2749 completed, 479 terminated, 452 recruiting, 363 unknown. 4533 Phase 1, 1206 Phase 2.
Follow Endocrine System Diseases: new trials by email Literature Review of Endocrine System Diseases trials Research Report on Endocrine System Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Certepetide Phase 1b/2a Continuous Infusion Trial in mPDAC certepetide, nab-paclitaxel, gemcitabine - Pancreas Cancer, Pancreatic Carcinoma | Phase 1 / Phase 2 | Withdrawn | Lisata Therapeutics, Inc. | 2030-01-01 | 2025-06-06 | |
| cfMSC Therapy for Diabetes cfMSC therapy for diabetes - Type II Diabetes Mellitus | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 30 | 2027-06-30 | 2026-11-02 |
| Testing the Combination of Anti-Cancer Drugs, Selumetinib and DS-8201a (Trastuzumab Deruxtecan), for Advanced Pancreatic Ductal Adenocarcinoma Biospecimen Collection, Diagnostic Imaging Testing, Echocardiography Test - Advanced Pancreatic Ductal Adenocarcinoma, Metastatic Pancreatic Ductal Adenocarcinoma | Phase 1 / Phase 2 | Recruiting | National Cancer Institute (NCI) | 31 | 2027-06-01 | 2026-10-22 |
| Daraxonrasib in Resectable PDAC Daraxonrasib, Surgical Resection, Adjuvant Chemotherapy - Pancreatic Ductal Adenocarcinoma, Pancreatic Cancer | Phase 1 | Not yet recruiting | Dana-Farber Cancer Institute | 30 | 2027-04-13 | 2026-10-27 |
| A Phase I/IIa Study of EF-009 in Patients With Pancreatic Cancer EF-009 - Pancreatic Cancer | Phase 1 / Phase 2 | Not yet recruiting | Everfront Biotech Co., Ltd. | 30 | 2027-04-01 | 2026-09-11 |
| Placental Cells for Diabetic Foot Ulcers Placenta Stem Cells - Diabetic Foot Ulcer | Phase 1 | Not yet recruiting | Wake Forest University Health Sciences | 12 | 2027-03-01 | 2026-10-23 |
| A Study of Perioperative Navlimetostat Combined With Modified FOLFIRINOX in Patients With MTAP-Deleted Pancreatic Cancer Navlimetostat, mFOLFIRINOX Treatment Regimen - Pancreatic Ductal Adenocarcinoma (PDAC) | Phase 1 / Phase 2 | Not yet recruiting | Daniel Nussbaum, M.D. | 18 | 2027-01-15 | 2026-11-02 |
| ENCRT-103-hPI: Evaluation of an Immune-protected ENCRT-103-hPI Containing Primary Human Islets in Adults With Type 1 Diabetes, With and Without Standard-of-care Portal Vein Islet Infusion. ENCRT-103-hPI encompasses the ENC-103 device, which will be implanted once loaded with primary islet cargo. - Type 1 Diabetes | Phase 1 | Not yet recruiting | Encellin | 10 | 2027-01-06 | 2026-08-20 |
| A Study Testing the Safety and Possible Benefits of an Ear Injection of a New Compound, Paliroden, in People With Type 2 Diabetes Who Have Difficulty Understanding Speech in Noisy Situations CIL001 (Paliroden), Placebo - Cochlear Synaptopathy | Phase 1 / Phase 2 | Not yet recruiting | Cilcare SAS | 135 | 2027-01-01 | 2026-10-26 |
| Human Models of Selective Insulin Resistance: Pancreatic Clamp Insulin human, Octreotide Acetate, Glucagon - Insulin Resistance, Hyperinsulinemia | Phase 1 | Not yet recruiting | Columbia University | 36 | 2027-01-01 | 2026-02-06 |
| Sequential Immune Modulation and Antigen-Specific Tolerance Induction for Disease Modification in Recent-Onset Type 1 Diabetes Teplizumab, Intralymphatic Insulin Immunotherapy (ILIT) - Type 1 Diabetes Mellitus (T1DM), Type 1 Diabetes Mellitus | Phase 1 | Not yet recruiting | Abdullah Kars | 60 | 2027-01-01 | 2026-05-27 |
| 64Cu-DOTA A2 scFv-Fc2 DM With Positron Emission Tomography for the Imaging of Patients With Locally Advanced or Metastatic PSCA-Expressing Pancreatic Cancer Biospecimen Collection, Copper Cu 64-DOTA-A2DM, Positron Emission Tomography - Locally Advanced Pancreatic Adenocarcinoma, Metastatic Pancreatic Adenocarcinoma | Phase 1 | Not yet recruiting | City of Hope Medical Center | 15 | 2026-12-16 | 2026-05-27 |
| Evaluation of Superiority of Valsartan+Celecoxib+Metformin Over Metformin Alone in Type 2 Diabetes Patients Metformin, Val, Cel and Met XR Low, Val, Cel and Met XR High - Type 2 Diabetes, High Blood Pressure | Phase 1 / Phase 2 | Withdrawn | ARKAY Therapeutics | 2026-12-10 | 2026-07-16 | |
| ANO31905 in Combination With Chemotherapy for CLDN18.2-Positive Locally Advanced Unresectable or Metastatic Pancreatic Cancer ANO31905, AG [gemcitabine+nab-paclitaxel], mFOLFIRINOX [Oxaliplatin+irinotecan+leucovorin+fluorouracil] - Pancreatic Cancer | Phase 1 / Phase 2 | Recruiting | Anova Innovation Limited | 84 | 2026-12-01 | 2026-10-23 |
