20 unknown, 15 completed, 4 active not recruiting, 4 recruiting. 54 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 54 | Unknown 20, Completed 15, Active not recruiting 4, Recruiting 4, Withdrawn 4, Enrolling by invitation 3, Not yet recruiting 3, Terminated 1 |
Follow Chronic Hepatitis B: new trials by email Literature Review of Chronic Hepatitis B trials Research Report on Chronic Hepatitis B
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Sequential PD-1 Antibody and Pegylated Interferon Therapy for Nucleos(t)Ide Analogue-suppressed Chronic Hepatitis B Sintilimab, Pegylated Interferon-α 2b, Nucleos(t)ide Analogues - Chronic Hepatitis B | Not applicable | Not yet recruiting | Beijing 302 Hospital | 60 | 2026-09-01 | 2026-09-09 |
| Union-FAST: An Intelligent-Agent Intervention to Increase Antiviral Treatment Uptake in Diagnosed-but-Untreated Hepatitis B Patients Agent Intelligence education - Chronic Hepatitis B | Not applicable | Not yet recruiting | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 2000 | 2026-05-01 | 2026-04-09 |
| Assessment of Treatment Adherence and Associated Factors in Chronic HepB Patients Supported by HBVCare HBVCare Mobile App - Chronic Hepatitis B | Not applicable | Recruiting | Institute of Gastroenterology and Hepatology, Vietnam | 70 | 2026-04-15 | 2026-05-15 |
| Effects of Peginterferon Consolidation Therapy on Hepatic cccDNA Dynamics in CHB Patients Achieving Clinical Cure. Peginterferon α-2b based injection - Chronic Hepatitis b | Not applicable | Not yet recruiting | Xiamen Hospital of Traditional Chinese Medicine | 30 | 2025-04-20 | 2025-04-09 |
| Research on Clinical Recovery and Maintenance Strategies for CHB baseline anti-HBs titer - Chronic Hepatitis b, Hepatitis B Vaccine | Not applicable | Recruiting | Beijing Municipal Administration of Hospitals | 285 | 2024-11-01 | 2025-01-31 |
| Sequential Combination Therapy With PD-1 Antibody and Peg-IFNα in CHB Patients Sintilimab, NAs, Peg-IFNα-2b - Chronic Hepatitis B | Not applicable | Unknown | Beijing 302 Hospital | 50 | 2024-06-15 | 2024-06-20 |
| The Treatment of PD-1 Antibody Combined With Peg-IFNα in NAs-suppressed CHB Patients Sintilimab, Peg-IFNα-2b, NAs - Chronic Hepatitis B | Not applicable | Active not recruiting | Beijing 302 Hospital | 45 | 2024-05-17 | 2026-03-18 |
| Composite Probiotics Stabilize Lipid Metabolism in Chronic Hepatitis B Patients:A Clinical Trial Probiotic - Chronic Hepatitis B | Not applicable | Completed | Wecare Probiotics Co., Ltd. | 84 | 2024-03-30 | 2025-04-16 |
| Fine Needle Aspiration (FNA) Evaluation of the Intrahepatic HBV Reservoir and Its Immunological Characteristics in Chronically HBV-infected Patients Investigation of the intrahepatic compartment using the fine needle aspiration (FNA) technique, Creation of a serum biobank, FNA feasibility and acceptability questionnaire - Chronic Hepatitis b | Not applicable | Recruiting | Hospices Civils de Lyon | 100 | 2024-03-08 | 2026-04-21 |
| Pegylated Interferon α in Previously Interferon-treated CHB（Leading Study） Peginterferon α-2b based treatment group, NAs monotherapy group - Chronic Hepatitis b | Not applicable | Recruiting | Qing XIe | 2016 | 2024-02-04 | 2024-03-21 |
| Clinical Study of Antiviral Therapy Combined With Novel Immunotherapy for CHB in Adults Peg interferon alfa-2b - Chronic Hepatitis b, Immunotherapy | Not applicable | Enrolling by invitation | Beijing Ditan Hospital | 180 | 2023-12-01 | 2025-01-15 |
| Chronic Hepatitis B Patients With Concurrent MAFLD: Cohort Study and Exercise Intervention. exercise - Chronic Hepatitis B, Non-alcoholic Fatty Liver Disease | Not applicable | Enrolling by invitation | National Taiwan University Hospital | 100 | 2023-08-01 | 2023-07-21 |
| Study on Screening, Verification and Intervention of High-risk Patients With Liver Cancer NAs（"Entecavir"or"Tenofovir"or"Tenofovir alafenamide"） combined with interferon treatments, NAs （"Entecavir"or"Tenofovir"or"Tenofovir alafenamide"） treatments - Hepatocellular Carcinoma, Chronic Hepatitis B | Not applicable | Unknown | Zhongshan Hospital (Xiamen), Fudan University | 2215 | 2023-02-10 | 2023-02-10 |
