22 completed, 4 terminated, 2 unknown, 2 withdrawn. 17 Phase 2, 10 Phase 1, 3 Not applicable, 3 Phase 3.
Follow Ewing's Sarcoma: new trials by email Literature Review of Ewing's Sarcoma trials Research Report on Ewing's Sarcoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Randomized Controlled Study Comparing the Safety and Efficacy of Irinotecan Hydrochloride Liposome Injection Combined With Temozolomide and Vincristine (NALIRI-VT) Versus Irinotecan Combined With Temozolomide and Vincristine (VIT) in Patients With Advanced Ewing's Sarcoma Irinotecan Hydrochloride Liposome Injection Combined with Temozolomide and Vincristine (NALIRI-VT), Irinotecan Combined with Temozolomide and Vincristine (VIT) - Ewing's Sarcoma | Phase 2 | Not yet recruiting | Tang Xiaodong | 74 | 2025-08-10 | 2025-07-29 |
| A Post-treatment Program to Identify and Manage Complications Related to Oncology or Hematology Treatments in Cancer Survivors. PASCA intervention - Late Effects, Testicular Germ Cell Tumor Mixed | Not applicable | Active not recruiting | Centre Leon Berard | 500 | 2020-12-24 | 2025-09-05 |
| Phase I Trial of Universal Donor NK Cell Therapy in Combination With ALT803 Natural Killer (NK) Cells, ALT803 - Acute Myeloid Leukemia, Myelodysplastic Syndrome | Phase 1 | Completed | Brenda Cooper, MD | 14 | 2018-05-22 | 2023-02-21 |
| Assessment of Healing and Function After Reconstruction Surgery for Bone Sarcomas Toronto Extremity Salvage Score, Musculoskeletal Tumor Society Score, Timed Get Up and Go Test - Bone Sarcoma, Osteosarcoma | Recruiting | Memorial Sloan Kettering Cancer Center | 300 | 2018-02-14 | 2026-04-17 | |
| Pbi-shRNA™ EWS/FLI1 Type 1 LPX in Subjects With Advanced Ewing's Sarcoma pbi-shRNA™ EWS/FLI1 Type 1 Lipoplex - Ewing's Sarcoma, Ewing Family of Tumors | Phase 1 | Completed | Gradalis, Inc. | 7 | 2016-10-01 | 2023-11-13 |
| Erlotinib in Combination With Temozolomide in Treating Relapsed/Recurrent/Refractory Pediatric Solid Tumors Erlotinib, Temozolomide - Glioma, Rhabdomyosarcoma | Phase 2 | Withdrawn | Washington University School of Medicine | 2016-08-06 | 2019-09-09 | |
| A Two-part Phase IIb Trial of Vigil (Bi-shRNAfurin and GMCSF Augmented Autologous Tumor Cell Immunotherapy) in Ewing's Sarcoma Vigil, Temozolomide, Irinotecan - Ewing's Sarcoma | Phase 2 | Completed | Gradalis, Inc. | 22 | 2016-02-10 | 2022-12-22 |
| Study to Find a Safe Dose and Show Early Clinical Activity of Weekly Nab-paclitaxel in Pediatric Patients With Recurrent/ Refractory Solid Tumors nab-paclitaxel - Neuroblastoma, Rhabdomyosarcoma | Phase 1 / Phase 2 | Completed | Celgene | 107 | 2013-12-04 | 2019-12-27 |
| Post-operative Radiotherapy in Poor Responders Ewing's Sarcoma Patients External Beam Radiotherapy - Ewing's Sarcoma | Phase 3 | Withdrawn | Children's Cancer Hospital Egypt 57357 | 2012-09-01 | 2016-01-12 | |
| Effects of Preoperative Physical Therapy in Patients With Lower Extremity Malignancy Endurance, Strengthening, Stretching - Osteosarcoma, Ewing's Sarcoma | Not applicable | Completed | St. Jude Children's Research Hospital | 20 | 2012-09-01 | 2015-12-04 |
| Olaparib in Adults With Recurrent/Metastatic Ewing's Sarcoma Olaparib - Ewing's Sarcoma | Phase 2 | Completed | Massachusetts General Hospital | 12 | 2012-05-01 | 2017-05-19 |
| Differentiation of Bone Sarcomas and Osteomyelitis With Ferumoxytol-Enhanced MRI Feraheme, Magnetic Resonance Imaging (MRI) scan - Bone Cancer, Chondrosarcoma | Phase 2 | Completed | Heike E Daldrup-Link | 32 | 2011-08-01 | 2023-12-27 |
| Cyclophosphamide, Doxorubicin, Vincristine w/ Irinotecan and Temozolomide in Ewings Sarcoma Irinotecan, Vincristine, Temozolomide - Bone Cancer, Ewing's Sarcoma | Phase 2 | Terminated | Stanford University | 3 | 2011-05-01 | 2017-11-24 |
| Aflac ST0901 CHOANOME - Sirolimus in Solid Tumors sirolimus - Ewing's Sarcoma, Osteosarcoma | Phase 1 | Completed | Emory University | 18 | 2011-04-01 | 2020-05-29 |