| A Study of LG00313112 in Participants With Advanced Solid Malignancies Harboring a TP53 Y220C Mutation LG00313112 - Ovarian Cancer, Small Cell Lung Cancer | Phase 1 / Phase 2 | Not yet recruiting | LG Chem | 250 | 2026-12-01 | 2026-08-07 |
| PDAC Regression and Intraoperative Surgical Margin With Neoadjuvant TAMP (PRISM-TAMP) Gemcitabine Delivered by Transarterial Microperfusion - Pancreatic Ductal Adenocarcinoma (PDAC), Borderline Resectable Pancreatic Cancer | Phase 1 / Phase 2 | Not yet recruiting | University of Vermont | 10 | 2026-12-01 | 2026-03-17 |
| Study Examining the Safety and Toxicity of Stereotactic Body Radiotherapy (SBRT) Followed by PCX12 Immunotherapy Delivered by Intratumoral Injection for the Treatment of Patients With Locally Advanced Pancreatic Adenocarcinoma (LAPC) PCX-12 - Pancreatic Adenocarcinoma | Phase 1 | Not yet recruiting | Haoming (Carl) Qiu | 24 | 2026-12-01 | 2026-02-05 |
| A Study of MC001 in Patients With Advanced or Metastatic Pancreatic Ductal Adenocarcinoma (PDAC) and Other Folate Receptor Alpha (FRĪ±)-Expressing Solid Tumors MC001 - Pancreatic Ductal Adenocarcinoma (PDAC), Advanced Solid Tumor Cancer | Phase 1 | Not yet recruiting | Medicovestor, Inc | 40 | 2026-12-01 | 2026-11-03 |
| A Clinical Trial of MK-6255 to Treat Endometrial and Ovarian Cancer (MK-6255-001) MK-6255, CD8 PET Tracer, Acetaminophen - Ovarian Neoplasms, Endometrial Neoplasms | Phase 1 | Not yet recruiting | Merck Sharp & Dohme LLC | 80 | 2026-11-13 | 2026-10-13 |
| Hepatic Artery Infusion of Carfilzomib in Participants With Liver Metastatic Disease Previously Treated With Hepatic Artery Infusion Pump Therapy Carfilzomib - Colorectal Neoplasms, Neoplasms | Phase 1 | Not yet recruiting | National Cancer Institute (NCI) | 20 | 2026-11-11 | 2026-11-06 |
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Diabetes Mellitus, Type 2 (1091) · Pancreatic Neoplasms (1055) · Ovarian Neoplasms (1024) · Diabetes Mellitus (716) · Breast Neoplasms (420) · Diabetes Mellitus, Type 1 (420) · Carcinoma, Non-Small-Cell Lung (382) · Colorectal Neoplasms (363) · Stomach Neoplasms (277) · Neoplasms (266) · Carcinoma, Ovarian Epithelial (249) · Fallopian Tube Neoplasms (249) · Neoplasm Metastasis (217) · Endometrial Neoplasms (214) · Lung Neoplasms (210)
Neoplasms by Site (2174) · Endocrine Gland Neoplasms (2167) · Neoplasms (1983) · Nutritional and Metabolic Diseases (1962) · Metabolic Diseases (1928) · Glucose Metabolism Disorders (1899) · Urogenital Diseases (1461) · Female Urogenital Diseases and Pregnancy Complications (1432) · Female Urogenital Diseases (1423) · Digestive System Diseases (1388) · Diabetes Mellitus (1345) · Digestive System Neoplasms (1340) · Gonadal Disorders (1300) · Genital Diseases (1295)
Gemcitabine (304) · Carboplatin (144) · Metformin (138) · Paclitaxel (135) · 130-nm albumin-bound paclitaxel (114) · pembrolizumab (102) · Albumin-Bound Paclitaxel (91) · Cyclophosphamide (87) · Bevacizumab (82) · Oxaliplatin (74) · Cisplatin (71) · Fluorouracil (71) · Taxes (62) · Nivolumab (61) · semaglutide (61)
Novo Nordisk A/S (274) · Eli Lilly and Company (129) · National Cancer Institute (NCI) (125) · AstraZeneca (117) · Pfizer (78) · Merck Sharp & Dohme LLC (68) · GlaxoSmithKline (57) · M.D. Anderson Cancer Center (52) · Chong Kun Dang Pharmaceutical (48) · Sanofi (43) · Jiangsu HengRui Medicine Co., Ltd. (41) · Memorial Sloan Kettering Cancer Center (40) · Boehringer Ingelheim (30) · Mayo Clinic (29) · City of Hope Medical Center (27)
United States (2376) · China (485) · Germany (409) · United Kingdom (230) · Canada (213) · South Korea (205) · Spain (181) · Australia (165) · Japan (143) · France (139) · Netherlands (104) · Belgium (96) · Italy (81) · Denmark (72) · Israel (59)
PMID 25387217, PMID 39863139, PMID 28205039, PMID 33813736, PMID 25581159, PMID 33969456, PMID 34213819, PMID 30402720, PMID 18035553, PMID 18424759, PMID 18557726, PMID 19066739, PMID 20236866, PMID 22634621, PMID 28357715, PMID 28946756, PMID 32379297, PMID 34041713, PMID 37598000, PMID 37735841, PMID 38770818, PMID 40056080, PMID 40132910, PMID 42023429, PMID 15100156, PMID 16394300, PMID 17284531, PMID 19475464, PMID 19487640, PMID 19949018, PMID 21819160, PMID 22002018, PMID 22473314, PMID 23549864, PMID 23607606, PMID 25603819, PMID 25656305, PMID 26068866, PMID 26225223, PMID 27779572, PMID 28349387, PMID 29669934, PMID 29671202, PMID 29679103, PMID 29995186, PMID 30565096, PMID 31132118, PMID 32362346, PMID 32385714, PMID 32433237
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