27 recruiting, 20 completed, 10 unknown, 5 active not recruiting. 43 Not applicable, 5 Phase 2, 3 Phase 3, 2 Phase 4, 1 Phase 1.
Follow Congenital Diaphragmatic Hernia: new trials by email Literature Review of Congenital Diaphragmatic Hernia trials Research Report on Congenital Diaphragmatic Hernia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia BALT GOLDBALL 2 detachable latex ballon, BALTACCIBDPE100 Microcatheter, Storz fetoscopic operating sheath and miniature telescope/fetoscope - Congenital Diaphragmatic Hernia | Not applicable | Recruiting | Mauro H. Schenone | 20 | 2026-12-01 | 2026-03-19 |
| Measuring Heart Health in Both Term, Preterm and Unwell Newborn Babies With an Advanced Ultrasound Method: Speckle Tracking Echocardiography Premature Baby, Pulmonary Hypertension of Newborn | Not yet recruiting | Birmingham Women's NHS Foundation Trust | 190 | 2026-09-01 | 2026-07-07 | |
| North American Fetal Therapy Network Prospective Registry for Long-term Outcome Following Fetoscopic Endoluminal Tracheal Occlusion in Severe Left and Right Congenital Diaphragmatic Hernia Fetoscopic Endoluminal Tracheal Occlusion, Standard of Care - Congenital Diaphragmatic Hernia | Enrolling by invitation | Mayo Clinic | 80 | 2026-08-31 | 2026-08-18 | |
| Safety and Efficacy of Fetoscopic Endoluminal Tracheal Occlusion (FETO) in Congenital Diaphragmatic Hernia (CDH) FETO with Goldballoon Detachable Balloon (GOLDBAL2) along with the Delivery Microcatheter (BALTACCI-BDPE100) - Congenital Diaphragmatic Hernia | Not applicable | Recruiting | Dr Erin Perrone | 40 | 2026-06-17 | 2026-06-29 |
| Efficacy of Inhaled Nitric Oxide in Congenital Diaphragmatic Hernia Inhaled Nitric Oxide - Congenital Diaphragmatic Hernia, Pulmonary Hypertension | Phase 4 | Not yet recruiting | Asan Medical Center | 40 | 2025-11-01 | 2025-11-25 |
| De-implementing Inhaled Nitric Oxide for Congenital Diaphragmatic Hernia Inhaled Nitric Oxide (iNO) use, De-implementation of Inhaled Nitric Oxide (iNO) use - Congenital Diaphragmatic Hernia | Phase 4 | Recruiting | The University of Texas Health Science Center, Houston | 600 | 2025-11-01 | 2026-08-18 |
| Palliative Care Needs of Children With Rare Diseases and Their Families Family Centered pediatric palliative care for family caregivers of children with rare diseases. - Trisomy 13 Syndrome, Arthrogryposis Congenita Multiplex With Intestinal Atresia | Not applicable | Enrolling by invitation | Children's National Research Institute | 480 | 2025-10-02 | 2026-01-28 |
| Safety and Efficacy of FETO in CDH Phase III FETO, Fetal Endoluminal Tracheal Occlusion - Congenital Diaphragmatic Hernia, Pulmonary Hypoplasia | Phase 3 | Recruiting | Children's Hospital Medical Center, Cincinnati | 75 | 2025-09-30 | 2025-09-22 |
| Safety and Efficacy of Fetoscopic Endoluminal Tracheal Occlusion in Congenital Diaphragmatic Hernia Fetoscopic Endoluminal Tracheal Occlusion (FETO) Procedure - Congenital Diaphragmatic Hernia | Phase 3 | Not yet recruiting | Oregon Health and Science University | 80 | 2025-09-01 | 2025-09-02 |
| Effect of Melatonin on Pulmonary Hypertension in Full Term Neonates Melatonin, nitric oxide generator - Congenital Peumonia, Persistent Pulmonary Hypertension of Newborn | Not applicable | Recruiting | Ain Shams University | 52 | 2025-07-01 | 2026-10-22 |
| Prospective Registry for Long-term Outcomes Following FETO in Severe Left and Right CDH Fetal Treatment Arm (FETO Group) - Congenital Diaphragmatic Hernia, Congenital Abnormalities | Not applicable | Recruiting | Johns Hopkins University | 80 | 2025-06-23 | 2026-04-23 |
| Safety and Efficacy of FETO in CDH: A Phase III Trial FETO with GoldBAL2 Balloon and BALTACCIBDPE100 Catheter - Congenital Diaphragmatic Hernia, Pulmonary Hypoplasia | Not applicable | Recruiting | Holly L Hedrick, MD | 80 | 2025-04-07 | 2026-07-22 |
| North American Fetal Therapy Network for Long-term Outcome Following Fetoscopic Endoluminal Tracheal Occlusion in Severe Left and Right Congenital Diaphragmatic Hernia Fetal Treatment arm (FETO Group) - Congenital Diaphragmatic Hernia | Not applicable | Recruiting | The University of Texas Health Science Center, Houston | 80 | 2025-03-04 | 2026-10-20 |
| Preliminary Study of Pediatric Diaphragmatic Elastography Ultrasonic elastography - Congenital Diaphragmatic Hernia | Not applicable | Not yet recruiting | University Hospital, Strasbourg, France | 80 | 2024-11-15 | 2024-10-30 |
