10 completed. 10 Phase 3, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 10 | Completed 10 |
| Phase 2 | 1 | Completed 1 |
Follow Chronic Rhinosinusitis: new trials by email Literature Review of Chronic Rhinosinusitis trials Research Report on Chronic Rhinosinusitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study Evaluating the Efficacy and Safety of Intranasal Administration of OPN-375 in Subjects With Chronic Rhinosinusitis Without the Presence of Nasal Polyps OPN-375 - Chronic Rhinosinusitis | Phase 3 | Completed | Optinose US Inc. | 223 | 2019-06-06 | 2023-12-21 |
| Study Evaluating the Efficacy and Safety of Intranasal Administration of OPN-375 in Subjects With Chronic Rhinosinusitis With or Without the Presence of Nasal Polyps OPN-375 - Chronic Rhinosinusitis | Phase 3 | Completed | Optinose US Inc. | 332 | 2018-11-27 | 2024-05-29 |
| An Extension Study of Omalizumab in Participants With Chronic Rhinosinusitis With Nasal Polyps Omalizumab, Placebo - Nasal Polyps, Chronic Rhinosinusitis | Phase 3 | Completed | Hoffmann-La Roche | 249 | 2018-05-09 | 2022-04-04 |
| Xylitol for Chronic Sinusitis Xylitol, Saline - Chronic Rhinosinusitis, Rhinosinusitis | Phase 2 / Phase 3 | Completed | Ochsner Health System | 1 | 2018-03-01 | 2023-04-07 |
| A Clinical Trial of Omalizumab in Participants With Chronic Rhinosinusitus With Nasal Polyps Omalizumab, Placebo - Nasal Polyps, Chronic Rhinosinusitis | Phase 3 | Completed | Hoffmann-La Roche | 127 | 2017-11-21 | 2020-03-23 |
| A Clinical Trial of Omalizumab in Participants With Chronic Rhinosinusitis With Nasal Polyps Omalizumab, Placebo - Nasal Polyps, Chronic Rhinosinusitis | Phase 3 | Completed | Hoffmann-La Roche | 138 | 2017-11-15 | 2020-03-23 |
| Sinupret Extract Coated Tablets in Chronic Rhinosinusitis Sinupret extract coated tablets, Placebo coated tablets - Chronic Rhinosinusitis | Phase 3 | Completed | Bionorica SE | 572 | 2016-04-28 | 2018-02-28 |
| Mitomicin C for Prevention Postoperative Endoscopic Sinus Surgery Synechia and QOL in Chronic Rhinosinusitis Mitomicin C, Identical placebo solution - Chronic Rhinosinusitis, Postoperative Nasal Synerchia | Phase 3 | Completed | Mahidol University | 224 | 2015-03-01 | 2018-05-23 |
| Oral Versus Topical Antibiotics for Chronic Rhinosinusitis Exacerbations oral levofloxacin, nebulized levofloxacin - Chronic Rhinosinusitis | Phase 3 | Completed | University of Rochester | 33 | 2013-10-01 | 2021-03-24 |
| Nasal Inhalation of Dornase Alfa (Pulmozyme) in Patients With Cystic Fibrosis and Chronic Rhinosinusitis Pulmozyme - Cystic Fibrosis, Chronic Rhinosinusitis | Phase 3 | Completed | University of Jena | 5 | 2005-12-01 | 2014-12-04 |
Nasal Polyps (3) · Cystic Fibrosis (1) · Rhinosinusitis (1) · Sinusitis (1)
Respiratory Tract Diseases (5) · Nose Diseases (4) · Otorhinolaryngologic Diseases (4) · Pathological Conditions, Anatomical (3) · Pathological Conditions, Signs and Symptoms (3) · Polyps (3) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1) · Digestive System Diseases (1) · Genetic Diseases, Inborn (1) · Infant, Newborn, Diseases (1) · Infections (1) · Lung Diseases (1) · Pancreatic Diseases (1) · Paranasal Sinus Diseases (1) · Respiratory Tract Infections (1)
Omalizumab (3) · Levofloxacin (1) · Mitomycin (1) · Sinupret (1) · Sodium Chloride (1) · Xylitol (1) · dornase alfa (1)
Hoffmann-La Roche (3) · Optinose US Inc. (2) · Bionorica SE (1) · Mahidol University (1) · Ochsner Health System (1) · University of Jena (1) · University of Rochester (1)
United States (7) · Poland (6) · Germany (4) · Russia (4) · United Kingdom (4) · Canada (3) · Czechia (3) · Mexico (3) · Spain (3) · Ukraine (3) · Belgium (2) · Bulgaria (2) · France (2) · Georgia (2) · Hungary (2)
Jennifer Carothers (2) · John Messina (2) · Jochen G. Mainz, M.D. (1) · Li-Xing Man, MD, MPA, Msc (1) · Pawin Numthavaj, M.D. (1)
PMID 37951571, PMID 38197558, PMID 33548517, PMID 33710614, PMID 34382434, PMID 37214171, PMID 42647052, PMID 42692406, PMID 15023840, PMID 15316237, PMID 15510034, PMID 17405780, PMID 17882910, PMID 21994147, PMID 23378777, PMID 23785241, PMID 27394715, PMID 28390807, PMID 8281565, PMID 9755259
2017 (3), 2015 (1)