Association Between Inflammatory Markers and Pain Intensity in Patients With Sickle Cell Disease
| Registry | NCT07865039 |
|---|---|
| Status | Not yet recruiting |
| Study type | Observational |
| Enrollment | 75 (Estimated) |
| Sponsor | Assiut University (Other) |
| Conditions | Sickle Cell Disease |
| Dates | start 2026-11-01 (estimated), primary completion 2029-03-01 (estimated), completion 2029-05-01 (estimated), first posted 2026-10-08, last updated 2026-10-08 |
| Locations | 1 site in Egypt |
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This observational cross-sectional study aims to assess the relationship between inflammatory markers and pain intensity in adult patients with sickle cell disease. The study will evaluate inflammatory markers in patients with different clinical presentations, including steady state and vaso-occlusive crisis.
Sickle cell disease is a chronic hematological disorder characterized by recurrent complications, including painful vaso-occlusive crises. Inflammatory and hematological markers may vary according to the clinical state and may be associated with the severity of pain.
This observational cross-sectional study will evaluate adult patients with sickle cell disease presenting in different clinical states, including steady state and vaso-occlusive crisis. Clinical history and examination findings will be recorded, including pain intensity assessed using the Visual Analog Scale (VAS), type of clinical presentation, duration of crisis, and length of hospital stay when applicable.
Laboratory investigations will include complete blood count with differential, from which neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) will be calculated, as well as C-reactive protein (CRP), lactate dehydrogenase (LDH), and D-dimer. Other relevant routine laboratory investigations will also be recorded when available.
The study will assess the association between inflammatory markers and pain intensity and will compare these markers among different clinical presentations, particularly steady state and vaso-occlusive crisis. The study will also explore relationships between these markers and relevant hematological and biochemical parameters.
| Arm | Type | Interventions | Description |
|---|---|---|---|
| Adult Patients with Sickle Cell Disease | Adult patients with sickle cell disease will be evaluated according to their clinical presentation, including steady state and vaso-occlusive crisis. Clinical data, pain intensity, and relevant laboratory parameters including inflammatory and hematological markers will be assessed. No intervention will be assigned as part of the study. |
Sex: All, ages: 18 Years to any
Inclusion Criteria: * Adults aged ≥18 years. Confirmed diagnosis of sickle cell disease. Patients attending or admitted to the Internal Medicine Department during the study period. Willingness to participate and provide informed consent. Exclusion Criteria: * Patients younger than 18 years. Acute infection or sepsis Autoimmune or chronic inflammatory diseases. Malignancy End-stage renal disease on dialysis. Chronic liver disease Blood transfusion within the preceding four weeks Recent surgery or trauma (within the preceding four weeks. Refusal to participate.
| Facility | City | Country | Status |
|---|---|---|---|
| Assiut University Hospitals | Asyut, Asyut Governorate | Egypt |