193 completed, 57 recruiting, 34 unknown, 12 not yet recruiting. 323 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 323 | Completed 193, Recruiting 57, Unknown 34, Not yet recruiting 12, Terminated 12, Active not recruiting 10, Enrolling by invitation 4, Withdrawn 1 |
Follow Chromosome Disorders: new trials by email Literature Review of Chromosome Disorders trials Research Report on Chromosome Disorders
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Regulating Together for Prader-Willi Syndrome: A Group Behavioral Therapy for Emotion Dysregulation Regulating Together group therapy - Prader-Willi Syndrome | Not applicable | Recruiting | Children's Mercy Hospital Kansas City | 10 | 2027-01-01 | 2026-09-02 |
| Effects of a Pacifier on Obstructive Sleep Apnea and Its Repercussions in Infants With Down Syndrome CURAPROX pacifier use, Pacifier diary, Polysomnography (PSG) to explore OSA - Obstructive Sleep Apnea, Down Syndrome (Trisomy 21) | Not applicable | Not yet recruiting | Hospices Civils de Lyon | 50 | 2026-11-02 | 2026-10-07 |
| Single Session Support for Parents of Children With Neurodevelopmental Disabilities Struggling With Anxious Avoidance EMPOWER-ND - Neurodevelopmental Disorders, Autism Spectrum Disorder (ASD) | Not applicable | Not yet recruiting | Boston University Charles River Campus | 50 | 2026-11-01 | 2026-10-27 |
| Vestibular Stimulation Versus Foot Intrinsic Muscle Exercises in Children With Down Syndrome Vestibular Stimulation Exercises, Foot Intrinsic Muscle Exercises - Down Syndrome, Balance Impairment | Not applicable | Not yet recruiting | Shalamar Institute of Health Sciences | 48 | 2026-09-02 | 2026-08-21 |
| Pilot Evaluation of the Developed Syntactic-Semantic Visual Configuration Intervention for Children With Language Impairment Syntactic-Semantic Visual Configuration Intervention (SSVCI) - Language Impairment, Autism | Not applicable | Not yet recruiting | Riphah International University | 20 | 2026-09-01 | 2026-08-26 |
| Executive Function Play Opportunities for Children With Down Syndrome EXPO, EXPO Extended, EXPO Foundations - Down Syndrome, Trisomy 21 | Not applicable | Not yet recruiting | Colorado State University | 150 | 2026-09-01 | 2026-08-28 |
| Home and Community Use of a Suspension Walker in Pre-Walking Infants With Down Syndrome suspension walker - Down Syndrome | Not applicable | Not yet recruiting | University of Southern California | 12 | 2026-09-01 | 2026-06-05 |
| HomeGrown: A Family-based Lifestyle Intervention to Support Healthy Development of Young Children With Down Syndrome The HomeGrown, Waitlist - Down Syndrome, Child Obesity | Not applicable | Active not recruiting | UNC Lineberger Comprehensive Cancer Center | 38 | 2026-04-16 | 2026-09-03 |
| Animal Fun Program and Kinesthetic Development in Down Syndrome Animal fun program - Kinesthetic Illusion | Not applicable | Completed | Riphah International University | 25 | 2026-04-01 | 2026-09-30 |
| Adapting RDAD for DS Remote Exercise Sessions, Caregiver Education Sessions - Down Syndrome (DS), Alzheimer's Disease (AD) | Not applicable | Recruiting | University of Kansas Medical Center | 40 | 2026-03-31 | 2026-08-03 |
| Optical Imaging in X-linked Disorders. Clinical assessment, Parental questionnaires, Cognitive assessment - Fragile X Syndrome (FXS), Creatine Transporter Deficiency | Not applicable | Recruiting | Hospices Civils de Lyon | 118 | 2026-03-30 | 2026-05-15 |
| Effects of Bubble Cushion Exercises on Postural Control in Children With Down Syndrome Bubble cushion exercises - Down Syndrome | Not applicable | Completed | Riphah International University | 22 | 2026-03-25 | 2026-08-11 |
| Effects of the Otago Exercise Program on Balance, Endurance, and Motor Coordination in Children With Down Syndrome OTAGO Exercises, Conventional Physical Therapy - Down Syndrome | Not applicable | Completed | Riphah International University | 30 | 2026-03-02 | 2026-09-28 |
| Comparative Study of Two Applications on Muscle Strength, Balance and Motor Function in Children With Down Syndrome. virtual reality, whole body vibration - Down Syndrome, Vibration Therapy | Not applicable | Completed | Cairo University | 40 | 2026-02-22 | 2026-09-11 |
