373 completed, 164 unknown, 108 recruiting, 66 terminated. 293 Not applicable, 172 Phase 2, 125 Phase 1, 54 Phase 3, 14 Phase 4.
Follow Colon Cancer: new trials by email Literature Review of Colon Cancer trials Research Report on Colon Cancer
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| This is a Phase 1/1b Study to Evaluate the Safety and Preliminary Antitumor Activity of LTZ-232 in Participants With Advanced/Metastatic Colorectal Cancer and Other Solid Tumors LTZ-232 - Colorectal Cancer, Advanced/Metastatic Solid Tumor | Phase 1 | Recruiting | LTZ Therapeutics, Inc. | 152 | 2026-12-01 | 2026-10-20 |
| ctDNA and TEP Levels in Colon Cancer Additional Peripheral Venous Blood Sampling for ctDNA and TEP Biomarker Analysis - Colon Cancer | Not applicable | Not yet recruiting | Institute of Oncology Ljubljana | 80 | 2026-11-01 | 2026-10-07 |
| Analysis of Breath Volatile Organic Compounds Using Mass Spectrometry Proton Transfer Reaction Mass Spectrometry Analysis - Pancreas Cancer, Hepatocellular Carcinoma | Not yet recruiting | University of Oklahoma | 2000 | 2026-10-01 | 2026-07-29 | |
| Cemiplimab With Fianlimab for Resectable Non-Metastatic Colon Cancer Cemiplimab + Fianlimab [Fixed Dose Combination (FDC)] - Colon Cancer | Phase 2 | Not yet recruiting | John Strickler, M.D. | 24 | 2026-10-01 | 2026-08-27 |
| A Phase 1 Study of DEM301 in Participants With Metastatic Colorectal Cancer DEM301 - Metastatic Colorectal Cancer, Colon Cancer | Phase 1 | Recruiting | DEM BioPharma, Inc. | 60 | 2026-10-01 | 2026-10-15 |
| Improving Colorectal Cancer Screening Uptake Through Education and Stool-Based Testing Outreach Colorectal Cancer Education Materials, Cologuard test kit, Fecal immunochemical test kit - Colorectal Cancer (CRC) Screening, CRC Screening | Not applicable | Not yet recruiting | Washington University School of Medicine | 200 | 2026-09-30 | 2026-08-24 |
| Neoadjuvant Pembrolizumab and Porustobart in Resectable pMMR/MSS Colon Cancer Pembrolizumab, Porustobart - Colon Cancer | Phase 2 | Recruiting | Solstice Oncology, Inc. | 100 | 2026-09-30 | 2026-10-22 |
| Tafolecimab Combined With Chemoimmunotherapy as Neoadjuvant Treatment for pMMR/MSS Locally Advanced Colon Cancer Tafolecimab, Sintilimab - Colon Cancer, PCSK9 Inhibitor | Phase 2 | Recruiting | Daping Hospital and the Research Institute of Surgery of the Third Military Medical University | 70 | 2026-09-20 | 2026-09-25 |
| ctDNA-Guided Immunotherapy for dMMR/MSI-H Colon Cancer PD-1 inhibitor, CTLA-4 inhibitor, ctDNA/MRD testing - Colon Cancer, Deficient Mismatch Repair | Phase 2 | Recruiting | Fudan University | 23 | 2026-09-14 | 2026-09-25 |
| Innovative and Cooperative Pathway Integrating Oncogeriatric, Pharmaceutical and Pharmacological Follow-up in Elderly Patients. Experimental - Elderly, Breast Cancer | Phase 4 | Not yet recruiting | Gustave Roussy, Cancer Campus, Grand Paris | 794 | 2026-09-01 | 2026-09-03 |
| Radiogenomic Profiling of Dendritic Cells and Macrophages to Predict Recurrence in Colorectal Liver Metastasis Radiogenomic and Immune Profiling, Prospective Radiogenomic and ctDNA Profiling - Colo-rectal Cancer, Liver Metastases | Not yet recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 210 | 2026-09-01 | 2026-08-06 | |
| Improving Prognostication in Colon Cancer Blood draw for the laboratory assessment - Colon Cancer, Colon Adenocarcinoma | Not yet recruiting | Universitaire Ziekenhuizen KU Leuven | 400 | 2026-09-01 | 2026-06-29 | |
