14 completed, 9 recruiting, 2 active not recruiting, 1 available. 7 Phase 1, 7 Phase 2, 5 Not applicable, 3 Phase 3.
Follow Central Nervous System Tumor: new trials by email Literature Review of Central Nervous System Tumor trials Research Report on Central Nervous System Tumor
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Illuminate: A Clinical Study Evaluating CAR T Immune Cell Therapy (BCB-276) for Patients With Diffuse Intrinsic Pontine Glioma (DIPG). BCB-276 - Diffuse Intrinsic Pontine Glioma, DIPG | Phase 2 | Recruiting | BrainChild Bio, Inc | 75 | 2026-09-04 | 2026-10-28 |
| A Clinical Prediction Model for Surgical Site Infection After Central Nervous System Tumor Surgery ML-Based Enhanced Intervention Package for SSI Prevention, Standard Postoperative Care - Surgical Site Infection (SSI), Central Nervous System Tumor | Not applicable | Recruiting | Ming Yang | 500 | 2025-06-01 | 2026-01-30 |
| Somatic Mosaicism in Twins Discordant for Childhood Cancer Biospecimen collection, Questionnaire Administration - Pediatric Central Nervous System Tumor, Central Nervous System Tumor | Recruiting | Children's Oncology Group | 50 | 2024-06-03 | 2026-10-01 | |
| Effect and Safety of Ocoxin Oral Solution on the Quality of Life of Paediatric Patients With Advanced Stage Solid Tumours Ocoxin Oral solution - Advanced Cancer, Advanced Solid Tumor | Not applicable | Unknown | Catalysis SL | 40 | 2024-04-28 | 2024-04-12 |
| A Study of Avutometinib for People With Solid Tumor Cancers Avutometinib - Refractory Cancer, CNS Tumors | Phase 1 | Completed | Memorial Sloan Kettering Cancer Center | 3 | 2023-10-20 | 2026-11-04 |
| Brain Slice Explants to Predict Drug Response in Brain Tumors Biospecimen collection - Central Nervous System Tumor | Recruiting | UNC Lineberger Comprehensive Cancer Center | 50 | 2023-07-27 | 2026-09-04 | |
| Fluorescence Detection of Adult Primary Central Nervous System Tumors With Tozuleristide and the Canvas System tozuleristide, Canvas imaging system, Surgical resection of tumor - Central Nervous System Tumor | Phase 2 | Completed | John Yu | 50 | 2021-09-30 | 2026-07-10 |
| ONC206 for Treatment of Newly Diagnosed, Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant CNS Tumors ONC206, Standard of Care Radiation Therapy, Optional Proton (1H) MR spectroscopy (MRS) - Diffuse Midline Glioma (DMG), Glioblastoma | Phase 1 | Recruiting | Sabine Mueller, MD, PhD | 208 | 2021-08-23 | 2026-06-11 |
| Tissue Collection for Drug Screening and Bioanalysis Central Nervous System Tumor | Recruiting | Weill Medical College of Cornell University | 500 | 2020-07-22 | 2025-12-17 | |
| Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors SCRI-CARB7H3(s); B7H3-specific chimeric antigen receptor (CAR) T cel - Central Nervous System Tumor, Diffuse Intrinsic Pontine Glioma | Phase 1 | Recruiting | Seattle Children's Hospital | 90 | 2019-12-11 | 2026-04-13 |
| Mapping Draining Lymph Nodes in CNS Malignancies Tc-99m tilmanocept - Central Nervous System Neoplasms, Central Nervous System Tumor | Phase 1 | Terminated | Washington University School of Medicine | 14 | 2019-12-03 | 2023-12-21 |
| Biological Characterisation of High Risk CHildhood Cancer in Children, Adolescents and Young Adults (MICCHADO) Sampling on blood, bone marrow and cerebrospinal fluid - Neuroblastoma, Rhabdomyosarcoma | Not applicable | Active not recruiting | Institut Curie | 600 | 2018-04-20 | 2025-03-18 |
| SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry Clinical Trial Matching - Cancer, Metastatic, Cancer | Recruiting | Massive Bio, Inc. | 50000 | 2018-01-01 | 2025-10-28 | |
| Safety and Dose Finding Study of Neratinib in Children and Young Adults With Cancer That Has Returned or Not Responded to Treatment Neratinib - Solid Tumor, Central Nervous System Tumor | Phase 1 / Phase 2 | Active not recruiting | Memorial Sloan Kettering Cancer Center | 14 | 2016-10-01 | 2026-11-04 |
