75 completed, 46 recruiting, 26 unknown, 13 not yet recruiting. 107 Not applicable, 10 Phase 2, 9 Phase 3, 8 Phase 4, 1 Phase 1.
Follow Internal Hernia: new trials by email Literature Review of Internal Hernia trials Research Report on Internal Hernia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Image-Guided Herniorrhaphy Study Image-Guided Herniorrhaphy - Hernia, Hernia Abdominal Wall | Not applicable | Not yet recruiting | University of California, Davis | 30 | 2026-12-01 | 2026-08-31 |
| Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia BALT GOLDBALL 2 detachable latex ballon, BALTACCIBDPE100 Microcatheter, Storz fetoscopic operating sheath and miniature telescope/fetoscope - Congenital Diaphragmatic Hernia | Not applicable | Recruiting | Mauro H. Schenone | 20 | 2026-12-01 | 2026-03-19 |
| Antireflux Surgery Without Preoperative Esophageal Manometry Preoperative workup without high-resolution esophageal manometry, Standard preoperative workup with high-resolution esophageal manometry - GERD, Hiatal Hernia | Not applicable | Not yet recruiting | McMaster University | 96 | 2026-10-01 | 2026-08-10 |
| Preoperative Predictors of Symptom Improvement After Laparoscopic Fundoplication Laparoscopic Nissen fundoplication, Laparoscopic Toupet fundoplication - Gastroesophageal Reflux Disease, Hiatal Hernia | Recruiting | Minia University | 470 | 2026-09-20 | 2026-09-22 | |
| Measuring Heart Health in Both Term, Preterm and Unwell Newborn Babies With an Advanced Ultrasound Method: Speckle Tracking Echocardiography Premature Baby, Pulmonary Hypertension of Newborn | Not yet recruiting | Birmingham Women's NHS Foundation Trust | 190 | 2026-09-01 | 2026-07-07 | |
| Pilot Trial of Fetoscopic Endoluminal Tracheal Occlusion (FETO) in Fetuses With Severe CDH Goldballoon Detachable Balloon (GOLDBAL2) - Severe Congenital Diaphragmatic Hernia | Not applicable | Not yet recruiting | NYU Langone Health | 10 | 2026-09-01 | 2026-08-17 |
| North American Fetal Therapy Network Prospective Registry for Long-term Outcome Following Fetoscopic Endoluminal Tracheal Occlusion in Severe Left and Right Congenital Diaphragmatic Hernia Fetoscopic Endoluminal Tracheal Occlusion, Standard of Care - Congenital Diaphragmatic Hernia | Enrolling by invitation | Mayo Clinic | 80 | 2026-08-31 | 2026-08-18 | |
| Safety and Efficacy of Fetoscopic Endoluminal Tracheal Occlusion (FETO) in Congenital Diaphragmatic Hernia (CDH) FETO with Goldballoon Detachable Balloon (GOLDBAL2) along with the Delivery Microcatheter (BALTACCI-BDPE100) - Congenital Diaphragmatic Hernia | Not applicable | Recruiting | Dr Erin Perrone | 40 | 2026-06-17 | 2026-06-29 |
| Fetal Endoscopic Tracheal Occlusion (FETO) Trial for Congenital Diaphragmatic Hernia (CDH) Placement of the GOLDBAL2 balloon - Diaphragmatic Hernia | Not applicable | Recruiting | Vincent Duron | 10 | 2026-05-28 | 2026-06-29 |
| Comparison of Laparoscopic Nissen Fundoplication and Hill-Snow Repair for Hiatus Hernia With Endoscopic Evaluation Laparoscopic Hill-Snow repair, Laparoscopic Nissen Fundoplication - Hiatal Hernia With Gastroesophageal Reflux Disease | Not applicable | Not yet recruiting | Minia University | 40 | 2026-03-01 | 2026-02-04 |
| Phrenoesophageal Ligament Reconstruction With Mesh Phrenoesophageal Ligament Reconstruction with Mesh: A New Approach to Hiatal Hernia Repair (Alinasser's Technique), Classic approach - Hiatus Hernia, Gastreoesophageal Reflux Disease | Not applicable | Not yet recruiting | Clinical Trial Aseer | 60 | 2025-12-20 | 2025-11-26 |
| Efficacy of Inhaled Nitric Oxide in Congenital Diaphragmatic Hernia Inhaled Nitric Oxide - Congenital Diaphragmatic Hernia, Pulmonary Hypertension | Phase 4 | Not yet recruiting | Asan Medical Center | 40 | 2025-11-01 | 2025-11-25 |
| De-implementing Inhaled Nitric Oxide for Congenital Diaphragmatic Hernia Inhaled Nitric Oxide (iNO) use, De-implementation of Inhaled Nitric Oxide (iNO) use - Congenital Diaphragmatic Hernia | Phase 4 | Recruiting | The University of Texas Health Science Center, Houston | 600 | 2025-11-01 | 2026-08-18 |
| Palliative Care Needs of Children With Rare Diseases and Their Families Family Centered pediatric palliative care for family caregivers of children with rare diseases. - Trisomy 13 Syndrome, Arthrogryposis Congenita Multiplex With Intestinal Atresia | Not applicable | Enrolling by invitation | Children's National Research Institute | 480 | 2025-10-02 | 2026-01-28 |
| Safety and Efficacy of FETO in CDH Phase III FETO, Fetal Endoluminal Tracheal Occlusion - Congenital Diaphragmatic Hernia, Pulmonary Hypoplasia | Phase 3 | Recruiting | Children's Hospital Medical Center, Cincinnati | 75 | 2025-09-30 | 2025-09-22 |
