10 completed, 2 recruiting, 1 terminated, 1 unknown. 14 Phase 2, 2 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 14 | Completed 10, Recruiting 2, Terminated 1, Unknown 1 |
| Phase 1 | 2 | Completed 1, Terminated 1 |
| Phase 3 | 2 | Completed 1, Recruiting 1 |
Follow Amenorrhea: new trials by email Literature Review of Amenorrhea trials Research Report on Amenorrhea
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Investigate Mibavademab in Adult Women With Functional Hypothalamic Amenorrhea Mibavademab, Placebo - Functional Hypothalamic Amenorrhea, FHA | Phase 2 | Recruiting | Regeneron Pharmaceuticals | 34 | 2026-03-11 | 2026-11-04 |
| The Role of Estrogen in the Neurobiology of Eating Disorders 17-β estradiol transdermal patches, Placebo Patch, Micronized progesterone 200 MG - Eating Disorders, Hypoestrogenemia | Phase 2 | Completed | Massachusetts General Hospital | 122 | 2019-06-13 | 2026-11-05 |
| Autologous PRP Intra Ovarian Infusion to Restore Ovarian Function in Menopausal Women Autologous PRP intra ovarian infusion, Autologous PFP intra ovarian infusion - Infertility, Female, Anovulatory Infertility | Phase 2 / Phase 3 | Recruiting | Genesis Athens Clinic | 100 | 2019-05-21 | 2026-07-08 |
| Atherosclerosis, Immune Mediated Inflammation and Hypoestrogenemia in Young Women 17beta Estradiol, Transdermal placebo patch, Progesterone - Estrogen Deficiency, Cardiovascular Disease (CVD) | Phase 2 | Completed | Cedars-Sinai Medical Center | 29 | 2017-01-01 | 2025-03-13 |
| Androgen Excess as a Cause for Adipogenic Dysfunction in PCOS Women Flutamide, Placebo - Polycystic Ovary Syndrome (PCOS) | Phase 2 | Completed | University of California, Los Angeles | 23 | 2013-04-01 | 2025-01-10 |
| Determination of the Lowest, Safe and Effective Dose of Proellex Proellex - Amenorrhea | Phase 1 / Phase 2 | Completed | Repros Therapeutics Inc. | 52 | 2010-08-01 | 2014-07-28 |
| Study of Leptin for the Treatment of Hypothalamic Amenorrhea r-metHuLeptin, Oral Contraceptive Pills (OCPs), Placebo - Amenorrhea | Phase 2 | Completed | Beth Israel Deaconess Medical Center | 20 | 2010-04-01 | 2017-05-17 |
| Treatment of Menorrhagia in Women With Thrombocytopenia Using Platelets or Platelets and Hormones Lo-Ovral Oral Contraceptive Pills, Placebo - sugar pill - Aplastic Anemia, Menorrhagia | Phase 1 / Phase 2 | Terminated | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | 1 | 2007-11-01 | 2013-07-19 |
| A Trial to Evaluate DR-2021 in Women With Secondary Amenorrhea DR-2021a, DR-2021b, DR-2021c - Amenorrhea | Phase 2 | Completed | Duramed Research | 180 | 2005-09-01 | 2014-07-30 |
| Effects of Anorexia Nervosa on Bone Mass in Adolescents Physiologic Estrogen/progesterone, Placebo - Anorexia Nervosa | Phase 2 / Phase 3 | Completed | Massachusetts General Hospital | 110 | 2003-07-01 | 2021-11-02 |
| GnRH Analogue for Ovarian Function Preservation in Hematopoietic Stem Cell Transplantation Patients Leuprolide Acetate, Questionnaire, Hematopoietic Stem Cell Transplantation - Amenorrhea, Premature Ovarian Failure | Phase 2 | Completed | M.D. Anderson Cancer Center | 60 | 2002-11-01 | 2013-07-09 |
| A Long-Term Study to Evaluate the Safety of Asoprisnil and Estrogen Administration to Postmenopausal Women Asoprisnil/Premarin - Postmenopause | Phase 2 | Completed | Abbott | 18 | 2001-04-01 | 2008-05-29 |
| A Study to Evaluate the Safety and Effectiveness of Asoprisnil and Estrogen Administration to Postmenopausal Women Asoprisnil/Premarin, Placebo and Premarin - Amenorrhea, Postmenopause | Phase 2 | Completed | Abbott | 105 | 2000-09-01 | 2008-05-29 |
| Pulsatile GnRH in Anovulatory Infertility GnRH, Pump - Hypogonadotropic Hypogonadism, Amenorrhea | Phase 2 | Unknown | Massachusetts General Hospital | 270 | 1989-01-01 | 2017-07-12 |
Anorexia Nervosa (2) · Infertility, Female (2) · Anemia, Aplastic (1) · Anovulation (1) · Cardiovascular Diseases (1) · Feeding and Eating Disorders (1) · Hirsutism (1) · Hyperandrogenism (1) · Hypogonadism (1) · Infertility (1) · Kallmann Syndrome (1) · Menorrhagia (1) · Oligomenorrhea (1) · Polycystic Ovary Syndrome (1)
Menstruation Disturbances (14) · Pathologic Processes (14) · Pathological Conditions, Signs and Symptoms (14) · Female Urogenital Diseases (6) · Female Urogenital Diseases and Pregnancy Complications (6) · Genital Diseases (6) · Urogenital Diseases (6) · Genital Diseases, Female (5) · Endocrine System Diseases (3) · Gonadal Disorders (3) · Adnexal Diseases (2) · Congenital Abnormalities (2) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (2) · Disorders of Sex Development (2) · Infertility (2)
Progesterone (4) · Estrogens, Conjugated (USP) (2) · asoprisnil (2) · Estradiol (1) · Flutamide (1) · Gonadotropin-Releasing Hormone (1) · Hematopoietic Stem Cell Transplantation (1) · Leuprolide (1) · Stem Cell Transplantation (1) · Surveys and Questionnaires (1) · metreleptin (1) · recombinant methionyl human leptin (1) · telapristone acetate (1)
Massachusetts General Hospital (3) · Abbott (2) · Beth Israel Deaconess Medical Center (1) · Cedars-Sinai Medical Center (1) · Duramed Research (1) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1) · Genesis Athens Clinic (1) · M.D. Anderson Cancer Center (1) · Regeneron Pharmaceuticals (1) · Repros Therapeutics Inc. (1) · University of California, Los Angeles (1)
United States (11) · Greece (1)
Agni Pantou, MD (1) · Chrisandra Shufelt, MD (1) · Christos S Mantzoros, MD, ScD (1) · Daniel Dumesic, MD (1) · Janet E Hall, M.D. (1) · Laura M Sterling, MD (1) · Madhusmita Misra, M.D., M.P.H. (1) · Madhusmita Misra, MD (1) · Naoto Ueno, MD, PhD (1) · Noel Bairey-Merz, MD (1) · Pamela Stratton, MD (1)
PMID 21464293, PMID 21593494, PMID 21660636, PMID 21698665, PMID 21741057, PMID 22282904, PMID 22728230, PMID 23341491, PMID 23382191, PMID 24021517, PMID 24703486, PMID 25148234, PMID 32034419, PMID 33045195, PMID 33051459, PMID 36400597, PMID 37610989, PMID 39097160, PMID 40294815
M01RR001032 (1), R01DK062249 (1), R01MH116205 (1), R34HD048526 (1), U54HD028138 (1)