23 completed. 23 Phase 2, 8 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 23 | Completed 23 |
| Phase 1 | 8 | Completed 8 |
Follow Brain Tumor: new trials by email Literature Review of Brain Tumor trials Research Report on Brain Tumor
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Phase 2 Ascending Dose Safety and Efficacy Study of RVP-001, a Manganese-based MRI Contrast Agent RVP-001 - Central Nervous System (CNS) Lesions, Brain Metastases | Phase 2 | Completed | Reveal Pharmaceuticals Inc. | 18 | 2024-08-15 | 2025-12-26 |
| LUMINOS-101: Lerapolturev (PVSRIPO) and Pembrolizumab in Patients With Recurrent Glioblastoma lerapolturev, pembrolizumab - Glioblastoma, Recurrent Glioblastoma | Phase 2 | Completed | Istari Oncology, Inc. | 25 | 2020-10-21 | 2025-06-05 |
| Study of Tesevatinib Monotherapy in Patients With Recurrent Glioblastoma Tesevatinib - Glioblastoma, Recurrent Glioblastoma | Phase 2 | Completed | Kadmon Corporation, LLC | 40 | 2016-06-01 | 2021-09-22 |
| Treatment of Relapsed and/or Chemotherapy Refractory Advanced Malignancies by CART133 anti-CD133-CAR vector-transduced T cells - Liver Cancer, Pancreatic Cancer | Phase 1 / Phase 2 | Completed | Chinese PLA General Hospital | 20 | 2015-06-01 | 2019-12-17 |
| Trial Evaluating an Enhanced Physical Activity Intervention to Improve Cognitive Late Effects in Children Treated With Cranial Radiation for Brain Tumors Physical Activity - Brain Tumor | Phase 2 | Completed | National Cancer Institute (NCI) | 36 | 2014-08-21 | 2026-10-26 |
| Safety of BBB Opening With the SonoCloud SonoCloud, Carboplatin - Glioblastoma, Glioma | Phase 1 / Phase 2 | Completed | Assistance Publique - Hôpitaux de Paris | 27 | 2014-07-01 | 2018-10-12 |
| Repeated Super-Selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Newly Diagnosed GBM Bevacizumab - Glioblastoma Multiforme, Brain Tumor | Phase 1 / Phase 2 | Completed | Northwell Health | 31 | 2013-02-01 | 2024-01-30 |
| Phase I-II Everolimus and Sorafenib in Recurrent High-Grade Gliomas everolimus, sorafenib - Brain Tumor, Glioblastoma | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 86 | 2012-10-02 | 2022-06-01 |
| Proton Radiotherapy for Pediatric Brain Tumors Requiring Partial Brain Irradiation Proton radiotherapy - Brain Tumor, Low Grade Glioma | Phase 2 | Completed | Massachusetts General Hospital | 100 | 2011-02-01 | 2025-06-03 |
| Safety Study of Replication-competent Adenovirus (Delta-24-rgd) in Patients With Recurrent Glioblastoma delta-24-RGD adenovirus - Brain Tumor, Recurring Glioblastoma | Phase 1 / Phase 2 | Completed | Erasmus Medical Center | 20 | 2010-06-01 | 2015-03-09 |
| Suberoylanilide Hydroxamic Acid (SAHA), Bevacizumab, Daily Temozolomide for Recurrent Malignant Gliomas Vorinostst/Bevacizumab/Temozolomide - Brain Tumor, Glioblastoma | Phase 1 / Phase 2 | Completed | Katy Peters | 48 | 2009-10-01 | 2013-06-24 |
| Safe Study of Dendritic Cell (DC) Based Therapy Targeting Tumor Stem Cells in Glioblastoma Dendritic cell vaccine with mRNA from tumor stem cells - Glioblastoma, Brain Tumor | Phase 1 / Phase 2 | Completed | Oslo University Hospital | 20 | 2009-01-01 | 2015-10-20 |
| PPX, Temozolomide, and Concurrent Radiation for Newly Diagnosed Brain Tumors PPX +TMZ+XRT - Brain Tumor | Phase 2 | Completed | howard safran | 25 | 2008-10-01 | 2020-02-17 |
| Avastin in Combination With Radiation (XRT) & Temozolomide, Followed by Avastin, Temozolomide and Irinotecan for Glioblastoma (GBM) and Gliosarcomas Avastin, Temozolomide, Radiation Therapy (XRT) - Glioblastoma, Gliosarcoma | Phase 2 | Completed | Duke University | 125 | 2007-07-01 | 2014-05-07 |
| Radiation Therapy in Treating Young Patients With Gliomas radiation therapy - Brain Tumor, Central Nervous System Tumor | Phase 2 | Completed | Children's Oncology Group | 92 | 2006-11-01 | 2019-08-07 |