| QL1706 Combined With Standard Therapy for Conversion Therapy of Synchronous Liver Metastases From Colon Cancer: a Multicenter, Single-arm, Exploratory Study QL1706 (Iparomlimab/Tuvonralimab) - Colon Cancer, Synchronous Liver Metastases | Phase 2 | Not yet recruiting | Fujian Medical University | 30 | 2026-08-15 | 2026-06-16 |
| COLOFLOW: Laser Speckle Contrast Imaging Versus Near-infrared Fluorescence Imaging With Indocyanine Green Laser Speckle Contrast Imaging - Leakage, Anastomotic, Colon Cancer | Not yet recruiting | Leiden University Medical Center | 30 | 2026-08-01 | 2026-07-22 | |
| The Role of Total Abdominal Autonomic Nerve Preservation During the Resection of Right/Left Colon Cancer: Prospective Clinical Trial Abdominal autonomic nerve preserverd in the TNP arm - Colon Cancer, Nerve Preserve | Active not recruiting | Fudan University | 200 | 2026-07-01 | 2026-09-17 | |
| Distribution and Analysis of Metastatic Lymph Nodes in Colorectal Cancer Patients (DIAMOND) Colon Cancer, Rectal Cancer | Not yet recruiting | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | 1200 | 2026-07-01 | 2026-06-09 | |
| Statewide Unified Network for Remote Intervention of Strength and Exercise Exercise, Stretching - Gastric Cancer (Diagnosis), Esophagus Cancer | Not applicable | Not yet recruiting | AdventHealth Translational Research Institute | 120 | 2026-07-01 | 2026-05-19 |
| A Study of SHY-ONC6, a Novel Proteasome Inhibitor, in Adults With Advanced or Metastatic Solid Tumors SHY-ONC6 - Advanced or Metastatic Solid Tumors, Triple Negative Breast Cancer (TNBC) | Phase 1 | Recruiting | SHY Therapeutics | 30 | 2026-06-24 | 2026-10-22 |
| Frequency of Care for Peripherally Inserted Central Vascular Access In the Prevention of Marsi Weekly dressing for peripherally inserted central catheters, 15 days dressing change for peripherally inserted central catheters, peripherally inserted central catheters - Colon Cancer, Cancer Pancreas | Not applicable | Enrolling by invitation | Institut Català d'Oncologia | 150 | 2026-06-10 | 2026-07-13 |
| ICG in Colon Cancer Indocyanine green (ICG) injection for intraoperative lymph node imaging, Laparoscopic Colon Cancer Resection - Colon Cancer, ICG (Indocyanine Green) | Not applicable | Not yet recruiting | Tanta University | 25 | 2026-06-01 | 2026-06-12 |
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Douglas K Rex, MD (4) · Ian Gralnek, Prof. (4) · Erin Van Blarigan, ScD (3) · Franco Carli, Professor (3) · Michael Sawyer, MD (3) · Ori Segol, Dr. (3) · Alberto Sobrero, MD (2) · Alessandro Repici, MD (2) · Anders Jakobsen, DMSc (2) · Aya Kamaya (2) · Conor P. Delaney, MD, PhD (2) · Diansan Su, Dr. (2) · Electra Paskett (2)
PMID 35588252, PMID 37162250, PMID 22070868, PMID 25071111, PMID 25952085, PMID 26049686, PMID 26348120, PMID 26438146, PMID 27432417, PMID 33538338, PMID 36657661, PMID 10400410, PMID 10615079, PMID 11413430, PMID 11743810, PMID 11910487, PMID 12135020, PMID 12436148, PMID 12550116, PMID 12750250, PMID 13129557, PMID 15199546, PMID 15273542, PMID 1544146, PMID 15494283, PMID 15758907, PMID 1598671, PMID 16041502, PMID 16413414, PMID 16422163, PMID 16452248, PMID 16600928, PMID 16810012, PMID 16813622, PMID 16926320, PMID 16943394, PMID 16943400, PMID 17005947, PMID 17045238, PMID 17538089, PMID 17545532, PMID 17761300, PMID 17943760, PMID 17956350, PMID 18034250, PMID 18197583, PMID 18198412, PMID 18279948, PMID 18304416, PMID 18458834
2023 (3), 2025 (3), 2015 (2), 2019 (2), P30CA015704 (2), P30CA046934 (2), 2008 (1), 2009 (1), 2017 (1), 2018 (1), I01HX000878 (1), N01CN35000 (1), N01CN35157 (1), N01CN95015 (1), P01CA078673 (1)