7 completed, 4 recruiting, 2 terminated, 1 active not recruiting. 9 Phase 1, 5 Phase 2, 2 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 9 | Completed 5, Recruiting 2, Active not recruiting 1, Terminated 1 |
| Phase 2 | 5 | Recruiting 3, Completed 1, Terminated 1 |
| Not applicable | 2 | Completed 1, Withdrawn 1 |
Follow Astrocytoma, Grade III: new trials by email Literature Review of Astrocytoma, Grade III trials Research Report on Astrocytoma, Grade III
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Phase IB 2 Dose Trial of IRS-1 HSV C134 (IND 17296) Administered Intratumorally in Patients With Recurrent Malignant Glioma C134 - Glioblastoma, Glioblastoma (GBM) | Phase 1 | Active not recruiting | James Markert, MD | 12 | 2025-06-02 | 2026-08-13 |
| Study of Olutasidenib and Temozolomide in HGG Olutasidenib + TMZ - High Grade Glioma, Astrocytoma | Phase 2 | Recruiting | Rigel Pharmaceuticals | 60 | 2025-02-01 | 2026-09-01 |
| A Study of Debio 0123 in Combination With Temozolomide in Adult Participants With Recurrent or Progressive Glioblastoma and of Debio 0123 in Combination With Temozolomide and Radiotherapy in Adult Participants With Newly Diagnosed Glioblastoma Debio 0123, Temozolomide, Radiotherapy - Glioblastoma IDH (Isocitrate Dehydrogenase) Wildtype, Astrocytoma, Grade III | Phase 1 / Phase 2 | Recruiting | Debiopharm International SA | 116 | 2023-05-15 | 2026-09-22 |
| The SUPRAMAX Study: Supramaximal Resection Versus Maximal Resection for High-Grade Glioma Patients (ENCRAM 2201) Supramaximal resection, Maximal safe resection - Glioblastoma, High-grade Glioma | Recruiting | Jasper Gerritsen | 784 | 2022-01-01 | 2024-02-22 | |
| Tadalafil to Overcome Immunosuppression During Chemoradiotherapy for IDH-wildtype Grade III-IV Astrocytoma Tadalafil - Grade III Astrocytoma, Grade IV Astrocytoma | Phase 1 | Completed | Washington University School of Medicine | 18 | 2021-05-14 | 2023-06-13 |
| Study Of NOVOTTF-200A In Bevacizumab-Naive Subjects With Recurrent Grade III Malignant Astrocytoma NOVOTTF-200A - Astrocytoma, Grade III | Not applicable | Completed | Daniela A. Bota | 1 | 2020-05-21 | 2026-02-17 |
| Radiotherapy in IDH Mutated Glioma: Evaluation of Late Outcomes Astrocytoma, Grade II, Astrocytoma, Grade III | Completed | Erasmus Medical Center | 80 | 2019-12-10 | 2024-10-15 | |
| FORWARD Optune and Adjuvant TMZ in Grade II/III Astrocytoma TTFields with adjuvant temozolomide - Astrocytoma, Grade II, Astrocytoma, Grade III | Phase 2 | Terminated | University of Florida | 1 | 2019-05-20 | 2021-09-23 |
| Study of Stereotactic Radiosurgery to the Subventricular Zone in Malignant Gliomas Stereotactic Radiosurgery - Glioblastoma, Astrocytoma, Grade III | Not applicable | Withdrawn | Northwell Health | 2018-12-24 | 2023-03-15 | |
| Trial of Newly Diagnosed High Grade Glioma Treated With Concurrent Radiation Therapy, Temozolomide and BMX-001 BMX-001, Radiation Therapy, Temozolomide - High Grade Glioma, Astrocytoma, Grade III | Phase 1 / Phase 2 | Completed | BioMimetix JV, LLC | 177 | 2018-09-25 | 2025-06-08 |
| Multi-kinase Inhibitor TG02 (TG02) in Elderly Newly Diagnosed or Adult Relapsed Patients With Anaplastic Astrocytoma or Glioblastoma. TG02, Radiation Therapy, Temozolomide - Astrocytoma, Grade III, Glioblastoma | Phase 1 | Completed | European Organisation for Research and Treatment of Cancer - EORTC | 71 | 2018-06-12 | 2025-11-26 |
