294 completed, 86 unknown, 24 active not recruiting, 24 terminated. 136 Phase 2, 85 Phase 3, 72 Phase 1, 70 Phase 4, 66 Not applicable.
Follow Diabetic Macular Edema: new trials by email Literature Review of Diabetic Macular Edema trials Research Report on Diabetic Macular Edema
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study of CU06-1004 in Patients With Daibetic Macular Edema CU06-1004, Placebo Control - DME, Diabetic Macular Edema | Phase 2 | Not yet recruiting | Curacle Co., Ltd. | 156 | 2026-12-01 | 2026-10-23 |
| South Asian Patients With Diabetic Macular Oedema Treated With Faricimab Assessing the Efficacy, Durability, and Safety (SEAFAR Study) Intravitreal anti-VEGF injection, Faricimab - Diabetic Macular Edema | Phase 4 | Not yet recruiting | Birmingham and Midland Eye Centre Sandwell and west Birmingham NHS trust | 120 | 2026-11-01 | 2026-08-07 |
| Changes in Intraocular Pressure After Intravitreal Injection Diabetic Macular Edema, Neovascular Age-Related Macular Degeneration | Not yet recruiting | Assiut University | 50 | 2026-10-01 | 2026-09-17 | |
| Blepharoptosis After Repeated Intravitreal Anti-VEGF Injections: A Prospective Study Repeated intravitreal anti-VEGF injection with eyelid speculum - Blepharoptosis, Age-Related Macular Degeneration | Recruiting | Abdulkadir Küçük | 60 | 2026-09-25 | 2026-10-22 | |
| Suprachoroidal Triamcinolone Acetonide Monotherapy in Treatment-naive Center Involving Diabetic Macular Edema Suprachoroidal triamcinolone acetonide injection - Diabetic Macular Edema | Phase 2 | Not yet recruiting | Khyber Girls Medical College | 25 | 2026-09-21 | 2026-10-13 |
| Speculum-Free Intravitreal Injection Using Cotton-Tipped Applicator Retraction: Pain, Procedure Time, Patient Satisfaction, and Safety Eyelid Speculum Retraction, Cotton-Tipped Applicator Retraction - Neovascular Age-Related Macular Degeneration (nAMD), Diabetic Macular Edema | Not applicable | Active not recruiting | Jakkrit Juhong | 129 | 2026-09-09 | 2026-09-25 |
| Intranasal Delivery of Octreotide for Treatment of Diabetic Macular Edema Octreotide (drug), Placebo - Diabetic Macular Edema | Phase 1 | Withdrawn | University of Alabama at Birmingham | 2026-08-31 | 2026-10-13 | |
| Lactiplantibacillus Plantarum 299v Probiotic Supplementation in Patients With Diabetic Macular Edema Lactobacillus plantarum 299v - Diabetic Macular Edema | Phase 2 | Recruiting | Massachusetts Eye and Ear Infirmary | 36 | 2026-06-23 | 2026-09-30 |
| A Study to Assess the Use of Artificial Intellignce to Predict Eye Treatment Changes in Adult Participants With Diabetic Macular Edema Diabetic Macular Edema | Withdrawn | AbbVie | 2026-05-30 | 2026-08-28 | ||
| A Study in People With Diabetic Macular Edema to Test How Well Different Doses of BI 3812465 Are Tolerated Low dose BI 3812465, Medium dose BI 3812465, High dose BI 3812465 - Diabetic Macular Edema | Phase 1 / Phase 2 | Recruiting | Boehringer Ingelheim | 49 | 2026-05-14 | 2026-10-14 |
| Study of the SCD411 Prefilled Syringe for Treating Adults With Wet Age-Related Macular Degeneration, Retinal Vein Occlusion, Diabetic Macular Edema, or Diabetic Retinopathy SCD411 0.05mL (2mg) - Neovascular (Wet) Age-Related Macular Degeneration, Retinal Vein Occlusion | Phase 2 | Completed | Sam Chun Dang Pharm. Co. Ltd. | 33 | 2026-05-13 | 2026-06-08 |
| Clinical Study to Compare Efficacy and Safety of AVT29 and Eylea HD in Participants With Diabetic Macular Edema AVT29 (proposed aflibercept HD biosimilar), Eylea HD (aflibercept HD) - Diabetic Macular Edema | Phase 3 | Recruiting | Alvotech Swiss AG | 256 | 2026-04-22 | 2026-04-30 |
| A Study to Evaluate the Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of RO7823653 in Participants With Diabetic Macular Edema (DME) RO7823653, Faricimab - Diabetic Macular Edema | Phase 1 | Recruiting | Genentech, Inc. | 93 | 2026-04-21 | 2026-10-09 |
| Effectiveness of Multidisciplinary Protocolised Interventions on IVT Non-adherence Rates multidisciplinary protocolized intervention (MPI), Routine medical care & monitoring - Diabetic Macular Edema, Neovascular (Wet) Age-Related Macular Degeneration | Not applicable | Not yet recruiting | Singapore Eye Research Institute | 200 | 2026-04-01 | 2026-05-05 |
