301 completed, 46 unknown, 41 terminated, 21 withdrawn. 205 Phase 2, 179 Phase 1, 33 Phase 3, 24 Not applicable, 4 Early Phase 1.
Follow Brain and Central Nervous System Tumors: new trials by email Literature Review of Brain and Central Nervous System Tumors trials Research Report on Brain and Central Nervous System Tumors
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Novel Indenoisoquinolone CMYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent Glioblastoma LMP744, Conventional Surgery or Biopsy - Recurrent Glioblastoma, Glioblastoma IDH (Isocitrate Dehydrogenase) Wildtype | Phase 1 / Phase 2 | Recruiting | National Institute of Neurological Disorders and Stroke (NINDS) | 40 | 2026-07-15 | 2026-10-16 |
| Study of MT027 in Patients with Brain, Meninges, and Spinal Cord Metastatic Solid Tumors MT027 cells suspension - Brain (Nervous System) Cancers, Brain and Central Nervous System Tumors | Phase 1 | Not yet recruiting | Suzhou Maximum Bio-tech Co., Ltd. | 12 | 2025-01-01 | 2024-12-19 |
| AXL Inhibitor BGB324 in Treating Participants With Recurrent Glioblastoma Undergoing Surgery BGB 324 (before surgery), BGB 324 (after surgery) - Brain and Central Nervous System Tumors | Early Phase 1 | Terminated | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 10 | 2020-01-02 | 2024-02-08 |
| Study of GDC-0084 in Pediatric Patients With Newly Diagnosed Diffuse Intrinsic Pontine Glioma or Diffuse Midline Gliomas GDC-0084, radiation therapy - Brain and Central Nervous System Tumors | Phase 1 | Completed | St. Jude Children's Research Hospital | 27 | 2018-11-19 | 2023-01-18 |
| A Study Assessing Pamiparib With Radiation and/or Temozolomide (TMZ) in Participants With Newly Diagnosed or Recurrent Glioblastoma Pamiparib, TMZ, Radiation - Brain and Central Nervous System Tumors | Phase 1 / Phase 2 | Completed | BeiGene USA, Inc. | 116 | 2017-07-24 | 2025-02-04 |
| BBBD Followed By Methotrexate and Carboplatin With or Without Trastuzumab in Treating Women With Breast Cancer That Has Spread to the Brain trastuzumab, carboplatin, methotrexate - Brain and Central Nervous System Tumors, Breast Cancer | Phase 1 / Phase 2 | Withdrawn | OHSU Knight Cancer Institute | 2013-10-01 | 2017-04-21 | |
| Mibefradil Dihydrochloride and Temozolomide in Treating Patients With Recurrent Glioma temozolomide, 3'-deoxy-3'-[18F]fluorothymidine, pharmacological study - Brain and Central Nervous System Tumors | Phase 1 | Completed | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 28 | 2012-05-31 | 2019-05-22 |
| Studying Gene Expression and Location in Samples From Patients With Brain Tumors gene expression analysis, genetic linkage analysis, microarray analysis - Brain and Central Nervous System Tumors | Completed | Children's Oncology Group | 10 | 2012-04-01 | 2016-05-18 | |
| Studying Gene Expression in Samples From Patients With Rhabdoid Tumors DNA analysis, gene expression analysis, mutation analysis - Brain and Central Nervous System Tumors, Kidney Cancer | Completed | Children's Oncology Group | 25 | 2012-03-01 | 2016-07-14 | |
| Bortezomib, Temozolomide, and Regional Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme or Gliosarcoma bortezomib + temozolomide+ radiation therapy - Brain and Central Nervous System Tumors | Phase 2 | Completed | Jonsson Comprehensive Cancer Center | 24 | 2011-10-03 | 2020-08-28 |
| Modafinil in Treating Children With Memory and Attention Problems Caused by Cancer Treatment for a Brain Tumor modafinil, placebo - Brain and Central Nervous System Tumors, Cognitive/Functional Effects | Phase 2 | Completed | University of South Florida | 112 | 2011-08-01 | 2021-08-13 |
| Olaparib and Temozolomide in Treating Patients With Relapsed Glioblastoma olaparib, temozolomide, gene expression analysis - Brain and Central Nervous System Tumors | Phase 1 | Completed | Cancer Research UK | 34 | 2011-07-01 | 2018-02-05 |
| Imetelstat Sodium in Treating Young Patients With Refractory or Recurrent Solid Tumors or Lymphoma imetelstat sodium, laboratory biomarker analysis, pharmacological study - Brain and Central Nervous System Tumors, Lymphoma | Phase 1 | Completed | Children's Oncology Group | 34 | 2011-05-01 | 2014-01-30 |
| Gene Mutation in Samples From Young Patients With Pleuropulmonary Blastoma Syndrome at Risk for Developing Cancer DNA analysis, cytogenetic analysis, gene expression analysis - Brain and Central Nervous System Tumors, Hereditary Wilms Tumor | Completed | Children's Oncology Group | 31 | 2011-05-01 | 2016-07-11 | |
| Everolimus, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme concurrent RAD001 10 mg/day, concurrent temozolomide, Radiation therapy - Brain and Central Nervous System Tumors | Phase 1 / Phase 2 | Completed | Radiation Therapy Oncology Group | 279 | 2010-12-01 | 2022-06-09 |
