3200 completed, 695 terminated, 646 unknown, 572 recruiting. 5896 Phase 2, 1206 Phase 1, 451 Phase 3.
Follow Endocrine System Diseases: new trials by email Literature Review of Endocrine System Diseases trials Research Report on Endocrine System Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Inhibiting GABA Transaminase to Relieve Obesity Induced Hyperinsulinemia and Insulin Resistance Vigabatrin Pill, Placebo oral tablet - Hyperinsulinism, Insulin Resistance | Phase 2 | Withdrawn | University of Arizona | 2030-04-15 | 2025-07-30 | |
| Certepetide Phase 1b/2a Continuous Infusion Trial in mPDAC certepetide, nab-paclitaxel, gemcitabine - Pancreas Cancer, Pancreatic Carcinoma | Phase 1 / Phase 2 | Withdrawn | Lisata Therapeutics, Inc. | 2030-01-01 | 2025-06-06 | |
| Testosterone Therapy With or Without Finasteride After Spinal Cord Injury: TRT-SCI Trial testosterone cypionate, finasteride, placebo injection - Spinal Cord Injury, Spinal Cord Injuries | Phase 2 / Phase 3 | Not yet recruiting | VA Office of Research and Development | 300 | 2027-10-01 | 2026-08-04 |
| Postpartum Semaglutide to Reduce Cardiometabolic Risk After Gestational Diabetes Mellitus Semaglutide (Wegovy) weekly injection - Gestational Diabetes Mellitus (GDM), Metabolic Syndrome | Phase 2 / Phase 3 | Not yet recruiting | University of Massachusetts, Worcester | 226 | 2027-09-01 | 2026-09-28 |
| GLP-1 RA for Stage 1 Type 1 Diabetes Semaglutide, Placebo - Stage 1 Diabetes Mellitus, Type 1 | Phase 2 | Not yet recruiting | Children's Hospital Medical Center, Cincinnati | 15 | 2027-09-01 | 2026-02-24 |
| Ampligen Combined With SOC Versus SOC Alone Following First-Line Therapy in Subjects With LAPC Rintatolimod - Pancreatic Cancer | Phase 2 | Suspended | AIM ImmunoTech Inc. | 90 | 2027-08-01 | 2026-08-19 |
| cfMSC Therapy for Diabetes cfMSC therapy for diabetes - Type II Diabetes Mellitus | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 30 | 2027-06-30 | 2026-11-02 |
| Clinical Trial of DN022150 Combined With AG Chemotherapy as First-line Treatment for Locally Advanced or Metastatic Pancreatic Cancer With KRAS G12D Mutation DN022150+AG( Stage I ）, DN022150+AG（Stage II）, placebo+AG（Stage II） - Pancreatic Cancer, Pancreatic Carcinoma | Phase 2 / Phase 3 | Not yet recruiting | Jiangxi Kvvit Pharmaceutical Co., Ltd. | 465 | 2027-06-06 | 2026-06-18 |
| A Dose Ranging Study to Examine TDS-Testosterone 5% Testosterone, Pump Sprayer - Hypogonadotropism | Phase 2 | Not yet recruiting | Transdermal Delivery Solutions Corp | 48 | 2027-06-01 | 2026-09-30 |
| Testing the Combination of Anti-Cancer Drugs, Selumetinib and DS-8201a (Trastuzumab Deruxtecan), for Advanced Pancreatic Ductal Adenocarcinoma Biospecimen Collection, Diagnostic Imaging Testing, Echocardiography Test - Advanced Pancreatic Ductal Adenocarcinoma, Metastatic Pancreatic Ductal Adenocarcinoma | Phase 1 / Phase 2 | Recruiting | National Cancer Institute (NCI) | 31 | 2027-06-01 | 2026-10-22 |
| A Phase I/IIa Study of EF-009 in Patients With Pancreatic Cancer EF-009 - Pancreatic Cancer | Phase 1 / Phase 2 | Not yet recruiting | Everfront Biotech Co., Ltd. | 30 | 2027-04-01 | 2026-09-11 |
| (Z)-Endoxifen in Girls With MAS-Associated Peripheral Precocious Puberty (Z)-endoxifen - Precocious Puberty, Gonadotropin-dependent | Phase 2 | Not yet recruiting | Atossa Therapeutics, Inc. | 6 | 2027-03-01 | 2026-10-09 |
| STOMP OUT: A Phase 2 Study To Evaluate The Effects Of Ivonescimab In Patients With Unresectable/Metastatic Adrenocortical Carcinoma (ACC) Or Unresectable Pheochromocytoma/Paraganglioma (PPGL) Ivonescimab - Adrenocortical Carcinoma, Pheochromocytoma | Phase 2 | Not yet recruiting | M.D. Anderson Cancer Center | 20 | 2027-02-07 | 2026-09-18 |
| Losartan and Paclitaxel in Platinum Resistant Ovarian Cancer losartan, Paclitaxel - Platinum Resistant Ovarian Cancer | Phase 2 | Not yet recruiting | Massachusetts General Hospital | 27 | 2027-02-01 | 2026-09-22 |
| A Study of Perioperative Navlimetostat Combined With Modified FOLFIRINOX in Patients With MTAP-Deleted Pancreatic Cancer Navlimetostat, mFOLFIRINOX Treatment Regimen - Pancreatic Ductal Adenocarcinoma (PDAC) | Phase 1 / Phase 2 | Not yet recruiting | Daniel Nussbaum, M.D. | 18 | 2027-01-15 | 2026-11-02 |
