64 completed, 22 recruiting, 17 unknown, 14 terminated. 47 Not applicable, 21 Phase 2, 14 Phase 1, 9 Phase 4, 2 Phase 3.
Follow Dysostoses: new trials by email Literature Review of Dysostoses trials Research Report on Dysostoses
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effects of Tummy Time Associated With Therapeutic Positioning in Premature Newborns With Cranial Asymmetry Tummy Time Protocol - Premature Newborns, Cranial Asymmetry | Not applicable | Not yet recruiting | Hospital de Clinicas de Porto Alegre | 300 | 2026-10-01 | 2026-09-18 |
| Frontal Reconstruction Without Orbital Advancement for Moderate Metopic Craniosynostosis Frontal vault remodelling without orbital advancement - Metopic Craniosynostosis, Craniosynostosis | Not applicable | Not yet recruiting | Assiut University | 15 | 2026-10-01 | 2026-09-23 |
| Multimodal Mechanical, Tissue, Architectural, and Histological Evaluation of the Bone and Sutures of the Parietal Bone in an Infant With Craniosynostosis. Biological sample, bones sample and questionaires. - Craniostenosis | Not yet recruiting | Hospices Civils de Lyon | 80 | 2026-09-01 | 2026-06-16 | |
| Treatment for "Asymmetric Crying Facies" Botulinium toxin type A injection - Hemifacial Microsomia, Facial Nerve Paralysis | Not applicable | Recruiting | Xiaolei Jin | 60 | 2026-08-07 | 2026-09-28 |
| Evaluation of the Safety and Effectiveness of the CORUS™ Posterior Cervical Stabilization System 3D (PCSS 3D) for the Treatment of 2-level Cervical Degenerative Disease Circumferential Cervical Fusion (CCF), Anterior Cervical Discectomy and Fusion - Degenerative Disc Disease(DDD) | Not applicable | Not yet recruiting | Providence Medical Technology, Inc. | 225 | 2026-06-30 | 2026-07-23 |
| Futibatinib (TAS-120) in Patients With Advanced Biliary Tract Cancer Futibatinib, Zimberelimab, Durvalumab - Biliary Tract Cancer | Phase 3 | Recruiting | Taiho Pharmaceutical Co., Ltd. | 784 | 2026-06-24 | 2026-07-17 |
| Post-market Observational Clinical Study With the CE-marked Implantable Class IIb Medical Device "ITC CERVICAL" Cervical Disc Degenerative Disorder, Cervical Fusion | Completed | MT Ortho s.r.l. | 32 | 2026-05-01 | 2026-07-28 | |
| Clinical Evaluation of Patient-Specific 3D-Printed Titanium Implants for Facial Reconstruction. Patient-specific titanium implants for facial reconstruction - Hemifacial Microsomia, Mucormycosis | Not applicable | Recruiting | Latakia University | 30 | 2026-04-26 | 2026-06-17 |
| ASO Treatment for Syndromic Craniosynostoses Design of patient specific ASO - Craniosynostoses, Crouzon Syndrome | Recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 12 | 2026-04-20 | 2026-09-08 | |
| A Phase 1b/2 Study of the Safety and Efficacy of the Monoclonal Antibody OM-RCA-01 in Patients With Metastatic Tumors Expressing Fibroblast Growth Factor Receptor 1 humanized monoclonal anti-FGFR1 antibody OM-RCA-01 - Renal Cell Carcinoma Metastatic, Prostate Cancer Metastatic | Phase 1 / Phase 2 | Recruiting | Kidney Cancer Research Bureau | 58 | 2025-12-02 | 2026-01-21 |
| Surgical Corection of Congenital Proximal Radioulnar Synostosis Using Double Osteotomy Technique. derotation osteotomy utilizing Kirschner wires for the correction of congenital proximal radioulnar synostosis - Synostosis | Not applicable | Not yet recruiting | Sohag University | 1 | 2025-09-01 | 2025-09-09 |
| Effects of Corrective Helmet Therapy on Cervical Motion and Thermoregulation in Children With Positional Deformities cranial helmet therapy - observational - Plagiocephaly, Nonsynostotic, Brachycephaly | Not yet recruiting | Wroclaw University of Health and Sport Sciences | 270 | 2025-09-01 | 2025-10-01 | |
| Ocular Characteristics in Patients With Craniosynostosis Craniosynostosis, Strabismus | Recruiting | Centre Hospitalier Universitaire, Amiens | 65 | 2025-04-04 | 2026-02-12 | |
| Cranial Remolding Orthosis Registry MyCRO Band, Traditional CRO - Plagiocephaly, Brachycephaly | Not yet recruiting | Otto Bock HealthCare LP | 500 | 2025-04-01 | 2025-01-07 | |
| Opioid Sparing Effect of an ISP Nerve Block on Post-Op Pain Control in Posterior Cervical Spine Surgery Inter-semispinalis Plane Block, Opioids - Pain, Postoperative | Not applicable | Recruiting | Stony Brook University | 60 | 2025-02-21 | 2026-04-29 |
| Physical Activity and Community EmPOWERment Project PACE Program - Intellectual Disability, Neurodevelopmental Disorders | Not applicable | Recruiting | University of North Carolina, Chapel Hill | 376 | 2025-01-10 | 2026-02-23 |