| Fetal Endotracheal Occlusion (FETO) in Fetuses With Severe Congenital Diaphragmatic Hernia Fetal Endotracheal Occlusion (FETO) - Congenital Diaphragmatic Hernia | Not applicable | Withdrawn | Eyal Krispin | 2024-11-01 | 2026-04-29 | |
| Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia (FETO) BALT GoldbBAL2 Detachable Balloon, Catheter System - Congenital Diaphragmatic Hernia, Pulmonary Hypoplasia | Not applicable | Recruiting | Rodrigo Ruano | 10 | 2024-05-01 | 2026-02-23 |
| Infant Survival and Long-term Outcome Following Fetoscopic Endoluminal Tracheal Occlusion in Severe Left and Right Congenital Diaphragmatic Hernia, A Phase III Trial BALT GOLDBAL2 Balloon - Congenital Diaphragmatic Hernia | Not applicable | Active not recruiting | Inna Lobeck | 20 | 2024-04-14 | 2026-03-19 |
| Fetal Endoscopic Tracheal Occlusion for CDH (CDH) FETO with Goldballoon Detachable Balloon (GOLDBAL2) along with the Delivery Microcatheter (BALTACCI-BDPE100) - Congenital Diaphragmatic Hernia | Not applicable | Recruiting | University of California, Davis | 10 | 2024-02-12 | 2025-12-15 |
| An Exploratory Physiological Study of Post-operative Recovery in Surgical Neonates and Dimethylarginine:Arginine Levels Abdominal Surgery for congenital gut malformation in the first 5 days of life. - Gastroschisis, Congenital Diaphragmatic Hernia | Recruiting | Liverpool Women's NHS Foundation Trust | 30 | 2024-02-05 | 2025-09-29 | |
| Neurally Adjusted Ventilatory Assist for Neonates With Congenital Diaphragmatic Hernias Neurally Adjusted Ventilatory Assist, Assist Control Ventilation - Congenital Diaphragmatic Hernia | Not applicable | Unknown | King's College Hospital NHS Trust | 18 | 2023-05-26 | 2023-06-01 |
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Hernias, Diaphragmatic, Congenital (74) · Hypertension, Pulmonary (8) · Esophageal Atresia (4) · Hernia (4) · Congenital Abnormalities (3) · Gastroschisis (3) · Hernia, Diaphragmatic (3) · Hernia, Umbilical (3) · Esophageal atresia with or without tracheoesophageal fistula (2) · Meningomyelocele (2) · Pathological Conditions, Anatomical (2) · Persistent Fetal Circulation Syndrome (2) · Rare Diseases (2) · Respiratory Aspiration (2) · Respiratory Insufficiency (2)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (73) · Internal Hernia (73) · Pathological Conditions, Signs and Symptoms (73) · Pathological Conditions, Anatomical (72) · Congenital Abnormalities (71) · Hernia, Diaphragmatic (71) · Hernia (70) · Respiratory Tract Diseases (17) · Lung Diseases (12) · Cardiovascular Diseases (11) · Vascular Diseases (9) · Hypertension (8) · Digestive System Diseases (6) · Gastrointestinal Diseases (6) · Infant, Newborn, Diseases (6)
Data Collection (2) · Inosine (2) · Umbilical Cord Clamping (2) · Blood Specimen Collection (1) · Conversion to Open Surgery (1) · Endothelium-Dependent Relaxing Factors (1) · Fetoscopes (1) · Functional Residual Capacity (1) · Glucose (1) · Interactive Ventilatory Support (1) · Melatonin (1) · Milrinone (1) · Standard of Care (1) · Thoracoscopy (1)
University of Utah (4) · Assistance Publique - Hôpitaux de Paris (3) · Mayo Clinic (3) · Michael A Belfort (3) · The University of Texas Health Science Center, Houston (3) · Children's Hospital Medical Center, Cincinnati (2) · Children's Hospital of Philadelphia (2) · Dr Erin Perrone (2) · Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico (2) · Johns Hopkins University (2) · King's College London (2) · Universitaire Ziekenhuizen KU Leuven (2) · University Hospital, Lille (2) · University of Colorado, Denver (2) · University of Sao Paulo General Hospital (2)
United States (41) · United Kingdom (9) · France (8) · Canada (4) · Belgium (3) · Egypt (3) · Austria (2) · Brazil (2) · Italy (2) · Argentina (1) · Australia (1) · China (1) · Germany (1) · Poland (1) · Saudi Arabia (1)
Mauro Schenone, MD (3) · Anthony Johnson, DO (2) · Erin Perrone, MD (2) · Giacomo Cavallaro, MD, PhD (2) · Michael Belfort, MD, PhD (2) · Rodrigo Ruano, MD, PhD (2) · Agostino Pierro, Prof (1) · Ahmet A Baschat, MD (1) · Ahmet Baschat, MD (1) · Aimen Shaaban, MD (1) · Alireza Shamshirsaz, MD (1) · Alshimaa Azab, PhD (1) · Amel H Abo Elela, Prof (1) · Andrew Chon, MD (1)
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K23HD084727 (1), R01HD057036 (1), R01HD117137 (1), U10HD036790 (1), UG1HD021364 (1), UG1HD027851 (1), UG1HD027853 (1), UG1HD027880 (1), UG1HD027904 (1), UG1HD034216 (1), UG1HD040492 (1), UG1HD040689 (1), UG1HD053089 (1), UG1HD053109 (1), UG1HD068244 (1)