7 completed, 4 not yet recruiting, 4 unknown, 2 recruiting. 9 Not applicable, 1 Phase 1, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 9 | Completed 3, Not yet recruiting 3, Recruiting 2, Unknown 1 |
| Phase 1 | 1 | Unknown 1 |
| Phase 4 | 1 | Not yet recruiting 1 |
Follow Cervical Insufficiency: new trials by email Literature Review of Cervical Insufficiency trials Research Report on Cervical Insufficiency
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Azithromycin for Cerclage Prophylaxis Azithromycin Prophylaxis, Azithromycin Placebo, Cefazolin - Cervical Insufficiency | Phase 4 | Not yet recruiting | Wake Forest University Health Sciences | 80 | 2026-10-15 | 2026-10-27 |
| Personalized Care for Prenatal Stress Reduction & Prevention of Preterm Birth (PTB) Disparities Care coordination, Electronic massage, support gift #1 - Preterm Birth Complication, Preterm Birth | Not applicable | Not yet recruiting | University of North Carolina, Chapel Hill | 1228 | 2026-10-01 | 2026-09-29 |
| Use of Nitrous Oxide for Pain and Anxiety Management During Cervical Cerclage Removal Inhaled nitrous oxide - Preterm Delivery, Cervical Cerclage | Not applicable | Not yet recruiting | Kaplan Medical Center | 60 | 2026-05-01 | 2026-04-08 |
| Bed Rest With a Short Cervix on Preterm Birth Activity Restriction, No Activity Restriction - Preterm Birth, Cervical Insufficiency | Not applicable | Not yet recruiting | Julie Glavind | 6000 | 2026-05-01 | 2026-05-11 |
| Long-Term Patient-Reported Maternal Outcomes Following Abdominal Cerclage for the Prevention of Preterm Birth Abdominal cerclage (open or laparoscopic) - Cerclage, Cervical, Cervical Insufficiency | Enrolling by invitation | University of Aarhus | 1200 | 2025-03-05 | 2025-03-13 | |
| Optimal Timing of Routine Cervical Length Measurements During Anatomy Survey Cervical Length Measurement at the Beginning of the Anatomy Survey, Cervical Length Measurement at the End of the Anatomy Survey - Cervical Insufficiency, Preterm Birth | Not applicable | Recruiting | Henry Ford Health System | 550 | 2025-01-20 | 2026-03-09 |
| Nordic Randomized Trial on Laparoscopic Versus Vaginal Cerclage Laparoscopic cerclage, Vaginal cerclage - Preterm Birth, Cervical Insufficiency | Not applicable | Recruiting | University of Aarhus | 188 | 2024-01-31 | 2024-12-10 |
| Cervical Stiffness Assessment in High-risk Pregnancies for Preterm Birth Cervical Insufficiency, Cervical Stiffness | Completed | Luzerner Kantonsspital | 21 | 2023-07-27 | 2026-05-29 | |
| Preventing Preterm Birth With a Negative Pressure Cervical Cup: a Feasibility Study Hannah Cervical Cup (2 mm Delta), Hannah Cervical Cup (4 mm Delta), Hannah Cervical Cup (6 mm Delta) - Preterm Birth, Cervical Incompetence | Phase 1 | Unknown | Galena Innovations, LLC | 40 | 2023-04-01 | 2022-08-26 |
| Relation of the Area of Cerclage With Preterm Birth Type of cerclage procedure Mc Donald - Cervical Insufficiency | Unknown | Etlik Zubeyde Hanım Women's Health Care, Training and Research Hospital | 22 | 2022-01-21 | 2022-03-04 | |
| Intramuscular vs Rectal Progesterone in Preventing Preterm Labour After Cervical Cerclage Intramuscular Progesterone, Rectal Progesterone - Preterm Labour, Cervical Insufficiency | Not applicable | Completed | Hina Mukhtar | 820 | 2021-10-26 | 2025-12-29 |
| Effectiveness of Cervico-isthmic Cerclage Cervico-isthmic cerclage - Cerclage, Cervical, Cervical Insufficiency | Completed | Hospices Civils de Lyon | 45 | 2021-06-13 | 2022-01-11 | |