| Investigation of the Etiology of Hypertension and Endothelial Damage in Patients With Cytochrome P450 Oxidoreductase Deficiency Cytochrome P450 Oxidoreductase Deficiency, Hypertension | Completed | Ozge Bayrak Demirel | 51 | 2024-12-24 | 2025-09-08 | |
| EPBONF : Evaluation of the Safety and Effectiveness of a Medical Device Aimed at Guiding Orbito-naso-frontal Band Surgery, for the Treatment of Craniostenoses BONFIX system - Craniosynostoses | Not applicable | Not yet recruiting | Centre Hospitalier Universitaire de Besancon | 5 | 2024-12-01 | 2024-04-15 |
| Functionalized Bioink Delivering Biomolecules for the Treatment of Craniofacial Diseases multiomic profiling - Craniofacial Defects, Subtle, Skull Defect | Unknown | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 180 | 2024-10-07 | 2025-03-14 | |
| Driving Pressure-guided Tidal Volume Ventilation in the Acute Respiratory Distress Syndrome Tidal volume customization in the acute respiratory distress syndrome - Acute Respiratory Distress Syndrome ARDS | Not applicable | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 750 | 2024-09-01 | 2024-03-26 |
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Craniosynostoses (49) · Acrocephalosyndactylia (33) · Klippel-Feil Syndrome (27) · Goldenhar Syndrome (13) · Neoplasms (7) · Radiculopathy (7) · Syndactyly (7) · Intervertebral Disc Degeneration (6) · Rubinstein-Taybi Syndrome (6) · Breast Neoplasms (5) · Carcinoma, Transitional Cell (5) · Cholangiocarcinoma (5) · Plagiocephaly (5) · Plagiocephaly, Nonsynostotic (5) · Spinal Cord Diseases (5)
Bone Diseases (145) · Bone Diseases, Developmental (145) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (145) · Musculoskeletal Diseases (145) · Congenital Abnormalities (143) · Musculoskeletal Abnormalities (141) · Craniofacial Abnormalities (103) · Synostosis (89) · Limb Deformities, Congenital (43) · Syndactyly (35) · Craniosynostoses (32) · Nervous System Diseases (29) · Pathological Conditions, Signs and Symptoms (29) · Neoplasms (25)
Gene Fusion (6) · pemigatinib (6) · Saline Solution (5) · Sodium Chloride (5) · Tranexamic Acid (4) · infigratinib (3) · Aminocaproic Acid (2) · Blood Specimen Collection (2) · Bupivacaine (2) · Gemcitabine (2) · Ketamine (2) · Rogaratinib (2) · derazantinib (2) · erdafitinib (2) · pembrolizumab (2)
Incyte Corporation (7) · National Human Genome Research Institute (NHGRI) (6) · University Hospital, Bordeaux (4) · Assiut University (3) · Boston Children's Hospital (3) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (3) · Hospices Civils de Lyon (3) · Janssen Research & Development, LLC (3) · Seattle Children's Hospital (3) · Assistance Publique - Hôpitaux de Paris (2) · Basilea Pharmaceutica (2) · Baylor College of Medicine (2) · Eisai Co., Ltd. (2) · Northwestern University (2) · Providence Medical Technology, Inc. (2)
United States (65) · France (26) · Spain (16) · Italy (15) · Germany (14) · Japan (11) · United Kingdom (11) · Belgium (8) · South Korea (8) · Turkey (Türkiye) (7) · Brazil (6) · Switzerland (6) · Australia (5) · Netherlands (5) · Canada (4)
Ekaterine Asatiani, MD (2) · Matt Jenkins (2) · Teresa Helsten, MD (2) · Ahmed El Shanawany, M.D., Ph.D. (1) · Alfredo Addeo, MD (1) · Andrew Grossbach, MD (1) · Ann Van Heest, MD (1) · Anna MacDowall, MD, PhD (1) · Anouk Smeets, MD, PhD, Professor (1) · Arndt Rolfs, PhD, MD (1) · Azra Mehmood, PhD (1) · Barbara B Biesecker (1) · Basim A Slim (1)
PMID 16001919, PMID 16428493, PMID 16526927, PMID 17186250, PMID 17343269, PMID 17440368, PMID 17544854, PMID 17546030, PMID 17760493, PMID 17763894, PMID 17899471, PMID 17945777, PMID 18297062, PMID 18459881, PMID 18513295, PMID 18635960, PMID 18797362, PMID 19912236, PMID 20644427, PMID 20683987, PMID 20815729, PMID 20818389, PMID 21204214, PMID 21897172, PMID 21916134, PMID 21999260, PMID 22312170, PMID 22502768, PMID 22929249, PMID 23786919, PMID 23851801, PMID 24328759, PMID 24491036, PMID 24841516, PMID 25360528, PMID 25464842, PMID 25679233, PMID 25853124, PMID 25909093, PMID 26048034, PMID 26267434, PMID 26324363, PMID 26516824, PMID 26910679, PMID 27002187, PMID 27606930, PMID 27870340, PMID 28027242, PMID 28748333, PMID 28790902
2016 (3), 2019 (3), 2018 (2), 2017 (1), P01HD078233 (1), R01AG076678 (1), R01DE013813 (1), R01DE022438 (1), R42HD081712 (1)