54 completed, 11 unknown, 10 recruiting, 6 active not recruiting. 46 Phase 3, 33 Phase 2, 7 Phase 1, 6 Phase 4, 4 Not applicable.
Follow Thioguanine: new trials by email Literature Review of Thioguanine trials Research Report on Thioguanine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Testing Blinatumomab With or Without Revumenib in Patients With B-cell Acute Lymphoblastic Leukemia With a Genetic Change Requiring More Treatment Biospecimen Collection, Blinatumomab, Bone Marrow Aspiration - Acute Leukemia of Ambiguous Lineage, B Acute Lymphoblastic Leukemia | Phase 2 | Not yet recruiting | SWOG Cancer Research Network | 90 | 2026-10-14 | 2026-10-13 |
| Testing the Addition of Daratumumab to Chemotherapy for Treating Patients With Newly-Diagnosed T-Cell Lymphoblastic Leukemia (T-ALL) and T-Cell Lymphoblastic Lymphoma (T-LL) Biopsy Procedure, Biospecimen Collection, Bone Marrow Aspiration - Stage II T Lymphoblastic Leukemia/Lymphoma, Stage III T Lymphoblastic Leukemia/Lymphoma | Phase 2 / Phase 3 | Not yet recruiting | Children's Oncology Group | 1708 | 2026-08-28 | 2026-07-30 |
| Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia Asparaginase Erwinia chrysanthemi, Biospecimen Collection, Blinatumomab - Acute Leukemia of Ambiguous Lineage, B Acute Lymphoblastic Leukemia | Phase 2 | Recruiting | National Cancer Institute (NCI) | 153 | 2025-06-05 | 2026-10-27 |
| A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL) Biospecimen Collection, Blinatumomab, Bone Marrow Biopsy - B Acute Lymphoblastic Leukemia | Phase 2 | Recruiting | National Cancer Institute (NCI) | 222 | 2025-05-30 | 2026-10-27 |
| Therapy for Newly Diagnosed Patients With B-Cell Precursor Acute Lymphoblastic Leukemia and Lymphoma Dexamethasone, Vincristine, Inotuzumab - Acute Lymphoblastic Leukemia, Lymphoblastic Lymphoma | Phase 2 | Recruiting | St. Jude Children's Research Hospital | 128 | 2025-01-23 | 2026-07-16 |
| Adding Dasatinib Or Venetoclax To Improve Responses In Children With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia (ALL) Or Lymphoma (T-LLY) Or Mixed Phenotype Acute Leukemia (MPAL) Dexamethasone, Vincristine, Daunorubicin - T-cell Acute Lymphoblastic Leukemia, T-cell Lymphoma | Phase 2 | Recruiting | St. Jude Children's Research Hospital | 100 | 2024-12-27 | 2026-08-10 |
| Adding Targeted Drugs to Usual Chemotherapy for Adults With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia (T-ALL) and T-Cell Lymphoblastic Lymphoma (T-LBL) Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy - T Acute Lymphoblastic Leukemia, T Lymphoblastic Lymphoma | Phase 2 | Withdrawn | National Cancer Institute (NCI) | 2024-08-09 | 2024-05-17 | |
| DEC-C and Thioguanine for R/R AML Thioguanine (Tabloid ®), DecitabineCedazuridine (Inqovi ®) - Acute Myeloid Leukemia | Phase 2 | Withdrawn | Columbia University | 2024-04-01 | 2025-03-24 | |
| Thiopurine Enhanced Mutations for PD-1/Ligand-1 Efficacy Atezolizumab, 6-mercaptopurine, 6-thioguanine - Solid Tumor, Adult, Metastatic Cancer | Phase 1 / Phase 2 | Completed | Kristoffer Rohrberg | 18 | 2022-09-01 | 2026-01-14 |
| Ma-Spore ALL 2020 Study Prednisolone, Dexamethasone, Vincristine - B Lymphoblastic Leukemia | Phase 2 | Recruiting | National University Hospital, Singapore | 500 | 2020-03-04 | 2024-03-28 |
| Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and B-LLy Biospecimen Collection, Blinatumomab, Bone Marrow Aspiration - B Acute Lymphoblastic Leukemia, B Lymphoblastic Lymphoma | Phase 3 | Recruiting | Children's Oncology Group | 5951 | 2019-10-31 | 2026-08-25 |
| International Cooperative Treatment Protocol for Children and Adolescents With Lymphoblastic Lymphoma Cyclophosphamide, Cytarabine, Dexamethasone - Lymphoblastic Lymphoma, Childhood | Phase 3 | Recruiting | University Hospital Muenster | 683 | 2019-08-23 | 2026-05-06 |
| A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With Newly Diagnosed B-Lymphoblastic Leukemia Asparaginase Erwinia chrysanthemi, Blinatumomab, Cyclophosphamide - B Acute Lymphoblastic Leukemia, B Lymphoblastic Lymphoma | Phase 3 | Active not recruiting | National Cancer Institute (NCI) | 6720 | 2019-07-03 | 2026-10-01 |
| Ruxolitinib and Chemotherapy in Adolescents and Young Adults With Ph-like Acute Lymphoblastic Leukemia Ruxolitinib, Cyclophosphamide, Cytarabine - Acute Lymphoblastic Leukemia, ALL, Childhood | Phase 1 | Recruiting | University of Chicago | 15 | 2019-05-28 | 2026-06-29 |
