4 completed. 4 Phase 2, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 4 | Completed 4 |
| Phase 1 | 2 | Completed 2 |
Follow Cryptococcal Meningitis: new trials by email Literature Review of Cryptococcal Meningitis trials Research Report on Cryptococcal Meningitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Optimizing the Dose of Flucytosine for the Treatment of Cryptococcal Meningitis AMBITION trial control, Flucytosine - Cryptococcal Meningitis | Phase 2 | Completed | University of Minnesota | 48 | 2024-04-09 | 2025-08-27 |
| Encochleated Oral Amphotericin for Cryptococcal Meningitis Trial (EnACT) MAT2203, Amphotericin B - Cryptococcal Meningitis | Phase 1 / Phase 2 | Completed | Matinas BioPharma Nanotechnologies, Inc. | 178 | 2019-10-24 | 2023-03-31 |
| High-Dose Fluconazole for the Treatment of Cryptococcal Meningitis in HIV-Infected Individuals Fluconazole, Amphotericin B - Cryptococcal Meningitis, HIV Infections | Phase 1 / Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 168 | 2010-04-16 | 2021-11-04 |
| Amphotericin Alone or in Combination With Fluconazole for AIDS-Associated Meningitis Amphotericin B, Fluconazole - Cryptococcal Meningitis | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 143 | 2005-05-01 | 2012-05-16 |
Meningitis, Cryptococcal (4) · HIV Infections (2) · Bacterial Infections (1) · Meningitis (1)
Bacterial Infections and Mycoses (4) · Central Nervous System Diseases (4) · Central Nervous System Fungal Infections (4) · Central Nervous System Infections (4) · Cryptococcosis (4) · Infections (4) · Meningitis, Fungal (4) · Mycoses (4) · Nervous System Diseases (4) · Neuroinflammatory Diseases (4) · Meningitis (3) · Blood-Borne Infections (2) · Communicable Diseases (2) · Genital Diseases (2) · Immune System Diseases (2)
Amphotericin B (3) · Fluconazole (2) · Flucytosine (1) · amphotericin B, deoxycholate drug combination (1) · liposomal amphotericin B (1)
National Institute of Allergy and Infectious Diseases (NIAID) (2) · Matinas BioPharma Nanotechnologies, Inc. (1) · University of Minnesota (1)
Uganda (3) · Thailand (2) · United States (2) · India (1) · Kenya (1) · Peru (1) · South Africa (1) · Zimbabwe (1)
David B Meya (1) · David R Boulware (1) · Robert A. Larsen, MD (1) · Umesh G. Lalloo, MD, FRCP (1)
PMID 19441980, PMID 19897055, PMID 32747357, PMID 36780493, PMID 37606364, PMID 38943665, PMID 39972326, PMID 40665233, PMID 40795226