7 completed, 3 recruiting. 3 Not applicable, 2 Phase 1, 2 Phase 4, 1 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 3 | Recruiting 2, Completed 1 |
| Phase 1 | 2 | Completed 2 |
| Phase 4 | 2 | Completed 2 |
| Phase 2 | 1 | Completed 1 |
| Phase 3 | 1 | Completed 1 |
Follow Anal Fissure Chronic: new trials by email Literature Review of Anal Fissure Chronic trials Research Report on Anal Fissure Chronic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparative Outcomes of Inj Botox Alone vs Inj Botox Combined With Fissurectomy and Anoplasty in the Management of Chronic Anal Fissure Botulinum Toxin Type A (BOTOX) Injection, Botulinum Toxin Type A (BOTOX) Injection, Fissurectomy and Anoplasty - Anal Fissure Chronic | Not applicable | Recruiting | Islamabad Medical and Dental College | 108 | 2026-06-03 | 2026-06-26 |
| Comparison of Botulinum Toxin Injection and Lateral Internal Sphincterotomy in Chronic Anal Fissure Management Botulinum Toxin Type A (BOTOX) Injection, Lateral Internal Sphincterotomy - Anal Fissure Chronic | Not applicable | Completed | Islamabad Medical and Dental College | 90 | 2026-03-02 | 2026-08-13 |
| Pulsed Electromagnetic Field on Chronic Anal Fissure Healing PEMS, Lidocaine and general advice, Lidocaine cream and general advice - Anal Fissure Chronic | Phase 3 | Completed | Galala University | 100 | 2026-01-03 | 2026-07-27 |
| Effect of Enhanced Recovery After Surgery for Benign Anorectal Conditions Enhanced recovery after surgery protocol, Routine pathway - Anal Fistula, Anal Fissure Chronic | Not applicable | Recruiting | Mansoura University | 100 | 2024-12-17 | 2025-02-03 |
| Ultrasound Assessment After Surgery for Chronic Anal Fissure Anal Fissure Chronic | Recruiting | Hospital Clínico Universitario de Valencia | 66 | 2024-10-12 | 2026-09-17 | |
| Short-Term Outcome of Medical Vs. Surgical Management Of Chronic Anal Fissure Sucralfate, Azadirachtin, fissurectomy and lateral sphincterectomy - Anal Fissure Chronic | Phase 1 / Phase 2 | Completed | Suez Canal University | 99 | 2024-08-30 | 2024-11-08 |
| Effect of Phenytoin Cream on Wound Healing After Anal Fissure Surgery. phenytoin cream, no phenytoin cream - Anal Fissure Chronic, Anal Fissure | Phase 1 | Completed | Mansoura University | 50 | 2022-01-01 | 2024-10-09 |
| Efficacy and Safety of Propionibacterium Extract Gel Versus 0.4% Glyceryl Trinitrate Ointment in the Treatment of Chronic Anal Fissure: a Randomised Controlled Trial Propionibacterium Acnes, glyceryl trinitrate - Anal Fissure Chronic, Anal Fissure | Phase 4 | Completed | Treviso Regional Hospital | 120 | 2021-10-01 | 2022-11-15 |
| Short Term Results of Platelet-rich Plasma in the Treatment of Chronic Anal Fissure prp injection, Anrecta, sitz bath - Anal Fissure Chronic, PRP | Phase 4 | Completed | KTO Karatay University | 41 | 2019-01-01 | 2022-04-07 |
| The Efficacy of Botulinum Toxin Alone Versus Combined Botulinum Toxin and Topical Diltiazem in Chronic Anal Fissure Botulinum Toxin Type A Injection [Botox], Botulinum Toxin Type A Injection [Botox] + Diltiazem Hydrochloride 20 Mg/G Rectal Gel - Anal Fissure Chronic | Completed | Istanbul Medipol University Hospital | 217 | 2016-11-04 | 2024-09-04 |
Fissure in Ano (5) · Encopresis (1) · Hemorrhoids (1) · Rectal Fistula (1)
Anus Diseases (5) · Digestive System Diseases (5) · Gastrointestinal Diseases (5) · Intestinal Diseases (5) · Rectal Diseases (5) · Pathological Conditions, Signs and Symptoms (2) · Behavior (1) · Behavioral Symptoms (1) · Cardiovascular Diseases (1) · Digestive System Fistula (1) · Elimination Disorders (1) · Fistula (1) · Intestinal Fistula (1) · Mental Disorders (1) · Pathological Conditions, Anatomical (1)
Botulinum Toxins, Type A (3) · Diltiazem (1) · Injections (1) · Lateral Internal Sphincterotomy (1) · Nitroglycerin (1) · Phenytoin (1) · Pituitary Adenylate Cyclase-Activating Polypeptide (1) · Sucralfate (1) · azadirachtin (1) · chloropentaamminerhodium(III) (1) · hyperforin (1)
Islamabad Medical and Dental College (2) · Mansoura University (2) · Galala University (1) · Hospital Clínico Universitario de Valencia (1) · Istanbul Medipol University Hospital (1) · KTO Karatay University (1) · Suez Canal University (1) · Treviso Regional Hospital (1)
Egypt (4) · Pakistan (2) · Turkey (Türkiye) (2) · Italy (1) · Spain (1)
Marwa A Radwan, Ph.D. (1) · Mostafa Shalaby, MD, PhD (1) · Naciye Cigdem Arslan, MD (1)
PMID 15085902, PMID 17577213, PMID 29324868, PMID 33554390, PMID 33987779, PMID 36674651