| Finite Versus Continuous Nucleos(t)Ide Analogues for Chronic Hepatitis B Nuc Discontinuation, Entecavir or Tenofovir - Chronic Hepatitis b | Not applicable | Active not recruiting | E-DA Hospital | 360 | 2022-12-20 | 2023-03-31 |
| Functional Cure Rate of Peg-IFNα-2b Combined With TAF in HBeAg Negative CHB Patients PEG IFN α-2b; TAF - Chronic Hepatitis B | Not applicable | Completed | Huashan Hospital | 210 | 2022-09-01 | 2026-10-20 |
| The Effectiveness and Safety of TMF in the Treatment of Chronic Hepatitis B Patients With Normal ALT. Tenofovir Amibufenamide（TMF） - HBV Infection, Chronic Hepatitis b | Not applicable | Active not recruiting | Ruijin Hospital | 200 | 2022-06-08 | 2025-11-17 |
| A Follow-up Study of Peginterferon Alfa-2b Combined With TDF in Patients With Chronic Hepatitis B Peginterferon α-2b Injection; Tenofovir Alafenamide Fumarate - Chronic Hepatitis B | Not applicable | Enrolling by invitation | Xiamen Amoytop Biotech Co., Ltd. | 350 | 2022-03-18 | 2024-12-04 |
| Study on Clinical Program Optimization of Inactive Hepatitis B Surface Antigen (HBsAg) Carriers (IHCs) continuous treatment, pulse therapy - Chronic Hepatitis B | Not applicable | Unknown | Henan Provincial People's Hospital | 80 | 2021-10-01 | 2022-07-14 |
| COIN-B: COntrolled Interruption of Nucleos(t)Ide Analogue Treatment in Chronic Hepatitis B Infections Cessation of ongoing treatment - Chronic Hepatitis B | Not applicable | Unknown | University Hospital, Antwerp | 156 | 2021-07-28 | 2024-06-24 |
| Effort to Narrow the Gap Between in Accordance With Guidelines and Consent to Treat CHB Population in East of China Integrated intervention strategies - Chronic Hepatitis b | Not applicable | Unknown | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | 2000 | 2021-07-01 | 2021-07-28 |
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Hepatitis B, Chronic (54) · Hepatitis B (11) · Carcinoma, Hepatocellular (3) · Recurrence (2) · Arthritis, Rheumatoid (1) · Fatty Liver (1) · Fibrosis (1) · Hepatitis C, Chronic (1) · Insulin Resistance (1) · Liver Cirrhosis (1) · Medication Adherence (1) · Metabolic Syndrome (1) · Non-alcoholic Fatty Liver Disease (1) · Obesity (1)
Blood-Borne Infections (54) · Chronic Disease (54) · Communicable Diseases (54) · DNA Virus Infections (54) · Digestive System Diseases (54) · Disease Attributes (54) · Hepadnaviridae Infections (54) · Hepatitis (54) · Hepatitis, Chronic (54) · Hepatitis, Viral, Human (54) · Infections (54) · Liver Diseases (54) · Pathologic Processes (54) · Pathological Conditions, Signs and Symptoms (54) · Virus Diseases (54)
Tenofovir (8) · entecavir (6) · peginterferon alfa-2a (3) · peginterferon alfa-2b (3) · sintilimab (3) · Telbivudine (2) · nas (2) · tenofovir alafenamide (2) · Abatacept (1) · Antiviral Agents (1) · Blood Specimen Collection (1) · Combined Modality Therapy (1) · Educational Status (1) · Exercise (1) · Fecal Microbiota Transplantation (1)
Beijing 302 Hospital (3) · Beijing Ditan Hospital (3) · National Taiwan University Hospital (3) · Third Affiliated Hospital, Sun Yat-Sen University (3) · Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (2) · Henan Provincial People's Hospital (2) · Qing XIe (2) · The University of Hong Kong (2) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · Alexion Pharmaceuticals, Inc. (1) · Beijing Municipal Administration of Hospitals (1) · Chinese University of Hong Kong (1) · Chulalongkorn University (1) · Composite Interceptive Med Science (1) · E-DA Hospital (1)
China (28) · Taiwan (5) · Hong Kong (3) · India (3) · France (2) · South Korea (2) · United States (2) · Belgium (1) · Canada (1) · Germany (1) · Netherlands (1) · Singapore (1) · Thailand (1) · Turkey (Türkiye) (1) · Vietnam (1)
Jia Shang (2) · Liang Peng, Doctor (2) · Alben Sigamani, MD (1) · Chen-Hua Liu, MD (1) · Cheng-Chao Liang, MD (1) · Chun-Jen Liu, MD (1) · Chun-Jen Liu, Professor (1) · Ding-Shinn Chen, MD (1) · Dr S. K. Sarin, MD, DM (1) · Fu-Sheng Wang (1) · Guiqiang Wang, Ph.D (1) · H.R. Reesink, MD PhD (1) · Hao Wang, doctor (1) · Hong Ren (1)
PMID 22011297, PMID 23461618, PMID 24168259, PMID 29577029, PMID 30481882, PMID 31415381, PMID 32759300, PMID 34222435, PMID 35677040, PMID 36109430, PMID 37577817, PMID 38663455, PMID 39925891, PMID 40247234, PMID 40937079, PMID 40953786, PMID 40976664, PMID 41261561, PMID 41731678, PMID 42789423