10 completed, 6 recruiting, 4 withdrawn, 2 active not recruiting. 11 Phase 1, 6 Phase 2, 4 Not applicable, 1 Phase 3.
Follow Astrocytoma, Grade IV: new trials by email Literature Review of Astrocytoma, Grade IV trials Research Report on Astrocytoma, Grade IV
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| UNIty-Based MR-Linac Guided Adaptive RadioThErapy for High GraDe Glioma-4 Dose painting + Reduced Margins - Glioblastoma (GBM), Astrocytoma, Grade IV | Not applicable | Recruiting | Sunnybrook Health Sciences Centre | 60 | 2025-09-10 | 2026-03-09 |
| A Phase IB 2 Dose Trial of IRS-1 HSV C134 (IND 17296) Administered Intratumorally in Patients With Recurrent Malignant Glioma C134 - Glioblastoma, Glioblastoma (GBM) | Phase 1 | Active not recruiting | James Markert, MD | 12 | 2025-06-02 | 2026-08-13 |
| Study of Olutasidenib and Temozolomide in HGG Olutasidenib + TMZ - High Grade Glioma, Astrocytoma | Phase 2 | Recruiting | Rigel Pharmaceuticals | 60 | 2025-02-01 | 2026-09-01 |
| T Cells and Pembrolizumab for Recurrent and Newly Diagnosed Glioblastoma Allogeneic cytomegalovirus-specific T cells, Pembrolizumab - Glioblastoma Multiforme, Astrocytoma, Grade IV | Phase 1 / Phase 2 | Active not recruiting | Queensland Institute of Medical Research | 58 | 2024-02-08 | 2026-06-26 |
| The Addition of Chloroquine to Chemoradiation for Glioblastoma, Chloroquine - Glioblastoma, Astrocytoma, Grade IV | Phase 2 | Withdrawn | Maastricht Radiation Oncology | 2023-11-10 | 2023-11-18 | |
| Coaching for Coping in Glioblastoma Patients and Caregivers and Its Association With Compliance to TTFields Psychological intervention - Compliance, Patient, Glioblastoma | Not applicable | Unknown | University Hospital Tuebingen | 275 | 2023-10-01 | 2023-08-30 |
| Allogenic Adipose-Derived Mesenchymal Stem Cells for the Treatment of Recurrent Glioblastoma or Recurrent Astrocytoma in Patients Undergoing Craniotomy Allogeneic Adipose-derived Mesenchymal Stem Cells, Biospecimen Collection, Craniotomy - Recurrent Glioblastoma, IDH-Wildtype, Recurrent Astrocytoma, IDH-Mutant, Grade 4 | Phase 1 | Recruiting | Mayo Clinic | 20 | 2023-06-16 | 2026-04-02 |
| SIGMA (Safusidenib in IDH1 Mutant Glioma Maintenance) safusidenib, Placebo - Glioma, Astrocytoma, Grade IV | Phase 3 | Recruiting | Nuvation Bio Inc. | 365 | 2023-06-05 | 2026-10-19 |
| The SUPRAMAX Study: Supramaximal Resection Versus Maximal Resection for High-Grade Glioma Patients (ENCRAM 2201) Supramaximal resection, Maximal safe resection - Glioblastoma, High-grade Glioma | Recruiting | Jasper Gerritsen | 784 | 2022-01-01 | 2024-02-22 | |
| CYNK-001 IV and IC in Combination With IL2 in Surgical Eligible Recurrent GBM With IDH-1 Wild Type CYNK-001 systemic and Intra cavity administration - Astrocytoma, Grade IV, Glioblastoma | Phase 1 / Phase 2 | Withdrawn | Celularity Incorporated | 2021-09-01 | 2026-06-08 | |
| Tadalafil to Overcome Immunosuppression During Chemoradiotherapy for IDH-wildtype Grade III-IV Astrocytoma Tadalafil - Grade III Astrocytoma, Grade IV Astrocytoma | Phase 1 | Completed | Washington University School of Medicine | 18 | 2021-05-14 | 2023-06-13 |
| BIOhabitats: Biological Validation of Vascular Habitats Within Astrocytoma Grade 4 at Molecular, Cellular, and Histopathological Levels Astrocytoma, Grade IV, Glioblastoma | Completed | Juan M Garcia-Gomez | 50 | 2021-03-01 | 2025-07-08 | |
| Natural Killer Cell (CYNK-001) IV Infusion or IT Administration in Adults With Recurrent GBM CYNK001-IV, CYNK001-IT - Astrocytoma, Grade IV, Giant Cell Glioblastoma | Phase 1 | Terminated | Celularity Incorporated | 3 | 2020-10-01 | 2022-08-10 |
| ALBATROSS Study: International Multicenter Study for Prospective Validation of Imaging Biomarkers Calculated at Vascular Habitats of High-grade Gliomas Astrocytoma, Grade IV | Completed | Juan M Garcia-Gomez | 300 | 2020-06-01 | 2025-07-08 | |
