27 completed, 3 recruiting, 3 terminated, 2 not yet recruiting. 20 Not applicable, 12 Phase 1, 4 Phase 4, 2 Phase 3, 1 Early Phase 1.
Follow Vitamin K: new trials by email Literature Review of Vitamin K trials Research Report on Vitamin K
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| An Early-Stage Study in Multiple Clinics of How Afimkibart May Affect the Body's Processing of Medicines That Rely on Cytochrome P450 Enzymes in Participants With Ulcerative Colitis Afimkibart, Caffeine, Warfarin - Active Ulcerative Colitis | Phase 1 | Recruiting | Hoffmann-La Roche | 25 | 2026-06-29 | 2026-10-16 |
| Vitamin K for Perioperative Warfarin Management Vitamin K, Warfarin (standard without loading), Warfarin (standard with loading) - Anticoagulant Therapy | Phase 4 | Recruiting | University of Michigan | 20 | 2025-07-03 | 2026-04-13 |
| Bioavailability of Different Vitamin K Vitamers Studied Using 13C-labelled Vitamin K Vitamers Vitamin K - Bioavailability of Vitamin K | Not applicable | Not yet recruiting | University of Copenhagen | 20 | 2025-07-01 | 2025-06-27 |
| Vitamin K and Cognition in Coronary Heart Disease (NutriCog) Vitamin K, Placebo - Coronary Heart Disease | Not applicable | Not yet recruiting | Montreal Heart Institute | 40 | 2025-03-17 | 2025-03-04 |
| Tranxemic Acid and Vitamin K Injection to Control Upper Gastrointestinal Bleeding in Cirrhotic Patients Tranexamic Acid and vitamin K, Placebo - Upper Gastrointestinal Bleeding (UGIB), Variceal Bleeding | Phase 4 | Recruiting | Tanta University | 194 | 2024-12-02 | 2025-03-18 |
| Effects of Vitamin K on Lower-extremity Function in Adults With Osteoarthritis: Vitamin K, Placebo - Osteo Arthritis Knee | Not applicable | Active not recruiting | Tufts University | 37 | 2023-09-20 | 2025-09-17 |
| Study to Investigate the Effect of Rocatinlimab (AMG 451) on the Pharmacokinetics of Multiple Cytochrome P450 (CYP450) Substrates in Participants With Moderate to Severe Atopic Dermatitis Caffeine, Metoprolol, Midazolam - Atopic Dermatitis | Early Phase 1 | Completed | Amgen | 21 | 2023-06-03 | 2025-12-23 |
| Prevention of Cefoperazone-induced Coagulopathy Vitamin K - Antibiotic Side Effect | Phase 4 | Completed | Helwan University | 56 | 2023-02-25 | 2023-10-10 |
| Maternal and Neonatal Benefits of Prophylactic Administration of Vitamin K Before Elective Cesarean Section vitamin k - Vitamin K | Not applicable | Completed | National Research Centre, Egypt | 200 | 2021-07-30 | 2022-02-15 |
| A Drug-drug Interaction Study Of Fluzoparib (SHR3162) on Patients With Recurrent Ovarian Cancer fluzoparib - Recurrent Ovarian Cancer | Phase 1 | Completed | Jiangsu HengRui Medicine Co., Ltd. | 33 | 2021-06-25 | 2023-08-14 |
| Effect of Vitamin K Supplementation on Circulating Levels of Osteocalcin on the Bone Metabolism and Aging Vitamin K (MK7), Teriparatide - Bone Metabolism Disorder, Aging Disorder | Not applicable | Terminated | University of Milano Bicocca | 99 | 2020-11-24 | 2025-07-29 |
| The Clinical Effect of Vitamin K Administration in Type 2 Diabetic Patients Vitamin K, Placebo - Diabetes Mellitus, Type 2 | Not applicable | Completed | Cairo University | 106 | 2019-10-27 | 2023-01-25 |
| Comparison of Vitamin K Doses in Patients With Larger Burn Injuries Vitamin K - Burns | Phase 4 | Unknown | Joseph M. Still Research Foundation, Inc. | 50 | 2019-05-10 | 2021-08-25 |
| Underlying Causes of Low Vitamin K Status in Hemodialysis Patients Menakinon 7, Diet rich in vitamin K - Renal Insufficiency, Chronic | Not applicable | Completed | University of Copenhagen | 33 | 2018-02-22 | 2019-04-18 |
