448 completed, 207 unknown, 183 recruiting, 90 terminated. 347 Phase 2, 228 Not applicable, 216 Phase 1, 79 Phase 3, 19 Phase 4.
Follow Esophageal Cancer: new trials by email Literature Review of Esophageal Cancer trials Research Report on Esophageal Cancer
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Outside the Cage (OTC) Robotic Esophagectomy OTC MIE Esophagectomy - Esophageal Cancer | Phase 1 | Not yet recruiting | Centre hospitalier de l'Université de Montréal (CHUM) | 31 | 2027-01-01 | 2026-03-18 |
| A Study of LG00313112 in Participants With Advanced Solid Malignancies Harboring a TP53 Y220C Mutation LG00313112 - Ovarian Cancer, Small Cell Lung Cancer | Phase 1 / Phase 2 | Not yet recruiting | LG Chem | 250 | 2026-12-01 | 2026-08-07 |
| Evaluation of the Administration of Artificial Nutrition by Feeding Jejunostomy During Neoadjuvant Treatment on Postoperative Morbidity in the Context of Esophageal or Stomach Cancer Enteral or parenteral nutrition - Esophageal Cancer, Surgery Indication | Recruiting | University Hospital, Bordeaux | 670 | 2026-11-01 | 2026-05-13 | |
| Pharmacokinetics Study of Larotinib in Subjects With Impaired Hepatic Function Larotinib - Esophageal Cancer, Advanced Solid Tumor | Phase 1 | Withdrawn | Sunshine Lake Pharma Co., Ltd. | 2026-10-30 | 2026-09-28 | |
| Phase 1 Study of STRO-006 in Adults With Refractory Solid Tumors That Are Recurrent or Metastatic STRO-006, Pembrolizumab - Head & Neck Squamous Cell Carcinoma, Non-Small Cell Lung Cancer | Phase 1 | Recruiting | Sutro Biopharma, Inc. | 285 | 2026-10-19 | 2026-10-23 |
| Modular Robot-Assisted Versus Conventional Minimally Invasive Esophagectomy for Esophageal Cancer Modular Robot-Assisted Esophagectomy, Conventional Minimally Invasive Esophagectomy - Esophageal Cancer | Phase 3 | Recruiting | Ruijin Hospital | 160 | 2026-10-15 | 2026-10-22 |
| A Non-inferiority Study of Indocyanine Green-guided Sentinel Lymph Node Mapping Versus Conventional Lymph Node Dissection in Esophageal Cancer ICG-guided sentinel lymph node dissection, ICG-guided systematic lymph node dissection - Esophageal Cancer, Sentinel Lymph Node | Phase 3 | Not yet recruiting | Fujian Medical University Union Hospital | 200 | 2026-10-01 | 2026-08-26 |
| Zanidatamab Outcomes and Lived Experiences in Advanced HER2+ GEA Zanidatamab - Esophageal Cancer, GastroEsophageal Cancer | Not yet recruiting | Jazz Pharmaceuticals | 300 | 2026-10-01 | 2026-10-02 | |
| Concurrent Immunotherapy and Systemic Therapy With Stereotactic Body Radiation Therapy (SBRT) for Stage IV Cancers (COINSSS IV) Stereotactic Body Radiation Therapy (SBRT), Pembrolizumab, Nivolumab - Head and Neck Cancer, Non-Small Cell Lung Cancer | Phase 2 | Recruiting | Mark Bernard | 35 | 2026-09-09 | 2026-10-14 |
| A Study of 2141-V11 in People With Esophageal, Gastric, or Gastroesophageal Junction Adenocarcinoma Intratumoral 2141-V11, Nivolumab, Fluoropyrimidine - Esophageal Cancer, Advanced Esophageal Cancer | Phase 1 / Phase 2 | Recruiting | Memorial Sloan Kettering Cancer Center | 30 | 2026-09-04 | 2026-09-14 |