| The SAFE-Trial: Awake Craniotomy Versus Surgery Under General Anesthesia for Glioblastoma Patients. Awake craniotomy, Craniotomy under general anesthesia - Glioblastoma, Glioblastoma Multiforme | Not applicable | Recruiting | Jasper Gerritsen | 246 | 2019-04-01 | 2023-11-21 |
| Study of Stereotactic Radiosurgery to the Subventricular Zone in Malignant Gliomas Stereotactic Radiosurgery - Glioblastoma, Astrocytoma, Grade III | Not applicable | Withdrawn | Northwell Health | 2018-12-24 | 2023-03-15 | |
| Neural Stem Cell Based Virotherapy of Newly Diagnosed Malignant Glioma Neural stem cells loaded with an oncolytic adenovirus - Glioma, Anaplastic Astrocytoma | Phase 1 | Completed | Northwestern University | 12 | 2017-04-24 | 2023-01-20 |
| GliomaAI-Astro4: MRI-Based Detection of IDH Mutant Astrocytoma Grade 4 GliomaAI-Astro4 - Glioma, Glioma (Diagnosis) | Completed | Deep Learning Institute of Radiological Sciences | 1372 | 2017-03-14 | 2026-06-29 | |
| A Study to Evaluate the Safety, Tolerability and Immunogenicity of EGFR(V)-EDV-Dox in Subjects With Recurrent GBM EGFR(V)-EDV-Dox - Glioblastoma, Astrocytoma, Grade IV | Phase 1 | Completed | Engeneic Pty Limited | 9 | 2016-10-25 | 2025-06-03 |
| Vaccine Therapy for the Treatment of Newly Diagnosed Glioblastoma Multiforme pp65-shLAMP DC with GM-CSF, unpulsed PBMC and saline, Td - Glioblastoma Multiforme, Glioblastoma | Phase 2 | Completed | University of Florida | 175 | 2016-08-09 | 2025-01-14 |
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Glioblastoma (25) · Astrocytoma (10) · Glioma (9) · Brain Neoplasms (7) · Oligodendroglioma (3) · Gliosarcoma (2) · Lymphoma, Follicular (2) · Adenoviridae Infections (1) · Diffuse Intrinsic Pontine Glioma (1) · Disease (1) · Disease Progression (1) · Neoplasms (1) · Neoplasms by Site (1) · Patient Compliance (1) · Postoperative Complications (1)
Neoplasms by Histologic Type (25) · Neoplasms, Germ Cell and Embryonal (25) · Neoplasms, Glandular and Epithelial (25) · Neoplasms, Nerve Tissue (25) · Neoplasms, Neuroepithelial (25) · Neuroectodermal Tumors (25) · Neoplasms (24) · Glioma (16) · Astrocytoma (15) · Brain Diseases (7) · Central Nervous System Diseases (7) · Central Nervous System Neoplasms (7) · Nervous System Diseases (7) · Nervous System Neoplasms (7) · Neoplasms by Site (6)
Temozolomide (4) · Sodium Chloride (2) · Basiliximab (1) · Chloroquine (1) · Craniotomy (1) · Diphtheria Toxoid (1) · Granulocyte-Macrophage Colony-Stimulating Factor (1) · Magnetic Resonance Spectroscopy (1) · Psychosocial Intervention (1) · Radiation (1) · Radiosurgery (1) · Saline Solution (1) · Specimen Handling (1) · Tadalafil (1) · Tetanus Toxoid (1)
Celularity Incorporated (2) · Jasper Gerritsen (2) · Juan M Garcia-Gomez (2) · Washington University School of Medicine (2) · Centre hospitalier de l'Université de Montréal (CHUM) (1) · Deep Learning Institute of Radiological Sciences (1) · Engeneic Pty Limited (1) · James Markert, MD (1) · Maastricht Radiation Oncology (1) · Mayo Clinic (1) · Mustafa Khasraw, MBChB, MD, FRCP, FRACP (1) · National Cancer Institute (NCI) (1) · Northwell Health (1) · Northwestern University (1) · Nuvation Bio Inc. (1)
United States (15) · Australia (3) · Netherlands (3) · Belgium (2) · Canada (2) · Germany (2) · Spain (2) · China (1) · India (1) · New Zealand (1) · Switzerland (1) · United Kingdom (1)
Alexis M Demopoulos, MD (1) · Alfredo Quinones-Hinojosa, MD (1) · Arnaud Vincent, MD PhD (1) · Dina Randazzo, DO (1) · Duane Mitchell, MD, PhD (1) · Gary L Gallia, M.D., Ph.D (1) · Gavin Dunn, M.D., Ph.D. (1) · Himanshu Brahmbhatt, Ph. D (1) · Jasper Gerritsen, MD PhD (1) · Jennifer MacDiarmid, Ph.D (1) · Jiayi Huang, M.D. (1) · Kevin A Camphausen, M.D. (1) · Maciej S Lesniak, MD (1)
PMID 31676314, PMID 34214495, PMID 34290067, PMID 35569489
P50CA221747 (1), R01CA175517 (1)