16 completed, 14 recruiting, 13 unknown, 7 not yet recruiting. 9 Phase 2, 6 Phase 1, 3 Not applicable, 2 Early Phase 1, 1 Phase 3.
Follow Autoimmune Encephalitis: new trials by email Literature Review of Autoimmune Encephalitis trials Research Report on Autoimmune Encephalitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Basket Study of CTA313 in Participants With Active Autoimmune Diseases CTA313 UCAR T Cell Infusion - Systemic Lupus Erthematosus (SLE), Progressive Multiple Sclerosis (PMS) | Phase 1 | Not yet recruiting | Imviva Bio | 81 | 2026-12-01 | 2026-08-24 |
| A Safety and Efficacy Study Evaluating CTX112 in Subjects With Refractory Neurologic Autoimmune Disease CTX112 - Progressive Multiple Sclerosis (PMS), Neuromyelitis Optica | Phase 1 / Phase 2 | Not yet recruiting | CRISPR Therapeutics | 220 | 2026-11-01 | 2026-10-22 |
| Clinical Evaluation of a Novel DAB Chromogenic Tissue-Based Assay for Detecting Anti-GABABR Antibodies Autoimmune Encephalitis, Anti-NMDAR Encephalitis | Not yet recruiting | Third Affiliated Hospital, Sun Yat-Sen University | 300 | 2026-10-01 | 2026-10-05 | |
| A Study in Participants With Anti-NMDAR Encephalitis and Anti-NMDAR Autoantibody-Associated Psychiatric Disease ART5803, ART5803-Cohort D - Anti-N-methyl-D-aspartate Receptor (NMDAR) Encephalitis (ANRE), Anti-N-methyl-D-aspartate Receptor (NMDAR) Antibody-associated Psychiatric Disease | Phase 2 | Recruiting | Arialys Australia Pty Ltd | 30 | 2026-05-15 | 2026-05-12 |
| Tongji NADs Cohort No active interventions - Multiple Sclerosis, NMO Spectrum Disorder | Not yet recruiting | Tongji Hospital | 1550 | 2026-03-01 | 2026-01-21 | |
| A Study of C-CAR168 in the Treatment of Central Nervous System Autoimmune Diseases Refractory to Standard Therapy CD20/BCMA-directed CAR-T cells - Multiple Sclerosis (MS), Neuromyelitis Optica Spectrum Disorders (NMOSD) | Phase 1 | Not yet recruiting | Huashan Hospital | 15 | 2026-02-01 | 2026-01-15 |
| hUC-MSC-Exo Therapy for Autoimmune Encephalitis Human umbilical cord mesenchymal stem cell derived exosomes, Placebo Control - Autoimmune Encephalitis | Phase 1 / Phase 2 | Not yet recruiting | Xuanwu Hospital, Beijing | 38 | 2025-11-01 | 2025-08-20 |
| Study of Pathogenic Mechanisms and Identification of Novel Autoantibodies in Autoimmune Encephalitis Autoimmune Encephalitis | Recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 20 | 2025-07-31 | 2026-03-17 | |
| Universal Chimeric Antigen Receptor T-Cell （UCAR T-cell） Therapy Targeting CD19/B Cell Maturation Antigen （CD19/BCMA） in Patients With r/r Neurological Autoimmune Diseases UCAR T-cell - Neuromyelitis Optica Spectrum Disorders, Myasthenia Gravis | Early Phase 1 | Recruiting | Tianjin Huanhu Hospital | 12 | 2025-06-17 | 2025-12-15 |
| Phase 1 Study of ART5803 Safety and PK After IVIG in Healthy Participants ART5803, Intravenous immunoglobulin (IVIG) - Autoimmune Encephalitis Caused by N-Methyl D-Aspartate Receptor Antibody, Autoimmune Encephalitis Caused by N-Methyl D-Aspartate Receptor Antibody (Disorder) | Phase 1 | Completed | Arialys Therapeutics | 7 | 2025-02-25 | 2026-04-27 |
| A Multicentric Cohort of Autoimmune Encephalitis baseline data collection and follow-up - Autoimmune Encephalitis | Not yet recruiting | Xuanwu Hospital, Beijing | 200 | 2025-02-01 | 2025-01-06 | |
| Long-term Impact of NMDAR Encephalitis Autoimmune Encephalitis | Completed | Hospices Civils de Lyon | 20 | 2024-12-16 | 2025-12-23 | |
| Efficacy and Safety of Calculus Bovis Sativus (CBS) for Adult Encephalitis (CBSinEncephalitis) Calculus bovis sativus (CBS) - Encephalitis, Encephalitis, Viral | Not applicable | Recruiting | Tongji Hospital | 250 | 2024-09-30 | 2025-04-08 |
| Phase 1 Study of ART5803 in Healthy Participants ART5803 - Autoimmune Encephalitis | Phase 1 | Completed | Arialys Therapeutics | 64 | 2024-09-19 | 2026-04-27 |
| Biomarkers in Autoimmune Disease of Nervous System biomaker levels - Autoimmune Diseases of the Nervous System, Neuromyelitis Optica Spectrum Disorder | Recruiting | Tongji Hospital | 50000 | 2024-07-31 | 2026-07-29 | |