| A Phase 1, First-in-Human (FIH), Open-Label, Dose-Escalation and Dose Expansion Study of the Peptide Drug Conjugate (PDC), TS-104, as a Monotherapy in Subjects With Select Advanced Solid Tumors TS-104 - NSCLC (Non-small Cell Lung Cancer), HNSCC | Phase 1 | Recruiting | TwoStep Therapeutics, Inc. | 74 | 2026-09-02 | 2026-09-30 |
| NOMAD-GI: Molecular-guided Non-operative Management and Organ Preservation Strategy After Precision Therapy in Gastrointestinal Cancers Gastrointestinal Cancer, Gastric Cancer | Not yet recruiting | Peking University Cancer Hospital & Institute | 200 | 2026-09-01 | 2026-08-20 | |
| A Study of MGC030 in Participants With Advanced Solid Tumors MGC030 - Urothelial Cancer, GastroEsophageal Cancer | Phase 1 | Not yet recruiting | MacroGenics | 314 | 2026-09-01 | 2026-09-16 |
| Phase Ib Study of Oral R01 Monotherapy in Advanced Solid Tumors R01 - Squamous Cell Lung Cancer, Gastric Cancer | Phase 1 | Not yet recruiting | Beijing Anjianxi Bio-Medical Technology Co., Ltd. | 18 | 2026-09-01 | 2026-09-08 |
| Evaluation of the Distribution of 64Cu/68Ga Labeled CM500 in Healthy Volunteers and Patients With Cancer [64Cu]CM500, [68Ga]CM500, PET/MR - Bladder Cancer, Glioma | Early Phase 1 | Not yet recruiting | Lumina Pharmaceuticals Inc | 40 | 2026-09-01 | 2026-08-28 |
| Study of Adebrelimab Combined With Thymalfasin and Chemotherapy for Neoadjuvant Treatment of Esophageal Cancer Adebrelimab, Thymalfasin, Chemotherapy - Esophageal Cancer | Phase 2 | Not yet recruiting | The Affiliated Hospital of Putian University | 31 | 2026-08-30 | 2026-08-21 |
| High-Flow Nasal Cannula Oxygenation During Sedated Gastrointestinal Endoscopy in Patients With Chronic Obstructive Pulmonary Disease High-flow nasal cannula - Hypoxemia, Gastric Cancer (Diagnosis) | Not applicable | Not yet recruiting | Zhejiang University | 90 | 2026-08-29 | 2026-08-28 |
| An Exploratory Clinical Study of Accurate Efficacy Assessment of Neoadjuvant Immunotherapy in Locally Advanced Esophageal Squamous Cell Carcinoma Based on 68Ga-FAPI ([68Ga] Fibroblast Activation Protein Inhibitor)/¹⁸F-FDG (2-Deoxy-2-[¹⁸F]Fluoro-D-glucose) Dual Imaging Retlirafusp Alfa Plus Chemotherapy, Adebrelimab Plus Chemotherapy - Esophageal Cancer, ESCC | Phase 2 | Not yet recruiting | Tan Lijie | 92 | 2026-08-20 | 2026-08-18 |
| SL-28 for Advanced Solid Tumours SL-28 - Head & Neck Cancer, Pancreas Carcinoma | Phase 1 / Phase 2 | Recruiting | Second Life Therapeutics | 60 | 2026-08-14 | 2026-09-15 |
| Pharmacologic Therapies to Mitigate Radiation- Associated Heart Disease Atorvastatin and Lisinopril, Placebo - Chest Wall Tumor, Breast Cancer | Phase 2 | Recruiting | UNC Lineberger Comprehensive Cancer Center | 60 | 2026-08-12 | 2026-09-17 |
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Esophageal Neoplasms (1056) · Stomach Neoplasms (295) · Pancreatic Neoplasms (132) · Adenocarcinoma Of Esophagus (124) · Lung Neoplasms (120) · Carcinoma, Non-Small-Cell Lung (102) · Colorectal Neoplasms (98) · Head and Neck Neoplasms (91) · Esophageal Squamous Cell Carcinoma (90) · Breast Neoplasms (82) · Ovarian Neoplasms (81) · Liver Neoplasms (65) · Uterine Cervical Neoplasms (65) · Prostatic Neoplasms (61) · Urinary Bladder Neoplasms (57)