| HSV-tk + Valacyclovir + SBRT + Chemotherapy for Recurrent GBM ADV/HSV-tk (gene therapy) - Glioblastoma Multiforme, Astrocytoma, Grade III | Phase 1 / Phase 2 | Recruiting | David Baskin MD | 62 | 2017-12-11 | 2026-03-30 |
| Neural Stem Cell Based Virotherapy of Newly Diagnosed Malignant Glioma Neural stem cells loaded with an oncolytic adenovirus - Glioma, Anaplastic Astrocytoma | Phase 1 | Completed | Northwestern University | 12 | 2017-04-24 | 2023-01-20 |
| Trial of Heat Shock Protein Peptide Complex-96 (HSPPC-96) Vaccine Heat Shock Protein Peptide Complex-96 (HSPPC-96), Tumor Resection, Radiation - Glioblastoma Multiforme, Astrocytoma, Grade III | Phase 1 | Terminated | Ann & Robert H Lurie Children's Hospital of Chicago | 10 | 2016-07-01 | 2025-02-18 |
| Phase I Study of Mebendazole Therapy for Recurrent/Progressive Pediatric Brain Tumors Mebendazole - Medulloblastoma, Astrocytoma, Grade III | Phase 1 | Completed | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 16 | 2016-05-01 | 2022-06-23 |
Astrocytoma (15) · Glioblastoma (12) · Glioma (6) · Oligodendroglioma (4) · Brain Neoplasms (3) · Diffuse Intrinsic Pontine Glioma (2) · Lymphoma, Follicular (2) · Adenoviridae Infections (1) · Brain Stem Neoplasms (1) · Ependymoma (1) · Gliosarcoma (1) · Medulloblastoma (1) · Spinal Cord Neoplasms (1)
Neoplasms (15) · Neoplasms by Histologic Type (15) · Neoplasms, Germ Cell and Embryonal (15) · Neoplasms, Glandular and Epithelial (15) · Neoplasms, Nerve Tissue (15) · Neoplasms, Neuroepithelial (15) · Neuroectodermal Tumors (15) · Glioma (9) · Brain Diseases (4) · Central Nervous System Diseases (4) · Central Nervous System Neoplasms (4) · Neoplasms by Site (4) · Nervous System Diseases (4) · Nervous System Neoplasms (4) · Hemic and Lymphatic Diseases (2)
Temozolomide (4) · Radiotherapy (3) · 14-methyl-20-oxa-5,7,14,26-tetraazatetracyclo(19.3.1.1(2,6).1(8,12))heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene (1) · Genetic Engineering (1) · Genetic Therapy (1) · Mebendazole (1) · Mn(III) meso-tetrakis(N-n-butoxyethylpyridinium-2-yl)porphyrin (1) · Piperazine (1) · Radiation (1) · Radiosurgery (1) · Tadalafil (1) · Transurethral Resection of Bladder (1) · olutasidenib (1) · ovex (1) · vitespin (1)
Ann & Robert H Lurie Children's Hospital of Chicago (1) · BioMimetix JV, LLC (1) · Daniela A. Bota (1) · David Baskin MD (1) · Debiopharm International SA (1) · Erasmus Medical Center (1) · European Organisation for Research and Treatment of Cancer - EORTC (1) · James Markert, MD (1) · Jasper Gerritsen (1) · Northwell Health (1) · Northwestern University (1) · Rigel Pharmaceuticals (1) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (1) · University of Florida (1) · Washington University School of Medicine (1)
United States (13) · Netherlands (4) · Germany (3) · Switzerland (3) · Australia (1) · Austria (1) · Belgium (1) · Canada (1) · France (1) · New Zealand (1) · Spain (1) · United Kingdom (1)
Alexis M Demopoulos, MD (1) · Daniela Bota, MD (1) · David S Baskin, MD (1) · David Tran, MD, PhD (1) · Emilie Le Rhun (1) · Jasper Gerritsen, MD PhD (1) · Jiayi Huang, M.D. (1) · Katherine Peters, MD, PhD (1) · Kenneth J Cohen, MD (1) · Maciej S Lesniak, MD (1) · Maryam Fouladi, MD (1) · Michael J Fisher, MD (1) · Nicholas G Gottardo, MB FRACP PhD (1) · Santosh Valvi, FRACP, MSc (1) · Stewart Goldman, MD (1)
PMID 27098749, PMID 34214495, PMID 41544350
2017 (1), P50CA221747 (1)