16 completed, 2 unknown, 1 active not recruiting, 1 recruiting. 20 Phase 2, 2 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 20 | Completed 16, Unknown 2, Active not recruiting 1, Recruiting 1 |
| Phase 1 | 2 | Completed 1, Unknown 1 |
| Phase 3 | 2 | Completed 1, Unknown 1 |
Follow Endodermal Sinus Tumor: new trials by email Literature Review of Endodermal Sinus Tumor trials Research Report on Endodermal Sinus Tumor
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Agnostic Therapy in Rare Solid Tumors Nivolumab - Urachal Cancer, Parathyroid Carcinoma | Phase 2 | Active not recruiting | Instituto do Cancer do Estado de São Paulo | 28 | 2024-07-16 | 2026-10-13 |
| High-dose Chemotherapy as Second-line Drug Therapy for Relapsed Germ Cell Tumors High-dose chemotherapy (TI- 2 cycles, CE- 3 cycles ) - Germ Cell Tumor | Phase 2 | Recruiting | N.N. Petrov National Medical Research Center of Oncology | 25 | 2024-03-01 | 2025-08-03 |
| Thalidomide Combined With Chemotherapy in the Treatment of Relapsed or Refractory Yolk Sac Tumor Thalidomide combined with TGA chemotherapy (nab-paclitaxel + gemcitabine+ epirubicin) - Germ Cell Tumor, Yolk Sac Tumor | Phase 2 | Completed | Shandong First Medical University | 20 | 2021-11-11 | 2025-09-18 |
| Clinical Study of Chemotherapy in the Treatment of Recurrent/Refractory Yolk Sac Tumor in Children sirolimus combined with chemotherapy in the treatment of recurrent/refractory yolk sac tumor in children - Germ Cell Tumor, Yolk Sac Tumor | Phase 2 / Phase 3 | Completed | Shandong First Medical University | 32 | 2020-06-01 | 2025-09-19 |
| Combination Chemotherapy in Treating Young Patients With Recurrent or Resistant Malignant Germ Cell Tumors Carboplatin, Filgrastim, Ifosfamide - Childhood Extracranial Germ Cell Tumor, Childhood Extragonadal Malignant Germ Cell Tumor | Phase 2 | Completed | Children's Oncology Group | 20 | 2007-11-05 | 2018-08-29 |
| Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment sunitinib malate - Extragonadal Germ Cell Tumor, Ovarian Cancer | Phase 2 | Completed | Memorial Sloan Kettering Cancer Center | 10 | 2007-03-01 | 2015-10-27 |
| Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors pegfilgrastim, cisplatin, ifosfamide - Brain and Central Nervous System Tumors, Extragonadal Germ Cell Tumor | Phase 2 | Completed | Memorial Sloan Kettering Cancer Center | 60 | 2007-03-01 | 2017-11-28 |
| Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors carboplatin, etoposide, ifosfamide - Childhood Germ Cell Tumor, Ovarian Cancer | Phase 2 | Completed | Masonic Cancer Center, University of Minnesota | 23 | 2006-12-19 | 2022-05-17 |
| Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors filgrastim, lenograstim, pegfilgrastim - Brain and Central Nervous System Tumors, Extragonadal Germ Cell Tumor | Phase 1 / Phase 2 | Unknown | University of Southampton | 23 | 2006-11-01 | 2013-01-23 |
| Combination Chemotherapy in Treating Male Patients With Germ Cell Tumors bleomycin sulfate, carboplatin, cisplatin - Extragonadal Germ Cell Tumor, Teratoma | Phase 2 | Completed | Medical Research Council | 88 | 2005-06-01 | 2013-08-26 |
| Combination Chemotherapy and Pegfilgrastim in Treating Men With Metastatic Germ Cell Tumors bleomycin sulfate, pegfilgrastim, cisplatin - Extragonadal Germ Cell Tumor, Teratoma | Phase 2 | Completed | Cambridge University Hospitals NHS Foundation Trust | 20 | 2004-08-01 | 2013-08-07 |
| Ixabepilone in Treating Patients With Advanced Cisplatin-Refractory Germ Cell Tumors ixabepilone - Brain and Central Nervous System Tumors, Extragonadal Germ Cell Tumor | Phase 2 | Completed | Memorial Sloan Kettering Cancer Center | 29 | 2003-08-01 | 2013-06-24 |
| Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors filgrastim, recombinant interleukin-11 - Breast Cancer, Gestational Trophoblastic Tumor | Phase 2 | Completed | Fred Hutchinson Cancer Center | 2000-08-01 | 2010-04-02 | |
| Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon beclomethasone dipropionate - Breast Cancer, Chronic Myeloproliferative Disorders | Phase 1 / Phase 2 | Completed | Fred Hutchinson Cancer Center | 2000-07-01 | 2010-04-02 | |
| Combination Chemotherapy in Treating Men With Germ Cell Cancer bleomycin sulfate, filgrastim, cisplatin - Extragonadal Germ Cell Tumor, Teratoma | Phase 2 / Phase 3 | Unknown | European Organisation for Research and Treatment of Cancer - EORTC | 498 | 1998-10-01 | 2012-03-06 |
| Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation peripheral blood lymphocyte therapy - Breast Cancer, Chronic Myeloproliferative Disorders | Phase 2 | Completed | Fred Hutchinson Cancer Center | 1998-08-01 | 2011-11-30 | |
| Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer aldesleukin, recombinant interferon alfa, sargramostim - Breast Cancer, Chronic Myeloproliferative Disorders | Phase 2 | Completed | Cancer Treatment Centers of America | 40 | 1998-04-01 | 2013-03-26 |
| Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Relapsed Germ Cell Cancer filgrastim, carboplatin, etoposide - Brain and Central Nervous System Tumors, Extragonadal Germ Cell Tumor | Phase 2 | Completed | City of Hope Medical Center | 48 | 1997-02-01 | 2017-02-23 |
| Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Metastatic Testicular Cancer cisplatin, ifosfamide, paclitaxel - Testicular Germ Cell Tumor | Phase 2 | Completed | Medical Research Council | 25 | 1996-05-01 | 2013-12-19 |
| Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation infection prophylaxis and management - Cancer | Phase 2 | Completed | Fred Hutchinson Cancer Center | 30 | 1995-06-01 | 2010-06-17 |
Testicular Neoplasms (16) · Carcinoma, Embryonal (15) · Teratoma (15) · Seminoma (14) · Testicular Germ Cell Tumor (13) · Ovarian Neoplasms (10) · Carcinoma, Ovarian Epithelial (6) · Neuroblastoma (6) · Recurrence (6) · Teratoma, Testicular (6) · Breast Neoplasms (5) · Burkitt Lymphoma (5) · Dendritic Cell Sarcoma, Interdigitating (5) · Hodgkin Disease (5)
Mesonephroma (20) · Neoplasms by Histologic Type (20) · Neoplasms (19) · Urogenital Diseases (18) · Endocrine Gland Neoplasms (17) · Endocrine System Diseases (17) · Genital Diseases (17) · Genital Diseases, Male (17) · Genital Neoplasms, Male (17) · Gonadal Disorders (17) · Male Urogenital Diseases (17) · Neoplasms by Site (17) · Neoplasms, Germ Cell and Embryonal (17) · Testicular Diseases (17) · Urogenital Neoplasms (17)
Paclitaxel (7) · Cisplatin (6) · Filgrastim (6) · Ifosfamide (6) · Carboplatin (4) · Etoposide (4) · Bleomycin (3) · pegfilgrastim (3) · Drug Therapy (2) · Granulocyte Colony-Stimulating Factor (2) · 130-nm albumin-bound paclitaxel (1) · Beclomethasone (1) · Gemcitabine (1) · Interferon-alpha (1) · Interleukin-11 (1)
Fred Hutchinson Cancer Center (4) · Memorial Sloan Kettering Cancer Center (3) · Medical Research Council (2) · Shandong First Medical University (2) · Cambridge University Hospitals NHS Foundation Trust (1) · Cancer Treatment Centers of America (1) · Children's Oncology Group (1) · City of Hope Medical Center (1) · European Organisation for Research and Treatment of Cancer - EORTC (1) · Instituto do Cancer do Estado de São Paulo (1) · Masonic Cancer Center, University of Minnesota (1) · N.N. Petrov National Medical Research Center of Oncology (1) · University of Southampton (1)
United States (11) · United Kingdom (5) · China (2) · Australia (1) · Austria (1) · Belgium (1) · Brazil (1) · Canada (1) · Denmark (1) · France (1) · Germany (1) · Hungary (1) · Israel (1) · Italy (1) · Netherlands (1)
Jingfu Wang, MD (2) · Robert J. Motzer, MD (2) · Aleksei M Belyaev, MD,DSc,Prof. (1) · Anastasios Raptis, MD (1) · Camila MV Moniz, Doctor (1) · Carlos Rodriguez-Galindo (1) · Darren Feldman, MD (1) · David Hockenbery, MD (1) · Dean F. Bajorin, MD (1) · G. Mead, MD (1) · Gnanamba V. Kondagunta, MD (1) · Leona A. Holmberg, MD, PhD (1) · Malcolm D. Mason, MD (1) · Mary E. D. Flowers, MD (1) · Michael Williams, MD (1)
PMID 15999102, PMID 19547919, PMID 25001888
P30CA008748 (1), P30CA033572 (1), U10CA098543 (1)