Digestive System Diseases (1056) · Neoplasms by Site (1056) · Digestive System Neoplasms (1055) · Esophageal Diseases (1052) · Gastrointestinal Diseases (1052) · Gastrointestinal Neoplasms (1038) · Neoplasms (1003) · Head and Neck Neoplasms (965) · Stomach Diseases (298) · Neoplasms by Histologic Type (262) · Neoplasms, Glandular and Epithelial (230) · Carcinoma (204) · Respiratory Tract Diseases (201) · Respiratory Tract Neoplasms (194) · Lung Diseases (192)
Cisplatin (102) · Radiotherapy (93) · Fluorouracil (81) · Paclitaxel (76) · Oxaliplatin (44) · Carboplatin (43) · Irinotecan (42) · Docetaxel (41) · Surgical Procedures, Operative (34) · pembrolizumab (34) · Capecitabine (31) · Leucovorin (31) · Radiation (28) · Esophagectomy (27) · Drug Therapy (25)
Memorial Sloan Kettering Cancer Center (36) · Alliance for Clinical Trials in Oncology (20) · National Taiwan University Hospital (19) · M.D. Anderson Cancer Center (17) · National Cancer Institute (NCI) (17) · Dana-Farber Cancer Institute (16) · Sun Yat-sen University (15) · Fudan University (13) · Cancer Institute and Hospital, Chinese Academy of Medical Sciences (12) · Tianjin Medical University Cancer Institute and Hospital (12) · Chinese Academy of Medical Sciences (11) · University Medical Center Groningen (11) · Henan Cancer Hospital (10) · Roswell Park Cancer Institute (10) · Case Comprehensive Cancer Center (9)
United States (430) · China (260) · Canada (50) · Netherlands (49) · Taiwan (47) · France (39) · Germany (39) · United Kingdom (39) · Japan (33) · South Korea (33) · Belgium (26) · Spain (26) · Italy (23) · Australia (19) · Switzerland (17)
David H. Ilson, MD, PhD (11) · Aminah Jatoi, MD (8) · Peter Enzinger, MD (5) · Yelena Janjigian, MD (5) · David Paul Kelsen, MD (4) · Feng Wang (4) · Peter C. Enzinger, MD (4) · Shixiu Wu, MD (4) · Thomas Ruhstaller, MD (4) · Tingfeng Chen, MD (4) · Arlene A. Forastiere, MD (3) · Christian C Abnet, Ph.D. (3) · Clare Shaw, Phd (3)
PMID 33538338, PMID 26313683, PMID 26808342, PMID 18309943, PMID 19465425, PMID 22646630, PMID 24982463, PMID 28742685, PMID 30291834, PMID 30308612, PMID 36990609, PMID 37932848, PMID 40914168, PMID 10235156, PMID 10597014, PMID 10903602, PMID 11208820, PMID 11344392, PMID 11391598, PMID 11870157, PMID 12167786, PMID 12170022, PMID 12196376, PMID 12794247, PMID 12885811, PMID 14662544, PMID 14967461, PMID 15013589, PMID 15142632, PMID 15533252, PMID 15542799, PMID 15555621, PMID 15701501, PMID 1584260, PMID 16133799, PMID 16235286, PMID 16303863, PMID 16444191, PMID 16467544, PMID 16497828, PMID 16524973, PMID 16568451, PMID 16601427, PMID 16790829, PMID 16832602, PMID 16849759, PMID 17050876, PMID 17085003, PMID 17265786, PMID 17401004
2023 (9), U10CA032102 (5), 2017 (4), P30CA008748 (4), P30CA043703 (4), P30CA068485 (4), 2019 (3), 2025 (3), U10CA021115 (3), 2014 (2), 2018 (2), P30CA006973 (2), P30CA015083 (2), P30CA016672 (2), P30CA023074 (2)