| A Study to Evaluate the Effect of Ustekinumab on Cytochrome P450 Enzyme Activities Following Induction and Maintenance Dosing in Participants With Active Crohn's Disease or Ulcerative Colitis Ustekinumab IV Infusion, Ustekinumab SC Injection, Midazolam 2 mg - Crohn Disease, Ulcerative Colitis | Phase 1 | Terminated | Janssen Research & Development, LLC | 28 | 2018-02-02 | 2025-08-21 |
| A Study to Evaluate the Effect of Multiple Doses of CC-90001 on the Pharmacokinetics of Omeprazole, Midazolam, Warfarin, Rosuvastatin, Metformin, Digoxin, and Nintedanib in Healthy Adult Subjects CC-90001, Omeprazole, Midazolam - Heathy Volunteer | Phase 1 | Completed | Celgene | 56 | 2017-12-04 | 2019-01-25 |
| Effects of Fhytomenadione on Coronary Artery Calcification of Hemodialysis Patients phytomenadione, placebo solution - Coronary Calcification | Not applicable | Completed | Instituto Mexicano del Seguro Social | 60 | 2017-09-07 | 2020-01-29 |
| Vitamin K Supplementation Study in Healthy Volunteers (Aim 2B) Phase I, Buccal Swab Collection for DNA Isolation, Phase II, Vitamin K (Vitacost) Supplementation - Vitamin K Status | Not applicable | Terminated | University of Washington | 106 | 2017-08-25 | 2023-12-19 |
| Pharmacokinetic Drug-Drug Interaction Study of Rucaparib Caffeine, Warfarin, Omeprazole - Neoplasms | Phase 1 | Completed | pharmaand GmbH | 17 | 2016-04-01 | 2023-06-09 |
| Management of Decompensated HCV Cirrhotic Patients Sofosbuvir 400mg (Sovaldi) + Daclatasvir 60 mg (Daklinza) + Ribavirin 200 mg (Rebetol), vitamin K (Phytomenadione) 10 mg+ furosemide and spironolactone (Lasilactone) 50 mg + milk thistle (Silymarin) 140 mg + Albumin infusion - Decompensated Cirrhosis | Not applicable | Completed | Zagazig University | 80 | 2015-06-01 | 2018-12-05 |
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Osteoporosis (4) · Neoplasms (2) · Renal Insufficiency, Chronic (2) · Thrombosis (2) · Alzheimer Disease (1) · Arthritis, Rheumatoid (1) · Bone Diseases, Metabolic (1) · Burns (1) · Calciphylaxis (1) · Cardiovascular Diseases (1) · Colitis, Ulcerative (1) · Contusions (1) · Coronary Disease (1) · Crohn Disease (1) · Dermatitis, Atopic (1)
Janssen Research & Development, LLC (3) · Boehringer Ingelheim (2) · Tufts University (2) · University of Copenhagen (2) · University of North Carolina, Chapel Hill (2) · Amgen (1) · Bayer (1) · Biogen (1) · Bristol-Myers Squibb (1) · Cairo University (1) · Celgene (1) · Daiichi Sankyo (1) · HaEmek Medical Center, Israel (1) · Helwan University (1) · Hoffmann-La Roche (1)
United States (19) · Egypt (4) · Germany (4) · Belgium (3) · Poland (3) · Denmark (2) · United Kingdom (2) · Canada (1) · China (1) · Czechia (1) · Hungary (1) · Israel (1) · Italy (1) · Mexico (1) · Moldova (1)
Amr S Hanafy, md (1) · Francisco Ramirez-Valle, MD, PhD. (1) · Geoffrey Barnes, MD (1) · Gertruud C Bakker, PhD (1) · Guylaine Ferland, PhD (1) · Hamim Zahir, BPharm, PhD (1) · Hilda E Macias Cervantes, Doctor (1) · Jens Rikardt Andersen (1) · Jing Wang, Ph.D. (1) · Kenneth E Thummel, PhD (1) · Liv Forli, Dr (1)
PMID 15514282, PMID 16973975, PMID 18625626, PMID 18689371, PMID 18697901, PMID 19114462, PMID 19386744, PMID 19776145, PMID 20237066, PMID 20719580, PMID 21628633, PMID 22437558, PMID 22955514, PMID 23719555, PMID 24528331, PMID 25475601, PMID 25739929, PMID 26176325, PMID 27411694, PMID 30427584, PMID 30590596, PMID 30758786, PMID 31529295, PMID 37552330, PMID 39186385, PMID 41472909
2008 (1), 2017 (1), 2025 (1), K24HL179410 (1), P01GM116691 (1), R01AG019147 (1), R01HL069272 (1)