47 completed, 12 unknown, 6 terminated, 2 not yet recruiting. 71 Phase 3, 8 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 71 | Completed 47, Unknown 12, Terminated 6, Not yet recruiting 2, Withdrawn 2, Active not recruiting 1, Recruiting 1 |
| Phase 2 | 8 | Completed 6, Terminated 1, Unknown 1 |
Follow Agranulocytosis: new trials by email Literature Review of Agranulocytosis trials Research Report on Agranulocytosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy of an Empirical Treatment With Amoxicillin-clavulanate (AC) Compared to the Combination Amoxicillin-clavulanate and Ciprofloxacin (AC+C) in the Outpatient Care of Chemotherapy-induced Fever in Adult Haematology Patients. amoxicillin-clavulanate, Amoxicillin-clavulanate ciprofloxacin - C15.378 | Phase 3 | Not yet recruiting | Versailles Hospital | 1526 | 2026-03-01 | 2026-03-19 |
| Study Evaluating PEG-G-CSF Injectionin Preventing Neutropenia After Chemotherapy PEG-G-CSF injection (Kexing Biopharmaceutical Co., Ltd.), PEG-G-CSF injection (Neulasta®，Amgen Europe B.V.) - Neutropenia, Chemotherapy-Induced Febrile, Breast Neoplasm Female | Phase 3 | Active not recruiting | Kexing Biopharm Co., Ltd. | 250 | 2025-01-09 | 2025-11-25 |
| A Study of Mavorixafor in Participants With Congenital and Acquired Primary Autoimmune and Idiopathic Chronic Neutropenic Disorders Who Are Experiencing Recurrent and/or Serious Infections Mavorixafor, Placebo - Neutropenia | Phase 3 | Recruiting | X4 Pharmaceuticals | 176 | 2024-06-06 | 2026-08-06 |
| Early Neutropenic Fever De-escalation of Antibiotics Study Cessation of antibiotics - Hematologic Malignancy, Febrile Neutropenia | Phase 3 | Not yet recruiting | Brigham and Women's Hospital | 260 | 2024-03-01 | 2024-02-26 |
| Lapelga vs Gastrofil Grastofil®, Lapelga - Multiple Myeloma, Lymphoma | Phase 3 | Unknown | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 74 | 2023-11-01 | 2023-11-03 |
| A Trial of Fosfomycin vs Ciprofloxacin for Febrile Neutropenia Fosfomycin Calcium - Febrile Neutropenia | Phase 3 | Unknown | Fundación para la Investigación Biosanitaria del Principado de Asturias | 156 | 2022-03-14 | 2023-09-14 |
| Amoxicillin-clavulanate Alone or in Combination With Ciprofloxacin in Low-Risk Febrile Neutropenic Adult Patients: A Prospective, Double-blind, Randomized, Non-Inferiority Multicenter, Phase III Clinical Trial. Placebo, Amoxicillin Clavulanate, Ciprofloxacin - Febrile Neutropenia | Phase 3 | Withdrawn | Poitiers University Hospital | 2022-03-01 | 2022-03-31 | |
| Effect of Tranexamic Acid and Calcium Dobesilate for Bleeding of Endometrial Origin Tranexamic Acid, Calcium dobesilate (Doxium) - Heavy. Mentrual Bleeding, Abormal utèrine Bleeding | Phase 2 / Phase 3 | Completed | District Headquarters Teaching Hospital Sahiwal | 100 | 2022-01-01 | 2024-11-27 |
| A Study of Amphotericin B Liposome for Injection in Patients With Persistent Neutropenia and Fever Amphotericin B liposomes - Neutropenia and Fever | Phase 3 | Unknown | CSPC ZhongQi Pharmaceutical Technology Co., Ltd. | 93 | 2021-12-15 | 2021-11-05 |
| Phase 3 Study to Evaluate the Safety and Efficacy of YPEG-rhG-CSF in Malignancies Receiving Chemotherapy YPEG-rhG-CSF, rhG-CSF/PEG-rhG-CSF - Non-Myeloid Malignancy | Phase 3 | Completed | Xiamen Amoytop Biotech Co., Ltd. | 398 | 2020-10-16 | 2022-02-09 |
| Efficacy of Lithium Against Chemotherapy Induced Neutropenia in Breast Cancer Patients Lithium Carbonate - Neutropenia | Phase 3 | Completed | Al-Azhar University | 50 | 2020-08-01 | 2022-10-21 |
| Granulocyte Colony Stimulating Factor for for the Prevention of Febrile Neutropenia in Epithelial Ovarian Cancer Long-acting granulocyte colony stimulating factor, Short-acting granulocyte colony stimulating factor - Chemotherapy-induced Neutropenia, Febrile Neutropenia, Drug-Induced | Phase 3 | Unknown | Lei Li | 200 | 2019-10-01 | 2019-10-08 |
| Long-acting G-CSF for Febrile Neutropenia long-acting granulocyte colony stimulating factor, Short-term granulocyte colony stimulating factor - Epithelial Ovarian Cancer, Colony Stimulating Factors | Phase 3 | Unknown | Lei Li | 556 | 2018-11-10 | 2018-11-14 |
| Study to Compare the Efficacy and Safety of F-627 and GRAN® F-627, GRAN® - Breast Cancer, Neutropenia | Phase 3 | Completed | EVIVE Biotechnology | 242 | 2018-04-12 | 2025-04-20 |