| PTC299 in Treating Young Patients With Refractory or Recurrent Primary Central Nervous System Tumors VEGF inhibitor PTC299 - Brain and Central Nervous System Tumors | Phase 1 | Completed | Pediatric Brain Tumor Consortium | 28 | 2010-11-01 | 2015-05-04 |
| High-Dose Chemotherapy and Stem Cell Transplant in Treating Patients With Metastatic Germ Cell Tumors That Have Not Responded to First-Line Therapy filgrastim, pegfilgrastim, carboplatin - Brain and Central Nervous System Tumors, Extragonadal Germ Cell Tumor | Phase 2 | Unknown | Fondazione IRCCS Istituto Nazionale dei Tumori, Milano | 47 | 2010-10-01 | 2013-08-12 |
| Veliparib and Temozolomide in Treating Patients With Recurrent Glioblastoma temozolomide 60 mg x 21 days, temozolomide 75 mg x 21 days, ABT-888 20 mg x 21 days - Brain and Central Nervous System Tumors | Phase 1 / Phase 2 | Completed | Radiation Therapy Oncology Group | 257 | 2010-07-01 | 2017-07-02 |
| Vaccine Therapy, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme glioblastoma multiforme multipeptide vaccine IMA950, sargramostim, temozolomide - Brain and Central Nervous System Tumors | Phase 1 | Completed | Cancer Research UK | 45 | 2010-07-01 | 2015-10-14 |
| Biomarkers in Blood Samples From Young Patients With Newly Diagnosed Brain Tumors Undergoing Standard Radiation Therapy and Chemotherapy systemic chemotherapy, laboratory biomarker analysis, therapeutic surgical procedure - Brain and Central Nervous System Tumors | Not applicable | Withdrawn | Pediatric Brain Tumor Consortium | 2010-05-01 | 2019-04-01 |
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Central Nervous System Neoplasms (418) · Glioblastoma (219) · Astrocytoma (212) · Gliosarcoma (211) · Brain Neoplasms (184) · Oligodendroglioma (159) · Glioma (108) · Medulloblastoma (72) · Familial ependymoma (53) · Ependymoma (52) · Choroid Plexus Neoplasms (45) · Lymphoma (41) · Optic Nerve Glioma (40) · Sarcoma (32) · Meningioma (31)
Nervous System Neoplasms (418) · Neoplasms by Site (417) · Nervous System Diseases (417) · Neoplasms (411) · Neoplasms by Histologic Type (366) · Neoplasms, Germ Cell and Embryonal (335) · Neoplasms, Nerve Tissue (334) · Neoplasms, Glandular and Epithelial (328) · Neuroectodermal Tumors (326) · Neoplasms, Neuroepithelial (323) · Central Nervous System Diseases (225) · Brain Diseases (220) · Glioma (211) · Astrocytoma (86) · Neuroectodermal Tumors, Primitive (61)
Radiotherapy (103) · Temozolomide (84) · Carboplatin (39) · Chemotherapy, Adjuvant (35) · Filgrastim (34) · Carmustine (32) · Vincristine (30) · Cisplatin (27) · Etoposide (24) · Cyclophosphamide (23) · Peripheral Blood Stem Cell Transplantation (21) · Irinotecan (18) · Methotrexate (18) · Lomustine (16) · Thiotepa (16)
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (36) · Duke University (30) · National Cancer Institute (NCI) (24) · European Organisation for Research and Treatment of Cancer - EORTC (22) · Children's Cancer and Leukaemia Group (18) · Jonsson Comprehensive Cancer Center (16) · Memorial Sloan Kettering Cancer Center (16) · Radiation Therapy Oncology Group (16) · Pediatric Brain Tumor Consortium (15) · Children's Oncology Group (14) · Alliance for Clinical Trials in Oncology (12) · Northwestern University (11) · City of Hope Medical Center (9) · New Approaches to Brain Tumor Therapy Consortium (9) · St. Jude Children's Research Hospital (8)
United States (320) · Canada (44) · United Kingdom (41) · Netherlands (24) · Switzerland (24) · France (21) · Italy (18) · Germany (17) · Australia (16) · Ireland (14) · Belgium (13) · Austria (9) · Spain (8) · New Zealand (6) · Portugal (6)
Henry S. Friedman, MD (19) · Stuart A. Grossman, MD (12) · Jeffrey J. Raizer, MD (9) · Darell D. Bigner, MD, PhD (7) · Jonathan L. Finlay, MB, ChB (7) · Amar Gajjar, MD (6) · Howard A. Fine, MD (5) · Jan C. Buckner, MD (5) · Jana Portnow, MD (5) · Larry Kleinberg, MD (5) · Michael Prados, MD (5) · Timothy F. Cloughesy, MD (5) · David A. Walker (4) · Edward A. Neuwelt, MD (4)
PMID 23377664, PMID 33502920, PMID 35731991, PMID 10394416, PMID 10549493, PMID 11410496, PMID 11586105, PMID 11772431, PMID 11835236, PMID 12525516, PMID 12573762, PMID 12649108, PMID 12697884, PMID 12721262, PMID 12749710, PMID 12829671, PMID 14586216, PMID 14670747, PMID 14769135, PMID 14769136, PMID 14769138, PMID 14769140, PMID 15001263, PMID 15073861, PMID 15177491, PMID 15234047, PMID 15251162, PMID 15292713, PMID 15328187, PMID 15465203, PMID 15514370, PMID 15565574, PMID 15659504, PMID 15667956, PMID 15667958, PMID 15758009, PMID 15758010, PMID 15890570, PMID 16012795, PMID 16034522, PMID 16053699, PMID 16061868, PMID 16133802, PMID 16148284, PMID 16170172, PMID 16192602, PMID 16200343, PMID 16203762, PMID 16234526, PMID 16258095
U01CA062475 (11), P30CA006973 (10), P30CA033572 (9), U01CA081457 (6), P30CA006516 (4), P30CA043703 (4), P30CA008748 (3), P30CA016672 (3), P30CA022453 (3), P30CA015083 (2), P30CA016087 (2), P30CA072720 (2), U01CA062399 (2), U10CA025224 (2), 2004 (1)