5 completed. 5 Phase 3, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 5 | Completed 5 |
| Phase 2 | 1 | Completed 1 |
Follow Down Syndrome: new trials by email Literature Review of Down Syndrome trials Research Report on Down Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Blood Flow and Blood Pressure Investigation in Down Syndrome Exercise - Down Syndrome | Phase 3 | Completed | University of Illinois at Chicago | 48 | 2022-09-01 | 2024-04-18 |
| Efficacy Assessment of Systematic Treatment With Folinic Acid and Thyroid Hormone on Psychomotor Development of Down Syndrome Young Children thyroid hormone and folinic acid - Down Syndrome | Phase 3 | Completed | Institut Jerome Lejeune | 175 | 2012-04-02 | 2020-05-13 |
| Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic Lymphoma Cyclophosphamide, Cytarabine, Dexamethasone - Acute Lymphoblastic Leukemia, Adult B Lymphoblastic Lymphoma | Phase 3 | Completed | Children's Oncology Group | 9350 | 2010-08-11 | 2026-05-28 |
| Efficacy Study of Folinic Acid to Improve Mental Development of Children With Down Syndrome folinic acid - Down Syndrome | Phase 2 / Phase 3 | Completed | Institut Jerome Lejeune | 120 | 2000-10-01 | 2009-12-17 |
| Multicenter Vitamin E Trial in Aging Persons With Down Syndrome Alpha-Tocopherol, Sugar Pill - Alzheimer's Disease, Down Syndrome | Phase 3 | Completed | New York State Institute for Basic Research | 349 | 2000-09-01 | 2012-05-09 |
Alzheimer Disease (1) · Cognitive Dysfunction (1) · Dementia (1) · Motor Activity (1) · Precursor B-Cell Lymphoblastic Leukemia-Lymphoma (1) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (1)
Abnormalities, Multiple (5) · Chromosome Disorders (5) · Congenital Abnormalities (5) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (5) · Genetic Diseases, Inborn (5) · Intellectual Disability (5) · Nervous System Diseases (5) · Neurobehavioral Manifestations (5) · Neurologic Manifestations (5) · Behavior (1) · Brain Diseases (1) · Central Nervous System Diseases (1) · Cognition Disorders (1) · Hematologic Diseases (1) · Hemic and Lymphatic Diseases (1)
Leucovorin (3) · Calcium Dobesilate (1) · Cyclophosphamide (1) · Cytarabine (1) · Dexamethasone (1) · Doxorubicin (1) · Exercise (1) · Mercaptopurine (1) · Methotrexate (1) · Sugars (1) · Thioguanine (1) · Thyroid Hormones (1) · Vincristine (1) · Vitamin E (1) · alpha-Tocopherol (1)
Institut Jerome Lejeune (2) · Children's Oncology Group (1) · New York State Institute for Basic Research (1) · University of Illinois at Chicago (1)
France (2) · United States (2) · Australia (1) · Canada (1) · Ireland (1) · New Zealand (1) · Puerto Rico (1) · Switzerland (1)
Anne L Angiolillo (1) · Clotilde Mircher, MD (1) · Henri Blehaut, M.D. (1) · Howard F. Andrews, Ph.D. (1) · Mary C. Sano, Ph.D. (1) · Paul S. Aisen, M.D. (1) · Robert Motl, Ph.D. (1) · Tracy Baynard, Ph.D. (1) · Wei-Yann Tsai, Ph.D. (1)
PMID 20084109, PMID 31281181, PMID 33411585, PMID 34863019, PMID 37890117, PMID 39121442, PMID 39625363, PMID 40315406, PMID 40588365
R01AG016381 (1), U10CA098543 (1), U10CA180886 (1)