| Temozolomide in Treating Patients With Newly Diagnosed Anaplastic Oligodendroglioma or Mixed Oligoastrocytoma temozolomide - Central Nervous System Tumors, Brain Tumor | Phase 2 | Completed | The Cleveland Clinic | 29 | 2005-08-01 | 2018-09-18 |
| GW572016 to Treat Recurrent Malignant Brain Tumors lapatinib ditosylate, Adjuvant therapy, Conventional surgery - Glioma, Brain Tumor | Phase 2 | Completed | National Cancer Institute (NCI) | 9 | 2005-03-30 | 2018-07-05 |
| Carboplatin and Temozolomide (Temodar) for Recurrent and Symptomatic Residual Brain Metastases carboplatin, temozolomide - Brain Tumor, Brain Metastases | Phase 1 / Phase 2 | Completed | Ohio State University Comprehensive Cancer Center | 17 | 2004-10-01 | 2017-06-01 |
| Neoadjuvant Chemotherapy With or Without Second-Look Surgery Followed by Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Intracranial Germ Cell Tumors carboplatin, etoposide, ifosfamide - Brain Tumor, Central Nervous System Tumors | Phase 2 | Completed | Children's Oncology Group | 104 | 2004-01-01 | 2018-02-14 |
| Observation or Radiation Therapy and/or Chemotherapy and Second Surgery in Treating Children Who Have Undergone Surgery for Ependymoma filgrastim, carboplatin, cyclophosphamide - Brain Tumor, Central Nervous System Tumor | Phase 2 | Completed | Children's Oncology Group | 378 | 2003-08-01 | 2019-08-07 |
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Brain Neoplasms (23) · Glioblastoma (11) · Central Nervous System Neoplasms (7) · Glioma (5) · Astrocytoma (3) · Oligodendroglioma (3) · Gliosarcoma (2) · Medulloblastoma (2) · Neoplasms (2) · Optic Nerve Glioma (2) · Recurrence (2) · Blast Crisis (1) · Breast Neoplasms (1) · Burkitt Lymphoma (1) · Cachexia (1)
Brain Diseases (23) · Central Nervous System Diseases (23) · Neoplasms by Site (23) · Nervous System Diseases (23) · Nervous System Neoplasms (23) · Neoplasms (21) · Neoplasms by Histologic Type (19) · Neoplasms, Germ Cell and Embryonal (18) · Neoplasms, Glandular and Epithelial (17) · Neoplasms, Nerve Tissue (17) · Neoplasms, Neuroepithelial (17) · Neuroectodermal Tumors (17) · Central Nervous System Neoplasms (16) · Glioma (12) · Astrocytoma (11)
Carboplatin (4) · Radiotherapy (4) · Temozolomide (4) · Bevacizumab (3) · Chemotherapy, Adjuvant (2) · Cyclophosphamide (2) · Etoposide (2) · Neoadjuvant Therapy (2) · Peripheral Blood Stem Cell Transplantation (2) · Colony-Stimulating Factors (1) · Craniospinal Irradiation (1) · Cyproheptadine (1) · Everolimus (1) · Exercise (1) · Filgrastim (1)
Children's Oncology Group (4) · National Cancer Institute (NCI) (4) · Assistance Publique - Hôpitaux de Paris (1) · Chinese PLA General Hospital (1) · Duke University (1) · Erasmus Medical Center (1) · Istari Oncology, Inc. (1) · Kadmon Corporation, LLC (1) · Katy Peters (1) · Massachusetts General Hospital (1) · Northwell Health (1) · Ohio State University Comprehensive Cancer Center (1) · Oslo University Hospital (1) · Reveal Pharmaceuticals Inc. (1) · The Cleveland Clinic (1)
United States (19) · Canada (5) · Australia (4) · Switzerland (4) · Netherlands (3) · New Zealand (3) · Puerto Rico (3) · China (1) · France (1)
Ahmed Idbaih, MD, PhD (1) · Annick Desjardins, MD, FRCPC (1) · Carl Langberg, MD, PhD (1) · Clemens Dirven, MD PhD (1) · David M. Peereboom, MD (1) · Donald H. Mahoney, MD (1) · Edward G. Shaw, MD (1) · Einar O Vik-Mo, MD (1) · Gunnar Kvalheim, MD, PhD (1) · Gustav Gaudernack, PhD (1) · Herbert Newton, MD (1) · Howard Safran, MD (1) · Iver A Langmoen, MD, PhD (1) · Jennifer L. Mayer, MD (1) · Joel M. Cherlow, MD (1)
PMID 18623206, PMID 18989154, PMID 20381270, PMID 23817721, PMID 26645405, PMID 28057014, PMID 30118397, PMID 30717050, PMID 31545689, PMID 33312759
2014 (1), P30CA043703 (1), R44CA261240 (1), U10CA081920 (1)