| Safety and Efficacy of Fetoscopic Endoluminal Tracheal Occlusion in Congenital Diaphragmatic Hernia Fetoscopic Endoluminal Tracheal Occlusion (FETO) Procedure - Congenital Diaphragmatic Hernia | Phase 3 | Not yet recruiting | Oregon Health and Science University | 80 | 2025-09-01 | 2025-09-02 |
| Evaluating Clinical Hiatal Hernia Outcomes Using OviTex® OviTex Reinforced Tissue Matrix - Hiatal Hernia | Not applicable | Recruiting | Tela Bio Inc | 173 | 2025-07-25 | 2026-08-18 |
| Effect of Melatonin on Pulmonary Hypertension in Full Term Neonates Melatonin, nitric oxide generator - Congenital Peumonia, Persistent Pulmonary Hypertension of Newborn | Not applicable | Recruiting | Ain Shams University | 52 | 2025-07-01 | 2026-09-30 |
| Laparoscopic Hiatal Hernia Repair With Mesh Cruroplasty Hiatal Hernia (HH) repair using mesh cruroplasty during a Laparoscopic Sleeve Gastrectomy (LSG) - Hiatal Hernia, Sleeve Gastrectomy | Not applicable | Completed | Zagazig University | 20 | 2025-06-26 | 2026-03-24 |
| Prospective Registry for Long-term Outcomes Following FETO in Severe Left and Right CDH Fetal Treatment Arm (FETO Group) - Congenital Diaphragmatic Hernia, Congenital Abnormalities | Not applicable | Recruiting | Johns Hopkins University | 80 | 2025-06-23 | 2026-04-23 |
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Hernias, Diaphragmatic, Congenital (86) · Hernia, Hiatal (83) · Gastroesophageal Reflux (38) · Hernia, Diaphragmatic (23) · Hernia (11) · Hypertension, Pulmonary (10) · Esophageal Atresia (7) · Recurrence (6) · Congenital Abnormalities (5) · Esophagitis (4) · Barrett Esophagus (3) · Esophagitis, Peptic (3) · Gastroschisis (3) · Hernia, Umbilical (3)
Pathological Conditions, Signs and Symptoms (188) · Pathological Conditions, Anatomical (187) · Hernia (178) · Hernia, Diaphragmatic (160) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (90) · Congenital Abnormalities (85) · Digestive System Diseases (51) · Gastrointestinal Diseases (49) · Esophageal Diseases (45) · Esophageal Motility Disorders (38) · Deglutition Disorders (36) · Respiratory Tract Diseases (27) · Pathologic Processes (21) · Lung Diseases (17)
Fundoplication (6) · Blood Specimen Collection (3) · Data Collection (2) · Gastric Bypass (2) · Gastropexy (2) · Inosine (2) · Laparoscopy (2) · Surveys and Questionnaires (2) · Umbilical Cord Clamping (2) · Biopsy (1) · Bronchoscopy (1) · Bupivacaine (1) · Conversion to Open Surgery (1) · Endothelium-Dependent Relaxing Factors (1) · Fetoscopes (1)
Mayo Clinic (5) · The University of Texas Health Science Center, Houston (4) · University of Bologna (4) · University of Utah (4) · Assistance Publique - Hôpitaux de Paris (3) · EndoGastric Solutions (3) · Karolinska Institutet (3) · M.S.T. Medical Surgery Technology LTD. (3) · Michael A Belfort (3) · Minia University (3) · Rijnstate Hospital (3) · University Hospital, Lille (3) · University of California, San Francisco (3) · Zagazig University (3) · Beijing Friendship Hospital (2)
United States (91) · France (14) · United Kingdom (10) · Canada (9) · Egypt (8) · Sweden (8) · Germany (7) · Italy (7) · Netherlands (7) · Belgium (6) · Australia (3) · Austria (3) · China (3) · Saudi Arabia (3) · Spain (3)
Anders Thorell, Professor (3) · Mauro Schenone, MD (3) · Alshimaa Azab, PhD (2) · Anthony Johnson, DO (2) · Brant K Oelschlager, MD (2) · Dmitry Oleynikov, MD (2) · Erin Perrone, MD (2) · Giacomo Cavallaro, MD, PhD (2) · Hanmin Lee, MD (2) · Michael Belfort, MD, PhD (2) · Paul D Colavita, MD (2) · Rodrigo Ruano, MD, PhD (2) · Sandro Mattioli, MD (2) · Shawn D St. Peter, MD (2)
PMID 34808130, PMID 35032132, PMID 42335922, PMID 10493481, PMID 10801022, PMID 10945692, PMID 10986445, PMID 11084541, PMID 11997814, PMID 12861529, PMID 1290156, PMID 14614166, PMID 15287047, PMID 16567174, PMID 16585320, PMID 16769018, PMID 17177265, PMID 17332197, PMID 17587219, PMID 17890882, PMID 19658113, PMID 19960205, PMID 19961637, PMID 20143332, PMID 20980772, PMID 21251771, PMID 22146488, PMID 22170862, PMID 22895933, PMID 23026445, PMID 23186837, PMID 23328121, PMID 23401615, PMID 23604057, PMID 24055300, PMID 24113771, PMID 24405544, PMID 24947625, PMID 25389141, PMID 25448925, PMID 25941666, PMID 26226244, PMID 26227494, PMID 26377635, PMID 26463242, PMID 26895675, PMID 27005292, PMID 27574999, PMID 27926636, PMID 28002310
2019 (1), K23HD084727 (1), R01HD057036 (1), R01HD117137 (1), U10HD036790 (1), UG1HD021364 (1), UG1HD027851 (1), UG1HD027853 (1), UG1HD027880 (1), UG1HD027904 (1), UG1HD034216 (1), UG1HD040492 (1), UG1HD040689 (1), UG1HD053089 (1), UG1HD053109 (1)