| Neulasta-controlled Trial of F-627 in Women With Breast Cancer Receiving Myelotoxic Chemotherapy F-627, Neulasta - Breast Cancer, Neutropenia | Phase 3 | Completed | EVIVE Biotechnology | 393 | 2018-04-12 | 2023-07-03 |
| Reduced Dose of Pegfilgrastim as Support for Chemotherapy for Breast Cancer Pegfilgrastim - Neutropenia | Phase 3 | Completed | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | 122 | 2017-05-15 | 2024-03-19 |
| SPI-2012 vs Pegfilgrastim in Management of Neutropenia in Breast Cancer Participants With Docetaxel and Cyclophosphamide SPI-2012, Pegfilgrastim, Docetaxel - Neutropenia, Breast Cancer | Phase 3 | Completed | Spectrum Pharmaceuticals, Inc | 237 | 2017-05-10 | 2022-03-02 |
| A Study to Evaluate the Efficacy, Safety and Immunogenicity of Leucostim® Versus Neupogen® in Breast Cancer Patients Leucostim 5µg/kg/day, Neupogen 5µg/kg/day - Breast Cancer | Phase 3 | Completed | Dong-A ST Co., Ltd. | 143 | 2017-01-12 | 2020-12-28 |
| Early Stoppage Versus Continuation of Antimicrobial Therapy in Low Risk Pediatric Cancer Patients With Febrile Neutropenia, Before Recovery of Counts: -DALFEN Study stoppage of antibiotics, amoxycillin/clavulanic acid, levofloxacin - Neutropenia, Febrile, Pediatric Cancer | Phase 3 | Terminated | All India Institute of Medical Sciences | 142 | 2017-01-01 | 2019-02-01 |
| Placebo-controlled Trial of F-627 in Women With Breast Cancer Receiving Myelotoxic Chemotherapy F-627, Placebo - Breast Cancer, Neutropenia | Phase 3 | Completed | EVIVE Biotechnology | 122 | 2016-08-01 | 2021-05-05 |
Showing 20 of 71. Sign in to see all of them.
Neutropenia (56) · Breast Neoplasms (19) · Febrile Neutropenia (17) · Fever (10) · Neoplasms (10) · Leukemia, Myeloid, Acute (8) · Mycoses (7) · Infections (6) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (5) · Burkitt Lymphoma (4) · Carcinoma, Ovarian Epithelial (4) · Hodgkin Disease (4) · Hot Flashes (4) · Immunoblastic Lymphadenopathy (4) · Intraocular Lymphoma (4)
Cytopenia (71) · Hemic and Lymphatic Diseases (71) · Leukocyte Disorders (71) · Leukopenia (71) · Hematologic Diseases (68) · Neoplasms (31) · Neoplasms by Site (26) · Skin Diseases (22) · Skin and Connective Tissue Diseases (22) · Breast Diseases (19) · Pathological Conditions, Signs and Symptoms (18) · Infections (15) · Neoplasms by Histologic Type (14) · Neutropenia (14)
pegfilgrastim (16) · Filgrastim (12) · Amoxicillin-Potassium Clavulanate Combination (4) · Ciprofloxacin (4) · Amphotericin B (3) · Cefepime (3) · Cyclophosphamide (3) · Granulocyte Colony-Stimulating Factor (3) · Levofloxacin (3) · Amsacrine (2) · Caspofungin (2) · Cytarabine (2) · Docetaxel (2) · Etoposide (2) · Fluconazole (2)
Pfizer (4) · Amgen (3) · Children's Oncology Group (3) · EVIVE Biotechnology (3) · Sandoz (3) · European Organisation for Research and Treatment of Cancer - EORTC (2) · Jiangsu HengRui Medicine Co., Ltd. (2) · Lei Li (2) · National Institute of Allergy and Infectious Diseases (NIAID) (2) · Spectrum Pharmaceuticals, Inc (2) · Academisch Ziekenhuis Maastricht (1) · Al-Azhar University (1) · All India Institute of Medical Sciences (1) · Basilea Pharmaceutica (1) · Biocad (1)
United States (22) · China (9) · Canada (7) · France (7) · Germany (7) · Hungary (6) · Italy (6) · Russia (6) · India (5) · Netherlands (5) · Spain (5) · Ukraine (5) · Argentina (4) · Czechia (4) · Mexico (4)
Lei Li, M.D. (2) · A Vulto, PhD (1) · Alan K. Burnett, MD, FRCP (1) · Alexander Pecheny, PhD (1) · Andrei Horinko, MD (1) · Andrei Rusin, MD,PhD (1) · Andrei Sinykov, PhD (1) · Arne Simon, MD (1) · Bart JA Rijnders, MD, PhD (1) · Bogdan Kotiv, MD, PhD (1) · Bruce Sachais, MD, PHD (1) · Byakhov Michael, MD, PhD (1)
PMID 28637287, PMID 12660125, PMID 15459300, PMID 15718314, PMID 15761020, PMID 15806544, PMID 16932345, PMID 17251531, PMID 17317205, PMID 17339189, PMID 19467544, PMID 19596586, PMID 20038732, PMID 20231680, PMID 21394050, PMID 21837771, PMID 22271702, PMID 23317527, PMID 24166522, PMID 24618935, PMID 25020130, PMID 25851633, PMID 26122726, PMID 26333778, PMID 26619462, PMID 26796810, PMID 27020170, PMID 28459966, PMID 28597967, PMID 29524595, PMID 30824956, PMID 31022078, PMID 31220256, PMID 31467066, PMID 31688884, PMID 32944800, PMID 33384016, PMID 33891293, PMID 34858760, PMID 37561579, PMID 37891616, PMID 38103088, PMID 39272058, PMID 40098083, PMID 42164340, PMID 42606118
U10CA095861 (2), 2014 (1), 2016 (1), 2023 (1), 2025 (1), P30CA012197 (1), U01HL072268 (1), UG1CA189955 (1)