian Neoplasms (32) · Testicular Germ Cell Tumor (28) · Teratoma (27) · Central Nervous System Neoplasms (22) · Ovarian Germ Cell Cancer (14) · Endodermal Sinus Tumor (11) · Sarcoma (11) · Carcinoma, Embryonal (10) · Neuroblastoma (10) · Osteosarcoma (10) · Seminoma (10) · Liver Neoplasms (9) · Neuroectodermal Tumors, Primitive, Peripheral (9) · Medulloblastoma (8)
Neoplasms (44) · Neoplasms by Site (43) · Endocrine Gland Neoplasms (42) · Endocrine System Diseases (42) · Genital Diseases (42) · Gonadal Disorders (42) · Urogenital Diseases (42) · Urogenital Neoplasms (42) · Genital Diseases, Male (40) · Genital Neoplasms, Male (40) · Male Urogenital Diseases (40) · Testicular Diseases (39) · Neoplasms by Histologic Type (35) · Adnexal Diseases (32) · Female Urogenital Diseases (32)
Etoposide (19) · Carboplatin (17) · Cisplatin (14) · Filgrastim (14) · Ifosfamide (13) · Paclitaxel (10) · Peripheral Blood Stem Cell Transplantation (10) · Bleomycin (9) · Cyclophosphamide (7) · etoposide phosphate (4) · pegfilgrastim (4) · Radiotherapy (3) · Thiotepa (3) · Vinblastine (3) · Amifostine (2)
Memorial Sloan Kettering Cancer Center (10) · Children's Oncology Group (6) · Children's Cancer and Leukaemia Group (3) · UNICANCER (3) · City of Hope Medical Center (2) · European Organisation for Research and Treatment of Cancer - EORTC (2) · National Institutes of Health Clinical Center (CC) (2) · Alliance for Clinical Trials in Oncology (1) · BioNTech SE (1) · Cambridge University Hospitals NHS Foundation Trust (1) · Cancer Research Campaign Clinical Trials Centre (1) · Dana-Farber Cancer Institute (1) · Duke University (1) · Fondazione IRCCS Istituto Nazionale dei Tumori, Milano (1) · Mayo Clinic (1)
United States (30) · United Kingdom (9) · Canada (5) · France (5) · Australia (4) · Puerto Rico (4) · Ireland (3) · Italy (3) · Netherlands (3) · Switzerland (3) · Austria (2) · Belgium (2) · Denmark (2) · Germany (2) · Israel (2)
Robert J. Motzer, MD (4) · Brian H. Kushner, MD (2) · Darren Feldman, MD (2) · Gnanamba V. Kondagunta, MD (2) · A. Oakhill, MD (1) · Adam Glaser, MD (1) · AeRang Kim, MD (1) · Alessandro M. Gianni, MD (1) · Allen R. Chen, MD, PhD, MHS (1) · Brad H. Pollock, PhD (1) · David D. Hurd, MD (1) · David R. Freyer, DO, MS (1) · Dean F. Bajorin, MD (1) · Elizabeth Fox, MD (1)
PMID 15999362, PMID 16148284, PMID 16234526, PMID 16688776, PMID 16914576, PMID 17194908, PMID 17235042, PMID 18281544, PMID 19075272, PMID 19430790, PMID 19547919, PMID 19706807, PMID 20044751, PMID 20194867, PMID 25001888, PMID 25456363, PMID 27914822, PMID 39167741, PMID 9849694
P30CA008748 (4), P30CA033572 (2), 2005 (1), P30CA006516 (1), P30CA015083 (1), U10CA031946 (1)