| Cervical Stiffness Measurement in Cervical Insufficiency Pregnolia - Pregnancy Related, Cervical Insufficiency | Completed | Tufts Medical Center | 136 | 2020-01-15 | 2022-09-21 | |
| Cerclage vs Cervical Pessary in Women With Cervical Incompetence Cerclage, Cervical pessary - Cervical Insufficiency | Not applicable | Completed | Maternal-Infantil Vall d´Hebron Hospital | 60 | 2015-06-01 | 2021-03-18 |
| Investigation Into the Microorganisms in Pregnant Women Sequencing - Cervical Insufficiency, Preterm Birth | Unknown | Chinese University of Hong Kong | 200 | 2012-06-05 | 2023-10-05 | |
| Patient Attitudes Toward Ultrasound Measurement of Cervical Length Sequential ultrasound, Transvaginal ultrasound - Cervical Insufficiency | Not applicable | Unknown | Intermountain Women and Children's Research | 210 | 2011-11-01 | 2011-11-30 |
| Obstetric Outcome in Pregnancies Treated With Laparoscopic Cerclage Laparoscopic cerclage placement - Pre-Term, Cervical Insufficiency | Completed | University of Aarhus | 185 | 2011-05-01 | 2023-08-03 | |
| Multifactorial Approach to Emergent Cerclage Indomethacin and antibiotics (cefazolin or clindamycin) - Cervical Insufficiency | Not applicable | Completed | Northwestern University | 53 | 2010-03-01 | 2014-11-07 |
Uterine Cervical Incompetence (18) · Premature Birth (12) · Obstetric Labor, Premature (2) · Pregnancy Complications (2) · Abortion, Spontaneous (1) · Depression, Postpartum (1) · Hypertension, Pregnancy-Induced (1) · Motor Activity (1) · Patient Participation (1) · Pre-Eclampsia (1) · Stress, Psychological (1)
Abortion, Habitual (18) · Female Urogenital Diseases (18) · Female Urogenital Diseases and Pregnancy Complications (18) · Genital Diseases (18) · Genital Diseases, Female (18) · Urogenital Diseases (18) · Uterine Cervical Diseases (18) · Uterine Diseases (18) · Abortion, Spontaneous (17) · Pregnancy Complications (16) · Obstetric Labor Complications (13) · Obstetric Labor, Premature (11) · Behavior (2) · Behavioral Symptoms (1) · Cardiovascular Diseases (1)
Cefazolin (2) · Amyloid (1) · Anti-Bacterial Agents (1) · Aspirin (1) · Base Sequence (1) · Bed Rest (1) · Cerclage, Cervical (1) · Clindamycin (1) · Exercise (1) · Indomethacin (1) · Laparoscopy (1) · Meditation (1) · Progesterone (1) · Sleep (1) · myotrophin (1)
University of Aarhus (3) · Chinese University of Hong Kong (1) · Etlik Zubeyde Hanım Women's Health Care, Training and Research Hospital (1) · Galena Innovations, LLC (1) · Henry Ford Health System (1) · Hina Mukhtar (1) · Hospices Civils de Lyon (1) · Intermountain Women and Children's Research (1) · Julie Glavind (1) · Kaplan Medical Center (1) · Luzerner Kantonsspital (1) · Maternal-Infantil Vall d´Hebron Hospital (1) · Northwestern University (1) · Tufts Medical Center (1) · University of North Carolina, Chapel Hill (1)
United States (7) · Denmark (2) · France (1) · Hong Kong (1) · Israel (1) · Pakistan (1) · Spain (1) · Switzerland (1) · Turkey (Türkiye) (1)
Ashley C Crafton (1) · Can Tekin Iskender, MD (1) · Hina Mukhtar, MBBS (1) · Julie Glavind, MD, PhD (1) · Julie Glavind, Senior Consultant, MD, PhD (1) · Lise Q Krogh, MD (1) · Maria Goya, PhD (1) · Michael House, MD (1) · Niels Uldbjerg, DMSc (1) · Rachel Harrison, MD (1) · Raminder Khangura, MD (1) · Stephanie T Romero, MD (1)
PMID 24807330, PMID 40987744, PMID 42549482
2023 (1), R01MD017947 (1)