| Medical Marijuana in the Pediatric Central Nervous System Tumor Population Central Nervous System Tumor, Brain Tumor | Completed | University of Colorado, Denver | 19 | 2016-01-15 | 2024-08-29 | |
| Medical and Surgical Management of Patients With Brain Metastases Biological collection - Central Nervous System Tumor | Not applicable | Completed | Institut du Cancer de Montpellier - Val d'Aurelle | 105 | 2015-03-02 | 2020-10-19 |
| Dendritic Cell-based Immunotherapy for Advanced Solid Tumours of Children and Young Adults dendritic cells, Surgery as needed by the patient´s tumor and stage, Chemotherapy as needed by the patient´s tumor and stage - Sarcoma, Central Nervous System Tumor | Phase 1 / Phase 2 | Completed | Clinica Universidad de Navarra, Universidad de Navarra | 6 | 2014-09-30 | 2020-02-21 |
| Integrated Cancer Repository for Cancer Research Pancreatic Cancer, Thyroid Cancer | Recruiting | University of Nebraska | 999999 | 2013-11-01 | 2026-06-29 | |
| Longitudinal Study of Biomarkers Central Nervous System Tumor | Completed | Ann & Robert H Lurie Children's Hospital of Chicago | 100 | 2011-12-01 | 2025-02-19 | |
| Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy sodium thiosulfate, examination - Brain Tumor, Central Nervous System Tumor | Phase 3 | Completed | Children's Oncology Group | 131 | 2008-06-23 | 2023-11-09 |
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Central Nervous System Neoplasms (28) · Brain Neoplasms (13) · Neoplasms (6) · Astrocytoma (4) · Leukemia (4) · Medulloblastoma (4) · Sarcoma (4) · Ependymoma (3) · Glioblastoma (3) · Liver Neoplasms (3) · Neoplasms, Germ Cell and Embryonal (3) · Neuroblastoma (3) · Ovarian Neoplasms (3) · Spinal Cord Neoplasms (3) · Testicular Neoplasms (3)
Neoplasms by Site (28) · Nervous System Diseases (28) · Nervous System Neoplasms (28) · Neoplasms (22) · Neoplasms by Histologic Type (17) · Neoplasms, Glandular and Epithelial (14) · Neoplasms, Nerve Tissue (14) · Neuroectodermal Tumors (14) · Brain Diseases (13) · Central Nervous System Diseases (13) · Neoplasms, Neuroepithelial (13) · Neoplasms, Germ Cell and Embryonal (12) · Glioma (9) · Hemic and Lymphatic Diseases (5) · Neoplasms, Connective and Soft Tissue (5)
Radiotherapy (5) · Carboplatin (4) · Cyclophosphamide (3) · Etoposide (3) · Filgrastim (3) · Granulocyte Colony-Stimulating Factor (3) · Peripheral Blood Stem Cell Transplantation (2) · Radiation (2) · Temozolomide (2) · Vincristine (2) · etoposide phosphate (2) · Automobiles (1) · Cisplatin (1) · Colony-Stimulating Factors (1) · Drug Therapy (1)
Children's Oncology Group (9) · Memorial Sloan Kettering Cancer Center (2) · Ann & Robert H Lurie Children's Hospital of Chicago (1) · BrainChild Bio, Inc (1) · Catalysis SL (1) · Clinica Universidad de Navarra, Universidad de Navarra (1) · Institut Curie (1) · Institut du Cancer de Montpellier - Val d'Aurelle (1) · John Yu (1) · Massive Bio, Inc. (1) · Ming Yang (1) · Sabine Mueller, MD, PhD (1) · Seattle Children's Hospital (1) · St. Jude Children's Research Hospital (1) · UNC Lineberger Comprehensive Cancer Center (1)
United States (23) · Canada (8) · Australia (7) · Puerto Rico (5) · Switzerland (5) · Netherlands (4) · New Zealand (3) · France (2) · China (1) · Honduras (1) · Spain (1)
Andrew B Satterlee, PhD (1) · Barry L. Shulkin, MD, MBA (1) · Cori Abikoff, MD (1) · David R. Freyer, DO, MS (1) · Donald H. Mahoney, MD (1) · Edward G. Shaw, MD (1) · Jeffrey C. Allen, MD (1) · Jeffrey Greenfield, M.D. (1) · Jenny Poynter, PhD (1) · Joel M. Cherlow, MD (1) · John Yu, MD (1) · Kurt Fisher, MD, PhD (1) · Luc Bauchet, MD (1)
PMID 18497327, PMID 18623206, PMID 20381270, PMID 25854526, PMID 27914822, PMID 35157764, PMID 35468680, PMID 39775044, PMID 41256696, PMID 41798119, PMID 42788739
R01CA266596 (1), U10CA098543 (1)