| Treatment Protocol for Children and Adolescents With Acute Lymphoblastic Leukemia - AIEOP-BFM ALL 2017 Blinatumomab, Bortezomib, Cyclophosphamide - Acute Lymphoblastic Leukemia, Pediatric | Phase 3 | Recruiting | Martin Schrappe | 5000 | 2018-07-15 | 2025-04-06 |
| Inotuzumab Ozogamicin and Frontline Chemotherapy in Treating Young Adults With Newly Diagnosed B Acute Lymphoblastic Leukemia Allopurinol, Cytarabine, Daunorubicin Hydrochloride - B Acute Lymphoblastic Leukemia | Phase 3 | Recruiting | Alliance for Clinical Trials in Oncology | 303 | 2017-09-20 | 2026-10-19 |
| Imatinib Mesylate and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia Allogeneic Hematopoietic Stem Cell Transplantation, Calaspargase Pegol, Cyclophosphamide - Acute Lymphoblastic Leukemia, B Acute Lymphoblastic Leukemia | Phase 3 | Active not recruiting | Children's Oncology Group | 352 | 2017-08-08 | 2026-10-05 |
| Azacitidine and Combination Chemotherapy in Treating Infants With Acute Lymphoblastic Leukemia and KMT2A Gene Rearrangement Azacitidine, Biospecimen Collection, Computed Tomography - Acute Leukemia of Ambiguous Lineage, B Acute Lymphoblastic Leukemia | Phase 2 | Completed | National Cancer Institute (NCI) | 78 | 2017-04-01 | 2025-02-27 |
| Total Therapy XVII for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia and Lymphoma Prednisone, Vincristine, Daunorubicin - Acute Lymphoblastic Leukemia, Acute Lymphoblastic Lymphoma | Phase 2 / Phase 3 | Active not recruiting | St. Jude Children's Research Hospital | 790 | 2017-03-29 | 2026-06-17 |
| Thiopurine EnhAnced Maintenance Therapy Thioguanine (oral) - Acute Lymphoblastic Leukemia, Lymphoblastic Lymphoma | Phase 1 / Phase 2 | Completed | Kjeld Schmiegelow | 30 | 2016-10-01 | 2020-04-15 |
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Precursor Cell Lymphoblastic Leukemia-Lymphoma (38) · Leukemia (37) · Burkitt Lymphoma (14) · Leukemia, Biphenotypic, Acute (9) · Lymphoma (9) · Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (7) · Leukemia, Myeloid, Acute (6) · Anemia, Refractory, with Excess of Blasts (4) · Leukemia, Myelomonocytic, Chronic (4) · Myelodysplastic Syndromes (4) · Down Syndrome (3) · Leukemia, Monocytic, Acute (3) · Myeloproliferative Disorders (3) · Precursor B-Cell Lymphoblastic Leukemia-Lymphoma (3) · Anemia, Refractory (2)
Children's Oncology Group (24) · National Cancer Institute (NCI) (11) · St. Jude Children's Research Hospital (5) · European Organisation for Research and Treatment of Cancer - EORTC (3) · Goethe University (3) · Johann Wolfgang Goethe University Hospital (3) · M.D. Anderson Cancer Center (3) · SWOG Cancer Research Network (3) · Alliance for Clinical Trials in Oncology (2) · Dutch Childhood Oncology Group (2) · Kjeld Schmiegelow (2) · Medical Research Council (2) · Memorial Sloan Kettering Cancer Center (2) · National University Hospital, Singapore (2) · University Hospital Muenster (2)
United States (54) · Canada (30) · Australia (29) · Germany (17) · Puerto Rico (17) · Switzerland (17) · New Zealand (14) · Netherlands (9) · Austria (7) · Czechia (7) · Italy (7) · Belgium (6) · France (6) · United Kingdom (6) · Denmark (4)
Dieter Hoelzer, MD, PhD (3) · Dieter Hoelzer, MD,PhD (3) · Alan K. Burnett, MD, FRCP (2) · Anne L Angiolillo (2) · Martin Schrappe, MD, PhD (2) · Minnie Abromowitch, MD (2) · Naomi J. Winick, MD (2) · Tanya Trippett, MD (2) · Alan S. Gamis, MD, MPH (1) · Albert Assad, MD (1) · Alfred Reiter, MD (1) · Allen Eng Juh Yeoh, MBBS (1) · Allen Yeoh, MBBS (1) · Andrea Biondi (1) · Antony H. Goldstone, FRCP (1)
PMID 39121442, PMID 37890117, PMID 41671463, PMID 23007406, PMID 24970932, PMID 16105981, PMID 19144982, PMID 20154213, PMID 21719599, PMID 22442346, PMID 22493293, PMID 23233662, PMID 26590194, PMID 26888258, PMID 26913693, PMID 27561722, PMID 28751559, PMID 29148893, PMID 29284596, PMID 31601692, PMID 33496745, PMID 36603187, PMID 37021527, PMID 38446568, PMID 40315406, PMID 42085640, PMID 10499612, PMID 11426549, PMID 12111109, PMID 12153596, PMID 12694250, PMID 12780755, PMID 15087948, PMID 15154634, PMID 15368546, PMID 15801953, PMID 15952999, PMID 16136166, PMID 16333838, PMID 16556888, PMID 16609069, PMID 17032921, PMID 17170120, PMID 17170128, PMID 17312329, PMID 17315155, PMID 17989709, PMID 18039957, PMID 18048644, PMID 18089878
U10CA180886 (14), U10CA098543 (13), 2017 (2), U10CA032102 (2), U10CA180888 (2), 2009 (1), 2019 (1), F32CA141762 (1), P30CA072720 (1), P50GM115279 (1), R01CA090246 (1), R01CA140729 (1), R37CA036401 (1), U10CA098413 (1), U10CA180821 (1)