5 completed, 3 recruiting, 2 active not recruiting, 1 not yet recruiting. 12 Phase 1, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 12 | Completed 5, Recruiting 3, Active not recruiting 2, Not yet recruiting 1, Unknown 1 |
| Phase 2 | 2 | Completed 1, Unknown 1 |
Follow Endodermal Sinus Tumor: new trials by email Literature Review of Endodermal Sinus Tumor trials Research Report on Endodermal Sinus Tumor
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cytokine Armored GPC3 Specific Chimeric Antigen Receptor Expressing T-cells in Adults With Solid Tumors SC-CAR.GPC3xIL15.21 CAR T cells - Solid Tumor (Excluding CNS), Hepatocellular Carcinoma | Phase 1 | Not yet recruiting | Seattle Children's Hospital | 21 | 2026-04-01 | 2025-11-04 |
| Immunotherapy for Solid Tumor Malignancies in Pediatrics Using Interleukin-15 and -21 Armored Glypican-3-specific Chimeric Antigen Receptor T Cells SC-CAR.GPC3xIL15.21 CAR T cells - Solid Tumor (Excluding CNS), Liver Cell Carcinoma | Phase 1 | Recruiting | Seattle Children's Hospital | 21 | 2025-12-22 | 2026-02-17 |
| Immunotherapy For Adults With GPC3-Positive Solid Tumors Using IL-15 and IL-21 Armored GPC3-CAR T Cells 21.15.GPC3-CAR T cells - Hepatoblastoma, Hepatocellular Carcinoma | Phase 1 | Recruiting | Baylor College of Medicine | 21 | 2025-06-10 | 2025-11-03 |
| Interleukin-15 and -21 Armored Glypican-3-specific Chimeric Antigen Receptor Expressed in T Cells for Pediatric Solid Tumors CARE T cells - Liver Cancer, Rhabdomyosarcoma | Phase 1 | Recruiting | Baylor College of Medicine | 24 | 2024-05-24 | 2026-08-06 |
| Interleukin-15 Armored Glypican 3-specific Chimeric Antigen Receptor Expressed in T Cells for Pediatric Solid Tumors AGAR T cells - Liver Cancer, Rhabdomyosarcoma | Phase 1 | Active not recruiting | Baylor College of Medicine | 14 | 2021-08-08 | 2026-01-21 |
| Interleukin-15 Armored Glypican 3-specific Chimeric Antigen Receptor Expressed in Autologous T Cells for Solid Tumors CATCH T cells - Liver Cell Carcinoma, Solid Tumor | Phase 1 | Active not recruiting | Baylor College of Medicine | 12 | 2021-06-17 | 2026-03-06 |
| Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors filgrastim, lenograstim, pegfilgrastim - Brain and Central Nervous System Tumors, Extragonadal Germ Cell Tumor | Phase 1 / Phase 2 | Unknown | University of Southampton | 23 | 2006-11-01 | 2013-01-23 |
| Ipilimumab After Allogeneic Stem Cell Transplant in Treating Patients With Persistent or Progressive Cancer ipilimumab, therapeutic allogeneic lymphocytes - Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) | Phase 1 | Completed | National Cancer Institute (NCI) | 21 | 2003-04-01 | 2013-03-27 |
| Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon beclomethasone dipropionate - Breast Cancer, Chronic Myeloproliferative Disorders | Phase 1 / Phase 2 | Completed | Fred Hutchinson Cancer Center | 2000-07-01 | 2010-04-02 | |
| Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors recombinant interleukin-12 - Breast Cancer, Chronic Myeloproliferative Disorders | Phase 1 | Completed | Indiana University | 1997-10-01 | 2014-09-10 | |
| MEN-10755 in Treating Patients With Solid Tumors sabarubicin - Testicular Germ Cell Tumor, Unspecified Adult Solid Tumor, Protocol Specific | Phase 1 | Completed | European Organisation for Research and Treatment of Cancer - EORTC | 30 | 1997-06-01 | 2012-07-11 |
| Biological Therapy in Treating Patients With Metastatic Cancer CEA RNA-pulsed DC cancer vaccine - Breast Cancer, Colorectal Cancer | Phase 1 | Completed | Duke University | 24 | 1997-02-01 | 2013-02-22 |
Wilms Tumor (7) · Liposarcoma (6) · Liver Neoplasms (6) · Rhabdomyosarcoma (6) · Carcinoma, Hepatocellular (5) · Rhabdoid Tumor (5) · Testicular Germ Cell Tumor (5) · Testicular Neoplasms (5) · Breast Neoplasms (4) · Carcinoma, Ovarian Epithelial (4) · Ovarian Neoplasms (4) · Seminoma (4) · Burkitt Lymphoma (3) · Carcinoma, Embryonal (3)
Mesonephroma (12) · Neoplasms by Histologic Type (12) · Neoplasms, Germ Cell and Embryonal (12) · Neoplasms (11) · Neoplasms by Site (11) · Female Urogenital Diseases (10) · Female Urogenital Diseases and Pregnancy Complications (10) · Male Urogenital Diseases (10) · Urogenital Diseases (10) · Urogenital Neoplasms (10) · Carcinoma (8) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (8) · Neoplasms, Glandular and Epithelial (8) · Digestive System Diseases (7) · Digestive System Neoplasms (7)
Beclomethasone (1) · CTLA-4 Antigen (1) · Cisplatin (1) · Filgrastim (1) · Gemcitabine (1) · Ifosfamide (1) · Interleukin-12 Subunit p35 (1) · Ipilimumab (1) · Lenograstim (1) · Paclitaxel (1) · pegfilgrastim (1) · sabarubicin (1)
Baylor College of Medicine (4) · Seattle Children's Hospital (2) · Duke University (1) · European Organisation for Research and Treatment of Cancer - EORTC (1) · Fred Hutchinson Cancer Center (1) · Indiana University (1) · National Cancer Institute (NCI) (1) · University of Southampton (1)
United States (10) · United Kingdom (2) · Austria (1) · Belgium (1) · Denmark (1) · France (1) · Germany (1) · Netherlands (1) · Norway (1) · Switzerland (1)
David Steffin, MD (3) · Colleen Annesley (1) · Colleen Annesley, MD (1) · Corinne Summers (1) · Corinne Summers, MD (1) · David Hockenbery, MD (1) · Ewa Carrier (1) · G. Mead, MD (1) · Herbert K. Lyerly, MD (1) · Michael J. Robertson, MD (1) · Premal Lulla, MD (1) · Tannaz Armaghany, MD (1)
R01CA093891 (1)