| Rebound Therapy on Ventilatory Functions in Down Syndrome Chest Physical Therapy Protocol, Rebound Therapy Protocol - Down Syndrome | Not applicable | Not yet recruiting | Beni-Suef University | 40 | 2026-02-22 | 2026-02-20 |
| The Impact of Core Stability Versus Respiratory Muscle Strengthening Exercises on Bone Mineral Density in Children With Down Syndrome Core Stability Exercise Group, Respiratory Muscle Strengthening Group, Control /Conventional Physiotherapy Group - Down Syndrome (DS), Low Bone Mineral Density | Not applicable | Active not recruiting | Cairo University | 60 | 2026-02-20 | 2026-05-11 |
| Drumming Lessons' Influence on Children With Down Syndrome 2 months of drumming lessons given by a professional drummer with extensive experience working with children with Down syndrome, Lessons after measurement - Down Syndrome | Not applicable | Recruiting | Vanderbilt University | 30 | 2026-02-15 | 2026-05-19 |
| Resilience Training Intervention: Its Effect on Parental Acceptance/Rejection and Burden of Children With Down Syndrome resilience training intervention - Down Syndrome | Not applicable | Not yet recruiting | Ain Shams University | 50 | 2025-12-01 | 2025-12-29 |
| Effects of Bean Bag Tossing Game on Balance and Gait in Children With Down Syndrome. Bean Bag Tossing Game on Wedge, Bean Bag Tossing Game on Balance Board - Down Syndrome | Not applicable | Completed | Riphah International University | 38 | 2025-10-28 | 2026-09-30 |
| Effects of Jump Rope on Navicular Drop in Down Syndrome jumping rope and play activities, play activities - Down Syndrome | Not applicable | Recruiting | Riphah International University | 32 | 2025-10-28 | 2026-02-24 |
Showing 20 of 323. Sign in to see all of them.
Down Syndrome (217) · Prader-Willi Syndrome (39) · Fragile X Syndrome (21) · Intellectual Disability (17) · Sleep Apnea, Obstructive (16) · Autism Spectrum Disorder (14) · Obesity (13) · Turner Syndrome (13) · DiGeorge Syndrome (12) · Cerebral Palsy (10) · Klinefelter Syndrome (10) · Motor Activity (10) · Learning Disabilities (8) · Autistic Disorder (7) · Developmental Disabilities (7)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (323) · Congenital Abnormalities (322) · Genetic Diseases, Inborn (322) · Nervous System Diseases (287) · Abnormalities, Multiple (283) · Neurobehavioral Manifestations (279) · Neurologic Manifestations (279) · Intellectual Disability (261) · Pathological Conditions, Signs and Symptoms (63) · Signs and Symptoms (58) · Mental Disorders (53) · Nutritional and Metabolic Diseases (52) · Imprinting Disorders (47) · Nutrition Disorders (46)
Exercise (6) · Blood Specimen Collection (4) · Control Groups (4) · Equine-Assisted Therapy (4) · Minocycline (3) · Probiotics (3) · Surveys and Questionnaires (3) · Transcranial Direct Current Stimulation (3) · Waiting Lists (3) · Activator Appliances (2) · Continuous Positive Airway Pressure (2) · Drug Delivery Systems (2) · Educational Status (2) · Exenatide (2) · Exercise Movement Techniques (2)
Riphah International University (47) · Cairo University (9) · University of Kansas Medical Center (9) · Assistance Publique - Hôpitaux de Paris (8) · Hôpital le Vinatier (7) · Children's Hospital Medical Center, Cincinnati (6) · Institut Jerome Lejeune (6) · University Hospital, Toulouse (6) · Duke University (5) · Hospices Civils de Lyon (5) · Oregon Health and Science University (5) · University of Michigan (5) · Boston Children's Hospital (4) · University of Sao Paulo (4) · University of Seville (4)
United States (120) · Pakistan (49) · France (37) · Turkey (Türkiye) (16) · Egypt (15) · Spain (15) · Belgium (7) · Italy (7) · Denmark (6) · Netherlands (5) · Saudi Arabia (5) · United Kingdom (5) · Brazil (4) · Canada (4) · China (3)
Amy Bodde, PhD (2) · Andrea M Haqq, MD (2) · Binash Afzal, PHD* (2) · Brian Chicoine, MD (2) · Carles Lerin, PhD (2) · Michael Freemark, MD (2) · Stephan Eliez, Professor (2) · Thessa Hilgenkamp, PhD (2) · Abdullah Demirtas, MD (1) · Adil Munir, MS-PT (1) · Akito Hirakata, MD (1) · Aleena Irum, Ms-SLP (1) · Alexandra Benachi, MD, PhDi (1)
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K23HD109375 (2), R61HL151253 (2), 2016 (1), 3KL2TR002367-08S1 (1), 5TL1TR002318-07 (1), K12HD043494 (1), K12HD055931 (1), K23NS070337 (1), K23RR021979 (1), K99HD092606 (1), KL2TR002367 (1), R00HD092606 (1), R01AG063909 (1), R01AG076678 (1), R01AI047040 (1)