| Use of Racotumomab in Patients With Pediatric Tumors Expressing N-glycolylated Gangliosides racotumomab - Neuroblastoma, Ewing's Sarcoma | Phase 1 | Completed | Laboratorio Elea Phoenix S.A. | 15 | 2011-02-01 | 2015-07-29 |
| Study of Zalypsis® (PM00104) in Patients With Unresectable Locally Advanced and/or Metastatic Ewing Family of Tumors (EFT) Progressing After at Least One Prior Line of Chemotherapy Zalypsis - Ewing's Sarcoma, Primitive Neuroectodermal Tumor (PNET) | Phase 2 | Completed | PharmaMar | 17 | 2010-12-01 | 2021-10-29 |
| Safety Study of Recombinant Vaccinia Virus to Treat Refractory Solid Tumors in Pediatric Patients Recombinant Vaccinia GM-CSF; RAC VAC GM-CSF (JX-594) - Neuroblastoma, Rhabdomyosarcoma | Phase 1 | Completed | Jennerex Biotherapeutics | 6 | 2010-08-01 | 2016-01-21 |
| Study of Intensive Chemotherapy, Surgery and Radiotherapy to Treat Ewing's Sarcoma in Children and Young Adults Chemotherapy, Surgery, Radiotherapy - Ewing's Sarcoma | Phase 2 | Completed | Grupo Espanol de Investigacion en Sarcomas | 43 | 2010-03-30 | 2018-08-01 |
| Study in Localized and Disseminated Ewing Sarcoma Zoledronic acid, Busulfan, Treosulfan - Ewing's Sarcoma | Phase 3 | Completed | University Hospital Muenster | 907 | 2009-10-01 | 2019-10-22 |
| Efficacy of Dose Intensification in Patients With Non-metastatic Ewing Sarcoma Standard treatment (as per protocol ISG SSG III), Intensified chemotherapy - Ewing's Sarcoma | Phase 3 | Completed | Italian Sarcoma Group | 278 | 2009-01-22 | 2022-09-19 |
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Sarcoma, Ewing (33) · Rhabdomyosarcoma (13) · Osteosarcoma (11) · Sarcoma (9) · Neuroblastoma (7) · Wilms Tumor (5) · Bone Neoplasms (4) · Neoplasms (4) · Glioma (3) · Hodgkin Disease (3) · Neoplasm Metastasis (3) · Neuroectodermal Tumors (3) · Neuroectodermal Tumors, Primitive (3) · Brain Neoplasms (2) · Chondrosarcoma (2)
Neoplasms by Histologic Type (33) · Neoplasms, Bone Tissue (33) · Neoplasms, Connective Tissue (33) · Neoplasms, Connective and Soft Tissue (33) · Neoplasms (29) · Sarcoma (24) · Osteosarcoma (22) · Myosarcoma (13) · Neoplasms by Site (13) · Neoplasms, Muscle Tissue (13) · Neoplasms, Nerve Tissue (13) · Neoplasms, Germ Cell and Embryonal (11) · Neoplasms, Glandular and Epithelial (11) · Neoplasms, Neuroepithelial (11) · Neuroectodermal Tumors (9)
Temozolomide (5) · Cyclophosphamide (4) · Vincristine (4) · Doxorubicin (3) · Busulfan (2) · Dexrazoxane (2) · Drug Therapy (2) · Etoposide (2) · Irinotecan (2) · pegfilgrastim (2) · 130-nm albumin-bound paclitaxel (1) · ALT-803 (1) · Albumin-Bound Paclitaxel (1) · CD40 Ligand (1) · Cell Count (1)
National Cancer Institute (NCI) (7) · Gradalis, Inc. (2) · M.D. Anderson Cancer Center (2) · Ann & Robert H Lurie Children's Hospital of Chicago (1) · Brenda Cooper, MD (1) · Celgene (1) · Centre Leon Berard (1) · Children's Cancer Hospital Egypt 57357 (1) · Emory University (1) · Fudan University (1) · Grupo Espanol de Investigacion en Sarcomas (1) · Heike E Daldrup-Link (1) · Italian Sarcoma Group (1) · Jennerex Biotherapeutics (1) · King Faisal Specialist Hospital & Research Center (1)
United States (22) · France (3) · Italy (3) · Spain (2) · Argentina (1) · Canada (1) · China (1) · Egypt (1) · Germany (1) · Switzerland (1) · United Kingdom (1)
Crystal L Mackall, M.D. (3) · John Nemunaitis, MD (2) · Alan W Craft, Prof Sir MD (1) · Alok Kothari, M.D. (1) · Angela M. Corr, PT, DPT (1) · Armando Santoro, Prof. (1) · Brigitte C Widemann, M.D. (1) · Crystal Mackall, M.D. (1) · Cynthia E. Herzog, MD (1) · Daniel Prince, MD (1) · David Wald, MD, PhD (1) · Edwin Choy, MD PhD (1) · Eugenie S. Kleinerman, MD (1) · Fariba Navid, MD (1) · Guillermo Chantada, MD (1)
PMID 31401903, PMID 18676758, PMID 23071222, PMID 25374341, PMID 26154941, PMID 26271204, PMID 31553693, PMID 31876107, PMID 32554315, PMID 35427190, PMID 38524902, PMID 39796745, PMID 39833645
2008 (1), 2009 (1)