| COMO: A Phase 3 Randomized, Double-Masked Study Comparing the Efficacy of EYP-1901 Against Aflibercept in DME EYP-1901, Aflibercept (2.0 mg) - Diabetic Macular Edema, DME | Phase 3 | Active not recruiting | EyePoint Pharmaceuticals, Inc. | 240 | 2026-02-16 | 2026-10-02 |
| CAPRI: A Phase 3 Randomized, Double-Masked Study Comparing the Efficacy of EYP-1901 Against Aflibercept in DME EYP-1901, Aflibercept (2.0 mg) - Diabetic Macular Edema, DME | Phase 3 | Active not recruiting | EyePoint Pharmaceuticals, Inc. | 240 | 2026-02-09 | 2026-10-02 |
| Kamuvudine-9 (K9) in Diabetic Macular Edema Placebo Tablet: BID, Kamuvudine K9 - Diabetic Macular Edema | Phase 1 / Phase 2 | Recruiting | Dr. Bryan Strelow | 10 | 2026-02-01 | 2026-03-10 |
| Wide Field OCTA in Ocular Diseases Age - Related Macular Degeneration (AMD), Diabetic Macular Edema | Not yet recruiting | IRCCS San Raffaele | 200 | 2026-01-01 | 2025-12-30 | |
| OCT-Based Screening for Early Retinal Changes in Asymptomatic Diabetic Patients Spectral Domain OCT Imaging - Diabetic Macular Edema | Not yet recruiting | Assiut University | 112 | 2025-12-01 | 2025-11-18 | |
| Micropulse Laser Photocoagulation in Diabetic Macular Edema micropulse laser photocoagulation - Diabetic Macular Edema | Not applicable | Not yet recruiting | Sohag University | 50 | 2025-11-30 | 2025-12-05 |
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Diabetic Retinopathy (102) · Macular Edema (66) · Diabetes Mellitus (53) · Macular Degeneration (44) · Retinal Vein Occlusion (40) · Edema (16) · Retinal Diseases (16) · Vision Disorders (12) · Eye Diseases (10) · Cataract (8) · Diabetes Mellitus, Type 2 (8) · Wet Macular Degeneration (7) · Diabetes Mellitus, Type 1 (6) · Retinal Degeneration (5) · Glaucoma (4)
Eye Diseases (186) · Retinal Diseases (168) · Cardiovascular Diseases (136) · Vascular Diseases (136) · Endocrine System Diseases (132) · Diabetes Complications (102) · Diabetic Angiopathies (102) · Retinal Degeneration (93) · Diabetes Mellitus (79) · Glucose Metabolism Disorders (60) · Metabolic Diseases (60) · Nutritional and Metabolic Diseases (60) · Macular Degeneration (54) · Pathological Conditions, Signs and Symptoms (42) · Embolism and Thrombosis (40)
aflibercept (81) · Ranibizumab (75) · Bevacizumab (40) · Dexamethasone (36) · Calcium Dobesilate (31) · Triamcinolone Acetonide (20) · salicylhydroxamic acid (18) · Lasers (15) · faricimab (15) · Fluocinolone Acetonide (11) · Triamcinolone (8) · KH902 fusion protein (6) · brolucizumab (6) · pegaptanib (6) · Intravitreal Injections (5)
Novartis Pharmaceuticals (18) · Jaeb Center for Health Research (17) · Hoffmann-La Roche (14) · Allergan (8) · Shahid Beheshti University of Medical Sciences (8) · Regeneron Pharmaceuticals (7) · California Retina Consultants (6) · Johns Hopkins University (6) · Unity Health Toronto (6) · University of Sao Paulo (6) · Cairo University (5) · National Eye Institute (NEI) (5) · Alimera Sciences (4) · Association for Innovation and Biomedical Research on Light and Image (4) · Genentech, Inc. (4)
United States (205) · China (43) · Canada (37) · United Kingdom (27) · Germany (26) · Spain (26) · France (25) · Israel (22) · Italy (22) · Puerto Rico (22) · Hungary (19) · Czechia (18) · Poland (18) · Brazil (17) · Australia (16)
Arshad Khanani, MD (3) · Diana Do, MD (3) · Friedrich Asmus, MD (3) · Pablo Velazquez-Martin, MD (3) · Ahmed A Tabl (2) · Alexander J. Brucker, M.D. (2) · Catherine A Cukras, MD, PhD (2)
PMID 21571677, PMID 33206392, PMID 25439614, PMID 37585454, PMID 38758639, PMID 41534798, PMID 20008710, PMID 20427088, PMID 22999634, PMID 26519345, PMID 26581718, PMID 26802783, PMID 31654188, PMID 32411431, PMID 35085503, PMID 36246184, PMID 36774994, PMID 36897413, PMID 38158159, PMID 38852921, PMID 40634898, PMID 40668667, PMID 40688490, PMID 42373197, PMID 42771326, PMID 10372879, PMID 12177445, PMID 12386035, PMID 12453981, PMID 12714656, PMID 15294883, PMID 15715559, PMID 15802932, PMID 15992752, PMID 16154196, PMID 16736131, PMID 16968214, PMID 16978576, PMID 17070586, PMID 17123615, PMID 17420366, PMID 17544778, PMID 17765429, PMID 17917738, PMID 17936715, PMID 18054885, PMID 18316700, PMID 18662829, PMID 18698292, PMID 18784623
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