| Product Transference Study of Testagen™ TDS®-Testosterone Testagen® TDS Testosterone 5% HypoSpray® - Hypogonadotropism | Phase 2 | Not yet recruiting | Transdermal Delivery Solutions Corp | 96 | 2027-01-05 | 2026-05-27 |
| A Study Testing the Safety and Possible Benefits of an Ear Injection of a New Compound, Paliroden, in People With Type 2 Diabetes Who Have Difficulty Understanding Speech in Noisy Situations CIL001 (Paliroden), Placebo - Cochlear Synaptopathy | Phase 1 / Phase 2 | Not yet recruiting | Cilcare SAS | 135 | 2027-01-01 | 2026-10-26 |
| Mitigating DKA in Type 1 Diabetes for Safe Use of SGLT Inhibitors Using Dual Continuous Ketone and Glucose Monitoring. Sotagliflozin initiation - Type 1 Diabetes Mellitus, Chronic Kidney Disease (CKD) With Diabetes Mellitus (DM) | Phase 2 | Not yet recruiting | HealthPartners Institute | 80 | 2027-01-01 | 2026-10-23 |
| SHIELD-T1D: Shingrix and GLP-1 Agonist for Beta-Cell Preservation in Recent-Onset Type 1 Diabetes. Recombinant Zoster Vaccine (Shingrix; RZV), Semaglutide (Ozempic®), Placebo (saline injection) - Type 1 Diabetes Mellitus | Phase 2 | Not yet recruiting | Ministry of Health, Saudi Arabia | 240 | 2027-01-01 | 2026-05-29 |
| Vilastobart+Retifanlimab in BRCA or PALB2 Deficient PC vilastobart (XTX101), Retifanlimab - Pancreatic Cancer Metastatic | Phase 2 | Not yet recruiting | Massachusetts General Hospital | 40 | 2027-01-01 | 2026-08-14 |
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Pancreatic Neoplasms (1253) · Ovarian Neoplasms (1181) · Diabetes Mellitus, Type 2 (1019) · Diabetes Mellitus (729) · Diabetes Mellitus, Type 1 (514) · Fallopian Tube Neoplasms (364) · Carcinoma, Ovarian Epithelial (332) · Neoplasms (237) · Breast Neoplasms (203) · Thyroid Neoplasms (192) · Colorectal Neoplasms (181) · Carcinoma, Non-Small-Cell Lung (168) · Insulin Resistance (166) · Neoplasm Metastasis (165) · Obesity (165)
Neoplasms by Site (2889) · Endocrine Gland Neoplasms (2874) · Neoplasms (2785) · Nutritional and Metabolic Diseases (2150) · Metabolic Diseases (2105) · Glucose Metabolism Disorders (1985) · Urogenital Diseases (1921) · Female Urogenital Diseases and Pregnancy Complications (1853) · Female Urogenital Diseases (1827) · Gonadal Disorders (1642) · Diabetes Mellitus (1613) · Digestive System Diseases (1562) · Genital Diseases (1552) · Digestive System Neoplasms (1481)
Gemcitabine (482) · Carboplatin (220) · Paclitaxel (220) · Bevacizumab (171) · Metformin (167) · 130-nm albumin-bound paclitaxel (132) · Oxaliplatin (130) · Fluorouracil (126) · pembrolizumab (126) · Cisplatin (122) · Albumin-Bound Paclitaxel (112) · Capecitabine (102) · Cyclophosphamide (92) · Leucovorin (85) · Taxes (84)
National Cancer Institute (NCI) (193) · Eli Lilly and Company (85) · AstraZeneca (76) · M.D. Anderson Cancer Center (69) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (58) · Memorial Sloan Kettering Cancer Center (53) · Pfizer (50) · Novartis Pharmaceuticals (48) · GlaxoSmithKline (44) · Massachusetts General Hospital (43) · Mayo Clinic (43) · Novo Nordisk A/S (42) · Fudan University (41) · Hoffmann-La Roche (38) · Gynecologic Oncology Group (36)
United States (3066) · China (583) · Canada (505) · Germany (425) · United Kingdom (401) · Spain (351) · Italy (340) · France (332) · Australia (255) · South Korea (210) · Denmark (202) · Poland (196) · Belgium (194) · Japan (169) · Netherlands (165)
PMID 37185961, PMID 39863139, PMID 33107592, PMID 35170751, PMID 30957581, PMID 35472672, PMID 37407274, PMID 41805697, PMID 19005394, PMID 25387217, PMID 25504028, PMID 39735417, PMID 19238149, PMID 23438305, PMID 28324110, PMID 31194872, PMID 33337539, PMID 34091488, PMID 37934000, PMID 38770818, PMID 41044356, PMID 15273542, PMID 18035553, PMID 18424759, PMID 18557726, PMID 19066739, PMID 20236866, PMID 21561347, PMID 23922302, PMID 23940010, PMID 26241693, PMID 26894924, PMID 26961146, PMID 28756065, PMID 30765435, PMID 31401903, PMID 31606880, PMID 34677608, PMID 35537408, PMID 35797241, PMID 37598000, PMID 37916745, PMID 38018702, PMID 38649657, PMID 39963952, PMID 40341199, PMID 40576086, PMID 42836590, PMID 15834546, PMID 16172198
2023 (54), 2009 (38), 2016 (35), U10CA027469 (34), 2017 (33), 2018 (30), 2015 (29), U10CA180868 (28), 2014 (26), 2025 (26), 2019 (25), 2008 (23), P30CA008748 (13), P30CA015083 (13), N01CM62201 (12)