| Clinical Features and Prognostic Markers in Adult Patients With AE Requiring ICU Treatment None, non-interventional study - Autoimmune Encephalitis | Unknown | Central South University | 200 | 2024-06-01 | 2024-06-13 | |
| Impact of Confirmed Autoimmune Encephalitis on Brain Glucose Metabolism FDG PET - Autoimmune Encephalitis | Not applicable | Recruiting | Assistance Publique - Hôpitaux de Paris | 56 | 2024-05-31 | 2025-08-22 |
| Cohort Study on Neuroimmune Diseases in the Reproductive Age Neuromyelitis Optica Spectrum Disorders (NMOSD), Multiple Sclerosis | Recruiting | Third Affiliated Hospital, Sun Yat-Sen University | 100 | 2024-04-21 | 2026-06-17 | |
| Metabolic Imaging for Diagnosis and Prognostication of Autoimmune encephalitiS PET-Scan analysis - Paraneoplastic Neurological Syndrome, Autoimmune Encephalitis | Unknown | Hospices Civils de Lyon | 28 | 2024-03-01 | 2024-05-29 | |
| Predicting and Monitoring Outcomes in Autoimmune Encephalitis Observational study - Autoimmune Encephalitis | Unknown | Royal College of Surgeons, Ireland | 50 | 2023-11-01 | 2023-02-03 |
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Autoimmune Diseases of the Nervous System (55) · Encephalitis (8) · Multiple Sclerosis (8) · Neuromyelitis Optica (8) · Myasthenia Gravis (7) · Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (5) · Autoimmune Diseases (4) · Polyradiculoneuropathy, Chronic Inflammatory Demyelinating (4) · Stiff-Person Syndrome (4) · Anti-N-Methyl-D-Aspartate Receptor Encephalitis (3) · Guillain-Barre Syndrome (3) · Myositis (3) · Encephalomyelitis, Acute Disseminated (2) · Multiple Sclerosis, Chronic Progressive (2) · Anorexia Nervosa (1)
Immune System Diseases (55) · Nervous System Diseases (55) · Autoimmune Diseases (51) · Central Nervous System Diseases (18) · Brain Diseases (15) · Pathological Conditions, Signs and Symptoms (13) · Neoplasms (12) · Pathologic Processes (12) · Disease Attributes (11) · Neoplasms by Site (11) · Nervous System Neoplasms (11) · Neurodegenerative Diseases (11) · Neuroinflammatory Diseases (11) · Paraneoplastic Syndromes (11) · Paraneoplastic Syndromes, Nervous System (11)
Immunoglobulins, Intravenous (5) · Cyclophosphamide (2) · Immunologic Tests (2) · Rituximab (2) · Bortezomib (1) · Data Collection (1) · Erythropoietin (1) · Immunoglobulin G (1) · Lacosamide (1) · Methylprednisolone (1) · Methylprednisolone Hemisuccinate (1) · Minocycline (1) · Observation (1) · Plasma Exchange (1) · Saline Solution (1)
Hospices Civils de Lyon (16) · Tongji Hospital (4) · Xuanwu Hospital, Beijing (4) · Arialys Therapeutics (2) · Shen Chun-Hong (2) · Third Affiliated Hospital, Sun Yat-Sen University (2) · Arialys Australia Pty Ltd (1) · Assistance Publique - Hôpitaux de Paris (1) · Biocells Medical (1) · Brain Inflammation Collaborative (1) · CRISPR Therapeutics (1) · Central South University (1) · First Affiliated Hospital of Zhejiang University (1) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (1) · Green Cross Corporation (1)
France (17) · China (16) · South Korea (3) · United States (3) · Australia (2) · Italy (2) · United Kingdom (2) · Germany (1) · Japan (1) · Netherlands (1) · Poland (1) · Spain (1) · Sweden (1)
Sankalp Gokhale, MD, MBA (2) · Alasdair Coles, PhD FRCP (1) · Anna Rostedt Punga, Professor (1) · Benyan Luo, Ph.D (1) · Caroline Tilikete, Prof. (1) · Christian Geis, Prof. (1) · Chun-Hong Shen (1) · Dai-shi Tian, MD (1) · David W Carmichael, PhD MSci (1) · Joachim Burman, Assoc prof (1) · Junwei Hao, MD (1)
PMID 11113214, PMID 12393404, PMID 15564716, PMID 15817019, PMID 17262855, PMID 17538176, PMID 18417336, PMID 18851928, PMID 19680671, PMID 20427647, PMID 20605905, PMID 20829370, PMID 21163445, PMID 21865579, PMID 23151040, PMID 23290630, PMID 23568718, PMID 24360484, PMID 24763533, PMID 25392198, PMID 25573986, PMID 26187412, PMID 27267753, PMID 27399303, PMID 27412413, PMID 27575749, PMID 27886126, PMID 29143550, PMID 29159189, PMID 29293273, PMID 29406578, PMID 29476014, PMID 29549218, PMID 29956883, PMID 30578370, PMID 30675918, PMID 30679041, PMID 31174586, PMID 31292262, PMID 31495497, PMID 31900318, PMID 32052483, PMID 32641101, PMID 35129803, PMID 35816681, PMID 37479377, PMID 37658205, PMID 39242986, PMID 40425008, PMID 41101309
2019 (1)