5 completed, 2 recruiting, 1 active not recruiting, 1 terminated. 9 Phase 1, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 9 | Completed 5, Recruiting 2, Active not recruiting 1, Terminated 1 |
| Phase 2 | 3 | Recruiting 2, Completed 1 |
Follow Astrocytoma, Grade III: new trials by email Literature Review of Astrocytoma, Grade III trials Research Report on Astrocytoma, Grade III
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Phase IB 2 Dose Trial of IRS-1 HSV C134 (IND 17296) Administered Intratumorally in Patients With Recurrent Malignant Glioma C134 - Glioblastoma, Glioblastoma (GBM) | Phase 1 | Active not recruiting | James Markert, MD | 12 | 2025-06-02 | 2026-08-13 |
| A Study of Zedoresertib (Debio 0123) in Combination With Temozolomide in Adult Participants With Recurrent or Progressive Glioblastoma and of Zedoresertib (Debio 0123) in Combination With Temozolomide and Radiotherapy in Adult Participants With Newly Diagnosed Glioblastoma Zedoresertib, Temozolomide, Radiotherapy - Glioblastoma IDH (Isocitrate Dehydrogenase) Wildtype, Astrocytoma, Grade III | Phase 1 / Phase 2 | Recruiting | Debiopharm International SA | 116 | 2023-05-15 | 2026-10-28 |
| Tadalafil to Overcome Immunosuppression During Chemoradiotherapy for IDH-wildtype Grade III-IV Astrocytoma Tadalafil - Grade III Astrocytoma, Grade IV Astrocytoma | Phase 1 | Completed | Washington University School of Medicine | 18 | 2021-05-14 | 2023-06-13 |
| Trial of Newly Diagnosed High Grade Glioma Treated With Concurrent Radiation Therapy, Temozolomide and BMX-001 BMX-001, Radiation Therapy, Temozolomide - High Grade Glioma, Astrocytoma, Grade III | Phase 1 / Phase 2 | Completed | BioMimetix JV, LLC | 177 | 2018-09-25 | 2025-06-08 |
| Multi-kinase Inhibitor TG02 (TG02) in Elderly Newly Diagnosed or Adult Relapsed Patients With Anaplastic Astrocytoma or Glioblastoma. TG02, Radiation Therapy, Temozolomide - Astrocytoma, Grade III, Glioblastoma | Phase 1 | Completed | European Organisation for Research and Treatment of Cancer - EORTC | 71 | 2018-06-12 | 2025-11-26 |
| HSV-tk + Valacyclovir + SBRT + Chemotherapy for Recurrent GBM ADV/HSV-tk (gene therapy) - Glioblastoma Multiforme, Astrocytoma, Grade III | Phase 1 / Phase 2 | Recruiting | David Baskin MD | 62 | 2017-12-11 | 2026-03-30 |
| Neural Stem Cell Based Virotherapy of Newly Diagnosed Malignant Glioma Neural stem cells loaded with an oncolytic adenovirus - Glioma, Anaplastic Astrocytoma | Phase 1 | Completed | Northwestern University | 12 | 2017-04-24 | 2023-01-20 |
| Trial of Heat Shock Protein Peptide Complex-96 (HSPPC-96) Vaccine Heat Shock Protein Peptide Complex-96 (HSPPC-96), Tumor Resection, Radiation - Glioblastoma Multiforme, Astrocytoma, Grade III | Phase 1 | Terminated | Ann & Robert H Lurie Children's Hospital of Chicago | 10 | 2016-07-01 | 2025-02-18 |
| Phase I Study of Mebendazole Therapy for Recurrent/Progressive Pediatric Brain Tumors Mebendazole - Medulloblastoma, Astrocytoma, Grade III | Phase 1 | Completed | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 16 | 2016-05-01 | 2022-06-23 |
Astrocytoma (9) · Glioblastoma (9) · Glioma (3) · Oligodendroglioma (2) · Adenoviridae Infections (1) · Brain Neoplasms (1) · Brain Stem Neoplasms (1) · Diffuse Intrinsic Pontine Glioma (1) · Ependymoma (1) · Gliosarcoma (1) · Lymphoma, Follicular (1) · Medulloblastoma (1)
Neoplasms (9) · Neoplasms by Histologic Type (9) · Neoplasms, Germ Cell and Embryonal (9) · Neoplasms, Glandular and Epithelial (9) · Neoplasms, Nerve Tissue (9) · Neoplasms, Neuroepithelial (9) · Neuroectodermal Tumors (9) · Glioma (6) · Brain Diseases (2) · Central Nervous System Diseases (2) · Central Nervous System Neoplasms (2) · Neoplasms by Site (2) · Nervous System Diseases (2) · Nervous System Neoplasms (2) · Brain Neoplasms (1)
Radiotherapy (3) · Temozolomide (3) · 14-methyl-20-oxa-5,7,14,26-tetraazatetracyclo(19.3.1.1(2,6).1(8,12))heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene (1) · Genetic Engineering (1) · Genetic Therapy (1) · Mebendazole (1) · Mn(III) meso-tetrakis(N-n-butoxyethylpyridinium-2-yl)porphyrin (1) · Piperazine (1) · Radiation (1) · Tadalafil (1) · Transurethral Resection of Bladder (1) · ovex (1) · vitespin (1)
Ann & Robert H Lurie Children's Hospital of Chicago (1) · BioMimetix JV, LLC (1) · David Baskin MD (1) · Debiopharm International SA (1) · European Organisation for Research and Treatment of Cancer - EORTC (1) · James Markert, MD (1) · Northwestern University (1) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (1) · Washington University School of Medicine (1)
United States (8) · Switzerland (2) · Austria (1) · France (1) · Germany (1) · Netherlands (1) · Spain (1)
David S Baskin, MD (1) · Emilie Le Rhun (1) · Jiayi Huang, M.D. (1) · Katherine Peters, MD, PhD (1) · Kenneth J Cohen, MD (1) · Maciej S Lesniak, MD (1) · Stewart Goldman, MD (1)
PMID 27098749, PMID 34214495, PMID 41544350
2017 (1), P50CA221747 (1)